On August 24, 2011, Ano, Yusuke; Tobisu, Mamoru; Chatani, Naoto published an article.Quality Control of Methyl 6-chloro-6-oxohexanoate The title of the article was Palladium-catalyzed direct ethynylation of C(sp3)-H bonds in aliphatic carboxylic acid derivatives. And the article contained the following:
The first catalytic alkynylation of unactivated C(sp3)-H bonds has been accomplished. The method allows for the straightforward introduction of an ethynyl group into aliphatic acid derivatives under palladium catalysis. This new reaction can be applied to the rapid elaboration of complex aliphatic acids, for example, via azide/alkyne cycloaddition The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Quality Control of Methyl 6-chloro-6-oxohexanoate
The Article related to quinolinyltriisopropylsilylpentynamide derivative preparation, quinolinylamide preparation bromoalkyne alkynylation palladium catalyst, acid chloride aminoquinoline amidation and other aspects.Quality Control of Methyl 6-chloro-6-oxohexanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics