On April 30, 2016, Al-Ghorbani, Mohammed; Pavankumar, G. S.; Naveen, P.; Thirusangu, Prabhu; Prabhakar, B. T.; Khanum, Shaukath Ara published an article.COA of Formula: C7H4ClNO4 The title of the article was Synthesis and an angiolytic role of novel piperazine-benzothiazole analogues on neovascularization, a chief tumoral parameter in neoplastic development. And the article contained the following:
A novel series of benzoic acid N’-[2-(4-benzothiazol-2-yl-piperazin-1-yl)-acetyl]-hydrazides (6a-j) were synthesized and characterized by IR, 1H, 13C NMR, elemental and mass spectral analyses. The in-vitro cytotoxicity and cell viability assay of the synthesized compounds 6a-j were evaluated against Dalton’s lymphoma ascites (DLA) cells. The authors’ results showed that compound 3-bromobenzoic acid N’-[2-(4-benzothiazol-2-yl-piperazin-1- yl)-acetyl]-hydrazide (6c) with a bromo group on Ph ring has showed promising antiproliferative efficacy. Further investigation of compound (6c) on in-vivo treatment model depicts the increased tumor suppression through inhibition of angiogenesis. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4
The Article related to piperazine benzothiazole analog preparation antitumor neovascularization structure activity, antiproliferative angiogenesis piperazine benzothiazole analog, angiogenesis, antiproliferative, dla cells, piperazine–benzothiazole and other aspects.COA of Formula: C7H4ClNO4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics