On October 31, 1996, Al-Darwich, M. J.; Plenevaux, A.; Lemaire, C.; Fiore, G. D.; Christiaens, L.; Comar, D.; Luxen, A. published an article.Quality Control of 4-Chloro-2-fluorotoluene The title of the article was Enantioselective syntheses of no-carrier-added (n.c.a.) (S)-4-chloro-2-[18F] fluorophenylalanine and (S)-(α-methyl)-4-chloro-2-[18f] fluorophenylalanine. And the article contained the following:
Title compounds I (R = H, Me) were prepared and labeled with no carrier added 18F through a radiochem. synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F]fluorobenzyl iodide and the lithium enolate of 1,3-imidazolidinones II. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatog. (HPLC) purification, with a radiochem. yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F] fluoride. The enantiomeric excesses were ≥97% for both mols. without chiral separation and the radiochem. and chem. purities were ≥98%. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Quality Control of 4-Chloro-2-fluorotoluene
The Article related to asym preparation fluorine 18 chlorofluorophenylalanine, phenylalanine chlorofluoromethyl fluorine 18 asym preparation, stereoselective alkylation imidazolidinone chlorofluorobenzyl iodide and other aspects.Quality Control of 4-Chloro-2-fluorotoluene
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Chloride – Wikipedia,
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