Month: October 2022

Reddy, Raju Jannapu; Shankar, Angothu; Kumari, Arram Haritha published the artcile< An Efficient Sequential One-Pot Approach for the Synthesis of C3-Functionalized Imidazo[1,2-a]pyridines under Transition-Metal Free Conditions>, HPLC of Formula: 128-09-6, the main research area is imidazopyridine preparation; bromomethyl ketone aminopyridine thiosulfonate sulfenylation.

A metal-free sequential one-pot three-component protocol is described for the synthesis of C3-functionalized imidazo[1,2-a]pyridines. A successive construction of imidazo[1,2-a]pyridine I (R = 4-MeC6H4, 2-naphthyl, 2-thienyl, etc.; R1 = SMe, naphthalen-1-ylsulfanyl, pyridin-2-ylsulfanyl, etc.; X = H, 6-Br, 6-Cl, 7-Me, 8-Me) followed by iodine-catalyzed sulfenylation has been achieved in a one-pot operation from readily available α-bromomethyl ketones RC(O)CH2Br, 2-aminopyridines II and thiosulfonates R1S(O)2Ar (Ar = C6H5, 1-naphthyl, 2-thienyl, etc.). An immense array of 3-sulfenylimidazo[1,2-a]pyridines I was obtained in good to high yields. Also, the method is extended for the synthesis of C3-halogenated imidazo[1,2-a]pyridines I (R1 = Br, Cl) using sodium halides NaY in the presence of K2S2O8. Notably, the reaction between α-bromomethyl ketones and 2-aminopyridines in the presence of K2S2O8 to yields 3-bromo-2-aryl-imidazo[1,2-a]pyridines I (R1 = Br), thus implying α-bromomethyl ketones to be served as brominating agent. Overall, the present sequential one-pot protocol is straightforward, operationally simple, tolerates a broad range of functional groups, and is reliable for gram-scale experiments

Asian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, HPLC of Formula: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu published the artcile< Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5-6 fused rings as alternative S1 moieties>, Recommanded Product: 4-Chloro-2-methoxybenzaldehyde, the main research area is cis diamino cyclohexane derivative factor Xa inhibitor structure.

A series of cis-1,2-diaminocyclohexane derivatives were synthesized with the aim of optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5-6 fused rings as alternative S1 moieties resulted in two compounds which demonstrated improved solubility and reduced food effect compared to the clin. candidate, compound A. Herein, we describe the synthesis and structure-activity relationship (SAR), together with the physicochem. properties and pharmacokinetic (PK) profiles of some prospective compounds

Bioorganic & Medicinal Chemistry published new progress about Anticoagulants. 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Recommanded Product: 4-Chloro-2-methoxybenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zou, Xi; Sun, Guangwu; Huang, Hai; Wang, Jinping; Yang, Wen; Sun, Jianwei published the artcile< Catalytic Enantioselective Synthesis of 1,4-Benzodioxepines>, Safety of Methyl 4-chloro-2-hydroxybenzoate, the main research area is benzodioxepine enantioselective synthesis intramol desymmetrization oxetane benzylic alc.

An efficient organocatalytic enantioselective synthesis of chiral 1,4-benzodioxepines is described. By proper incorporation of an intramol. oxetane desymmetrization process, a range of benzylic alcs. bearing an internal oxetane reacted in the presence of a suitable chiral phosphoric acid catalyst to form chiral 1,4-benzodioxepines with high enantioselectivity. This process provides a new catalytic asym. example of direct synthesis of seven-membered heterocycles with good stereocontrol.

Organic Letters published new progress about Aralkyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (oxetane). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Safety of Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Chang; Wei, Xian; Hu, Zhe; Yang, Dan; Mei, Shiliang; Zhang, Guilin; Su, Danlu; Zhang, Wanlu; Guo, Ruiqian published the artcile< A fluorescent probe for Cd2+ detection based on the aggregation-induced emission enhancement of aqueous Zn-Ag-In-S quantum dots>, Quality Control of 22519-64-8, the main research area is zinc silver indium sulfur quantum dot fluorescent probe cadmium.

A sensitive and selective fluorescent probe for the cadmium ion (Cd2+) was developed based on the aggregation-induced emission enhancement (AIEE) of Zn-Ag-In-S quantum dots (ZAIS QDs). The QDs were synthesized by a convenient hydrothermal method with L-cysteine as ligands, with the average size of 3.2 nm and the emission peak at 520 nm. The interference study indicated the good selectivity of the probe. It has a broad detection range from 25μM to 2 mM and the detection limit is 1.56μM. AIEE is triggered by the interaction between Cd2+ and thiol groups on the surface of QDs, which causes weaker electrostatic repulsion between QDs and the passivation of surface defects. To the best of our knowledge, this is the first report on the AIEE of quaternary QDs. The method was successfully applied to the determination of Cd2+ in water samples with recoveries between 98.1% and 103.3%. This work shows its potential as a candidate for Cd2+ detection and provides a new understanding of AIEE.

Analytical Methods published new progress about Absorption. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Quality Control of 22519-64-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jheng, Li-Cheng; Hsu, Chung-Yen; Yeh, Hong-Yi published the artcile< Anion Exchange Membranes Based on Imidazoline Quaternized Polystyrene Copolymers for Fuel Cell Applications>, Quality Control of 1592-20-7, the main research area is imidazoline quaternized polystyrene copolymer anion exchange membrane fuel cell; anion exchange membranes; fuel cells; imidazoline; polystyrene.

Imidazoline is a five-membered heterocycle derived by the partial reduction of one double bond of the imidazole ring. This work prepared new anion exchange membranes (AEMs) based on imidazoline quaternized polystyrene copolymers bearing N-β-hydroxyethyl oleyl imidazolinium pendent groups to evaluate the application potential for anion exchange membrane fuel cells (AEMFCs). For comparison, an imidazole quaternized polystyrene copolymer was also synthesized. The polymer chem. structure was confirmed by FTIR, NMR, and TGA. In addition, the essential properties of membranes, including ion exchange capacity (IEC), water uptake, and hydroxide conductivity, were measured. The alk. stabilities of imidazolium-based and imidazolinium-based AEMs were compared by means of the changes in the TGA thermograms, FTIR spectra, and hydroxide conductivity during the alk. treatment in 1M KOH at 60°C for 144 h. The results showed that the imidazolinium-based AEMs exhibited relatively lower hydroxide conductivity (5.77 mS/cm at 70°C) but much better alk. stability compared with the imidazolium-based AEM. The imidazolinium-based AEM (PSVBImn-50) retained 92% of its hydroxide conductivity after the alk. treatment. Besides, the fuel cell performance of the imidazolium-based and imidazolinium-based AEMs was examined by single-cell tests.

Membranes (Basel, Switzerland) published new progress about Anion exchange membranes. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Quality Control of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kent, Caitlin N.; Fulton, Mark G.; Stillwell, Kaylee J.; Dickerson, Jonathan W.; Loch, Matthew T.; Rodriguez, Alice L.; Blobaum, Anna L.; Boutaud, Olivier; Rook, Jerri L.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W. published the artcile< Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model>, Application of C7H8ClN, the main research area is thiazepane metabotropic glutamate receptor pos allosteric modulator parkinsons disease; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Structure-activity-relationship (SAR); mGlu(4).

A high throughput screen (HTS) identified a novel, but weak (EC50 = 6.2μM, 97% Glu Max) mGlu4 PAM chemotype based on a 1,4-thiazepane core, VU0544412. Reaction development and chem. optimization delivered a potent mGlu4 PAM VU6022296 (EC50 = 32.8 nM, 108% Glu Max) with good CNS penetration (Kp = 0.45, Kp,uu = 0.70) and enantiopreference. Finally, VU6022296 displayed robust, dose-dependent efficacy in reversing Haloperidol-Induced Catalepsy (HIC), a rodent preclin. Parkinson’s disease model.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiparkinsonian agents. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application of C7H8ClN.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cao, Ren-Fei; Yu, Lu; Huo, Yu-Xuan; Li, Yao; Xue, Xiao-Song; Chen, Zhi-Min published the artcile< Chiral Lewis Base Catalyzed Enantioselective Selenocyclization of 1,1-Disubstituted Alkenes: Asymmetric Synthesis of Selenium-Containing 4H-3,1-Benzoxazines>, SDS of cas: 128-09-6, the main research area is alkene aryl selenylsuccinimide diphenylphosphinoamino binaphthyl catalyst enantioselective selenocyclization; aryl selenyl benzoxazine preparation.

An enantioselective selenocyclization of 1,1-disubstituted alkenes was achieved for the first time, which was enabled by a novel combination of a chiral BINAM-derived sulfide and an achiral Lewis acid. Various selenium-containing 4H-3,1-benzoxazines, which were widely present in a range of medicinally relevant mols., were readily obtained in moderate to good yields and good to excellent enantioselectivities. A series of tetrasubstituted carbon stereocenters were facilely constructed.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boyd, Derek R.; Sharma, Narain D.; Harrison, John S.; Malone, John. F.; McRoberts, W. Colin; Hamilton, John T. G.; Harper, David B. published the artcile< Enzyme-catalyzed synthesis and reactions of benzene oxide/oxepine derivatives of methyl benzoates>, Related Products of 22717-55-1, the main research area is Phellinus enzyme benzoate ester metabolism.

A series of twelve benzoate esters was metabolized, by species of the Phellinus genus of wood-rotting fungi, to yield the corresponding benzyl alc. derivatives and eight salicylates. The isolation of a stable oxepine metabolite, from Me benzoate, allied to evidence of the migration and retention of a carbomethoxy group (the NIH Shift), during enzyme-catalyzed ortho-hydroxylation of alkyl benzoates to form salicylates, is consistent with a mechanism involving an initial arene epoxidation step. This mechanism was confirmed by the isolation of a remarkably stable, optically active, substituted benzene oxide metabolite of Me 2-(trifluoromethyl)benzoate, which slowly converted into the racemic form. The arene oxide was found to undergo a cycloaddition reaction with 4-phenyl-1,2,4-triazoline-3,5-dione to yield a crystalline cycloadduct whose structure and racemic nature was established by X-ray crystallog. The metabolite was also found to undergo some novel benzene oxide reactions, including epoxidation to give an anti-diepoxide, base-catalyzed hydrolysis to form a trans-dihydrodiol and acid-catalyzed aromatization to yield a salicylate derivative via the NIH Shift of a carbomethoxy group.

Organic & Biomolecular Chemistry published new progress about Enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Related Products of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhuyan, Samuzal; Gogoi, Abhijit; Basumatary, Joneswar; Gopal Roy, Biswajit published the artcile< Visible-Light-Promoted Metal-Free Photocatalytic Direct Aromatic C-H Oxygenation>, SDS of cas: 22717-55-1, the main research area is benzene alc photochem oxygenation; hydroxyalkyl benzene photochem oxygenation.

A mild atom-economic visible-light photocatalytic approach was developed for single-step synthesis of diverse aryl alcs., ethers and esters through direct C-H functionalization of aromatic ring at ambient condition. This approach used DDQ as photocatalyst and TBN as co-catalyst to facilitate the substitution of aromatic C-H by neutral nucleophile oxygen of water, alcs. and carboxylic acids and it used aerobic oxygen as the terminal oxidant to produce water as the only byproduct.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mishra, Aniket; Mukherjee, Upasana; Sarkar, Writhabrata; Meduri, Sudha Lahari; Bhowmik, Arup; Deb, Indubhusan published the artcile< Diastereoselective Spirocyclization of Cyclic N-Sulfonyl Ketimines with Nitroalkenes via Iridium-Catalyzed Redox-Neutral Cascade Reaction>, Recommanded Product: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is diastereoselective spirocyclization cyclic sulfonyl ketimine nitroalkene; iridium catalyst redox neutral cascade reaction.

An Ir(III)-catalyzed [3 + 2] annulation of weakly coordinating N-sulfonyl ketimines with challenging α, β-unsaturated nitro olefins has been achieved via redox-neutral C-H functionalization in the presence of a catalytic amount of silver hexafluoroantimonate. The generation of three consecutive stereogenic centers in a single step via direct C-H functionalization is the prime feature of this methodol. A wide array of pharmaceutically relevant nitro-substituted spirocyclic benzosultams was synthesized with good to excellent diastereoselectivity as well as in high yield starting from easily accessible substrates.

Organic Letters published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent) (stereoselective). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Recommanded Product: (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics