Month: October 2022

Rajput, Himadri; Changotra, Rahil; Kumar Sangal, Vikas; Dhir, Amit published the artcile< Photoelectrocatalytic treatment of recalcitrant compounds and bleach stage pulp and paper mill effluent using Au-TiO2 nanotube electrode>, Safety of 4-Chloro-2-methoxyphenol, the main research area is gold titanium dioxide chloroguaiacol nanotube photoelectrocatalytic treatment.

A simple anodization technique has been adopted for the synthesis of Au doped TiO2 nanotubes (Au/TiO2NTs) electrode. The physicochem. properties of Au/TiO2NTs electrodes have been studied using FE-SEM, Raman spectroscopy, FTIR, XRD, and UV-vis DRS anal. techniques and, compared with un-doped TiO2NTs electrodes. The optimization of process parameters has been carried out for the photoelectrocatalytic (PEC) degradation of 4-CG (4-Chloroguaiacol) under batch-mode experiments Au/TiO2 nanotube electrodes showed 84% degradation efficiency in 6 h under optimized conditions viz. 0.15 mM Au loading, 0.08 g L-1 electrolyte concentration, 0.03 A current and pH 3 under UV light irradiations. The degradation of 4-CG was validated with the quantification of generated ·OH and degradation intermediates/byproducts during the batch-mode PEC treatment. PEC degradation of 4-CG has also been assessed in recirculation mode to study the feasibility of synthesized Au/TiO2NTs electrodes to treat large volume of contaminant polluted wastewater. For the feasibility of industrial scale applications, pulp and paper mill effluent was subjected to the PEC degradation under recirculation mode using Au/TiO2NTs electrodes and significant reduction in COD and TOC values were observed Overall, the cost of elec. energy consumption was computed for all the batch and recirculation-mode PEC treatment of 4-CG as well as real pulp and paper mill effluent.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Absorption. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Safety of 4-Chloro-2-methoxyphenol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Suzuki, Takayoshi; Khan, Mohammed Naseer Ahmed; Sawada, Hideyuki; Imai, Erika; Itoh, Yukihiro; Yamatsuta, Katsura; Tokuda, Natsuko; Takeuchi, Jun; Seko, Takuya; Nakagawa, Hidehiko; Miyata, Naoki published the artcile< Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors>, COA of Formula: C8H8BrCl, the main research area is anilinobenzamide preparation selective sirtuin inhibitor; phenethyloxyanilinobenzamide preparation selective inhibition SIRT2; structure anilinobenzamide inhibition selectivity human sirtuin isoform.

Anilinobenzamides such as I [R = H, PhNHCO, PhNMeCO, PhCH2NHCO, PhCH2NMeCO, PhCH2CONH, PhCH2CONMe, cyclohexylmethoxy, Me2CHCH2O, PhCH2O, PhCH2CH2O, R2CH2CH2O, PhCH2CH2CH2O; R2 = 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 2-F3CC6H4, 3-F3CC6H4, 4-F3CC6H4, 2-FC6H4, 3-FC6H4, 4-FC6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 2-BrC6H4, 3-BrC6H4, 4-BrC6H4; R1 = H, (E)-PhCH:CH, (Z)-PhCH:CH, PhCH2CH2, PhNMeCO, PhNHCO, PhCONMe, PhCONH, R3CONH; R3 = Me, Me2CH, cyclohexyl, 4-piperidinyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl] were prepared as selective inhibitors of human sirtuin 2 (SIRT2), a deacetylase with potential involvement in neurodegenerative diseases such as Parkinson’s and Huntington’s diseases. In particular, phenethyloxyanilinobenzamides such as I (R = R2CH2CH2O; R1 = H; R2 = Ph, 3-FC6H4) were potent and selective SIRT2 inhibitors, with 3.5-fold greater SIRT2 inhibition and more than 35-fold greater selectivity for SIRT2 over SIRT1 and SIRT3 than the previously known dichlorophenylfuranylpropenamide SIRT2 inhibitor AGK2. I (R = PhCH2CH2; R1 = H) dose-dependently inhibited SIRT2 in human colon cancer HCT116 cells.

Journal of Medicinal Chemistry published new progress about Aromatic amides Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, COA of Formula: C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aktar, Bedriye Seda Kursun; Sicak, Yusuf; Tatar, Gizem; Oruc-Emre, Emine Elcin published the artcile< Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities>, Quality Control of 162046-61-9, the main research area is benzoyl hydrazone preparation antioxidant activity enzyme inhibition SAR; mol modeling.

Hydrazone compounds have high capacity in terms of antioxidant activity and enzyme inhibition activities such as anticholinesterase, tyrosinase, and urease. In this study, benzoyl hydrazones compounds RC(O)NHN=CHR1 (R = 4-ClC6H4, 2-F3CC6H4, 3,5-(CF3)2C6H3, etc.; R1 = 4-hydroxy-3,5-dimethoxyphenyl) were synthesized starting from 3,5-dimethoxy-4-hydroxybenzaldehyde. Antioxidant activity of the synthesized compounds was evaluated. In the β-carotene-linoleic acid and ABTS cation radical scavenging activities, compounds RC(O)NHN=CHR1 (R = 3,5-(CF3)2C6H3, R1 = 4-hydroxy-3,5-dimethoxyphenyl; R = 4-CH3OC6H4, R1 = 4-hydroxy-3,5-dimethoxyphenyl; R = 4-CF3OC6H4, R1 = 4-hydroxy-3,5-dimethoxyphenyl) stood out as the most active compounds, resp. In the anticholinesterase enzyme inhibition activity results, compound RC(O)NHN=CHR1 (R = 4-O2NC6H4, R1 = 4-hydroxy-3,5-dimethoxyphenyl) exhibited the best activity against AChE and BChE enzymes in the synthesis series. In addition, mol. docking anal. was performed to understand the inhibition mechanism of the synthesized compounds with target enzymes at the at. level. In the light of biol. activity and in silico studies, it has the potential to guide studies for the development of new drugs for Alzheimer disease in the future.

Turkish Journal of Chemistry published new progress about Antioxidants. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Quality Control of 162046-61-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wan, Zhuoya; Sun, Jingjing; Xu, Jieni; Moharil, Pearl; Chen, Jing; Xu, Junchi; Zhu, Junjie; Li, Jiang; Huang, Yixian; Xu, Pengfei; Ma, Xiaochao; Xie, Wen; Lu, Binfeng; Li, Song published the artcile< Dual functional immunostimulatory polymeric prodrug carrier with pendent indoximod for enhanced cancer immunochemotherapy>, Application of C9H9Cl, the main research area is cancer immunostimulatory anticancer agent doxorubicin indoximod tumor microenvironment immunity; Immuno-oncology; Immunochemotherapy; Indoleamine 2,3-dioxygenase; Indoximod.

Immunotherapy based on checkpoint blockade has been regarded as one of the most promising approaches towards many types of cancers. However, low response rate hinders its application due to insufficient tumor immunogenicity and immunosuppressive tumor microenvironment. To achieve an overall enhanced therapeutic outcome, we developed a dual-functional immuno-stimulatory polymeric prodrug carrier modified with pendent indoximod, an indoleamine 2,3-dioxygenase (IDO) inhibitor that can be used to reverse immune suppression, for co-delivery of Doxorubicin (Dox), a hydrophobic anticancer agent that can promote immunogenic cell death (ICD) and elicit antitumor immunity. The resulted carrier denoted as POEG-b-PVBIND, consisting of poly (oligo (ethylene glycol) methacrylate) (POEG) hydrophilic blocks and indoximod conjugated hydrophobic blocks, is rationally designed to improve immunotherapy by synergistically modulating the tumor microenvironment (TME). Our data showed that Dox-triggered ICD promoted intra-tumoral infiltration of CD8+ T cells and IFN-γ-production by CD8+ T cells. Meanwhile, cleaved indoximod significantly increased CD8+ T cell infiltration while reducing the immunosuppressive T regulatory cells (Tregs). More importantly, Dox/POEG-b-PVBIND micelles led to significantly improved tumor regression in an orthotopic murine breast cancer model compared to both Dox-loaded POEG-b-PVB micelles (a control inert carrier) and POEG-b-PVBIND micelles alone, confirming combination effect of indoximod and Dox in improving the overall antitumor activity. Indoleamine 2,3-dioxygenase (IDO) is an enzyme that can induce immune suppressive microenvironment in tumors. As a well-studied IDO inhibitor, indoximod (IND) represents a promising agent for cancer immunotherapy and could be particularly useful in combination with other chemotherapeutic agents. However, three major problems hinder its application: (1) IND is barely soluble in water; (2) IND delivery efficiency is limited (3) simultaneous delivery of two agents into tumor site is still challenging. Currently, most reports largely focus on improving the pharmacokinetic profile of IND alone via different formulations such as IND prodrug and IND nanocrystal. However, there is limited information about IND based co-delivery systems, especially for delivering hydrophobic chemotherapeutic agents. Here, we developed a new dual-functional polymeric prodrug carrier modified with a number of pendent IND units (denoted as POEG-b-PVBIND). POEG-b-PVBIND shows immunostimulatory and antitumor activities by itself. More importantly, POEG-b-PVBIND polymer is able to self-assemble into nano-sized micelles that are highly effective in formulating and codelivering other hydrophobic agents including doxorubicin (Dox), sunitinib (Sun), and daunorubicin (Dau), which can elicit antitumor immunity via promoting immunogenic cell death (ICD). We have shown that our new combination therapy led to a significantly improved antitumor activity in an aggressive murine breast cancer model (4T1.2).

Acta Biomaterialia published new progress about Animal organ. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rajan, Ida Angel Priya Samuel; Subramani, Muthuraman; Pushparathinam, Gopinath; Rajendran, Saravanakumar published the artcile< Environmentally Benign Transamidation Protocol for Weakly Nucleophilic Aromatic Amines with N-Acyl-2-piperidinones: Catalyst-, Additive-, Base- and Solvent-Free Condition>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is amide chemoselective green preparation; amine acyl piperidinone transamidation.

Transamidation of weakly nucleophilic aromatic amines was achieved under melt conditions and in absence of catalyst, activating agent, base and solvent to obtain amides RC(O)NHR1 [R = Me, Ph, 4-ClC6H4, etc.; R1 = 4-MeC6H4, 4-FC6H4, 2-OHC6H4, etc.]. Chemoselectivity of the protocol was demonstrated with transamidation of aniline-bearing protic carboxylic acid group and wide range of anilines. Broad applicability of the process was demonstrated with the synthesis of bioactive natural product amide, Avenanthranamide-A. Byproduct was isolated for re-use in synthesis of starting amide, manifests atom economy and sustainability of the protocol. The developed protocol was environmentally benign, operationally simple yet versatile for protection-deprotection free synthesis of amides, peptides and amide-based drugs.

Asian Journal of Organic Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shao, Pengcheng P.; Ye, Feng; Chakravarty, Prasun K.; Varughese, Deepu J.; Herrington, James B.; Dai, Ge; Bugianesi, Randal M.; Haedo, Rodolfo J.; Swensen, Andrew M.; Warren, Vivien A.; Smith, McHardy M.; Garcia, Maria L.; McManus, Owen B.; Lyons, Kathryn A.; Li, Xiaohua; Green, Mitchell; Jochnowitz, Nina; McGowan, Erin; Mistry, Shruti; Sun, Shu-Yu; Abbadie, Catherine; Kaczorowski, Gregory J.; Duffy, Joseph L. published the artcile< Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain>, Electric Literature of 5335-40-0, the main research area is aminopiperidine sulfonamide preparation calcium channel analgesic SAR.

The voltage-gated calcium channel Cav2.2 (N-type calcium channel) is a critical regulator of synaptic transmission and has emerged as an attractive target for the treatment of chronic pain. We report here the discovery of sulfonamide-derived, state-dependent inhibitors of Cav2.2. In particular, 19 (I) is an inhibitor of Cav2.2 that is selective over cardiac ion channels, with a good preclin. PK and biodistribution profile. This compound exhibits dose-dependent efficacy in preclin. models of inflammatory hyperalgesia and neuropathic allodynia and is devoid of ancillary cardiovascular or CNS pharmacol. at the doses tested. Importantly, 19 exhibited no efficacy in Cav2.2 gene-deleted mice. The discovery of metabolite 26 confounds further development of members of this aminopiperidine sulfonamide series. This discovery also suggests specific structural liabilities of this class of compounds that must be addressed.

Journal of Medicinal Chemistry published new progress about Allodynia. 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Electric Literature of 5335-40-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Terasaki, Masanori; Abe, Ryoko; Makino, Masakazu; Tatarazako, Norihisa published the artcile< Chronic toxicity of parabens and their chlorinated by-products in Ceriodaphnia dubia>, Formula: C8H7ClO3, the main research area is Ceriodaphnia paraben chlorinated byproduct chronic toxicity; Ceriodaphnia dubia; chlorinated by-products; chronic toxicity; multivariate analyses; preliminary risk assessment.

The chronic toxicity of 12 compounds of parabens and their chlorinated byproducts was investigated using 7-day Ceriodaphnia dubia test under static renewal condition in order to generate information on how to disinfect byproducts of preservatives that are discharged in aquatic systems. The mortality and inhibition of reproduction tended to increase with increasing hydrophobicity and decreased with the degree of chlorination of parabens. The EC50 values for mortality, offspring number, and first brood production ranged between 0.30-3.1, 0.047-12, and 1.3-6.3 mg L-1, resp. For the number of neonates, the most sensitive endpoint, the no-observed-effect concentration (NOEC) and lowest-observed-effect concentration (LOEC) values ranged from 0.63 to 10 mg L-1 and from 1.2 to 19 mg L-1, resp. Methylparaben (MP), benzylparaben (BnP), and dichlorinated BnP (Cl2BnP) elicited a significant decrease in offspring numbers even at their lowest concentration tested; the NOEC for these compounds was determined to be less than the lowest test concentration (1.3, 0.04, and 0.63 mg L-1 for MP, BnP, and Cl2BnP, resp.). Propylparaben (PP), chlorinated PP, isopropylparaben (iPP), and chlorinated iPP exhibited nonmonotonic concentration-dependent response; their NOEC and LOEC values could not be determined The multivariate approach involving principal component anal. and hierarchical cluster anal. revealed four groups that corresponded to the toxicol. profiles of parabens. Our results suggested that disinfection of parabens by chlorination could reduce aquatic toxicity of original compounds The findings obtained in our study together with the data available on paraben concentrations in aquatic systems can be used to perform preliminary risk assessment by comparing the predicted environmental concentration (PEC) with the predicted no-effect concentration (PNEC) for the marine aquatic environment. The calculated PEC/PNEC ratios ranged from 0.0012 to 0.2, with the highest value observed in MP. This suggested that there are negligible environmental risks for aquatic organisms at current use levels. © 2013 Wiley Periodicals, Inc. Environ Toxicol, 2013.

Environmental Toxicology published new progress about Aquatic toxicity. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Formula: C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jiajia; Xia, Yuanzhi; Lee, Sunwoo published the artcile< Transamidation for the Synthesis of Primary Amides at Room Temperature>, Related Products of 17082-09-6, the main research area is primary amide synthesis transamidation tosyl amide lactam benzamide.

Various primary amides have been synthesized using the transamidation of various tertiary amides under metal-free and mild reaction conditions. When (NH4)2CO3 reacts with a tertiary amide bearing an N-electron-withdrawing substituent, such as sulfonyl and diacyl, in DMSO at 25°C, the desired primary amide product is formed in good yield with good functional group tolerance. In addition, N-tosylated lactam derivatives afforded their corresponding N-tosylamido alkyl amide products via a ring opening reaction.

Organic Letters published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lyu, Xue-Li; Huang, Shi-Sheng; Huang, Yuan-Qiong; Song, Hong-Jian; Liu, Yu-Xiu; Li, Yong-Qiang; Yang, Shao-Xiang; Wang, Qing-Min published the artcile< Rhodium(III)-Catalyzed Cross-Coupling of Sulfoxonium Ylides with Quinoline-8-carboxaldehydes for Synthesis of Quinoline-1,3-diketones>, COA of Formula: C9H7ClO, the main research area is quinoline diketone preparation; sulfoxonium ylide quinoline carboxaldehyde coupling reaction rhodium catalyst.

Herein, a protocol for rhodium(III)-catalyzed aldehydic C(sp2)-H acylmethylation reactions of quinoline-8-carboxaldehydes I (R = H, 6-(4-methoxyphenyl), 5-(naphthalen-1-yl), etc.) using sulfoxonium ylides R1C(O)CH=S(O)Me2 (R1 = Ph, propan-2-yl, adamantan-1-yl, etc.) as carbene precursors to afford 1,3-diketones II, which readily tautomerized to their enol forms was reported. The reaction mechanism was determined by synthesizing the key intermediate, a five-membered-ring acylrhodium species were determined

Asian Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Yansong; Lu, Zijing; Wang, Pengcheng; Xu, Jianing; Wang, Li; Fan, Yong published the artcile< Immobilized dyes within anionic indium coordination polymer for photocatalytic 1O2 generation>, Product Details of Cl3H8InO4, the main research area is immobilized dye anionic indium coordination polymer photocatalytic singlet oxygen.

A new anionic indium coordination polymer, (Me2NH2)[In(OH-BDC)2]·H2O (1), has been designed and synthesized under solvothermal conditions based on organic ligand 5-hydroxyisophthalic acid. 1 exhibits a 2D layered structure with rhombic windows, which is stacked to form 3D supramol. network by the π-π stacking interactions of Ph rings of ligand in adjacent layers. It not only shows excellent resistance to acid or basic conditions but also has good tolerance to various common solvents. Moreover, due to the neg. charge of the host framework, it shows remarkable selective adsorption for pos. charge dyes such as methylene blue (MB), rhodamine B (RhB) and crystal violet (CV), and the removal rates are higher than 90%. In particular, the adsorption capability of 1 to RhB is higher than most CPs based adsorbents. In addition, MB@1 is a high-efficiency reactive oxygen species (ROS) producer with good photocatalytic activity for the oxidation of 1,5-dihydroxynaphthalene (1,5-DHN) and can be recycled five times without loss of activity. To our knowledge, it is the first time that dye@CP was used for ROS production and photooxidation of 1,5-DHN.

Microporous and Mesoporous Materials published new progress about Adsorption. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Product Details of Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics