Month: October 2022

Song, Ming-Yu; Cao, Chen-Yu; He, Qiu-Rui; Dong, Qing-Miao; Li, Ding; Tang, Jiang-Jiang; Gao, Jin-Ming published the artcile< Constructing novel dihydrofuran and dihydroisoxazole analogues of isocombretastatin-4 as tubulin polymerization inhibitors through [3+2] reactions>, Application In Synthesis of 53581-86-5, the main research area is dihydrofuran dihydroisoxazole isocombretastatin analog preparation tubulin polymerization inhibitor; Combretastatin-4; Dihydrofuran; Dihydroisoxazole; Isocombretastatin-4; Tubulin polymerization inhibitors; [3+2] reactions.

[3+2] Reactions play a key role in constructing various pharmaceutical moleculars. In this study, using Mn(OAc)3 mediated and 1,3-dipolar [3+2] cyclization reactions, 38 novel dihydrofuran and dihydroisoxazole analogs of isoCA-4 were synthesized as inhibitors of tubulin polymerization Among them, compound 6g (5-(3-(4-chlorophenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazol-5-yl)-2-methoxyphenol) was found to be the most potent cytotoxic agents against PC-3 cells with IC50 value of 0.47 μM, and compound 5p ((5-(3-hydroxy-4-methoxyphenyl)-2-phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydrofuran-3-yl)(phenyl)methanone) exhibted highest activity on HeLa cells with IC50 vaule of 2.32 μM. Tubulin polymerization assay revealed that 6g was a dose-dependent and effective inhibitor of tubulin assembly. Immunohistochem. studies and cell cycle distribution anal. indicated that 6g severely disrupted microtubule network and significantly arrested most cells in the G2/M phase of the cell cycle in PC-3 cells. In addition, mol. docking studies showed that two chiral isomers of 6g can bind efficiently and similarly at colchicine binding site of tubulin.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Application In Synthesis of 53581-86-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arikawa, Yasuyoshi; Nishida, Haruyuki; Kurasawa, Osamu; Hasuoka, Atsushi; Hirase, Keizo; Inatomi, Nobuhiro; Hori, Yasunobu; Matsukawa, Jun; Imanishi, Akio; Kondo, Mitsuyo; Tarui, Naoki; Hamada, Teruki; Takagi, Terufumi; Takeuchi, Toshiyuki; Kajino, Masahiro published the artcile< Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)>, Recommanded Product: 3-(Methylsulfonyl)benzenesulfonyl Chloride, the main research area is pyrrole fluorophenylpyridinylsulfonyl preparation gastric acid secretion inhibitor; proton potassium ATPase gastric inhibitor pyrrole fluorophenylpyridinylsulfonyl.

In our pursuit of developing a novel and potent potassium-competitive acid blocker (P-CAB), we synthesized pyrrole derivatives focusing on compounds with low log D and high ligand-lipophilicity efficiency (LLE) values. Among the compounds synthesized, the compound I exhibited potent H+,K+-ATPase inhibitory activity and potent gastric acid secretion inhibitory action in vivo. Its maximum efficacy was more potent and its duration of action was much longer than those of proton pump inhibitors (PPIs). Therefore, compound I (1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate, TAK-438) was selected as a drug candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer, and other acid-related diseases.

Journal of Medicinal Chemistry published new progress about Digestive tract disease. 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Recommanded Product: 3-(Methylsulfonyl)benzenesulfonyl Chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Liang; Li, Meng; Gao, Qingyu; Chen, Chuanfeng published the artcile< Synthesis and properties of new organic luminescent materials based on halogen-substituted phthalimides>, Application In Synthesis of 118-45-6, the main research area is halogen phthalimide preparation crystal structure fluorescence phosphorescence spectral property.

A new kind of organic luminescent materials containing halogen-substituted phthalimide group and carbazole subunit have been conveniently synthesized. They not only showed strong aggregation-induced emission (AIE) effect, but also exhibited thermally activated delayed fluorescence (TADF) in films and crystallization-induced room-temperature phosphorescence (RTP) properties. Especially, RTP with marked afterglow for Br-AI-Cz was observed by naked eye, which could be used as the promising smart materials for the encryption application.

Youji Huaxue published new progress about Aggregation-induced emission. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application In Synthesis of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Wen-Li; Jin, Ren-Hua published the artcile< A unique polymersome covered by loop-cluster polyamine corona>, Product Details of C9H9Cl, the main research area is methyloxazoline phenyloxazoline amphiphilic diblock RAFT polymerization self assembly.

In this work, we synthesized a new comb-like copolymer (c-iMP) possessing amphiphilic diblock side chains consisting of poly(methyloxazoline) (PMOZ) and poly(phenyloxazoline) (PPOZ) via reversible addition-fragmentation chain-transfer (RAFT) polymerization of p-choloromethylstyene (CMS) and cationic ring-opening polymerization (CROP) of 2-methyl-2-oxazoline (MOZ) and 2-phenyl-2-oxazoline (POZ). Then, by performing selective hydrolysis of the hydrophilic PMOZ block, the PMOZ block was transformed into PEI (polyethylenimine) from which comb-like copolymers (c-iEP) possessing two blocks of PEI (E) and PPOZ (P) were produced. The comb-copolymers c-iEP showed unique self-assembling behavior in water to give an unusual polymersome covered by a loop-cluster polyamine corona. The polymersome showed extreme toughness and stability without collapse and fusion even at dry conditions and could be transformed into capsules. This is the first example of polymersome without free-ends on the vesicle wall which could include Ag ions inside and could deposit silica around the wall to form hybrid hollow spheres.

RSC Advances published new progress about Aggregates. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Product Details of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fotsch, Christopher; Biddlecome, Gloria; Biswas, Kaustav; Chen, Jian Jeff; D’Amico, Derin C.; Groneberg, Robert D.; Han, Nianhe Bruce; Hsieh, Feng-Yin; Kamassah, Augustus; Kumar, Gondi; Lester-Zeiner, Dianna; Liu, Qingyian; Mareska, David A.; Riahi, Babak Bobby; Wang, Yueh-Ju Judy; Yang, Kevin; Zhan, James; Zhu, Joe; Johnson, Eileen; Ng, Gordon; Askew, Benny C. published the artcile< A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core>, COA of Formula: C7H6Cl2O2S, the main research area is bradykinin receptor antagonist piperidine tetralin preparation SAR.

The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. In this report, we describe a new class of B1 receptor antagonists that contain the piperidine acetic acid tetralin core. A structure-activity relationship for these analogs is described in this paper. The most potent compounds from this class have IC50s < 20 nM in a B1 receptor functional assay. One of these compounds, I, shows modest oral bioavailability in rats. Bioorganic & Medicinal Chemistry Letters published new progress about Bradykinin B1 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, COA of Formula: C7H6Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Trachtenberg, Edward N.; Odian, Geo. published the artcile< Conjugative transmission in cyclopropane systems>, Computed Properties of 90940-40-2, the main research area is .

The pK values of a series of m- and p-substituted trans-2-phenylcyclopropanecarboxylic acids (I) in dilute aqueous solution at 25° were determined potentiometrically and the Hammett ρ for the reaction was calculated The pK values were determined for the following I (substituent and pK given): m-NO2 4.408, p-NO2 4.448, m-Cl 4.514, p-Cl 4.529, p-H 4.570, p-AcNH 4.570, p-Me 4.597, p-MeO 4.617. For comparison were determined the pK values for the following p-XC6H4(CH2)2CO2H (X and pK given): NO2 4.542, Cl 4.655, H 4.709, Me 4.737, MeO 4.751. The values of ρ for trans-PhCH:CHCO2H, trans-2-phenylcyclopropanecarboxylic acid, and Ph(CH2)2CO2H were 0.466, 0.182, and 0.212 (0.204), resp.; these values indicate that the cyclopropane ring does not transmit conjugation.

Journal of the American Chemical Society published new progress about Conjugation (bond). 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Computed Properties of 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Belen’kii, L. I.; Gromova, G. P.; Krayushkin, M. M. published the artcile< Protonation and electrophilic trichloromethylation of 2,5- and 2,4-dichlorothiophenes>, Application In Synthesis of 31166-29-7, the main research area is electrophilic trichloromethylation chlorothiophene; protonation chlorothiophene.

Trichloromethylation of 2,5-dichlorothiophene (I) and 2,4-dichlorothiophene (II) with CCl4 and AlCl3 has been studied. The reaction of I was directed to position 3 with formation of 2,5-dichloro-3-(trichloromethyl)thiophene, the process being complicated by the formation of the isomeric 3,5-dichloro-2-(trichloromethyl)thiophene (III), and 4,5-dichloro-2-(trichloromethyl)thiophene, as well as linked products, i.e. a mixture of bis(dichlorothienyl)dichloromethanes. Trichloromethylation of II smoothly leads to III, along with a small amount of bis(3,5-dichloro-2-thienyl)dichloromethane. It was also found that as a result of protonation under the effect of HCland AlCl3, I was converted into II, which, under the reaction conditions exists in the form of σ-complex, i.e. the 2H-3,5-dichlorothiophenium ion, stable at room temperature The mechanism of trichloromethylation of I, including the ipso-attack by the CCl3+ cation and isomerization during protonation, is discussed.

Gazzetta Chimica Italiana published new progress about 31166-29-7. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, Application In Synthesis of 31166-29-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Im, Jeong Kyun; Yang, ByeongDo; Jeong, Ilju; Choi, Jun-Ho; Chung, Won-jin published the artcile< N-Chlorination-induced, oxidative ring contraction of 1,4-dimethoxyphthalazines>, Name: 5-Chloroisobenzofuran-1,3-dione, the main research area is dimethoxyphthalazine trichloroisocyanuric acid chlorination oxidative ring contraction; chlorophthalimide preparation.

A rarely explored oxidative ring contraction of electron-rich 1,2-diazine was described. Upon treatment with an electrophilic chlorinating reagent (TCICA), 1,4-dimethoxyphthalazines undergo an N-chlorination-induced ring contraction that was accompanied by the loss of one nitrogen atom. The scope of this unusual reactivity was examined with a range of 1,4-dimethoxyphthalazine derivatives In addition, a mechanism proceeding via a bicyclic species was proposed on the basis of an isolated reaction intermediate and DFT calculations

Tetrahedron Letters published new progress about Chlorination. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Name: 5-Chloroisobenzofuran-1,3-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Luo, Guoli; Liu, Yongchun; Ding, Na; Li, Xiaoxiao; Zhao, Zhigang published the artcile< Metal-Free C-H Functionalization of Allenamides: An Access to Branched Allylic Esters>, Safety of 1-Chloropyrrolidine-2,5-dione, the main research area is branched allylic ester preparation allenamide acyloxylation functionalization carboxylic acid.

A regioselective acyloxylation with carboxylic acids at the proximal carbon of allenamides by an N-iodosuccinimide-mediated C-H functionalization is reported. The reaction proceeds rapidly, is scalable to a gram scale, and displays a broad substrate scope, providing an efficient and practical protocol for the synthesis of branched allylic esters. Notably, protected amino acids were tolerated under the reaction conditions and afforded allylic amino acid esters in moderate yields.

ACS Omega published new progress about Acyloxylation. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Safety of 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics