Month: October 2022

Wang, Wenyuan; Chen, Hongjin; Yue, Youfeng; Zhang, Rui; Liu, Jian published the artcile< Electropolymerization of V-shape D-A-D type monomers for efficient and tunable electrochromics>, Recommanded Product: 4,5-Dimethoxybenzene-1,2-diamine, the main research area is electrochromic triphenylamine quinoxaline derivative preparation electrochem polymerization.

Five novel donor-acceptor-donor (D-A-D) type monomers (VQ1 ∼ VQ5) with a common V-shape configuration have been developed and further electropolymerized for electrochromic applications. The monomers were designed by introducing two triphenylamine groups into the 2- and 3- position of the quinoxaline derivates, resp. These redox-active monomers could be electrodeposited robustly on the ITO electrodes in an electrolyte solution via the oxidative coupling reactions between triphenylamine radical cations. The obtained thin polymer films (PVQ1 ∼ PVQ5) exhibited reversible redox behaviors and obvious color changes upon voltage variation. All these polymers exhibited excellent electrochromic performances involving high optical contrast (over 70%), short response time (less than 2 s) and high coloration efficiency (over 200 cm2 C-1). Moreover, the optical properties of these polymers in both neutral state and oxidation state can be tuned by variation of the addnl. substituents on the quinoxaline parts, resp.

Dyes and Pigments published new progress about Absorption spectra. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Recommanded Product: 4,5-Dimethoxybenzene-1,2-diamine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chien, Chih-Wei; Liu, Kwang-Ting; Lai, Chung K. published the artcile< Substituent effects in columnar β-diketonate metallomesogens>, Computed Properties of 3964-57-6, the main research area is diketonate copper palladium complex homologous series columnar mesophase preparation; crystal structure copper palladium diketonate complex; substituent effect copper palladium diketonate complex mesophase; liquid crystal copper palladium diketonate columnar mesophase preparation; metallomesogen diketonate columnar mesophase preparation.

A systematic study of the mesomorphic properties of two homologous series of copper(II) and palladium(II) complexes (1a-b) derived from unsym. β-diketonate derivatives (I) containing a variety of functional substituents (X = H, CH3, C2H5, OCH3, Cl, Br, I, CN) on the Ph ring is reported. These disk-like mols. all contain eight n-octyloxy chains, required for the formation of columnar phases appended to the central β-diketonate core. All complexes exhibited columnar phases studied by DSC, polarized optical microscopy and powder x-ray diffraction. The mesomorphic results indicated that all compounds formed stable enantiotropic columnar mesophases, and the formation of columnar phases was strongly dependent on the electronic and/or the steric factors of the substituents. For compounds containing bulky substituents (i.e. X = Me, Et) a rectangular columnar phase (Colr) was observed, however, other compounds containing electron-withdrawing substituents (i.e. X = Cl, Br, I) exhibited a hexagonal columnar phase (Colh). Most of the palladium(II) complexes, except for X = CH3 and OCH3 derivatives, have lower clearing temperatures than those of the copper(II) analogs, and this is probably due to a weaker mol. interaction between the cores in the palladium(II) complexes. Lattice constants for these two types of compound obtained by powder x-ray diffraction are insensitive to the metal center incorporated. These values were all relatively close in magnitude, which indicated that the two structures were quite similar. A satisfactory linear relation with a correlation coefficient of 0.974 between the clearing temperatures and the Hammett σp constants of substituents was obtained only for the copper complexes.

Journal of Materials Chemistry published new progress about Crystal structure. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 3964-57-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Xiu-dong; Ge, Bing-chen; Xu, Jiang-ping; Zhou, Zhong-zhen published the artcile< Synthesis, crystal structure and antitumor activity of 6-chloro-1-((6-chloropyridin-3-yl)methyl)-3-phenyl-1H-benzofuro[3,2-c]pyrazole>, Computed Properties of 22717-55-1, the main research area is benzofuropyrazole preparation crystal structure antitumor activity.

The title compound 6-chloro-1-((6-chloropyridin-3-yl)methyl)-3-phenyl-1H-benzofuro[3,2-c]pyrazole (I, C21H13Cl2N3O, Mr = 394.26) was synthesized and characterized by elemental anal., 1H NMR, 13C NMR and X-ray single-crystal diffraction. The structure reveals that the crystal belongs to the triclinic system, space group P1 with a = 7.8829(8), b = 10.3281(10), c = 11.7615(12)Å, α = 83.5552(2), β = 79.921(2), γ = 70.189(2) degree, V = 885.54(15)Å3, Z = 2, Dc = 1.479 g/cm3, μ = 0.383 mm-1, F(000) = 404, R = 0.0538 and wR = 0.1335 for 2453 observed reflections with I>2σ(I). The result revealed that the crystal structure of the title compound I was stabilized by three C-Cl···π interactions and π···πstacking interaction. In addition, the preliminary investigation showed that I exhibited remarkably good antitumor activity against the MCF-7 and A549 cell lines.

Chinese Journal of Structural Chemistry published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kubota, Chihiro; Morita, Daisuke; Fujita, Keisuke; Yamamoto, Sonoka; Suzuki, Toyoko; Okano, Kentaro; Funahashi, Masahiro; Horie, Masaki; Mori, Atsunori published the artcile< Thermally-induced doping of the regioregular polythiophene bearing alkylene spacered benzene-sulfonate group at the side chain>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is regioregular polythiophene alkylene spacered benzene sulfonate conductivity.

Regioregular polythiophene bearing a benzenesulfonate group, which involved an alkylene spacer between thiophene and benzene ring, was synthesized. The obtained polythiophene was shown to improve its conductivity by heating the polymer thin film through the transformation of the ester group into the corresponding sulfonic acid.

Heterocycles published new progress about Electric current-potential relationship. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ge, Qianqian; Liang, Xian; Ding, Liang; Hou, Jianqiu; Miao, Jibin; Wu, Bin; Yang, Zhengjin; Xu, Tongwen published the artcile< Guiding the self-assembly of hyperbranched anion exchange membranes utilized in alkaline fuel cells>, Safety of 1-(Chloromethyl)-4-vinylbenzene, the main research area is hyperbranched polyvinylbenzyl chloride diamine crosslinked anion exchange membrane; self assembly hyperbranched anion exchange membrane alk fuel cells.

Anion exchange membrane fuel cells (AEMFCs) can efficiently convert chem. energy into electricity at high pH. However, as the critical component, the existing anion exchange membranes (AEMs), cannot have both high stability and high conductivity, which is intrinsic to the conventional linear AEMs. To address this, here we report hyperbranched AEMs cross-linked by diamines and proposed a strategy to guide the self-assembly of hyperbranched AEMs, thereby regulating the membrane microphase morphol. We found that the chain length of the diamine crosslinking agents plays a significant role in guiding the formation of microphase separated morphol. inside hyperbranched AEMs and influences eventually the membrane conductivity and stability. The hyperbranched membrane HBM-6C exhibits the most distinct microphase separated morphol., leading to high conductivity and improved alk. stability. For instance, the hydroxide conductivity of HBM-6C membrane is 27.18 mS cm-1 at 30 °C, 2.7 times of the linear counterpart membrane [PTMVPMA][OH] (10 mS cm-1). A H2/O2 AEMFC assembled with HBM-6C membrane herein demonstrates a maximum power d. of 97 mW cm-2 at a c.d. of 190 mA cm-2. Our results would pave the way towards AEMs with novel chain architecture and stimulate further improvement in AEMFC performance.

Journal of Membrane Science published new progress about Alkaline fuel cells. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Safety of 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyganowski, Piotr published the artcile< Fully recyclable gold-based nanocomposite catalysts with enhanced reusability for catalytic hydrogenation of p-nitrophenol>, Category: chlorides-buliding-blocks, the main research area is nitrophenol hydrogenation recyclable gold nanocomposite catalyst reusability.

Nanocomposite (NC) materials, which demonstrate catalytic activity under mild conditions, have garnered considerable attention due to the environmental hazards associated with aromatic nitro compounds Herein, a novel in-situ synthesis of NCs with zero-valent Au (Au°) is proposed. These materials are based on suspension copolymers with mol. reactors that enable the fabrication of Au° and the enhancement of both the catalytic activity and reusability. NCs were obtained using amino-based nanoreactors (3-14 mmol per g of a polymer) derived from polyethyleneimine (PEI), 1-(2-hydroxyethyl)piperazine (HEP), 1,4-bis(3-aminopropyl)piperazine (APP). The resultant Au@PEI, Au@HEP, and Au@APP NCs were investigated using optical microscopy, SEM, and TEM. Addnl., the physiochem. structures of both the polymeric matrix and Au° were evaluated using, i.a., FT-IR and XRD. The so-obtained NCs were used as nanocatalysts (NCats) for the catalytic hydrogenation of 4-nitrophenol (4-NP) under mild conditions. The method developed for the synthesis of NCs produced gold-based NCats with 25-37% Au° content. The synergism between the polymeric matrix and Au° enabled the hydrogenation of 4-NP within approx. 30-38 min with a rate constants of 0.071 min-1 (Au@HEP) and 0.028 min-1 (Au@APP) and, resp. The spherical millimetric morphol. of the polymeric support facilitated the facile recyclability of NCats that maintained their catalytic activity for more than 10 cycles of 4-NP reduction

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about Hydrogenation. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gao, Mingshan; Duan, Lei; Luo, Jinfeng; Zhang, Lianwen; Lu, Xiaoyun; Zhang, Yan; Zhang, Zhang; Tu, Zhengchao; Xu, Yong; Ren, Xiaomei; Ding, Ke published the artcile< Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors>, Safety of 3-Chloro-5-methylaniline, the main research area is pyrazolopyrimidinylethynylbenzamide preparation discoidin domain receptor 1 inhibitor; antitumor activity pharmacokinetics pyrazolopyrimidine substituted ethynylbenzamide.

Discoidin domain receptor 1 (DDR1) is an emerging potential mol. target for new anticancer drug discovery. The authors have discovered a series of 3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl) ethynyl)benzamides that are selective and orally bioavailable DDR1 inhibitors. The two most promising compounds (I and II) inhibited the enzymic activity of DDR1, with IC50 values of 6.8 and 7.0 nM, resp., but were significantly less potent in suppressing the kinase activities of DDR2, Bcr-Abl, and c-Kit. Further study revealed that I bound with DDR1 with a Kd value of 0.6 nM, while it was significantly less potent to the other 455 kinases tested. The S(35) and S(10) selectivity scores of I were 0.035 and 0.008, resp. The compounds also potently inhibited the proliferation of cancer cells expressing high levels of DDR1 and strongly suppressed cancer cell invasion, adhesion, and tumorigenicity. Preliminary pharmacokinetic studies suggested that they possessed good PK profiles, with oral bioavailabilities of 67.4% and 56.2%, resp.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Safety of 3-Chloro-5-methylaniline.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kerru, Nagaraju; Gummidi, Lalitha; Bhaskaruni, Sandeep V. H. S.; Maddila, Surya Narayana; Jonnalagadda, Sreekantha B. published the artcile< Ultrasound-assisted synthesis and antibacterial activity of novel 1,3,4-thiadiazole-1H-pyrazol-4-yl-thiazolidin-4-one derivatives>, Related Products of 70057-67-9, the main research area is diphenylpyrazolyl phenylthiadiazolyl thiazolidinone preparation ultrasonication green chem antibacterial SAR.

An efficient multicomponent method was reported for the synthesis of biol. active 1,3,4-thiadiazole-1H-pyrazol-4-yl-thiazolidin-4-one hybrids I [R = H, 3-Cl, 3,4,5-tri-MeO, etc.] from the reaction of pyrazole-4-carbaldehyde, 5-(substituted phenyl)-1,3,4-thiadiazol-2-amines and 2-mercaptoacetic acid in ethanol under ultrasound irradiation Reactions gave excellent yields (91-97%) of desired products in short times (55-65 min) at 50°C. All the twelve new thiazolidin-4-one derivatives I were fully characterized by spectroscopic techniques and were screened for their antibacterial activity. Among the screened hybrids, derivatives I [R = 3-O2N, 4-O2N] showed fourfold (MBC = 156.3μg/cm3) and twofold (MBC = 312.5μg/cm3) stronger potency against Pseudomonas aeruginosa strain as compared to the standard ciprofloxacin. SAR studies revealed the importance of the functional groups on the Ph ring of 1,3,4-thiadiazol-2-amine moiety for varying bacterial activity. The electron-withdrawing (NO2) group at para- and meta-position played a significant role in enhancing the antibacterial activity. The prominent features of the described protocol are excellent yields, green protocol, catalyst-free, high atom economy (94%) and excellent carbon efficiency (98%).

Monatshefte fuer Chemie published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Related Products of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Rongrong; Yang, Zhipeng; Xu, Hui; Zhao, Hongkun published the artcile< Measurement and calculation of solid-liquid phase equilibrium for ternary 4-chlorophthalic anhydride + 3-chlorophthalic anhydride + acetone system>, Recommanded Product: 5-Chloroisobenzofuran-1,3-dione, the main research area is chlorophthalic acetone ternary system solid liquid phase equilibrium.

The solid-liquid phase equilibrium for ternary system of 4-chlorophthalic anhydride + 3-chlorophthalic anhydride + acetone was measured at different temperatures and the mutual solubility was obtained. Four isothermal phase diagrams were constructed according to the exptl. solubility There existed two pure solid phases at each temperature in the studied system, pure 4-chlorophthalic anhydride and pure 3-chlorophthalic anhydride, which were identified by the wet residue method of Schreinemakers’. The crystallization regions of the pure two solids increase with the decrease in temperature The exptl. solid-liquid phase equilibrium for ternary system was calculated using the Wilson and NRTL models, and the corresponding binary interaction parameters were obtained according to the solubility of binary system. The calculated results agree well with the exptl. data at different temperature Both the models give acceptable results for the investigated systems.

Fluid Phase Equilibria published new progress about Crystallization. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Recommanded Product: 5-Chloroisobenzofuran-1,3-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics