Month: October 2022

Takebuchi, Haruka; Kubosawa, Hiroki; Jin, Ren-Hua published the artcile< Synthesis and Thermo-responsiveness of Double Hydrophilic Block Copolymers with PNIPAM Coils and Poly(methyloxazoline)/Poly(ethyleneimine) Combs>, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene, the main research area is isopropylacrylamide methyloxazoline ethyleneimine comb coil block copolymer hydrophilicity thermoresponsivity.

Two types of double-hydrophilic comb-coil block copolymers, (PVBC-g-PMOZ)-b-PNIPAM and (PVBC-g-PEI)-b-PNIPAM, possessing combs of poly(methyloxazoline) (PMOZ)/crystalline poly(ethyleneimine) (PEI) and coils of thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) were synthesized by a combination of RAFT block copolymerization of 4-chloromethyl styrene and N-isopropylacrylamide (NIPAM), ring-opening polymerization of 2-methyloxazoline, and the selective hydrolysis of PMOZ. These polymers showed remarkable thermo-responsiveness to give thermo-induced aggregates with different morphologies.

Chemistry Letters published new progress about Cationic ring-opening polymerization. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Yu; Yang, Cheng-Li; Ye, Lei; Dong, Zhi-Bing published the artcile< Copper-Catalyzed C-S Formation for the Synthesis of Benzyl Phenyl Sulfides from Dithiocarbamates>, Recommanded Product: 1-Chloro-2-(chloromethyl)benzene, the main research area is benzyl phenyl sulfide green preparation; phenyl dithiocarbamate benzyl halide coupling copper catalyst.

An odorless and efficient protocol for the synthesis of benzyl Ph sulfides RSCH2R1 [R = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R1 = Ph, 4-MeOC6H4, 2-BrC6H4, etc.] was reported. Starting from environmentally friendly Ph dithiocarbamates and com. available benzyl halides as starting materials, the target compounds (benzyl Ph sulfides) could be obtained smoothly and easily by using copper salt as catalyst and Cs2CO3as base. This method featured ligand/additive-free, the use of readily available starting materials, inexpensive catalysts, and good substrate suitability, illustrating its potentially synthetic value for the convenient preparation of some biol. active mols.

Synthesis published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Recommanded Product: 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zinser, Caroline M.; Warren, Katie G.; Meadows, Rebecca E.; Nahra, Fady; Al-Majid, Abdullah M.; Barakat, Assem; Islam, Mohammad S.; Nolan, Steven P.; Cazin, Catherine S. J. published the artcile< Towards environmentally friendlier Suzuki-Miyaura reactions with precursors of Pd-NHC (NHC = N-heterocyclic carbene) complexes>, Synthetic Route of 1435-43-4, the main research area is palladium NHC complex preparation catalyst green Suzuki Miyaura; green Suzuki Miyaura aryl halide boronic palladium NHC catalyst.

The preparation of [NHC·H][Pd(η3-R-allyl)Cl2] complexes is disclosed and represents a facile, atom-economical, environmentally friendly and rapid synthesis. These palladates are immediate synthetic precursors to the well-known [Pd(NHC)(η3-R-allyl)Cl] complexes. Their activation leading to catalytically relevant species has been studied in the Suzuki-Miyaura reaction. The need for an activation step prior to the catalysis was examined The reaction scope showcases its ease and breadth in terms of functional group tolerance. Electron-donating and electron-withdrawing aryl chlorides and bromides were coupled effectively as well as heteroatom-containing and sterically hindered aryl halides. The catalytic reaction was conducted in ethanol with a weak and inexpensive inorganic base.

Green Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Synthetic Route of 1435-43-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Koo, Hyungmo; Kim, Hun Young; Oh, Kyungsoo published the artcile< (E)-Selective Friedel-Crafts acylation of alkynes to β-chlorovinyl ketones: Defying isomerizations in batch reactions by flow chemistry approaches>, Related Products of 17082-09-6, the main research area is beta chlorovinyl ketone diastereoselective preparation; alkyne acyl chloride Friedel Crafts acylation trichloroaluminum promoted flow.

The Friedel-Crafts acylation of alkynes stereoselectively provides (Z)-β-chlorovinyl ketones, whereas the AlCl3-promoted reaction yields a mixture of stereoisomeric β-chlorovinyl ketones. To develop the (E)-selective synthesis of β-chlorovinyl ketones (E)-RC(Cl):C(R2)COR1 [R = n-pentyl, c-hexyl, (CH2)2Ph, etc., R1 = cyclopropyl, Ph, 2-thienyl, etc., R2 = H, n-propyl], a flow chem. approach was devised for the Friedel-Crafts acylation of alkynes with acyl chlorides that defied the facile (E) → (Z) isomerization under AlCl3-promoted reaction conditions. Compared to batch reactions, the flow chem. approach provided a fast, clean, high yielding and stereoselective synthetic route to (E)-β-chlorovinyl ketones.

Organic Chemistry Frontiers published new progress about Acid halides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Pingping; Liu, Xu; Wang, Shi; Zeng, Qinghui; Wang, Zhinan; Li, Zengxi; Zhang, Liaoyun published the artcile< Confining Hyperbranched Star Poly(ethylene oxide)-Based Polymer into a 3D Interpenetrating Network for a High-Performance All-Solid-State Polymer Electrolyte>, Name: 1-(Chloromethyl)-4-vinylbenzene, the main research area is hyperbranched star PEO interpenetrating network solid polymer battery electrolyte; solid lithium battery electrolyte PEO polystyrene nanoconfinement crosslinking; 3D rigid framework; all-solid-state polymer electrolyte; hyperbranched star polymer; lithium-ion battery; nanoconfinement.

The original poly(ethylene oxide)-based polymer electrolytes normally show low ionic conductivity and inferior mech. property, which greatly restrict their practical application in all-solid-state lithium-ion batteries (LIBs). In this work, a hyperbranched star polymer with poly(ethylene glycol) Me ether methacrylate flexible chain segments is embedded into a three-dimensional (3D) interpenetrating crosslinking network created by the rapid one-step UV-derived photopolymerization of the cross-linker (ethoxylated trimethylolpropane triacrylate) in the presence of lithium salt. The rigid 3D network framework provides the polymer electrolyte with not only enhanced mech. behavior, including film-forming and dendrite-inhibiting capabilities, but also nanoconfinement effects, which can speed up polymer chain segmental dynamics and reduce the crystallinity of the polymer. Depending on this unique rigid-flexible coupling network, the prepared solid polymer electrolyte shows enhanced ionic conductivity (6.8 × 10-5 S cm-1 at 50 °C), widened electrochem. stability window (5.1 V vs Li/Li+), and enough mech. stability to suppress the growth of uneven Li dendrite (the Li sym. cells can operate steadily at both current densities of 0.05 and 0.1 mA cm-2 for 1000 h). Moreover, the assembled LiFePO4//Li cell also exhibited good cycle performance at 50 °C, making the hyperbranched star polymer electrolyte with a nanoconfined crosslinking structure to have potential application in high-safety and high-performance LIBs.

ACS Applied Materials & Interfaces published new progress about Activation energy. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Name: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yun-Feng; Wei, Ya-Feng; Tian, Jun; Zhang, Juan; Chang, Hong-Hong; Gao, Wen-Chao published the artcile< N-Thiohydroxy Succinimide Esters (NTSEs): Versatile Reagents for Selective Acyl and Acylthio Transfer>, HPLC of Formula: 128-09-6, the main research area is thiohydroxy succinimide ester preparation regioselective acyl transfer reaction.

Differentiation between similarly reactive sites in mols. represents an ongoing challenge of organic synthesis. Herein we described one kind of versatile reagents, N-thiohydroxy succinimide esters (NTSEs), serving as both acyl and acylthio surrogates for the diverse synthesis of ketones, thioesters, amides, and acyl disulfides by selective cleavage of similarly reactive C-S and N-S bonds.

Organic Letters published new progress about Amides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, HPLC of Formula: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Ming; Yao, Yu; Han, Yutong; Xie, Lili; Zhao, Xueling; Barsan, Nicolae; Zhu, Zhigang published the artcile< Ultrasensitive gas sensor based on nanocube In2O3-CNH composite at low operating temperature>, Product Details of Cl3H8InO4, the main research area is Indium oxide carbon nanohorn composite ultrasensitive gas sensor.

A facile solvothermal route prepared In2O3/CNH nanocomposites with different CNH concentrations All nanocomposites’ structural and morphol. properties were investigated by XRD, FESEM, TEM, XPS, and BET. The H2S sensing performance of the sensors based on them was tested, operated between 40°C and 300°C. The results showed that the optimal composition is In2O3/CNH (2 wt%) with a sensor signal to 2 ppm H2S, at an operating temperature of 70°C, of almost 3000. The sensors demonstrated excellent selectivity, low impact of humidity and good reproducibility and stability. The superior sensor performance is related to the p-n junction formation between the CNH and In2O3, which determines the increase of the surface band bending and the sensor response. The gas sensing mechanism is thoroughly discussed, and the In2O3/CNH nanocomposite sensor can be considered an ideal candidate for high-performance detection of H2S with low-power consumption.

Sensors and Actuators, B: Chemical published new progress about Band structure. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Product Details of Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Emert-Sedlak, Lori A.; Loughran, H. Marie; Shi, Haibin; Kulp, John L. III; Shu, Sherry T.; Zhao, Jielu; Day, Billy W.; Wrobel, Jay E.; Reitz, Allen B.; Smithgall, Thomas E. published the artcile< Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists>, SDS of cas: 16799-05-6, the main research area is antiviral HIV AIDS Nef antagonist; Antiretroviral drug discovery; HIV Nef; HIV-1; Nef inhibitors.

The HIV-1 Nef accessory factor enhances viral replication and promotes immune system evasion of HIV-infected cells, making it an attractive target for drug discovery. Recently the authors described a novel class of diphenylpyrazolodiazene compounds that bind directly to Nef in vitro and inhibit Nef-dependent HIV-1 infectivity and replication in cell culture. However, these first-generation Nef antagonists have several structural liabilities, including an azo linkage that led to poor oral bioavailability. The azo group was therefore replaced with either a one- or two-carbon linker. The resulting set of nonazo analogs retained nanomolar binding affinity for Nef by surface plasmon resonance, while inhibiting HIV-1 replication with micromolar potency in cell-based assays without cytotoxicity. Computational docking studies show that these nonazo analogs occupy the same predicted binding site within the HIV-1 Nef dimer interface as the original azo compound Computational methods also identified a hot spot for inhibitor binding within this site that is defined by conserved HIV-1 Nef residues Asp108, Leu112, and Pro122. Pharmacokinetic evaluation of the nonazo B9 analogs in mice showed that replacement of the azo linkage dramatically enhanced oral bioavailability without substantially affecting plasma half-life or clearance. The improved oral bioavailability of nonazo diphenylpyrazolo Nef antagonists provides a starting point for further drug lead optimization in support of future efficacy testing in animal models of HIV/AIDS.

Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, SDS of cas: 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Weibel, Peter A.; Hesse, Manfred published the artcile< Mass spectrometric behavior of nitrogen-containing compounds. 19. Substituent effect on mass spectrometric fragmentation. N-methylβ,β'-diphenyldiethylamines>, Reference of 16799-05-6, the main research area is mass spectra diphenethylamine; amine diphenethyl mass spectra.

The mass spectra of the title amines (I; R = H, p-NO2, m-NH2, p-F, m-OMe, etc.), prepared from N-methylphenethylamine reaction with RC6H4CH2CH2Br (R same as above) were examined The main mass spectral fragmentation mechanisms were discussed.

Helvetica Chimica Acta published new progress about Amines Role: PRP (Properties). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Reference of 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lutterbeck, Carlos Alexandre; Kern, Deivid Ismael; Machado, Enio Leandro; Kuemmerer, Klaus published the artcile< Evaluation of the toxic effects of four anti-cancer drugs in plant bioassays and its potency for screening in the context of waste water reuse for irrigation>, Product Details of C7H17Cl2N2O3P, the main research area is Lactuca Allium seedling anticancer drug toxicity potency; Anti-cancer drugs; Cytotoxicity; Genotoxicity; Mutagenicity; Phytotoxicity.

Anti-cancer drugs are compounds that are of high environmental relevance because of their lack of specific mode of action. They can be extremely harmful to living organisms even at low concentrations The present study evaluated the toxic effects of four frequently used anti-cancer drugs against plant seedlings, namely Cyclophosphamide (CP), Methotrexate (MTX), 5-Fluorouracil (5-FU) and Imatinib (IM). The phytotoxicity experiments were performed with Lactuca sativa seedlings whereas cytotoxicity, genotoxicity and mutagenicity investigations were performed with the well-established Allium cepa assays. MTX was the most phytotoxic compound, followed by 5-FU, CP and IM. Significant differences in the Mitotic Indexes (MI) were observed in three of the studied compounds (MTX, 5-FU and CP), indicating potential cytotoxic activity of these substances. Chromosome aberrations were registered in cells that were exposed to 5-FU, CP and IM. All the four compounds caused the formation of micronucleated cells indicating mutagenic potential. Besides, the assays performed with MTX samples presented a high number of cell apoptosis (cell death). Although it is unlikely that the pharmaceuticals concentrations measured in the environment could cause lethal effects in plants, the obtained results indicate that these compounds may affect the growth and normal development of these plants. So, both tests can constitute important tools for a fast screening of environmental contamination e.g. in the context of the reuse of treated wastewater and biosolids of agricultural purpose.

Chemosphere published new progress about Allium cepa. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Product Details of C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics