Month: October 2022

Joseph, Alex; Pai, Aravinda; Srinivasan, K. K.; Kedar, Tukaram; Thomas, Angel Treasa; Jessy, E. M.; Singla, Rajeev K. published the artcile< Synthesis and anticancer activity of some novel 3-(1,3,4-thiadiazol-2-yl)-quinazolin-4(3H)-ones>, Synthetic Route of 70057-67-9, the main research area is thiadiazolylquinazolinone preparation anticancer; quinazolinone thiadiazolyl preparation anticancer.

The synthesis of various thiadiazole-substituted quinazolin-4(3H)-ones was reported. Novel 3-(1,3,4-thiadiazol-2-yl)quinazolin-4(3H)-ones were synthesized by reaction of 5-alkyl/aryl-1,3,4-thiadiazol-2-amines with 2-methyl/phenyl-4H-1,3-benzoxazin-4-ones in the presence of pyridine. All the synthesized compounds were characterized by spectra and phys. data. In vitro anticancer activity of all the synthesized compounds was determined by MTT assay on HeLa cells. Most active compounds from in vitro studies were further evaluated for in vivo activity on Liquid tumor (Ehrlich’s Ascites Carcinoma; EAC)-induced mice. The anticancer activity of one of the compounds was comparable to that of cisplatin against HeLa cells, and this compound was also effective in preventing the growth of tumor in mice as indicated by decrease in progressive gain in body weight as well as increase in life span.

Orbital: The Electronic Journal of Chemistry published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Synthetic Route of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bradley, D. C.; Prevedorou-Demas, C. published the artcile< Metal oxide trialkylsilyl oxide polymers. II. Zirconium oxide trimethylsilyl oxide polymers>, Synthetic Route of 16799-05-6, the main research area is .

The partial hydrolysis of tetrakis(trimethylsilyloxy)zirconium in dioxane has been studied. Solid polymeric [ZrOx(OSiMe3)4-2x]n, which were soluble in organic solvents, were obtained. The variation of the number average degree of polymerization, n, as a function of the degree of hydrolysis, x, was analyzed in terms of structural models. At 150° in vacuo, the polymers disproportionated to tetrakis(trimethylsilyloxy)zirconium and more highly condensed polymers [ZrOy(OSiMe3)(4-2y)]m, where y > x, and m > n.

Journal of the Chemical Society published new progress about Hydrolysis. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Synthetic Route of 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hannout, I. B.; El-Sharief, A. M. S.; Ismail, I. M.; Mohamed, Y. A.; Ammar, Y. A.; Zahran, M. A. published the artcile< Some alkylated and chlorinated benzenesulfonamides with expected insecticidal and bactericidal activities>, Computed Properties of 42413-03-6, the main research area is benzenesulfonamide chloro preparation bactericide; chlorobenzenesulfonamide preparation bactericide.

Benzenesulfonic acid derivatives I (R1 = alkylamino, cyclohexylamino, substituted anilino, furfurylamino, pyrimidinylamino, substituted phenoxy) and II (R2 = cyclohexylamino, substituted anilino, pyridylamino, piperidino, morpholino) were prepared from the resp. benzenesulfonyl chlorides. I and II exhibited bactericidal activity.

Egyptian Journal of Pharmaceutical Sciences published new progress about 42413-03-6. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Computed Properties of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ali, Shaukat; van Mil, Harald G. J.; Richardson, Michael K. published the artcile< Large-scale assessment of the zebrafish embryo as a possible predictive model in toxicity testing>, Safety of 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is zebrafish embryo drug toxicity.

Background: In the drug discovery pipeline, safety pharmacol. is a major issue. The zebrafish has been proposed as a model that can bridge the gap in this field between cell assays (which are cost-effective, but low in data content) and rodent assays (which are high in data content, but less cost-efficient). However, zebrafish assays are only likely to be useful if they can be shown to have high predictive power. We examined this issue by assaying 60 water-soluble compounds representing a range of chem. classes and toxicol. mechanisms. Methodol./Principal Findings: Over 20,000 wild-type zebrafish embryos (including controls) were cultured individually in defined buffer in 96-well plates. Embryos were exposed for a 96 h period starting at 24 h post fertilization. A logarithmic concentration series was used for range-finding, followed by a narrower geometric series for LC50 determination Zebrafish embryo LC50 (log mmol/L), and published data on rodent LD50 (log mmol/kg), were found to be strongly correlated (using Kendall’s rank correlation tau and Pearson’s product-moment correlation). The slope of the regression line for the full set of compounds was 0.73403. However, we found that the slope was strongly influenced by compound class. Thus, while most compounds had a similar toxicity level in both species, some compounds were markedly more toxic in zebrafish than in rodents, or vice versa. Conclusions: For the substances examined here, in aggregate, the zebrafish embryo model has good predictivity for toxicity in rodents. However, the correlation between zebrafish and rodent toxicity varies considerably between individual compounds and compound class. We discuss the strengths and limitations of the zebrafish model in light of these findings.

PLoS One published new progress about Alkaloids Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study). 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Safety of 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Haibing; Pei, Xueliang; Fang, Xingzhong published the artcile< Comparative study on polyimides from isomeric 3,3'-, 3,4'-, and 4,4'-linked bis(thioether anhydride)s>, HPLC of Formula: 118-45-6, the main research area is polyimide isomeric thioether anhydride preparation thermal mech property.

Three isomeric bis(thioether anhydride) monomers, 4,4′-bis(2,3-dicarboxyphenylthio) di-Ph ketone dianhydride (3,3′-PTPKDA), 4,4′-bis(3,4-dicarboxyphenylthio) di-Ph ketone dianhydride (4,4′-PTPKDA), and 4-(2,3-dicarboxyphenylthio)-4′-(3,4-dicarboxyphenylthio) di-Ph ketone dianhydride (3,4′-PTPKDA), were prepared through multistep reactions. Their structures were determined via Fourier transform IR, NMR, and elemental anal. Three series of polyimides (PIs) were prepared from the obtained isomeric dianhydrides and aromatic diamines in N-methyl-2-pyrrolidone (NMP) via the conventional two-step method. The PIs showed excellent solubility in common organic solvents such as chloroform, N,N-dimethylacetamide, and NMP. Their glass transition temperatures decreased according to the order of PIs on the basis of 3,3′-PTPKDA, 3,4′-PTPKDA, and 4,4′-PTPKDA. The 5% weight loss temperatures (T5%) of all PIs in nitrogen were observed at 504-519 °C. The rheol. properties of isomeric PI resins based on 3,3′-PTPKDA/4,4′-oxydianiline/phthalic anhydride showed lower complex viscosity and better melt stability compared with the corresponding isomers from 4,4′- and 3,4′-PTPKDA. In addition, the PI films based on three isomeric dianhydrides and on 2,2′-bis(trifluoromethyl)benzidine had a low moisture absorption of 0.27-0.35%. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about Absorption (water). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, HPLC of Formula: 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P. published the artcile< Small molecule inhibitors of anthrax lethal factor toxin>, Category: chlorides-buliding-blocks, the main research area is anthrax lethal factor toxin quinoline structure activity preparation; Anthrax; Bacillus anthracis; Botulinum neurotoxin A; Desymmetrized; Hybrid compound; Lethal factor; Light chain; Matrix metalloprotease; Quinoline; Zinc metalloprotease.

This manuscript describes the preparation of new small mol. inhibitors of Bacillus anthracis lethal factor. The authors’ starting point was the sym., bis-quinolinyl compound (I) (NSC 12155). Optimization of one half of this mol. led to new LF inhibitors that were desymmetrized to afford more drug-like compounds

Bioorganic & Medicinal Chemistry published new progress about Anthrax lethal factors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Wei; Qi, Xinxin; Wu, Xiao-Feng published the artcile< Palladium-Catalyzed Thiocarbonylation of Benzyl Chlorides with Sulfonyl Chlorides for the Synthesis of Arylacetyl Thioesters>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is arylacetyl thioester preparation; chloromethyl benzene sulfonyl chloride thiocarbonylation palladium catalyst.

A convenient procedure for the synthesis of thioesters RCH2C(O)SR1 (R = Ph, 3,4-dimethylphenyl, naphthalen-1-yl, thiophen-3-yl, etc.; R1 = Ph, 2,4,6-trimethylphenyl, naphthalen-1-yl, etc.) has been developed via a palladium-catalyzed thiocarbonylation of benzyl chlorides RCH2Cl with sulfonyl chlorides R1S(O)2Cl. Various arylacetyl thioesters were produced in good yields by using sulfonyl chlorides as an odorless sulfur source. Furthermore, W(CO)6 exhibited dual roles as both a solid CO surrogate and reductant here.

Advanced Synthesis & Catalysis published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ganesan, Divakar; Chennapuram, Madhu; Begum, Zubeda; Seki, Chigusa; Okuyama, Yuko; Kwon, Eunsang; Uwai, Koji; Tokiwa, Michio; Tokiwa, Suguru; Takeshita, Mitsuhiro; Nakano, Hiroto published the artcile< Sugar based γ-amino alcohol organocatalyst for asymmetric michael addition of β-keto esters with nitroolefins>, Application In Synthesis of 5153-70-8, the main research area is sugar amino alc organocatalyst Michael addition ketoester nitroolefin.

Sugar based γ-amino alc. was used in asym. Michael addition of β-keto esters with nitroolefins for the first time affording the corresponding several chiral Michael adducts bearing quaternary chiral carbon center in moderate to good chem. yields and stereoselectivities (up to 98%, up to dr. 95:5, up to 84% ee).

Heterocycles published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Deng, Xiangping; Liu, Renbo; Li, Junjian; Li, Zhongli; Liu, Juan; Xiong, Runde; Lei, Xiaoyong; Zheng, Xing; Xie, Zhizhong; Tang, Guotao published the artcile< Design, synthesis, and preliminary biological evaluation of 3',4',5'-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents>, Quality Control of 22717-55-1, the main research area is trimethoxy flavonoid salicylate derivative antitumor tubulin mol docking.

According to the pharmacophore combination principle, a set of new 3′,4′,5′-trimethoxy flavonoid salicylate derivatives were designed, synthesized, and evaluated for biol. activity. The cytotoxicity evaluation revealed that compound 10v exhibited higher potency than 5-Fu against HCT-116 cells. Preliminary biol. activity studies showed that compound 10v could inhibit the colony formation and migration of HCT-116 cells. Besides, the Hoechst 33258 staining assay and flow cytometry revealed that treatment with compound 10v induced the apoptosis of HCT-116 cells in a concentration-dependent manner, while it had no effect on their cell cycle. The WB anal. suggested that HIF-1α, tubulin, HK-2, and PFK might be the potential pharmacophore targets of compound 10v. Tubulin was a potential drug target for compound 10v, which was explained by analyzing the crystal structure of compound 10v complexed with tubulin. These results indicated that compound 10v might be a promising anti-tumor agent candidate, deserving further optimization and evaluation.

New Journal of Chemistry published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Quality Control of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ning, Hui; Fei, Xiang; Tan, Zhonghao; Wang, Wenhang; Yang, Zhongxue; Wu, Mingbo published the artcile< In situ-fabricated In2S3-reduced graphene oxide nanosheet composites for enhanced CO2 electroreduction to formate>, Product Details of Cl3H8InO4, the main research area is indium trisulfide reduced graphene oxide nanosheet composite; electrochem reduction catalyst.

The use of renewable electricity to catalyze carbon dioxide reduction is a promising method for CO2 utilization. However, the lack of highly efficient catalysts for CO2 reduction seriously limits its industrial applications. As a prototype, an ultrathin indium sulfide nanosheet (In2S3 NS) was synthesized and fabricated in situ on reduced graphene oxide (RGO) to obtain an In2S3-RGO composite. Induced by the two-dimensional (2D) structure of graphene oxide, the thickness of the In2S3 NSs was reduced from 30.2 to 3.9 nm. Simultaneously, the (440) plane of In2S3 NSs was preferentially grown parallel to the graphene plane, which was proven to possess a higher selectivity in catalyzing CO2 electroreduction to formate than the (111) and (311) planes by d. functional theory calculations Attributed to the 2D structure and full exposure of the (440) planes, a large electrochem. active surface area and high d. of optimum active sites were both realized on the In2S3-RGO hybrids, leading to 91% faradaic efficiency of formate at -1.2 V vs. The reversible hydrogen electrode in 0.1 M KHCO3 is 3.5 times that of bulk In2S3 (26%). Our work provides an effective way to prepare 2D transition metal catalysts with controllable crystal face exposure for specific reactions.

ACS Applied Nano Materials published new progress about Density functional theory. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Product Details of Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics