Month: October 2022

Zhu, Ming-Ming; Fang, Yu; Chen, Yan-Chen; Lei, Yu-Qing; Fang, Li-Feng; Zhu, Bao-Ku; Matsuyama, Hideto published the artcile< Antifouling and antibacterial behavior of membranes containing quaternary ammonium and zwitterionic polymers>, Quality Control of 1592-20-7, the main research area is antifouling antibacterial membrane; Antibacterial; Antifouling; Membrane; Quaternary ammonium; Zwitterionic polymer.

To overcome the organic-/bio- fouling of the membrane, a dual-functional ultrafiltration membrane containing quaternary ammonium and zwitterionic polymers via quaternization and surface radical polymerization was designed, and its antifouling and antibacterial behavior was studied. In this work, poly(vinylidene fluoride)/poly(Me methacrylate-co-dimethylamino-2-Et methacrylate) (PVDF/P(MMA-co-DMAEMA)) blend membrane was quaternized by p-chloromethyl styrene (p-CMS), and the double bonds were introduced onto the membrane surface, which further participated in the polymerization of zwitterionic monomers on the membrane surface. The results indicated that the resultant membrane exhibited obviously improved hydrophilicity and weak pos. charge (isoelec. point, 7.49). The membrane presented higher flux recovery ratio and lower protein adhesion compared with the pure PVDF membrane. Meanwhile, the membrane showed high-efficiency broad-spectrum antibacterial performance, i.e., the bacteria killing efficiency of S. aureus and E. coli reached 98.2% and 97.0%, resp. Moreover, the membrane effectively inhibited bacterial adhesion, which is important for the long-term antibacterial properties of membrane. This antifouling and antibacterial PVDF membrane may have potential in the long-term filtration process, especially when dealing with microbiol. contaminated water.

Journal of Colloid and Interface Science published new progress about Antibacterial agents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Quality Control of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Granchi, Carlotta; Lapillo, Margherita; Glasmacher, Sandra; Bononi, Giulia; Licari, Cristina; Poli, Giulio; El Boustani, Maguie; Caligiuri, Isabella; Rizzolio, Flavio; Gertsch, Jurg; Macchia, Marco; Minutolo, Filippo; Tuccinardi, Tiziano; Chicca, Andrea published the artcile< Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor>, COA of Formula: C8H7ClO3, the main research area is benzoylpiperidine monoacylglycerol lipase inhibitor optimization antitumor.

Monoacylglycerol lipase (MAGL) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiol. and pathol. processes. The therapeutic potential of MAGL is linked to several diseases, including cancer. The development of MAGL inhibitors has been greatly limited by the side effects associated with the prolonged MAGL inactivation. Importantly, it could be preferable to use reversible MAGL inhibitors in vivo, but nowadays only few reversible compounds have been developed. In the present study, structural optimization of a previously developed class of MAGL inhibitors led to the identification of compound 23, which proved to be a very potent reversible MAGL inhibitor (IC50 = 80 nM), selective for MAGL over the other main components of the endocannabinoid system, endowed of a promising antiproliferative activity in a series of cancer cell lines and able to block MAGL both in cell-based as well as in vivo assays.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 85740-98-3 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mushtaq, Nafeesa; Sidra, Lala Rukh; Chen, Guofei; Tang, Yongmei; Xu, Lubo; Fang, Xingzhong published the artcile< Synthesis of cardo containing asymmetric poly(ether-naphthalimide-phthalimide)s>, Synthetic Route of 118-45-6, the main research area is cardo asym polyethernaphthalimidephthalimide.

A series of cardo based asym. polyimides containing bulky rigid naphthalimide and phthalimide groups were prepared from asym. monomer bishaloimide and bisphenols by solution polycondensation. Bishalo(naphthalimide-phthalimide) monomers containing different terminal leaving groups (Cl, F, NO2) were synthesized, and the reactivity difference of these monomers was compared for the successful synthesis of polyimides. The inherent viscosities of the polyimides were in the range 0.51 – 0.60 dL g-1 in N-methyl-2-pyrrolidone at 30 °C. These polyimides demonstrated good organosoly. and mech. properties with tensile strengths of 93 – 120 MPa, tensile moduli of 3.5 – 5.3 GPa and elongations at break of 2.8% – 4.3%. The polyimides showed high glass transition temperatures (Tg) ranging from 330 to 363 °C. The 10% weight loss (T10%) of asym. polyimides reached 436 – 500 °C in nitrogen and 417 – 476 °C in air. The water uptake of the polyimides was in the range 0.35% – 0.72%. © 2017 Society of Chem. Industry.

Polymer International published new progress about Cardo polymers, polyether-polyimides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Synthetic Route of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Robbins, Daniel W.; Hartwig, John F. published the artcile< A C-H Borylation Approach to Suzuki-Miyaura Coupling of Typically Unstable 2-Heteroaryl and Polyfluorophenyl Boronates>, Recommanded Product: 1-Chloro-3,5-difluorobenzene, the main research area is borylation Suzuki Miyaura coupling iridium palladium catalyst; heteroaryl polyfluorophenyl boronate preparation Suzuki Miyaura coupling.

A method for the synthesis of biaryls and heterobiaryls from arenes and haloarenes without the intermediacy of unstable boronic acids is described. Pinacol boronate esters that are analogous to unstable boronic acids are formed in high yield by iridium-catalyzed C-H borylation of heteroarenes and fluoroarenes. These boronates are stable in the solid state or in solution and can be generated and used in situ. They couple with aryl halides in the presence of simple palladium catalysts, providing a convenient route to biaryl and heteroaryl products that have been challenging to prepare via boronic acids.

Organic Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Recommanded Product: 1-Chloro-3,5-difluorobenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Harrill, Joshua A.; Freudenrich, Theresa; Wallace, Kathleen; Ball, Kenneth; Shafer, Timothy J.; Mundy, William R. published the artcile< Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment>, Formula: C7H17Cl2N2O3P, the main research area is primary cortical cell developmental neurotoxicity battery; Assay suite; Concentration-response; Developmental neurotoxicity; High content imaging; In vitro models; Toxicity screening.

Medium- to high-throughput in vitro assays that recapitulate the critical processes of nervous system development have been proposed as a means to facilitate rapid testing and identification of chems. which may affect brain development. In vivo neurodevelopment is a complex progression of distinct cellular processes. Therefore, batteries of in vitro assays that model and quantify effects on a variety of neurodevelopmental processes have the potential to identify chems. which may affect brain development at different developmental stages. In the present study, the results of concentration-response screening of 67 reference chems. in a battery of high content imaging and microplate reader-based assays that evaluate neural progenitor cell proliferation, neural proginitor cell apoptosis, neurite initiation/outgrowth, neurite maturation and synaptogenesis are summarized and compared. The assay battery had a high degree of combined sensitivity (87%) for categorizing chems. known to affect neurodevelopment as active and a moderate degree of combined specificity (71%) for categorizing chems. not associated with affects on neurodevelopment as inactive. The combined sensitivity of the assay battery was higher compared to any individual assay while the combined specificity of the assay battery was lower compared to any individual assay. When selectivity of effects for a neurodevelopmental endpoint as compared to general cytotoxicity was taken into account, the combined sensitivity of the assay battery decreased (68%) while the combined specificity increased (93%). The identity and potency of chems. identified as active varied across the assay battery, underscoring the need for use of a combination of diverse in vitro models to comprehensively screen chems. and identify those which potentially affect neurodevelopment. Overall, these data indicate that a battery of assays which address many different processes in nervous system development may be used to identify potential developmental neurotoxicants and to distinguish specific from generalized cytotoxic effects with a high degree of success.

Toxicology and Applied Pharmacology published new progress about Apoptosis. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Formula: C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ambala, Srinivas; Singh, Rohit; Singh, Maninder; Cham, Pankaj Singh; Gupta, Ria; Munagala, Gurunadham; Yempalla, Kushalava Reddy; Vishwakarma, Ram A.; Singh, Parvinder Pal published the artcile< Metal-free, room temperature, acid-K2S2O8 mediated method for the nitration of olefins: an easy approach for the synthesis of nitroolefins>, Application In Synthesis of 5153-70-8, the main research area is alkene sodium nitrate potassium persulfate TFA promoter diastereoselective nitration; nitroalkene preparation.

A simple, room temperature method for the nitration of olefins by using inexpensive sodium nitrite as a source of nitro groups in the presence of trifluoroacetic acid (TFA) and potassium persulfate (K2S2O8) under an open atm. Styrenes and mono-substituted olefins give stereo-selective corresponding E-nitroolefins under optimized conditions, however, 1,1-bisubstituted olefins give a mixture of E- and Z-nitroolefins. The optimized conditions work well with electron-donating, electron-withdrawing, un-substituted and heterocyclic styrenes and mono-substituted olefins and gave corresponding nitroolefins with good to excellent yields.

RSC Advances published new progress about Alkenes, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Komoto, Chiho; Nakamura, Tsutomu; Ohmoto, Nobuko; Kobayashi, Hironao; Yagami, Tatsurou; Nishiguchi, Kohshi; Iwaki, Koichi; Kuwahara, Akiko; Yamamori, Motohiro; Okamura, Noboru; Okumura, Katsuhiko; Sakaeda, Toshiyuki published the artcile< Three-dimensional, but not two-dimensional, culture results in tumor growth enhancement after exposure to anticancer drugs>, Application In Synthesis of 6055-19-2, the main research area is collagen gel droplet embedded culture drug sensitivity test chemosensitivity; cervical carcinoma WST1 assay anticancer.

Previously, we have adapted a recently developed three-dimensional chemosensitivity test, the collagen gel droplet embedded culture drug sensitivity test (CD-DST), for evaluation of chemosensitivity of 12 anticancer drugs against colorectal adenocarcinoma, and surprisingly, it was found that tumor growth enhancement was occasionally observed even after exposure to anticancer drugs. In this study, the CD-DST was applied for human cervical carcinoma cell line HeLa-Ohio (HeLa) cells and its MDR1/P-glycoprotein-overexpressing subline, Hvr100-6 cells, and 12 anticancer drugs were assessed in terms of chemosensitivity and deterioration of tumor, and the results were compared with those by two-dimensional WST-1 assay. Growth enhancement was observed in Hvr100-6 cells, not in HeLa cells, for mitomycin C with the ratio of total volume of colonies in the treated group to that in the untreated group (T/C%) of 135.0%, doxorubicin with T/C% of 162.5% and cyclophosphamide with T/C% of 122.0%, and this was not observed in WST-1 assay. Multidrug resistance was detected both for CD-DST and WST-1 assay. The values of T/C% in CD-DST were comparable with or higher than those of the survival fraction (%) in WST-1 assay, and modification of WST-1 assay procedure gave similar results, suggesting a higher resistance in three-dimensional than in two-dimensional culture. Further investigations should be addressed to the association of MDR1/P-glycoprotein with tumor growth enhancement.

Kobe Journal of Medical Sciences published new progress about Antitumor agents. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Application In Synthesis of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Yonghui; Yang, Ting; Liu, Qian; Ma, Yingli; Yang, Liuqing; Zhou, Ling; Xiang, Zhijun; Cheng, Ziqiang; Lu, Sijie; Orband-Miller, Lisa A.; Zhang, Wei; Wu, Qianqian; Zhang, Kathleen; Li, Yi; Xiang, Jia-Ning; Elliott, John D.; Leung, Stewart; Ren, Feng; Lin, Xichen published the artcile< Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists>, Application In Synthesis of 35852-58-5, the main research area is arylaryloxy thiazolyl amide preparation RORt inverse agonist immunomodulator; Crystal structure; RORγt inverse agonists; Th17 cell differentiation; Thiazole ether amides.

A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode anal. of a RORγt partial agonist (2c) revealed by co-crystal structure in RORγt LBD suggests that the inverse agonists do not directly interfere with the interaction between H12 and the RORγt LBD. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as 3m with a pIC50 of 8.0. Selected compounds in the series showed reasonable activity in Th17 cell differentiation assay as well as low intrinsic clearance in mouse liver microsomes.

Bioorganic & Medicinal Chemistry published new progress about Cell differentiation inducers. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Application In Synthesis of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics