Month: October 2022

Barlaam, Bernard; Boiko, Scott; Boyd, Scott; Dry, Hannah; Gingipalli, Lakshmaiah; Ikeda, Timothy; Johnson, Tony; Kawatkar, Sameer; Lorthioir, Olivier; Pike, Andy; Pollard, Hannah; Read, Jon; Su, Qibin; Wang, Haiyun; Wang, Huimin; Wang, Lianghe; Wang, Peng; Edmondson, Scott D. published the artcile< Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is preparation pyrazolyl pyrimidine derivative structure SYK inhibitor; Diamine; Kinase selectivity; SYK.

Hybridization of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimization of a novel pyrimidine-based series of potent and selective SYK inhibitors, where the original aminomethylene group was replaced by a 3,4-diaminotetrahydropyran group. The initial compound 5 achieved excellent SYK potency. However, it suffered from poor permeability and modest kinase selectivity. Further modifications of the 3,4-diaminotetrahydropyran group were identified and the interactions of those groups with Asp512 were characterised by protein X-ray crystallog. Further optimization of this series saw mixed results where permeability and kinase selectivity were increased and oral bioavailability was achieved in the series, but at the expense of potent hERG inhibition.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents (potential as). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Saha, Arijit; Wu, Chia-Ming; Peng, Rui; Koodali, Ranjit; Banerjee, Subhash published the artcile< Facile Synthesis of 1,3,5-Triarylbenzenes and 4-Aryl-NH-1,2,3-Triazoles Using Mesoporous Pd-MCM-41 as Reusable Catalyst>, Related Products of 5153-70-8, the main research area is triarylbenzene preparation nitrostyrene denitrative cyclotrimerization MCM41 supported palladium catalyst; triazole preparation nitrostyrene denitrative cycloaddition MCM41 supported palladium catalyst.

We report mesoporous nano-Pd-MCM-41 catalyzed rapid and efficient synthesis of 1,3,5-triarylbenzenes via de-nitrative cyclotrimerization of β-nitrostyrenes. All the reactions were very fast and high yielding. The Pd-MCM-41 was also very effective in catalyzing de-nitrative [3+2] cycloaddition of β-nitrostyrenes with TMSN3 to synthesize 4-aryl-NH-1,2,3-triazoles. The catalyst was reused at least up to eight times with min. loss of catalytic activity.

European Journal of Organic Chemistry published new progress about [3+2] Cycloaddition reaction (denitrative). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Related Products of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kajigaeshi, Shoji; Shinmasu, Yoichi; Fujisaki, Shizuo; Kakinami, Takaaki published the artcile< Halogenation using quaternary ammonium polyhalides. XXVI [1]. Chlorination of phenols with benzyltrimethylammonium tetrachloroiodate>, COA of Formula: C8H7ClO3, the main research area is chlorination phenol benzyltrimethylammonium tetrachloroiodate.

The reaction of phenols with [PhCH2NMe3]+ [ICl4]- in CH2Cl2 at room temperature gave chloro-substituted phenols in 73-91% yields.

Chemistry Express published new progress about Chlorination. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Mingxi; Wang, Mingjin; Cao, Song published the artcile< Copper(I)-catalyzed trifluoromethylation of phthalic anhydride derivatives with (trifluoromethyl)trimethylsilane>, Electric Literature of 118-45-6, the main research area is phthalic anhydride fluoromethylsilane trifluoromethylation copper catalyst; naphthalic anhydride fluoromethylsilane trifluoromethylation copper catalyst; fluoromethylhydroxyisobenzofuran lactone preparation; fluoromethylhydroxynaphthopyranone lactone preparation.

An efficient copper-catalyzed trifluoromethylation of substituted phthalic anhydrides using (trifluoromethyl)trimethylsilane (Me3SiCF3) as a nucleophilic trifluoromethylating reagent in the presence of 1,10-phenanthroline and KF, followed by quenching the reaction mixture with water was developed. A possible mechanism was suggested.

Chinese Journal of Chemistry published new progress about Anhydrides, cyclic Role: RCT (Reactant), RACT (Reactant or Reagent). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Electric Literature of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shen, Chun-Hui; Chen, Yao; Xu, Xin-Jie; Li, Xue-Yang; Wen, Xiao-Ju; Liu, Zong-Tang; Xing, Rong; Guo, He; Fei, Zheng-Hao published the artcile< Efficient photocatalytic H2 evolution and Cr(VI) reduction under visible light using a novel Z-scheme SnIn4S8/CeO2 heterojunction photocatalysts>, Synthetic Route of 22519-64-8, the main research area is hydrogen chromium tin indium sulfide cerium oxide photocatalyst photocatalysis; Cr(VI) reduction; H(2) production; SnIn(4)S(8)/CeO(2); Z-scheme.

Semiconductor photocatalysis technol. is a promising method for hydrogen production and water pollution treatment. Here, the SnIn4S8/CeO2 (SISC) composites were fabricated by a stirring and calcination method, and the mass ratio of SnIn4S8 to CeO2 was optimized. The 50 wt% SISC heterojunction photocatalyst has the highest visible light catalytic activity. The degradation rate of hexavalent chromium (Cr (VI)) is 98.8% in 75 min of light irradiation, which is 2.48 times that of pure CeO2. Besides, the 50 wt% SISC composite photocatalyst also has the highest photocatalytic hydrogen production efficiency (0.6193 mmol g-1 h-1), which exhibits a higher photocatalytic activity than pure CeO2 and SnIn4S8. The enhanced photocatalytic performance can be attributed to the Z-scheme heterojunction structure between CeO2 and SnIn4S8, which can effectively sep. and transfer photo-generated charges, thereby reducing the recombination of photo-generated carriers. We hope this work can provide ideas for constructing Z-scheme heterojunction structures and improving photocatalytic activity under visible light.

Journal of Hazardous Materials published new progress about Band gap. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Synthetic Route of 22519-64-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Koini, Eftychia N.; Alvonitis, Nicolaos; Calogeropoulou, Theodora published the artcile< Simple and efficient method for the halogenation of oxygenated aromatic compounds>, Application of C8H7ClO3, the main research area is oxygenated benzene acetic acid hydrogen peroxide hydrohalic chlorination bromination; arylchloride arylbromide preparation.

An efficient and mild method for the chlorination and bromination of oxygenated aromatics, with good regioselectivity and excellent yields, using a combination of HX/H2O2/AcOH in petroleum ether is presented. The effect of ultrasound was investigated.

Synlett published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (oxygenated). 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application of C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Riddell, Adam B.; Michalski, Michelle M.; Snowdon, Monika R.; Hirst, Mark J.; Schwan, Adrian L. published the artcile< N-Sulfanylimides as the Sulfur Source for Alkyl Allenyl Sulfoxides via [2,3]-Sigmatropic Rearrangement>, Synthetic Route of 128-09-6, the main research area is propargyl alc sulfanylsuccinimide sigmatropic rearrangement; alkyl allenyl sulfoxide preparation.

In this paper, N-sulfanylsuccinimides (thiosuccinimides) were shown to be a viable replacement for sulfenyl chlorides. A number of allenyl alkyl sulfoxides were prepared in fair to good yields (21-73%, 21 examples). In addition, some butyn-1,4-diols could be selectively monofunctionalized to form allenyl sulfoxides (26-71%) with a hydroxyalkyl group geminal to the sulfur. Butynediols also permitted synthetic access to dienes via successive sulfenate ester formation and [2,3]-sigmatropic rearrangement reactions. N-2-Trimethylsilylethylthosucinimides were among the highest yielding of the thioimides.

ChemistrySelect published new progress about [2,3]-Sigmatropic rearrangement. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Synthetic Route of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Nickel-Catalyzed Direct Synthesis of Quinoxalines from 2-Nitroanilines and Vicinal Diols: Identifying Nature of the Active Catalyst>, Computed Properties of 27841-33-4, the main research area is nitroaniline benzenediamine vicinal diol nickel dehydrogenative coupling cyclocondensation catalyst; quinoxaline preparation.

The inexpensive and simple NiBr2/1,10-phenanthroline system-catalyzed synthesis of a series of quinoxalines from both 2-nitroanilines and 1,2-diamines is demonstrated. The reusability test for this system was performed up to the seventh cycle, which afforded good yields of the desired product without losing its reactivity significantly. Notably, during the catalytic reaction, the formation of the heterogeneous Ni-particle was observed, which was characterized by PXRD, XPS, and TEM techniques.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Computed Properties of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics