Month: October 2022

Losev, Vladimir N.; Parfenova, Victoriya V.; Elsuf’ev, Evgeney V.; Borodina, Elena V.; Metelitsa, Segey I.; Trofimchuk, Anatoliy K. published the artcile< Separation and preconcentration followed by ICP-OES and ICP-MS determination of precious metals using silica gel chemically modified with dithiocarbamate groups>, SDS of cas: 128-09-6, the main research area is metal silica gel dithiocarbamate separation preconcentration ICPOES ICPMS.

Silica gel chem. modified with dithiocarbamate groups (DTCS) was used for separation and preconcentration of precious metals and their subsequent determination in geol. samples and their processing products by inductively coupled plasma optical emission spectrometry and inductively coupled plasma mass spectrometry. DTCS was characterized by TGA/DSC, FT-IR, and CHNS-anal. DTCS quant. extracted Au3+, Pd2+, Pt2+, Pt4+ at 20°C from 0.5 to 4.0 M HCl media and Rh3+, Ir4+, Ru4+, and Os4+ at 95°C in the presence of 0.025 M SnCl2. Two-column procedure was proposed to sep. precious metals from matrix components and to sep. kinetically inert precious metals from kinetically labile ones.

Separation Science and Technology (Philadelphia, PA, United States) published new progress about Adsorbents. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ferro, Stefania; Buemi, Maria Rosa; De Luca, Laura; Agharbaoui, Fatima E.; Pannecouque, Christophe; Monforte, Anna-Maria published the artcile< Searching for novel N1-substituted benzimidazol-2-ones as non-nucleoside HIV-1 RT inhibitors>, Product Details of C8H8BrCl, the main research area is benzimidazolone synthesis HIV1 reverse transcriptase inhibitor; Benzimidazolones; Design; RTs mutant; Reverse transcriptase inhibitors; Synthesis.

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent an integral part of the currently available combination antiretroviral therapy (cART) contributing to reduce the AIDS-mortality and turned the disease from lethal to chronic. In this context we recently reported a series of 6-chloro-1-(3-methylphenylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. In this paper, we describe the design and the synthesis of two novel series of benzimidazolone analogs in which the linker moiety between the Ph ring and the sulfonyl group was modified and new small lipophilic groups on the benzyl sulfonyl pendant were introduced. All the new obtained compounds were evaluated as RT inhibitors and were also tested against RTs containing single amino acid mutations. Finally, mol. docking studies were performed in order to rationalize the observed activity of the most promising compound

Bioorganic & Medicinal Chemistry published new progress about Anti-HIV agents. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Product Details of C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pandit, Neelanjana; Shah, Kamal; Agrawal, Neetu; Upmanyu, Neeraj; Shrivastava, Sushant K.; Mishra, Pradeep published the artcile< Synthesis, characterization and biological evaluation of some novel fluoroquinolones>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is fluoroquinolone thiadiazole derivative preparation bactericide fungicide.

Different derivatives of fluoroquinolones were synthesized by combining them with different thiadiazoles. The synthesized compounds were characterized by IR spectroscopy, proton NMR and mass spectral data. The compounds were screened for their antibacterial and antifungal activity. Ciprofloxacin thiadiazole 7c (I) showed good antibacterial as well as antifungal activities, whereas 13c and 13e (II; R1 = Cl, R2 = H and R1 = R2 = OMe, resp.) showed antibacterial and antifungal activity resp. Sparfloxacin derivative 8c (III) showed both antibacterial and antifungal activity. Sparfloxacin derivatives 14b and 14e (IV; R1 = H, R2 = Cl and R1 = R2 OMe) showed antibacterial and antifungal activity resp.

Medicinal Chemistry Research published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Doherty, Ann T.; Hayes, Julie E.; Molloy, Jennifer; Wood, Catherine; O’Donovan, Mike R. published the artcile< Bone marrow micronucleus frequencies in the rat after oral administration of cyclophosphamide, hexamethylphosphoramide or gemifloxacin for 2 and 28 days>, Synthetic Route of 6055-19-2, the main research area is cyclophosphamide monohydrate hexamethylphosphoramide Factive bone marrow micronucleus genotoxicity.

Cyclophosphamide (CPA), hexamethylphosphoramide (HMPA) and gemifloxacin (GF) were administered orally to Han Wistar rats for 2 and 28 days up to their maximum tolerated doses. For CPA, the sensitivity, as measured by the increases at the lowest active dose, was greater after 28 days. However, published data show that blood levels at 28 days are the same as at 2 days. The sensitivity to HMPA was also greater at 28 days but toxicokinetic anal. showed a reduction in blood levels. Although apparently anomalous, this probably reflected increased metabolism of HMPA to its genotoxic metabolite, formaldehyde. In contrast, GF gave a clear increase in micronucleus frequency after 2 doses but not after 28 and the maximum dose tolerated for 28 days gave blood levels 80% greater than the same dose after 2 days. It is apparent that for these three compounds there are differences between responses after dosing for 2 and 28 days that cannot be ascribed simply to differences in blood levels. It is important to note that although the responses were quant. different, the two established rodent carcinogens gave pos. results at both sampling times. Because rodent oncogenicity data are not available for GF, it is not known whether the pos. or neg. result in the rat bone marrow micronucleus test is predictive. The purpose of this work was not to support the use of either acute or sub-chronic dosing for the rat micronucleus assay but to point out that sampling times can give both qual. and quant. different results.

Toxicology Research (Cambridge, United Kingdom) published new progress about Bone marrow. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Synthetic Route of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sherbrook, Evan M.; Jung, Hoimin; Cho, Dasol; Baik, My-Hyun; Yoon, Tehshik P. published the artcile< Bronsted acid catalysis of photosensitized cycloadditions>, Application In Synthesis of 17082-09-6, the main research area is imidazolylpropenone preparation alkene ruthenium Bronsted acid catalyst photochem cycloaddtion; imidazolylcarbonyl cyclobutane preparation diastereoselective.

Authors showed that Bronsted acids can also modulate the reactivity of excited-state organic reactions. Bronsted acids dramatically increase the rate of Ru(bpy)32+-sensitized [2 + 2] photocycloadditions between C-cinnamoyl imidazoles and a range of electron-rich alkene reaction partners. A combination of exptl. and computational studies supported a mechanism in which the Bronsted acid co-catalyst accelerates triplet energy transfer from the excited-state [Ru*(bpy)3]2+ chromophore to the Bronsted acid activated C-cinnamoyl imidazole. Computational evidence further suggested the importance of driving force as well as geometrical reorganization, in which the protonation of the imidazole decreases the reorganization penalty during the energy transfer event.

Chemical Science published new progress about [2+2] Cycloaddition reaction, stereoselective (photochem.). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lee, Mee-Young; Seo, Chang-Sebo; Kim, Ji-Young; Shin, Hyeun-Kyoo published the artcile< Genotoxicity evaluation of Oryeong-san water extract using in vitro and in vivo tests>, Name: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is Salmonella Escherichia Oryeong san water extract genotoxicity.

Background: Oryeong-san, a mixture of five herbal plants, is a well-known therapy for renal-associated diseases such as those manifesting edema, dysuria, and oliguria. Methods: In the present study, we investigate the potential genotoxic effects of a water extract of Oryeong-san (ORSE) in three mutagenicity assays (an in vitro bacterial reverse mutation assay (Ames test) with Salmonella typhimurium and Escherichia coli strains, an in vitro mammalian chromosomal aberration test using Chinese hamster lung cells, and an in vivo micronucleus test using ICR mice bone marrow). Results: ORSE showed no genotoxicity in the Ames test up to 5000 μg/plate; the in vitro chromosome aberration test showed no significant structural aberrations with and without the S9 mix up to 5000 μg/mL, or the in vivo micronucleus test up to 2000 mg/kg body weight Conclusions: In conclusion, under the current test conditions, ORSE seems safe for use; however, other genotoxicity tests (e.g. sister-chromatid exchange or Comet) or chronic toxicity tests are warranted.

BMC Complementary and Alternative Medicine published new progress about Alisma orientale. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Name: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Chao; Irshad, Faisal; Luo, Maowei; Zhao, Yujun; Ma, Xinbin; Wang, Shengping published the artcile< Ruthenium Complexes Immobilized on an Azolium Based Metal Organic Framework for Highly Efficient Conversion of CO2 into Formic Acid>, Application of C24H36Cl4Ru2, the main research area is ruthenium complex metal organic framework catalyst carbon dioxide hydrogenation; formic acid carbon dioxide hydrogenation catalyst.

A series of efficient heterogenized ruthenium catalysts designated as Rux-NHC-MOF (x=1, 2, 3; NHC=N-heterocyclic carbene; MOF=metal organic framework) were successfully synthesized by the immobilization of different ruthenium complexes RuCl3, [RuCp*Cl2]2 (Cp*=pentamethylcyclopentadienyl) and [Ru(C6Me6)Cl2]2 (C6Me6=hexamethylbenzene) on an azolium based MOF through post-synthetic metalation. The heterogenized catalysts were subsequently accessed for the catalytic hydrogenation of CO2 to formic acid. The resulting Ru3-NHC-MOF catalyst exhibited the highest activity because of its stronger electron-donating ability of C6Me6 ligand of [Ru(C6Me6)Cl2]2 complex, which is favorable for CO2 hydrogenation reaction. A high turnover number (TON) value up to 3803 was obtained at 120° under a total pressure of 8 MPa (H2/CO2=1) for 2 h with K2CO3 additive in N,N-Dimethylformamide (DMF) solvent. Furthermore, the heterogenized Ru3-NHC-MOF catalyst was effectively recovered through filtration without significant loss of catalytic activity.

ChemCatChem published new progress about Crystallinity. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Application of C24H36Cl4Ru2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jolivalt, C.; Neuville, L.; Boyer, F. D.; Kerhoas, L.; Mougin, C. published the artcile< Identification and Formation Pathway of Laccase-Mediated Oxidation Products Formed from Hydroxyphenylureas>, Safety of Methyl 4-chloro-2-hydroxybenzoate, the main research area is laccase oxidation hydroxyphenylurea polyaromatic compound quinone.

Hydroxyphenylureas are the first main metabolites formed in the environment from pesticide and biocide urea compounds Because fungi release potent exocellular oxidases, we studied the ability of laccases produced by the white rot fungus, T. versicolor, to catalyze in vitro the transformation of five hydroxyphenylureas, to identify transformation pathways and mechanisms. Our results establish that the pH of the reaction has a strong influence on both the kinetics of the reaction and the nature of the transformation products. Structural characterization by spectroscopic methods (NMR, mass spectrometry) of eleven transformation products shows that laccase oxidizes the substrates to quinones or to polyaromatic oligomers. Slightly acidic conditions favor the formation of quinones as final transformation products. In contrast, at pH 5-6, the quinones further react with the remaining substrate in solution to give hetero-oligomers via carbon-carbon or carbon-oxygen bond formation. A reaction pathway is proposed for each of the identified products. These results demonstrate that fungal laccases could assist the transformation of hydroxyphenylureas.

Journal of Agricultural and Food Chemistry published new progress about C-C bond formation. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Safety of Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Yingying; Huang, Xin; Lv, Guanghui; Lai, Ruizhi; Lv, Songyang; Li, Jianglian; Hai, Li; Wu, Yong published the artcile< Iridium-Catalyzed Carbenoid Insertion of Sulfoxonium Ylides for Synthesis of Quinoxalines and β-Keto Thioethers in Water>, Product Details of C9H7ClO, the main research area is keto thioether green preparation carbenoid insertion annulation water; quinoxaline green preparation carbenoid insertion annulation water.

Sulfoxonium ylides as safe carbene precursors are described for iridium-catalyzed carbene insertions and annulation, providing a facile and green approach to access a variety of quinoxaline derivatives in water. This water-mediated method also allows the preparation of β-keto thioethers under mild condition.

European Journal of Organic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent) (ortho). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Product Details of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Matin, Priyanka; Rahman, Rezaur Md; Huda, Durul; Bakri, Muhammad Khusairy Bin; Uddin, Jamal; Yurkin, Yuriy; Burkov, Andrey; Kuok, Kuok King; Matin, Mohammed Mahbubul published the artcile< Application of synthetic acyl glucopyranosides for white-rot and brown-rot fungal decay resistance in aspen and pine wood>, HPLC of Formula: 17082-09-6, the main research area is acyl glucopyranoside fungi decay resistance wood.

Due to its non-toxicity and environmentally friendly nature, carbohydrate based fatty acid (CFA) esters are encouragingly used as antimicrobials and synthetic intermediates. They also are notably applied in food, surfactant, and pharmaceutical industries. In this respect, Me 2,6-di-O-isopentanoyl-α-D-glucopyranoside (2), synthesized in a single step from Me α-D-glucopyranoside (1), was converted into four other 3,4-di-O-acyl esters (3 – 6). All the newly synthesized CFA esters (2 – 6) were applied for the first time to study decay resistances of aspen (Populus tremula) and pine (Pinus sibirica) wood from decay caused by white-rot (Polyporous versicolor L.ex. Fr.) and brown-rot (Postia placenta (Fr). Cke.) fungi. Most of these CFA esters protected these woods from fungal attack, reduced deterioration, and preserved the weight percentage of woods at a certain point. It is noted that the CFA esters compounds reduced the deterioration and suppressed the weight percentage loss of wood at a certain point and from low to moderate decay resistances against the selected fungi.

BioResources published new progress about Fungi, brown rot. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics