Month: October 2022

Xie, Huaijun; Chen, Jingwen; Huang, Yang; Zhang, Ruohan; Chen, Chang-Er; Li, Xuehua; Kadokami, Kiwao published the artcile< Screening of 484 trace organic contaminants in coastal waters around the Liaodong Peninsula, China: Occurrence, distribution, and ecological risk>, Application In Synthesis of 6055-19-2, the main research area is organic contaminant ecol risk peninsula water pollution; Coastal waters; Comprehensive analytical method; Risk assessment; Trace organic contaminants.

Human activities such as agriculture, aquaculture, and industry can lead to the pollution of coastal waters by trace organic contaminants (TrOCs), and the TrOCs can pose a threat to marine ecosystems. Therefore, it is essential to investigate the occurrence, distribution, and ecol. risk of the TrOCs in coastal waters. Previous studies adopting conventional anal. methods have focused on a limited number of targets. Herein, a comprehensive and systematic determination was undertaken to target 484 TrOCs in the waters around the Liaodong Peninsula, China. Eighty-six TrOCs were detected at concentrations of up to 350 ng L-1, and 25 TrOCs were detected at a frequency of >50%. Pesticides were the predominant pollutants, occurring at high concentrations with large detection frequencies. Ecol. risks were assessed for single pollutants and mixtures based on the risk quotient and concentration addition modeling, resp. The detected pesticides posed relatively high risk to aquatic organisms, while pharmaceuticals, consumer products, and other pollutants posed little or no risk. TrOC mixtures posed extremely high risk to aquatic organisms, which represented a significant threat to the marine environment and local communities. The results described here provide useful information that can inform China’s “”Action Plan for Prevention and Control of Water Pollution””.

Environmental Pollution (Oxford, United Kingdom) published new progress about Ecology. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Application In Synthesis of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Profit, E.; Solf, G. published the artcile< Chlorothiophenes>, COA of Formula: C5H2Cl2O2S, the main research area is .

The four isomeric dichlorothiophenes, 2,3- (I), 2,4- (II), 3,4- (III), and 2,5-dichlorothiophenes (IV), were examined relative to their reactivities in the Friedel-Crafts reaction. With β-chloropropionyl chloride (V), the resp. isomeric chloro ketone was synthesized in high yield. They showed local anesthetic activity about 5 times as strong as cocaine and about one half as strong as Falicain. The preparation of the four isomeric dichlorothiophenecarboxaldehydes in good yields was described. The chem. characteristics of 2,3-dichloro-5-acetylthiophene (VI) were studied. Some of the reactions of 2,3,5-trichlorothiophene (VII) were also studied. 2,3-Dichloro-4,5-thiophenedicarbox-aldehyde (0.5 g.) in 30 ml. 50% alc. refluxed 5 min. with 0.3 g. N2H4·H2O gave 0.3 g. 2,3-dichlorothieno[4,5-d]pyridazine, m. 194-5°. I (7.7 g.) and 8.1 g. V in 150 ml. CS2 treated under stirring and cooling with 7 g. AlCl3, then stirred 2 hrs. at room temperature, and decomposed gave 11.6 g. β-chloroethyl 2,3-dichloro-5-thienyl ketone (VIII), m. 67-8°. The following IX and their thiosemicarbazones or hydrazones were similarly obtained (R, % yield, m.p., derivative, and m.p. of derivative given): Me, 96, 66°, thiosemicarbazone, 217-18°; Et, 86, 56-7°, thiosemicarbazone, 184-6°; Pr, 78, 32-3°, thiosemicarbazone, 161°; Ph, 68, 62-3°, p-nitrophenylhydrazone, 201-3°; PhCH2, 93, 93°, p-nitrophenylhydrazone, 235-7°. VIII (1.2 g.) in 3.5 ml. alc. refluxed 10 hrs. gave 0.7 g. β-ethoxyethyl 2,3-dichloro-5-thienyl ketone, m. 17.5°. VIII (1.2 g.) in 3 ml. AcOH heated several minutes with 0.65 g. KOAc gave 1.3 g. β-acetoxyethyl 2,3-dichloro-5-thienyl ketone, m. 55-6°. VIII (1.2 g.) kept several days with 10 ml. C5H5N gave 1.1 g. IX (R = β-pyridiniumethyl chloride), m. 184-5° (decomposition). VIII (1.2 g.) in 10 ml. MeOH refluxed a short time with 0.6 g. KOAc, cooled, 0.7 g. α-naphthylamine in 10 ml. alc. added, and the mixture kept a short time gave 0.9 g. IX [R = β-(α-naphthylamino)ethyl] (X), m. 83-4°. IX.HCl (R = R1CH2CH2) (XI) were obtained by the following procedures: (A) As in the preparation of X the reaction mixture was poured into dilute HCl, unreacted ketone removed with Et2O, the aqueous solution made alk., extracted with Et2O, and the dried ethereal solution treated with dry HCl. (B) VI (3.9 g.), 0.025 mol. secondary amine-HCl, and 1 g. paraformaldehyde in 20 ml. alc. containing 2 drops concentrated HCl was refluxed 12 hrs. The following XI were thus obtained (R1, % yield, and m.p. given): Me2N, 60, 201-2°; Et2N, 74, 124-6°; piperidino, 77, 196-7°; 4-methylpiperidino, 59, 189-90°; 4-ethylpiperidino, 93, 197-8°; 4-propylpiperidino, 63, 199°; morpholino, 94, 208-10°. VIII (1.2 g.) in 10 ml. alc. refluxed with 0.35 g. KCN in 3 ml. H2O gave 1 g. IX (R = CH2CH2CN) (XII), m. 124-5° (cyclohexane). XII (1 g.) in 20 ml. concentrated HCl refluxed 4 hrs. gave IX (R = CH2CH2CO2H) (XIII), m. 120-1°. VIII (1.2 g.) in 3 ml. alc. refluxed with 0.7 g. NH2OH.HCl and 0.85 g. KOH in 5 cc. H2O gave 1.1 g. N,N-bis[β-(2,g-dichloro-5thenoyl)ethyl]hydroxylamine, m. 159-60°. 2,3-Dichloro-5chloroacetylthiophene (XIV), m. 61-2°, was prepared in 84% yield. XIV (1.15 g.) in 15 ml. C5H5N kept 1 day gave quant. IX (R = pyridiniummethyl chloride). XIV (2.3 g.) in 15 ml. alc. treated under cooling with 1.7 g. ammonium dithiocarbamate in alc. and kept 4 days at room temperature gave 2.3 g. 2-mercapto-4-(2,3-dichlorothien-5-yl)thiazole,m. 181-2°. I (0.05 mole) and 0.05 mole dicarboxylic monoester monochloride in 80 ml. CS2 treated under ice-cooling with 7.2 g. AlCl3, then stirred 3 hrs. at room temperature, and poured over ice gave the following XV (R, n, % yield, and m.p. given): Et, 0, 30, 57°; Me, 2, 44, 65-6°; Me, 3, 62, 67-8°; Me, 4, 47, 63-4°. XV refluxed in dilute aqueous KOH gave a nearly quant. yield of the corresponding acid (XVI) (n, % yield, and m.p. given): 0, quant., 126-7°; 2, quant., 120-1°; 3, quant., 113-15°; 4, quant., 93-4°; 5, 14, 86-8°. I (7.7 g.) and 3.9 g. succinoyl chloride in 50 ml. CS2 treated at -12° with 7 g. AlCl3, kept 40 min. at -10°, decomposed with ice, and the solids collected gave 0.6 g. 1,4-bis(2,3-dichloro-5-thienyl)-l,4- butanedione, m. 188-90°. 2,3-Dichloro-5-thenoylpropionic acid was obtained in 23.8% yield from the filtrates upon acidification. Similarly, 7.7 g. I and 4.5 g. glutaryl chloride with AlCl3 gave 4 g. 1,5-bis(2,3-dichloro-5-thienyl)-1,5-pentadione, m. 115°; thiosemicarbazone (21% yield) m. 220-2° (decomposition). 1,6Bis(2,3-dichloro-5-thienyl)-1,6-hexanedione, 82% yield, m. 133°, and 1,7-bis(2,3-dichloro-5-thienyl)heptane-1,7-dione, 42% yield, m. 74-5°, were similarly prepared The latter also afforded 14% 2,3-dichloro-5-thienylcaproic acid from the acidified filtrate. 2,3Dichloro-5-acetylthiophene semicarbazone m. 264-6°. VI (17.7 g.) treated with 10 g. (iso-PrO)3Al in 50 ml. iso-PrOH gave 14.5 g. α-(2,3-dichloro-5-thienyl)ethylcarbinol, b0.2 93-4°. VI (19.5 g.) added at 70° to 43 g. NaOH in 55 ml. H2O into which 32 g. Cl had been previously passed, the mixture stirred, treated with 10 g. NaHSO3, and the product acidified with concentrated HCl gave 16.2 g. 2,3-dichloro-5-thiophenecarboxylic acid (XVII), m. 194-6°. XVII (14 g.), 45 g. quinoline, and 4 g. Cu powder refluxed 2 hrs. under N gave 7.4 g. I, b10 55°,n20D 1.5651. I(5.1g.) in 50 cc. CS2 treated with 4.4 g. AlCl3 under ice-cooling, and the mixture treated in 10 min. with Cl2CHOMe, warmed 5 min. at 50°, and decomposed gave 4.85 g. 2,3-dichloro-5-thiophenecarboxaldehyde (XVIII), m. 56°. XVIII (1.81 g.) in 20 ml. MeOH treated with 2.3 g. dianilinoethane in 40 ml. MeOH gave 1.7 g. 1,3-diphenyl-2- (2,3-dichloro-5-thienyl)tetrahydroimidazole, m. 126-6.5°. VI (9.8 g.) refluxed 4 hrs. with 6 g. SeO2 in dioxane and kept overnight gave 7.9 g. 2,3-dichloro-5-thienylglyoxal (XIX), m. 94 5°; oxime m. 160°; semicarbazone m. 135-7°; thiosemicarbazone m. 191° (decomposition). XIX (0.22 g.) and 0.1 g. o-C6H4(NH2)2 in 5 ml. 50% alc. afforded an almost quant. yield of 2-(2,3-dichloro-5-thienyl)quinoxaline, m. 209-10°. VI (19.5 g.) kept 3 days at room temperature with 40 g. Zn-Hg and 80 ml. 5% HCl and refluxed 1 hr. with 10 ml. concentrated HCl gave 5.5 g. 2-ethyl-4chlorothiophene (XX), b14 67-8°, n20D 1.5399. XX (2 g.) treated in the cold with 4 ml. fuming HNO2 and 4 ml. Ac2O, shaken 2 hrs. at 0°, and distilled gave 1.9 g. 2-nitro-3-chloro-5-ethylthiophene, b14 158-60°. VI (19.5 g.) and 20 ml. 84% N2H4·H2O heated with 80 ml. (CH2OH)2, refluxed, H2O distilled until temperature reached 165°, treated at 90 o with 20 g. KOH, refluxed 1.5 hrs., and fractionated gave 2.4 g. 3-chloro-5-ethylthiophene, b14 67-8°, and 4.2 g. 2,3dichloro-5-ethylthiophene, b13 87-90°, n22D 1.5458. I (115 g.) in 200 ml. C6H6 treated with Na Hg amalgam gave 71 g. unchanged I and 6.3 g. 3-chlorothiophene (XXI), b. 135-7°. XXI (1.18 g.) and 0.9 g. AcCl in 20 ml. CS2 treated in the cold with 1.5 g. AlCl3 gave 1.2 g. 3-chloro-2-acetylthiophene (XXII), b15 117-18°. XXII treated with NaOCl in alk. solution gave 3-chlorothiophene-2-carboxylic acid (XXIIa), m. 183-5°. XXI (2.9 g.) and 3.7 g. HCONMe2 treated with 7.5 g. POCl3 gave 1.3 g. 3-chlorothiophene-2-carboxaldehyde (XXIII), b14 100-1°; semicarbazone m. 214-16°; thiosemicarbazone m. 213-14°. XXIII oxidized with KOH-H2O2 gave XXIIa. I (15.3 g.) and 24 ml. Ac2O treated at -20° with 20 ml. fuming HNO3 and 25 ml. Ac2O gave 11.7 g. 2,3-dichloro-5-nitrothiophene (XXIV), m. 56° XXIV (2 g.) in 10 ml. MeOH kept 1 hr. with 2 g. KOH in 20 ml. MeOH gave 0.7 g. 2-methoxy-3-chloro-5-nitrothiophene, m. 62°. XXIV (1 g.) in 20 ml. alc. left 16 hrs. at room temperature with 0.85 g. piperidine gave 0.8 g. 2-piperidino-3-chloro-5-nitrothiophene, m. 57-8°. Similarly, 1 g. XXIV and 1 g. 4-ethylpiperidine gave an almost quant. yield of 2-(4-ethylpiperidino)-3-chloro-5-nitrothiophene, m. 6970°. XXIV (1 g.) and 0.9 g. morpholine in alc. gave an almost quant. yield of 2-morpholino-3-chloro-5-nitrothiophene, m. 1045°. XXIV (1 g.) in 10 ml. alc. treated 15 min. with 1.1 g. PhSH and 1 g. NEt3 gave 0.9 g. 2-phenylthio-3-chloro-5-nitrothiophene, m. 96-7°. Similarly prepared were 53% 2-(p-tolylthio)-3chloro-5-nitrothiophene, m. 81-2°, and almost quant. 2-(pchlorophenylthio)-3-chloro-5-nitrothiophene, m. 93-4°. XXIV (5 g.) and 20 g. Zn granules stirred 2 hrs. at room temperature with 100 ml. concentrated HCl followed by acetylation gave 2.1 g. 3-chloro-5 acetamidothiophene (XXV), m. 191-2°. XXIV was similarly converted into 3-chloro-5-propionylaminothiophene (XXVI), m. 159°. XXV (1.8 g.) in 20 ml. Ac2O treated under stirring at -20° with 12 ml. fuming HNO3 and 15 ml. Ac2O, stirred 1 hr. at -10°, and stirred until the temperature reached 5° gave 1.3 g. 2,4dinitro-3-chloro-5-acetamidothiophene, m. 239-40°. XXVI similarly gave 92% 2,4-dinitro-3-chloro-5-propionylaminothiophene, m. 164-5°. A mixture of II and III (40 g.) in 1600 ml. alc. kept 4 weeks with 850 ml. cold saturated HgCl2 and 90 ml. 33% NaOAc gave 2,4-dichloro-5-chloromercurithiophene (XXVII), m. 183-5°. Crude XXVII dissolved in 400 ml. 2N HCl and steam distilled gave II, b12 54°, n20D 1.5660. II (1 g.), 0.7 g. ClCH2COCl, and 10 ml. CS2 treated with cooling with 1 g. AlICl3 gave 0.8 g. 2,4-dichloro-5-chloroacetylthiophene, m. 76-7°. The following 2,4-dichloro analogs of IX were similarly prepared (R, % yield, m.p., derivative, and m.p. derivative given): Me, 78, 35°; thiosemicarbazone, 215-16° (decomposition); Et, 87, 53°; thiosemicarbazone 169-70° (decomposition); Ph, 73, 32.5-33°, 2,4-dinitrophenylhydrazone, 225-7° (decomposition); PhCH2, 56, 29-30°, 2,4-dinitrophenylhydrazone, 185-7° (decomposition); CH2CH2Cl, 88, 40.5-1.5°, -, -. II (5.1 g.), 4 g. Cl2CHOMe, 40 ml. CS2, and 4.4 g. AlCl3 gave 5 g. 2,4-dichlorothiophene-5-carboxaldehyde (XXV-III), m. 35-6°; oxime m. 144-6°; semicarbazone m. 244-6°; thiosemicarbazone m. 238-40° (decomposition); p-nitrophenylhydrazone m. 264-6° (decomposition); nitromethylene derivative m. 90-1°. Oxidation of XXVIII with perhydrol in aqueous KOH gave quant. 2,4-dichlorothiophene-5-carboxylic acid, m. 186-7°. Nitration of II with fuming HNO3 in Ac2O at -15° gave 63% 2,4-dichloro-5-nitrothiophene (XXIX), b14 119°. XXIX was further nitrated with fuming HNO3 and H2SO4 to give 70.4% 2,4-dichloro-3,5-di-nitrothiophene, m. 97-8°. III (3 g.) and 2 g. ClCH2COCl in 20 ml. CS2 treated in the cold with 2.8 g. AlCl3 gave 4.2 g. 2-chloro-acetyl-3,4-dichlorothiophene, m. 70-1°. The following 2-acyl-3,4-dichlorothiophenes were obtained (R in 2-COR, % yield, m.p., derivative, and m.p. derivative given): Me, 87, 54°, thio-semicarbazone, 171-2°; Et, 71, 68°, thiosemicarbazone, 156-7°; Pr, 69, 43°, thiosemicarbazone, 114-15°; Ph, 67, 97-7.5°, 2,4-dinitrophenylhydrazone, 202-4° (decomposition); PhCH2, 68, 77-8°, 2,4-dinitrophenylhydrazone, 181-3° (decomposition); ClCH2CH2, 88, 61-2°, -, -. β-Chloroethyl 3,4-dichloro-2-thienyl ketone (1.2 g.) and 0.5 g. KOAc in 10 ml. MeOH refluxed a short time, then 10 min. with 0.5 g. morpholine, and treated with 60 ml. 4N HCl gave 1.5 g. β-morpholinoethyl 3,4-dichloro-2-thienyl ketone-HCl, m. 197-9°. III (5.1 g.) in 20 ml. Ac2O treated at -20° with 5 ml. fuming HNO3 and 10 ml. Ac2O gave 5.5 g. 2-nitro-3,4-dichlorothiophene (XXIXa), m. 72°. XXIXa (0.55 g.) in 10 ml. fuming HNO3 and concentrated H2SO4 gave 0.55 g. 2,5-dinitro-3,4-dichlorothiophene, m. 123-4°. III (5.1 g.), 4 g. Cl2CHOMe, and 4.4 g. AlCl3 in 40 ml. CS2 gave 3.4 g. 3,4-dichlorothiophene-2-carboxaldehyde (XXX), m. 61-2°; oxime m. 1513°; semicarbazone m. 257-8° (decomposition); thiosemicarbazone m. 226-8° (decomposition). Oxidation of XXX with perhydrol-KOH gave an almost quant. yield of 3,4-dichlorothiophene-2-carboxylic acid, m. 187-8°. III (5.1 g.) treated dropwise in 10 min. with 15 ml. 30% oleum, stirred 1 hr. at room temperature, poured on ice, and the crude product treated with PCl5 4 hrs. at 140° gave 6.5 g. 3,4-dichlorothiophene-2,5-bis(sulfonyl chloride) (XXXI), m. 13840°. XXXI (3.5 g.) refluxed 15 min. with 50 ml. concentrated NH4OH gave 1.8 g. 3,4-dichlorothiophene-2,5-disulfonamide, m. 278-80° (decomposition). IV (15.3 g.), 16.2 g. V, and 14 g. AlCl3 in 100 ml. CS2 stirred 5 hrs. gave 15.6 g. β-chloroethyl 2,5-dichloro-3-thienyl ketone (XXXII), m. 33-4°. XXXII (1.2 g.) in 10 ml. alc. heated with 0.3 g. KCN in 3 ml. H2O gave 1.15 g. the β-cyanoethyl analog (XXXIII), m. 67-8°. XXXIII (1.15 g.) in 40 ml. concentrated HCl refluxed 4 hrs. gave 0.2 g. β-(2,5-dichloro-3-thenoyl)propionic acid, m. 116-17°. The following 2,5-dichloro-3-thienyl βaminoethyl ketone-HCl salts were prepared as described above (R of the β-COCH2CH2R group, % yield, and m.p. given): piperidino, 91, 188-9°; 4-methylpiperidino, 71, 184-6°; 4-ethylpiperidino, 70, 183-5°; 4-propylpiperidino, 73, 167-9°; morpholino, 85, 194-6°. IV (15.3 g.), 14 g. AlCl3, and 11.5 g. Cl2CHOMe in 100 ml. CS2 gave 6.3 g. 2,5-dichlorothiophene-3-carboxaldehyde, m. 24-4.5% b15 105-6°; oxime m. 129-31°. VII (62 g.) treated 17 hrs. with 7.8 g. AcCl and 14 g. AlCl3 gave 7.1 g. 2,3,5-trichloro-4-acetylthiophene, m. 79°; thiosemicarbazone m. 230-3° (decomposition). The following compounds were similarly prepared: 47% 2,3,5-trichloro-4-propionylthiophene, m. 55-6° [thiosemicarbazone m. 215-16° (decomposition)]; 6% 2,3,5-trichloro-4 butyrylthiophene, m. 34° [thiosemicarbazone m. 178-9° (decomposition)]; 11% 2,3,5-trichloro-4-phenacylthiophene, m. 119°.

Journal fuer Praktische Chemie (Leipzig) published new progress about Reactivity (chemical). 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, COA of Formula: C5H2Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cai, Huan; Jiang, Yu; Zhang, Sheng; Cai, Ning-Ning; Zhu, Wen-Qian; Yang, Rui; Tang, Bo; Li, Zi-Yi; Zhang, Xue-Ming published the artcile< Culture bovine prospermatogonia with 2i medium>, Application of C4H4ClNO2, the main research area is culture bovine prospermatogonia 2i medium; cattle; cell culture; histone modification; prospermatogonia; testis.

Germplasm cryopreservation and expansion of gonocytes/prospermatogonia or spermatogonial stem cells (SSCs) are important; however, it’s difficult in cattle. Since inhibitors of Mek1/2 and Gsk3β (2i) can enhance pluripotency maintenance, effects of 2i-based medium on the cultivation of bovine prospermatogonia from the cryopreserved tissues were examined The testicular tissues of newborn bulls were well cryopreserved. High mRNA levels of prospermatogonium/SSC markers (PLZF, GFRα-1) and pluripotency markers (Oct4/Pouf5, Sox2, Nanog) were detected and the PLZF+/GFRα-1+ prospermatogonia were consistently identified immunohistochem. in the seminiferous cords. Using differential plating and Percoll-based centrifugation, 41.59% prospermatogonia were enriched and they proliferated robustly in 2i medium. The 2i medium boosted mRNA abundances of Pouf5, Sox2, Nanog, GFRα-1, PLZF, anti-apoptosis gene Bcl2, LIF receptor gene LIFR and enhanced PLZF protein expression, but suppressed mRNA expressions of spermatogonial differentiation marker c-kit and pro-apoptotic gene Bax, in the cultured prospermatogonia. It also alleviated H2O2-induced apoptosis of the enriched cells and decreased histone H3 lysine (K9) trimethylation (H3K9me3) and its methylase Suv39h1/2 mRNA level in the cultured seminiferous cords. Overall, 2i medium improves the cultivation of bovine prospermatogonia isolated from the cryopreserved testes, by inhibiting Suv39h1/2-mediated H3K9me3 through Mek1/2 and Gsk3β signalling, evidencing successful cryopreservation and expansion of bovine germplasm.

Andrologia published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Bax). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application of C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acharya, Badri Narayan; Ghorpade, RamaRao; Singh, Kshetra Pal; Kumar, Deo; Nayak, Sabita published the artcile< Synthesis and muscarinic acetylcholine receptor (mAChR) antagonist activity of substituted piperazine-triazoles>, Synthetic Route of 611-19-8, the main research area is dibenzyltriazolyl methyl piperazine preparation muscarinic acetylcholine receptor antagonist SAR; benzyltriazolyl methylpiperazinylchlorobenzonitrile preparation muscarinic acetylcholine receptor antagonist SAR docking.

This study described synthesis of a series of piperazine-triazole derivatives and their ex vivo evaluation for preliminary muscarinic acetylcholine receptor (mAChR) blocking activity on rat ileum model. A mol. based on benzonitrile piperazine triazole scaffold showed good tissue relaxation and blocking of neurotransmitter ACh in the ex vivo experiment

Monatshefte fuer Chemie published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Synthetic Route of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Joseph, Devaneyan; Lee, Sunwoo published the artcile< Reaction of Amide and Sodium Azide for the Synthesis of Acyl Azide, Urea, and Iminophosphorane>, Related Products of 17082-09-6, the main research area is acyl azide sym aromatic urea iminophosphorane preparation; amide sodium azide phosphine substitution Curtius rearrangement.

Amides reacted with NaN3 to give the acyl azides in DMF at 25°C and produce the sym. ureas in THF/H2O at 80°C via the sequential reaction of acyl substitution and Curtius rearrangement. All acyl azides were also obtained from the secondary amides via sequential reaction of p-toluenesulfonyl chloride and NaN3. In addition, keto-stabilized iminophosphoranes were prepared from a one-pot reaction of amides, NaN3, and phosphines.

Organic Letters published new progress about Acyl azides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thanneeru, Srinivas; Li, Weikun; He, Jie published the artcile< Controllable Self-Assembly of Amphiphilic Tadpole-Shaped Polymer Single-Chain Nanoparticles Prepared through Intrachain Photo-cross-linking>, HPLC of Formula: 17082-09-6, the main research area is assembly control amphiphilic tadpole diblock polymer single chain nanoparticle; cinnamoyl crosslinking photochem assembly micelle morphol.

We report the use of intramol. crosslinking chem. as a tool to control the self-assembly of amphiphilic diblock copolymers (di-BCPs). Two amphiphilic di-BCPs of poly(N,N’-dimethylacrylamide)-block-polystyrene (PDMA-b-PS) with photo-cross-linkable cinnamoyl groups in either hydrophobic or hydrophilic blocks were prepared using reversible addition-fragmentation chain transfer polymerization Intramol. photo-crosslinking of cinnamoyl groups led to the formation of tadpole-shaped polymer single-chain nanoparticles (SCNPs) consisting of a self-collapsed block as the “”head”” and an un-cross-linked block as the “”tail””. When intramol. photo-crosslinking was carried out in hydrophobic PS blocks, a clear morphol. transition from branched cylindrical micelles (for the linear di-BCP) to completely spherical micelles at a dimerization degree of ∼63% was observed A pattern of morphol. transitions from cylindrical micelles to spherical micelles is observed through stepwise downsizing the length of cylindrical micelles when increasing the self-collapse degree of PS blocks, whereas, in case of photo-crosslinking carried out in hydrophilic PDMA blocks, the size of micelles showed a dramatic increase due to the shift of hydrophobic-to-hydrophilic balance. When the crosslinking degree of PDMA blocks reached >60%, tadpole-shaped SCNPs assembled into nonconventional aggregates with a nonsmooth surface. Our results illustrate the impact of chain topologies on the self-assembly outcomes of amphiphilic di-BCPs, which likely opens a door to control the micellar morphologies from just one parent linear di-BCP, rather than resynthesizing BPCs with different volume fractions of the two blocks.

Langmuir published new progress about [2+2] Photocycloaddition reaction. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Bo; Mei, Qiong; An, Zexiu; Li, Mingxue; Qiu, Zhaoxu; Bo, Xiaofei; He, Maoxia published the artcile< Nonmetal-Doped C2N Nanosheets for Removal of Methoxyphenols: A First-Principles Study>, Recommanded Product: 4-Chloro-2-methoxyphenol, the main research area is nonmetal doped carbon nitride nanosheet removal Methoxyphenol DFT photocatalyst.

Through first-principles d. functional theory study on the optical, electronic, and adsorption characteristics of pure and three different nonmetal elements (B, P, and S)-doped C2N nanosheets, the effects of doping on photoelectronic and adsorption properties of these potential photocatalysts were determined Three main doping modes (d1, d2, and I3) were determined on the basis of the defect formation energy. The introduction of B, P, and S dopants resulted in more suitable band structures and broadened light absorption and generally promoted carrier migration of C2N materials. Remarkably, the B@d1 and P@d1 modes C2N have broadened light absorption, spatially separated e–h+ pairs, fast carrier migration, and excellent redox ability. They are strongly recommended for the photocatalytic water splitting and pollutant degradation In addition, the adsorption capacity of B@d1 and P@d1 modes C2N for pollutants was enhanced. Our computational results could provide some potential strategies for improving their photocatalytic characteristics and provide guidance for further exploration of the utilization of two-dimensional C2N materials.

ACS Applied Nano Materials published new progress about Absorption spectra. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Recommanded Product: 4-Chloro-2-methoxyphenol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Jie; Zhang, Yi; Cui, Yi-Wen; Li, Zhan-Mei; Song, Hong-Rui; Dong, Jin-Hua; Chen, Xiao-Guang; Xu, Bai-Ling published the artcile< Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzimidazol-7-yl)arenesulfonamide and N-aryl-(4-methoxy-1H-benzimidazol)-7-sulfonamide analogs of combretastatin A-4>, Computed Properties of 42413-03-6, the main research area is antitumor anticancer agent combretastatin analog preparation.

Benzimidazole derivatives [Combretastatin A-4 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol analogs] were designed and the synthesis of the target compounds was achieved using 4-methoxy-1H-benzimidazol-7-amine and 4-Methoxy-1H-benzimidazole-7-sulfonic acid as reactants. The title compounds were evaluated in-vitro against cell line HCT-8 (human epithelial intestinal adenocarcinoma, colon carcinoma), cell line BEL-7402 (hepatocellular carcinoma, human hepatoma, liver cancer cell line), cell line BGC 823 (human gastric cancer cell line, stomach adenocarcinoma), cell line A549 (human lung carcinoma cell line) and cell line A-2780 (human ovarian carcinoma cell line) and it was discovered that several compounds displayed cytotoxic activity against the HCT-8 cell line.

Journal of Asian Natural Products Research published new progress about Adenocarcinoma (epithelial adenocarcinoma, intestine). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Computed Properties of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ivanova, Yu. B.; Chizhova, N. V.; Shumilova, I. A.; Rusanov, A. I.; Mamardashvili, N. Zh. published the artcile< Acid-Base Properties of Polyhalogenated Tetraphenylporphyrins>, Application of C4H4ClNO2, the main research area is zinc Octabromotetrakisdichlorophenylporphyrinato Octachlorootetrakisdichlorophenylporphyrinato complex preparation; Octabromotetrakisdichlorophenylporphyrin Octachlorootetrakisdichlorophenylporphyrin tetrakisdichlorophenylporphyrin preparation acidity basicity constant.

[2,3,7,8,12,13,17,18-Octabromo-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]zinc(II) and [2,3,7,8,12,13,17,18-octachloro-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]zinc(II) were synthesized by halogenation of [5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]zinc(II) with N-bromosuccinimide and N-chlorosuccinimide, resp., in a mixture of chloroform with methanol. Treatment of the halogenated zinc porphyrins with trifluoroacetic acid in chloroform gave the corresponding free ligands. The isolated compounds were identified by electronic absorption, 1H NMR, and mass spectra. The acid-base properties of 5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin, 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin, and 2,3,7,8,12,13,17,18-octachloro-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin were studied in acetonitrile at 298 K. Their acidity and basicity constants and concentration ranges of their ionized forms were determined

Russian Journal of Organic Chemistry published new progress about Acid-base equilibrium. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application of C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tian, Zhenhao; Ding, Lele; Li, Kun; Song, Yunqing; Dou, Tongyi; Hou, Jie; Tian, Xiangge; Feng, Lei; Ge, Guangbo; Cui, Jingnan published the artcile< Rational Design of a Long-Wavelength Fluorescent Probe for Highly Selective Sensing of Carboxylesterase 1 in Living Systems>, Category: chlorides-buliding-blocks, the main research area is design long wavelength fluorescence sensing carboxylesterase 1.

Rational design of practical probes with excellent specificity and improved optical properties for a particular enzyme is always a big challenge. Herein, a practical and highly specific fluorescent probe for carboxylesterase 1 (CES1) was rationally designed using meso-carboxyl-BODIPY as the basic fluorophore based on the substrate preference and catalytic properties of CES1. Following mol. docking-based virtual screening combined with reaction phenotyping-based exptl. screening, we found that MMB (probe 7) exhibited the optimal combination of sensitivity and specificity toward human CES1 in contrast to other ester derivatives Under physiol. conditions, MMB could be readily hydrolyzed by CES1 and release MCB; such biotransformation brought great changes in the electronic properties at the meso position of the fluorophore and triggered a dramatic increase in fluorescence emission around 595 nm. Moreover, MMB was cell membrane permeable and was successfully applied to monitor the real activities of CES1 in various biol. samples including living cells, tissue slices, organs, and zebrafish. In summary, this study showed a good example for constructing specific fluorescent probe(s) for a target enzyme and also provided a practical and sensitive tool for real-time sensing of CES1 activities in complicated biol. samples. All these findings would strongly facilitate high-throughput screening of CES1 modulators and the studies on CES1-associated physiol. and pathol. processes.

Analytical Chemistry (Washington, DC, United States) published new progress about Danio rerio. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics