Month: October 2022

Kubo, Yuji; Shimada, Takuma; Maeda, Kentaro; Hashimoto, Yuta published the artcile< Thieno[1,3,2]oxazaborinine-containing aza-BODIPYs with near infrared absorption bands: synthesis, photophysical properties, and device applications>, Product Details of C9H7ClO, the main research area is thienooxazaborinine containing aza BODIPY preparation crystal structure cyclic voltammetry; fluorescence DFT thienooxazaborinine containing aza BODIPY.

As part of an ongoing study of near IR (NIR) absorbing dyes applicable to optoelectronics, thieno[1,3,2]oxazaborinine-containing aza-BODIPYs were synthesized for the first time. 3,5-Di(thiophene)-substituted N2O2-type 1 showed a NIR absorption band centered at 780 nm, with a molar absorptivity (εmax) of 5.51 × 104 M-1 cm-1 in CH2Cl2; however, it was easily hydrolyzed in solution In comparison, 3-thiophene-containing N2O-type analogs 2 and 3 had greater stability, and NIR absorption bands at 768 nm (εmax = 8.62 × 104 M-1 cm-1) and 779 nm (εmax = 6.32 × 104 M-1 cm-1), resp., in CH2Cl2. Notably, these dyes had longer absorption bands than those of all of the structurally constraining aza-BODIPYs reported thus far. CV measurements and theor. calculations indicated that this shift was the result of a higher-lying HOMO energy level generated by incorporation of thiophene into the aza-BODIPY core. As a potential device application, the 3-loaded film was prepared on indium tin oxide (ITO). The film showed a NIR absorption band at 827 nm, with a wide spectral range, and a λonset value of 897 nm; thus, its applicability as a NIR photodetector was evaluated through fabrication of a single-component device. The ITO/3 (85 nm)/Al (100 nm) device produced a photocurrent of 9.57 × 10-7 A cm-2 at a bias potential of 1 V upon illumination at 850 nm and a fluence of 130 μW cm-2. This demonstrated the potential of thieno[1,3,2]oxazaborinine-containing aza-BODIPY materials in optoelectronic applications such as NIR photodetectors.

New Journal of Chemistry published new progress about Crystal structure. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Product Details of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pourmazaheri, Helen; Soorni, Aboozar; Kohnerouz, Bahram Baghban; Dehaghi, Nafiseh Khosravi; Kalantar, Enayatollah; Omidi, Mansoor; Naghavi, Mohammad Reza published the artcile< Comparative analysis of the root and leaf transcriptomes in Chelidonium majus L.>, Safety of 1-Chloropyrrolidine-2,5-dione, the main research area is Chelidonium benzylisoquinoline alkaloid transcriptome gene ontol functional annotation.

Chelidonium majus is a traditional medicinal plant, which commonly known as a rich resource for the major benzylisoquinoline alkaloids (BIAs), including morphine, sanguinarine, and berberine. To understand the biosynthesis of C. majus BIAs, we performed de novo transcriptome sequencing of its leaf and root tissues using Illumina technol. Following comprehensive evaluation of de novo transcriptome assemblies produced with five programs including Trinity, Bridger, BinPacker, IDBA-tran, and Velvet/Oases using a series of k-mer sizes (from 25 to 91), BinPacker was found to produce the best assembly using a k-mer of 25. This study reports the results of differential gene expression (DGE), functional annotation, gene ontol. (GO) anal., classification of transcription factor (TF)s, and SSR and miRNA discovery. Our DGE anal. identified 6,028 transcripts that were up-regulated in the leaf, and 4,722 transcripts that were up-regulated in the root. Further investigations showed that most of the genes involved in the BIA biosynthetic pathway are significantly expressed in the root compared to the leaf. GO anal. showed that the predominant GO domain is “”cellular component””, while TF anal. found bHLH to be the most highly represented TF family. Our study further identified 10 SSRs, out of a total of 39,841, that showed linkage to five unigenes encoding enzymes in the BIA pathway, and 10 conserved miRNAs that were previously not detected in this plant. The comprehensive transcriptome information presented herein provides a foundation for further explorations on study of the mol. mechanisms of BIA synthesis in C. majus.

PLoS One published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Safety of 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seo, Kyutae; Kang, Hyo published the artcile< Vertical Orientation of Liquid Crystal on Polystyrene Substituted with n-Alkylbenzoate-p-oxymethyl Pendant Group as a Liquid Crystal Precursor>, Formula: C9H9Cl, the main research area is polystyrene oxymethyl pendant liquid crystal polymer film physicochem property; anisotropic material; liquid crystal; n-alkyl-p-hydroxybenzoate; orientation layer; polystyrene.

We synthesized a series of polystyrene derivatives modified with precursors of liquid crystal (LC) mols. via polymer modification reactions. Thereafter, the orientation of the LC mols. on the polymer films, which possess part of the corresponding LC mol. structure, was investigated systematically. The precursors and the corresponding derivatives used in this study include ethyl-p-hydroxybenzoate (homopolymer P2BO and copolymer P2BO#, where # indicates the molar fraction of ethylbenzoate-p-oxymethyl in the side chain (# = 20, 40, 60, and 80)), n-butyl-p-hydroxybenzoate (P4BO), n-hexyl-p-hydroxybenzoate (P6BO), and n-octyl-p-hydroxybenzoate (P8BO). A stable and uniform vertical orientation of LC mols. was observed in LC cells fabricated with P2BO#, with 40 mol% or more ethylbenzoate-p-oxymethyl side groups. In addition, the LC mols. were oriented vertically in LC cells fabricated with homopolymers of P2BO, P4BO, P6BO, and P8BO. The water contact angle on the polymer films can be associated with the vertical orientation of the LC mols. in the LC cells fabricated with the polymer films. For example, vertical LC orientation was observed when the water contact angle of the polymer films was greater than ∼86°. Good orientation stability was observed at 150°C and with 20 J/cm2 of UV irradiation for LC cells fabricated with the P2BO film.

Polymers (Basel, Switzerland) published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Chien Han; Jheng, Jia Kai; Juang, Tzong Yuan; Abu-Omar, Mahdi M.; Hsuan Lin, Ching published the artcile< Structure-property relationship of vinyl-terminated oligo(2,6-dimethyl-1,4-phenylene ether)s (OPEs): Seeking an OPE with better properties>, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene, the main research area is vinyl terminated oligodimethylphenylene ether.

Vinylbenzyl ether-terminated oligo(2,6-dimethyl-1,4-phenylene ether) (1) has been commercialized by Mitsubishi Gas Chem. in the name of OPE-2St. OPE (1) is used in high-frequency printed circuit board due to its low-dielec. characteristic after curing. However, for thermoset of (1), there is room for property improvement in thermal mech. property, dielec. property, oxygen permeation resistance, and so on. In this work, we report the preparation of three new oligo(2,6-dimethyl-1,4-phenylene ether)s: the vinyl benzoate-terminated OPE (2), the 3,5-bis(vinylbenzyl ether)benzyl ether-terminated OPE (3), and the 3,5-bis(vinylbenzyl ether)benzoate-terminated OPE (4), and compare their fundamental materials properties with the vinylbenzyl ether-terminated OPE (1). We discussed the effect of the number of vinyl groups (two or four) and the linker (benzyl ether or benzoate) on the properties of the four OPE thermosets. Through property evaluation and data analyses, we found that the thermoset of (4) show the highest Tg, modulus, oxygen permeation resistance, dimensional stability, and the lowest water absorption, and dielec. constant We also found that the toughness of thermoset of (4) can be significantly enhanced by the copolymerization with epoxy resin (HP7200) through the exchange reactions of benzoate and epoxy groups. In short, through properties comparison of four thermosets of (1-4), we demonstrate that (4) is a promising material for high-frequency printed circuit board.

European Polymer Journal published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Logsdon, Amanda L.; Herring, Betty J.; Lockard, Jarrett E.; Miller, Brittany M.; Kim, Hanna; Hood, Ronald D.; Bailey, Melissa M. published the artcile< Exposure to Green Tea Extract Alters the Incidence of Specific Cyclophosphamide-Induced Malformations>, Category: chlorides-buliding-blocks, the main research area is green tea extract cyclophosphamide monohydrate teratogenicity fetus natural pharmaceutical.

BACKGROUND: Green tea extract (GTE) has been shown to have antioxidative properties due to its high content of polyphenols and catechin gallates. Previous studies indicated that catechin gallates scavenge free radicals and attenuate the effects of reactive oxygen species. Cyclophosphamide (CP) produces reactive oxidative species, which can have adverse effects on development, causing limb, digit, and cranial abnormalities. The current study was performed to determine if exposure to GTE can decrease teratogenic effects induced by CP in CD-1 mice. METHODS: From gestation days (GD) 6-13, mated CD-1 mice were dosed with 400 or 800 mg/kg/d GTE; 100, 200, 400, or 800 mg/kg/d GTE + CP; CP alone, or the vehicle. GTE was given by gavage. CP (20 mg/kg) was given by i.p. injection on GD 10. Dams were sacrificed on GD 17, and their litters were examined for adverse effects. RESULTS: The highest GTE dose did not effectively attenuate, and in some cases exacerbated the neg. effect of CP. GTE alone was also associated with an increased incidence of microblepharia. Conversely, moderate GTE doses (200 and/or 400 mg/kg/d) attenuated the effect of CP on fetal weight and (GTE 200 mg/kg/d) decreased the incidences of certain defects resulting from CP exposure. CONCLUSIONS: Exposure of a developing mammal to moderate doses of GTE can modulate the effects of exposure to CP during development, possibly by affecting biotransformation, while a higher GTE dose tended to exacerbate the developmental toxicity of CP. GTE alone appeared to cause an adverse effect on eyelid development.

Birth Defects Research, Part B: Developmental and Reproductive Toxicology published new progress about Arm. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Genzer, Jerome D.; Huttrer, Charles P.; Van Wessem, G. C. published the artcile< Phenoxy- and benzyloxyalkyl thiocyanates>, HPLC of Formula: 16799-05-6, the main research area is .

A series of phenoxy- and benzyloxyalkyl thiocyanates was prepared for pharmacol. evaluation as fungicides against pathogenic fungi associated with dermatophytosis. Procedure 1: o-iso-PrC6H4OH (136 g.), then 250 g. Br(CH2)3Br, were added to 23 g. Na in 450 cc. absolute EtOH at a moderate rate, and the mixture refluxed 5 hrs., cooled, filtered, and fractionated. Procedure 2: p-MeC6H4O(CH2)4Cl was prepared from p-cresol, Cl(CH2)4Cl, and aqueous NaOH (Marvel and Tannenbaum, C.A. 23, 2162). Procedure 3: 139 g. p-O2NC6H4OH in 250 cc. absolute EtOH and 250 g. Br(CH2)3Br were added to 23 g. Na in 300 cc. absolute EtOH and the mixture refluxed 5 hrs. Procedure 4: 2 g. of the ester was heated with a slight excess of alc. KOH about 5 min. at 50°, the mixture poured into a large excess of cold water, and the solution acidified with 1:1 HCl. Procedure 5: 10 cc. xylene, then 20 g. o-ClC6H4CH2Cl in 9 cc. xylene were added (dropwise) to 1.6 g. Na in 18.6 g. (CH2OH)2, and the mixture refluxed 15 min., filtered, and fractionated. Procedure 6: 4.8 g. SOCl2 in 3.4 cc. CHCl3 was added to 7 g. o-ClC6H4CH2OCH2CH2OH in 4.5 g. cold Me2NPh (temperature kept at 20-30°), the mixture refluxed 30 min., cooled, poured into 50 cc. dilute HCl, the upper layer extracted twice with CHCl3, and the combined extracts fractionated. Procedure 7: 36 g. p-O2NC6H4OCH2CH2CH2Br and 15 g. KSCN in 80 cc. absolute EtOH were refluxed 6 hrs.; 7a: pure or crude bromide could be used; 7b: after the mixture was refluxed 9 hrs., 10 g. KI was added and the mixture refluxed 7 hrs. Procedure 8: 150 cc. alc., 52.7 g. Cl compound, 29.9 g. KSCN, and 1 g. powd. Cu were refluxed 24 hrs. Table I; Phenoxyalkyl halides, RC6H4(CH2)nX; R, n, X, B.p./mm., nD20, M.p., Yield (%), Procedure; , 4, Cl, 150°/0.2, 1.5215, , 21, 1; , 5, Cl, 116°/1.3, 1.5144, , 16, 1; o-Br, 2, Br, 116°/0.2, , , 63, 2; p-Br, 2, Br, , , 57°, 44, 2; o-Cl, 2, Br, 136°/5, 1.569, , 40, 2; m-Cl, 2, Br, 85°/0.1, 1.5680, , 23, 2; p-Cl, 2, Br, 108°/1, , 68°, 26, 2; o-Me, 2, Br, 100°/0.6, 1.5479, , 52, 2; m-Me, 2, Br, 80°/1.1, 1.5472, , 54, 2; p-Me, 2, Br, 110°/1, , 49°, 33, 2; p-Br, 3, Br, 150°/0.7, 1.5792, 50°, 53, 2; o-Cl, 3, Br, 120°/0.5, 1.5590, , 44, 2; m-Cl, 3, Br, 108°/1, 1.5580, , 31, 2; p-Cl, 3, Br, , , 37°, poor, 2; m-Me, 3, Br, 120°/2, 1.5422, , 10, 2; p-Br, 4, Cl, 128°/0.03, 1.5548, , 38, 2; o-Cl, 4, Cl, 130°/2, 1.5350, , 59, 2; m-Cl, 4, Cl, 114°/0.4, 1.5345, , 48, 2; o-Me, 4, Cl, 114°/1.5, 1.5189, , 26, 1; m-Me, 4, Cl, 93°/0.1, 1.5199, , 45, 1; p-Me, 4, Cl, 97°/0.2, 1.5180, , 20, 3; p-NO2, 3, Br, 155°/0.1, , , 35, 3; p-OMe, 2, Br, 95-104°/0.3, , , 14, 1; o-Me2CH, 2, Br, 80°/0.4, 1.5329, , 19, 2; o-Me2CH, 3, Br, 84°/0.1, , , 35, 1; 3,4-Me2C:, 2, Br, 90°/0.3, , , 21, 2; o-MeO2C 3, Br, 150-5°/1.4, , , 37, 1; p-MeO2C; 3, Br, 164°/1.5, , , 29, 1; o-MeO2C, 3, Cl, 140°/1.2, , , 37, 1; p-MeO2C, 3, Cl, 163°/3.2, , , 40, 1; o-HO2C, 3, Br, , , 71°, 100(from ester), 4; p-HO2C, 3, Br, , , 161°, 100, 4; o-HO2C, 3, Cl, , , 75°, 100, 4; p-HO2C, 3, Cl, , , 156-7°, 100, 4; Benzyloxyalkanols, RC6H4CH2OCH2O(CH2)nOH; , 2, 95°/0.25, 1.5209, 81, 5; , 3, 114°/0.9, 1.5184, 60, 5; , 5, 140°/0.4, 1.5099, 35, 5; o-Cl, 2, 84°/0.3, 1.5348, 84, 5; o-Cl, 3, 94°/0.5, 1.5245, 28, 5; o-Cl, 5, 139°/0.5, 1.5202, 54, 5; Benzyloxyalkyl chlorides, RC6H4CH2O(CH2)nCl; , 2, 75°/0.2, 1.5181, 77, 6a; , 3, 88°/0.5, 1.5113, 65, 6; , 4, 75°/0.7, 1.5109, 13, b; , 5, 86°/0.1, 1.5079, 75, 6; o-Cl, 2, 72°/0.1, 1.5339, 77, 6;o-Cl, 3, 120°/0.1, 1.5268, 48, 6; o-Cl, 5, 144°/1.6, 1.5193, 7, 6; Thenyloxy analog, b0.1 69-70°. Prepared from PhCH2OH, Na, and Cl(CH2)4Cl by refluxing 30 min., and distilling; Phenoxyalkyl thiocyanates, RC6H4O(CH2)nSCN; , 2, 152°/0.4, 1.5599, 81, 7; , 3, 125°/0.4, 1.5518, 83, 7; , 4, 155°/0.1, 1.5480, 38-9°, 37, 7b; p-Br, 2, , , 62-3°, 51, 7; o-Cl, 2, 180°/3.0, , 37-9°, 83, 7; m-Cl, 2, 126°/0.1, , , 33, 7; p-Cl, 2, 137°/0.1, 1.5710, 17, 7; o-Me, 2, 132°/0.3, , 60, 7; m-Me, 2, 158°/4.0, 1.5534, 63, 7; p-Me, 2, 130°/0.5, 1.5530, 66, 7; p-Br, 3, , , 48-9°, 53, 7,7a; o-Cl, 3, 165°/1.3, 1.5644, , 52, 7; m-Cl, 3, 164°/1.2, 1.5624, , 96, 7; p-Cl, 3, 50°/0.5, , , 40, 7; m-Me, 3, 138°/0.6, 1.5471, 42, 7; p-Br, 4, 180°/0.5, 1.5410, 66, 7b; m-Cl, 4, 186°/1.9, 1.5543, 55, 7b; o-Me, 4, 138°/0.1, 1.5533, 15, 7b; p-Me, 4, 193°/5.0, 1.5410, 27, 7b; o-HO2C, 3, , , 69-70°, 35, 7; p-HO2C, 3, , , 159°, 35, 7; p-O2N, 3, , , 53-4°, 44, 7; p-MeO, 2, 141°/0.4, , , 43, 7; o-Me2CH, 2, 123°/0.3, 1.5402, , 47, 7,7a; 3,4-Me2C:, 2, 130°/0.3, , , 51, 7; o-Me2CH, 3, 140°/0.1, 1.5363, , 60, 7,7a; o-Br, 2, 162°/1.7, , 1.5920, 51, 7; o-Cl, 4, 164°/0.5, 1.5544, , 40, 8; Benzyloxyalkyl thiocyanates, RC6H4CH2O(CH2)nSCN; , 3, 124°/0.1, 1.5348, 13, 8; , 5, 161°/0.6, 1.5292, 47, 8; o-Cl, 2, 160°/1.5, 1.5528, 16, 8; o-Cl, 3, 152°/0.8, 1.5506, 18, 8;

Journal of the American Chemical Society published new progress about Tinea pedis. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, HPLC of Formula: 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hafner, Andreas; Meisenbach, Mark; Sedelmeier, Joerg published the artcile< Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s>, Recommanded Product: 4-Chloro-2-methoxybenzaldehyde, the main research area is multigram scale boronic acid chem synthesis.

The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chem. on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chem. (chem. synthesis on a time scale of <1 s) with remarkable throughput (g/min) while mitigating the risk of blockages. Organic Letters published new progress about Boronic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Recommanded Product: 4-Chloro-2-methoxybenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Du, Guangyan; Rao, Suman; Gurbani, Deepak; Henning, Nathaniel J.; Jiang, Jie; Che, Jianwei; Yang, Annan; Ficarro, Scott B.; Marto, Jarrod A.; Aguirre, Andrew J.; Sorger, Peter K.; Westover, Kenneth D.; Zhang, Tinghu; Gray, Nathanael S. published the artcile< Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine>, Application of C7H8ClN, the main research area is drug target design SRC kinase inhibitor antitumor.

SRC is a major regulator of many signaling pathways and contributes to cancer development. However, development of a selective SRC inhibitor has been challenging, and FDA-approved SRC inhibitors, dasatinib and bosutinib, are multi-targeted kinase inhibitors. Here, we describe our efforts to develop a selective SRC covalent inhibitor by targeting cysteine 277 on the P-loop of SRC. Using a promiscuous covalent kinase inhibitor (CKI) SM1-71 as a starting point, we developed covalent inhibitor 15a, which discriminates SRC from other covalent targets of SM1-71 including TAK1 and FGFR1. As an irreversible covalent inhibitor, compound 15a exhibited sustained inhibition of SRC signaling both in vitro and in vivo. Moreover, 15a exhibited potent antiproliferative effects in nonsmall cell lung cancer cell lines harboring SRC activation, thus providing evidence that this approach may be promising for further drug development efforts.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application of C7H8ClN.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics