October 2022 - Page 257 of 286 - Chlorides-buliding-blocks

Barry, Vincent C.’s team published research in Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science in 1950 | CAS: 56966-48-4

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 2-Amino-2,4-dichlorodiphenyl ether

In 1950,Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science included an article by Barry, Vincent C.; Belton, J. G.; Conalty, M. L.; O’Rourke, L.; Twomey, D.. Safety of 2-Amino-2,4-dichlorodiphenyl ether. The article was titled 《Antituberculous substances. VII. Derivatives of diphenyl ether》. The information in the text is summarized as follows:

An attempt is made to relate antitubercular activity to chem. structure among Ph2O derivatives The dilution which completely inhibits the growth of Mycobacterium tuberculosis for 6 wk was determined in each case. The compounds tested and their effective dilution (in the presence and in the absence of blood serum, resp.) are given as follows: Ph2O, -, 1000. Derivatives containing 1 solubilizing group: 4-H2N, -, 35,000; 4-HO, -, 100,000; 4-HO2C, -, <5,000; 4-HO3S, -, <1,000; 4-guanyl, 10,000, 25,000; and 2-H2N, -, 10,000. Derivatives containing 1 halogen atom: 4-chloro-4'-amino, 10,000, 200,000; 2-chloro-4'-amino, -, 250,000; 2-chloro-4-amino, 10,000, 250,000; 2-chloro-4'-guanyl, 10,000, 50,000; 2-chloro-4-guanyl, 25,000, 25,000; 4-chloro-4'-guanyl, 50,000, 150,000; 4-chloro-4'-hydroxy, -, 300,000; 4-chloro-4'-carboxy, -, 50,000; 4,4'-diguanyl, 1,000, 10,000; 2-chloro-4,4'-diguanyl, 10,000, 25,000; 4-chloro-2'-amino, -, 10,000; and 4-chloro-2',4'-diamino, -, 10,000. Dihalogenated derivatives: 2,4'-dichloro-4-guanyl, 50,000, 100,000; 2,4-dibromo-4'-amino, -, 400,000; 2,4-dichloro-4'-amino, 10,000, 600,000; 4-amino-2,4'-dichloro, 25,000, 1,000,000; 4-amino-2,2'-dichloro, 10,000, 400,000; 2-amino-2',4-dichloro, -, 100,000; 2-amino-4,4'-dichloro, 10,000, 150,000; 4-amino-2',4'-dichloro, 5,000, 400,000; and 2,3-diiodo-4-amino, -, 600,000. Trihalogenated derivatives: 2,2-diiodo-4-amino-4'-chloro, 25,000, 1,000,000; 2,4,5-trichloro-4'-amino, 50,000, 500,000; 2,4,6-trichloro-4'-amino, 25,000, 500,000; 2,4,5-trichloro-4'-hydroxy, -, 400,000; 2,4,5-trichloro-2',4'-diamino, -, 25,000; 2,2',4-trichloro-4'-amino, 10,000, 1,000,000. Miscellaneous derivatives and other compounds: 3,4-dimethyl-4'-amino, 10,000, 50,000; 2-chloro-4-isobutyl-4'-amino, 10,000, 750,000; 3,5-dimethyl-4-chloro-4'-amino, 25,000, 500,000; 2-methyl-4-amino-4'-chloro, -, 300,000; 2-amino-4-methyl-2'-bromo, -, 25,000; 2-bromo-4-methyl-2'-amino, -, 25,000; 2-amino-4-nitro-4'-chloro, 5,000, 10,000; 2,2',4,5-tetrachloro-4'-amino-, 25,000, 1,000,000; 4,4'-diamino, -, 1,000; 4-amino-4'-hydroxy, 10,000, 50,000; 4-amino-4'-carboxy, -, 5,000; and 4-nitro-4'-carboxy, -, 25,000; 2-hydroxy-4-aminobenzoic acid (PAS), 200, 300; sulphetrone, <1000, <1000; and streptomycin, 500,000, 1,000,000. Similar tests were run to determine the dilution needed to inhibit growth of M. smegmatus for 6 days and data are given. The most active compounds are those in which the hydrophilic group occupies the para position to the O bridge and its basic or acidic character is not significant. A grouping which possesses high water solubility depresses biol. activity, as when 2 HO, 2 H2N, or 2 guanyl groups are present. Introduction of 1 or 2 Cl substituents increases the antitubercular activity; further halogenation has little addnl. effect. The greatest activity is shown by compounds in which the halogens are shared by both Bz nuclei. Compounds which most strongly depress O uptake of yeast cells have the highest antitubercular activity. All of the Ph2O derivatives tested required a dilution of 50,000 or less in the presence of serum (in vivo) as compared to an active dilution of 1:500,000 for streptomycin.2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Safety of 2-Amino-2,4-dichlorodiphenyl ether) was used in this study.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Wen-Kui’s team published research in Organic Letters in 2019-03-15 | 3240-10-6

Organic Letters published new progress about Acetamides Role: RCT (Reactant), RACT (Reactant or Reagent) (aryloxy). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Category: chlorides-buliding-blocks.

Yuan, Wen-Kui; Zhu, Ming-Hui; Geng, Rui-Sen; Ren, Guang-Yi; Zhang, Lin-Bao; Wen, Li-Rong; Li, Ming published the artcile< Construction of Benzofuran-3(2H)-one Scaffolds with a Quaternary Center via Rh/Co Relay Catalyzed C-H Functionalization/Annulation of N-Aryloxyacetamides and Propiolic Acids>, Category: chlorides-buliding-blocks, the main research area is benzofuranone preparation rhodium cobalt catalyzed annulation aryloxyacetamide propiolic acid.

An unprecedented synthesis of valuable benzofuran-3(2H)-one scaffolds with a quaternary center was developed via Rh/Co relay catalyzed C-H functionalization/annulation of N-aryloxyacetamides with propiolic acids in moderate to good yields. The reaction features the simultaneous construction of the benzofuran motif containing a C2 quaternary center and a C3 carbonyl group. The preliminary mechanism study verified that the O atom of C3 carbonyl group originates from mol. oxygen.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Budiman, Yudha P’s team published research in Chemistry – A European Journal in 2021-02-25 | 1435-43-4

Chemistry – A European Journal published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent) (fluorinated). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Quality Control of 1435-43-4.

Budiman, Yudha P.; Lorenzen, Sabine; Liu, Zhiqiang; Radius, Udo; Marder, Todd B. published the artcile< Base-Free Pd-Catalyzed C-Cl Borylation of Fluorinated Aryl Chlorides>, Quality Control of 1435-43-4, the main research area is palladium catalyzed carbon chloride bond activation borylation fluoroaryl chloride; fluoroaryl borane preparation; boronate ester; borylation; cross-coupling; fluoroarene; palladium-catalyzed.

Catalytic C-X borylation of aryl halides containing two ortho-fluorines is challenging, as most previous methods require stoichiometric amounts of base and the polyfluorinated aryl boronates suffer from protodeboronation, which is accelerated by ortho-F substituents. Herein, the authors report that a combination of Pd(dba)2 (dba = dibenzylideneacetone) with SPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl) as a ligand is efficient to catalyze the C-Cl borylation of aryl chlorides containing two ortho-F substituents. This method, conducted under base-free conditions, is compatible with the resulting di-ortho-fluorinated aryl boronate products which are sensitive to base.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sawodny, Wolfgang’s team published research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1967 | 1435-43-4

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 1435-43-4. 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Application In Synthesis of 1435-43-4.

Sawodny, Wolfgang; Niedenzu, Kurt; Hynes, John B.; Dawson, John W. published the artcile< Vibrational spectra of trihalo-s-triazines C3F3-nClnN3>, Application In Synthesis of 1435-43-4, the main research area is TRIAZINES VIBRATIONAL SPECTRA; HALOTRIAZINES VIBRATIONAL SPECTRA; TRIHALOTRIAZINES VIBRATIONAL SPECTRA.

The ir and Raman spectra of 2-fluoro-4,6-dichloro-s-triazine and 2,4-difluoro-6-chloro-s-triazine were recorded and an assignment of the normal vibrations in the series C3Cl3-nFnN3 is proposed. The ir spectra of the series C3Br3-nFnN3 are evaluated in somewhat less detail. 24 references.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bunnett, J F’s team published research in Journal of the American Chemical Society in 1949 | 31166-29-7

Journal of the American Chemical Society published new progress about Chlorination. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, COA of Formula: C5H2Cl2O2S.

Bunnett, J. F.; Bachman, D. M.; Snipper, L. P.; Maloney, J. H. published the artcile< Chlorination of 2-thiophenecarboxylic acid>, COA of Formula: C5H2Cl2O2S, the main research area is .

2-Thiophenecarboxylic acid (I) 3 g. (0.023 mole), NaOCl 0.042 mole, and excess NaOH in 400 cc. total volume were treated at pH 11.0 and 48° with 25 cc. 6 N HCl for 6 min. The temperature rose to 53°, the pH dropped to 1.3, and a white precipitate formed. After addition of 5 cc. 6 N HCl and 107 g. NaCl, the mixture was cooled and filtered to give 1.75 g. (46%) 5-chloro-2-thiophenecarboxylic acid (II), m. 134-7°, and, after recrystallization and sublimation, m. 149-50°, did not depress the m. p. of II prepared by KMnO4 oxidation of 5-chloro-2-acetylthiophene. Similarly 1.9 g. I (0.015 mole) and 0.037 mole NaOCl gave 0.4 g. (14%) 4,5-dichloro-2-thiophenecarboxylic acid, m. 194-4.5° (from H2O) (cf. m.p. 196-7° of Steinkopf and Kohler in C.A. 32, 3391.1). Oily by-products from several runs were combined to give a considerable fraction of 2,5-dichlorothiophene (III), b. 160-5°, nD16 1.5624; 3,4-dinitro derivative m. 85-5.5°. The by-product oil from a mixture of I and 3 moles NaOCl was a mixture of chlorinated thiophenes, with III the principal constituent.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Canosa, P’s team published research in Analytica Chimica Acta in 2006-08-04 | 3964-57-6

Analytica Chimica Acta published new progress about Bromides Role: OCU (Occurrence, Unclassified), RCT (Reactant), OCCU (Occurrence), RACT (Reactant or Reagent). 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Canosa, P.; Rodriguez, I.; Rubi, E.; Negreira, N.; Cela, R. published the artcile< Formation of halogenated by-products of parabens in chlorinated water>, COA of Formula: C8H7ClO3, the main research area is paraben halogenated product formation chlorinated water; sewage raw dichloro paraben pollution.

Chem. transformations of four alkyl esters of p-hydroxybenzoic acid, parabens, in chlorinated water samples are investigated. Quantification of the parent species and identification of their reaction byproducts were performed using gas chromatog./mass spectrometry. Experiments were accomplished considering free chlorine and paraben concentrations at the mg/L and μg/L level, resp. Concentration of water samples, using solid-phase extraction, and silylation of the target species were carried out in order to improve the detectability of parent species and their possible transformation products, achieving quantification limits at the low ng/L level. Under the employed exptl. conditions, the decrease in the concentrations of parabens followed pseudo-first-order kinetics. Half-life values obtained for model ultrapure water solutions were in good agreement with those observed in tap water samples. For the first type of sample, only two byproducts were detected for each paraben. They corresponded to chlorination of the aromatic ring in one or two carbons situated in ortho positions to the hydroxyl group. Both species were also generated after the addition of parabens to chlorinated tap water. Moreover, three new transformation products were noticed for each parent compound They were identified as bromo- and bromochloro-parabens, formed due to the existence of traces of bromide in tap water sources. Experiments carried out by mixing paraben-containing personal care products with tap water, containing free chlorine, confirmed the formation of all the above described halogenated byproducts. In addition, the presence of the di-chlorinated forms of Me and Pr paraben has been detected for first time in raw sewage water samples.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chan, Pei Qie’s team published research in Asian Journal of Organic Chemistry in 2018 | 22717-55-1

Asian Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application In Synthesis of 22717-55-1.

Chan, Pei Qie; Lee, Yean Kee; Abd Rahman, Noorsaadah published the artcile< Facile Intramolecular Cyclization of N-(2-Hydroxybenzoyl)hydrazones to N,N'-Diacetyl Benzo-1,3,4-oxadiazepine Derivatives>, Application In Synthesis of 22717-55-1, the main research area is diacetyl phenyl benzoxadiazepinone preparation; hydroxybenzoylhydrazone intramol cyclization sulfuric acid catalyst.

A facile synthesis of diacetyl-phenyl-benzoxadiazepinones I [R = Ph, 4-ClC6H3, 2-naphthyl, etc.; R1 = Ph, 4-MeSC6H4, 4-O2NC6H4, etc.] through sulfuric acid-catalyzed one-step intramol. cyclization of N-(2-hydroxybenzoyl)hydrazones was established and further the catalytic and substituent effects on the reactivity of this intramol. cyclization were investigated.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zheng, Yan’s team published research in Chemistry – A European Journal in 2021-11-22 | 17082-09-6

Chemistry – A European Journal published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Formula: C9H7ClO.

Zheng, Yan; Dong, Mengke; Qu, Erdong; Bai, Jin; Wu, Xiao-Feng; Li, Wanfang published the artcile< Pd-Catalyzed Carbonylative Synthesis of 4H-Benzo[d][1,3]Oxazin-4-Ones Using Benzene-1,3,5-Triyl Triformate as the CO Source>, Formula: C9H7ClO, the main research area is benzooxazinone preparation; bromoaryl amide benzene triyltriformate carbonylative cross coupling catalyst palladium; benzoxazinone; carbonylation; heterocycles; palladium; synthetic methods.

A facile synthesis of 4H-benzo[d][1,3]oxazin-4-one derivatives I [R1 = 6-F, 8-Me, 7-Cl, etc.; R2 = Me, n-Pr, t-Bu, etc.] by Pd-catalyzed carbonylative cross-coupling between N-(ortho-bromoaryl)amides and benzene-1,3,5-triyl triformate (TFBen) was developed. This procedure does not require the toxic and flammable gas CO as the carbonyl source and tolerates a wide scope of functional groups. Remarkably, 4H-benzo[d][1,3]oxazin-4-ones incorporated to natural products and drugs could be constructed by this method.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Igarashi, Susumu’s team published research in Chemical & Pharmaceutical Bulletin in 2000-11-30 | 3964-57-6

Chemical & Pharmaceutical Bulletin published new progress about 3964-57-6. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 3-chloro-4-hydroxybenzoate.

Igarashi, Susumu; Inami, Hiroshi; Hara, Hiromu; Koutoku, Hiroshi; Oritani, Hiroyuki; Mase, Toshiyasu published the artcile< A novel class of inhibitors for human and rat steroid 5α-reductases: synthesis and biological evaluation of indoline and aniline derivatives>, Name: Methyl 3-chloro-4-hydroxybenzoate, the main research area is steroid reductase inhibitor carboxyphenoxyindoline carboxyphenoxyaniline preparation.

Searching for novel nonsteroidal inhibitors of human and rat prostatic 5α-reductases led to a new series of indoline and aniline derivatives that showed potent inhibitory activities for both enzymes. Among them, 3-chloro-4-{[1-(4-phenoxybenzyl)indolin-5-yl]oxy}benzoic acid (YM-36117) showed a more potent inhibitory activity for the human enzyme than ONO-3805 with an IC50 value of 5.3 nM and a reduced rat prostatic dihydrotestosterone (DHT) concentration by oral administration. The synthesis and the structure-activity relationships of these indoline and aniline derivatives are presented.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Pengfei’s team published research in Journal of Agricultural and Food Chemistry in 2019-10-30 | 35852-58-5

Journal of Agricultural and Food Chemistry published new progress about Fungicides. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Computed Properties of 35852-58-5.

Zhang, Pengfei; Guan, Aiying; Xia, Xiaoli; Sun, Xufeng; Wei, Siyuan; Yang, Jinlong; Wang, Junfeng; Li, Zhinian; Lan, Jie; Liu, Changling published the artcile< Design, Synthesis, and Structure-Activity Relationship of New Arylpyrazole Pyrimidine Ether Derivatives as Fungicides>, Computed Properties of 35852-58-5, the main research area is pyrimidine ether preparation fungicidal activity structure activity relationship; fungicidal activities; intermediate derivatization method (IDM); pyrimidine ether derivatives; structure−activity relationship.

To explore a novel fungicide effectively against cucumber downy mildew (CDM), a series of new arylpyrazole containing pyrimidine ether derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). The structures of synthesized compounds were identified by 1H NMR, 13C NMR, elemental analyses, MS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Especially, compound I (EC50 = 1.22 mg/L) displayed significantly higher bioactivity than that of com. fungicides diflumetorim and flumorph and nearly equal effect to that of cyazofamid. The relationship between the structure and fungicidal activity of the synthesized compounds was discussed as well. The study showed that compound I was a promising fungicide candidate for further development.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics