Month: October 2022

Reference of Sodium chlorideIn 2021 ,《The effects of sodium chloride on proteins aggregation, conformation and gel properties of pork myofibrillar protein Running Head: Relationship aggregation, conformation and gel properties》 appeared in Journal of Food Science and Technology (New Delhi, India). The author of the article were Kang, Zhuang-Li; Zhang, Xue-hua; Li, Xiang; Song, Zhao-jun; Ma, Han-jun; Lu, Fei; Zhu, Ming-ming; Zhao, Sheng-ming; Wang, Zheng-rong. The article conveys some information:

The objective of this study was to evaluate relationship with aggregation, secondary structures and gel properties of pork myofibrillar protein with different sodium chloride (1%, 2% and 3%). When the sodium chloride increased from 1 to 3%, the active sulfhydryl, surface hydrophobicity, hardness and cooking yield of myofibrillar protein were increased significantly (p < 0.05), the particle size, total sulfhydryl and Zeta potential were decreased significantly (p < 0.05), these meant the aggregations of pork myofibrillar protein were decreased. The changes of proteins aggregation induced the strongest intensity band of Amide I shifted up from 1660 cm-1 to 1661 cm-1, meanwhile, the β-sheet structure content was increased significantly (p < 0.05) with the sodium chloride increased. From the above, the lower proteins aggregation and higher β-sheet structure content could improve the water holding capacity and texture of pork myofibrillar protein gel. After reading the article, we found that the author used Sodium chloride(cas: 7647-14-5Reference of Sodium chloride)

Sodium chloride(cas: 7647-14-5) has been used for the preparation of tris buffered saline, phosphate buffered saline, MPM-2 (mitotic protein monoclonal 2) cell lysis buffer, immunoprecipitation wash buffer, LB (Luria-Bertani) media and dialysis buffer.Reference of Sodium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained H2S release profiles》 were Bhattacherjee, Debojit; Sufian, Abu; Mahato, Sulendar K.; Begum, Samiyara; Banerjee, Kaustav; De, Sharmistha; Srivastava, Hemant Kumar; Bhabak, Krishna P.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Related Products of 620-20-2 The author mentioned the following in the article:

Temperature- and solvent-induced selective synthesis of trisulfides and disulfides is demonstrated. A remarkable selectivity was achieved using Na2S as a sulfur-transfer agent under mild, greener, catalyst-free and additive-free conditions. This study reveals trisulfides as a better model than disulfides in general for a sustained release of H2S and potent anti-cancer activities. In the part of experimental materials, we found many familiar compounds, such as 3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and enzyme-based evaluation of analogues L-tyrosine thiol carboxylic acid inhibitor of metallo-β-lactamase IMP-1》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. These research results belong to Khalili Arjomandi, Omid; Kavoosi, Mahboubeh; Adibi, Hadi. Related Products of 620-20-2 The article mentions the following:

The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete metallo-β-lactamases (enzymes that inactivate β-lactam antibiotics) are increasingly prevalent and have become a major worldwide threat to human health. These bacteria are resistant to β-lactam antibiotics and MBL-inhibitor/β-lactam antibiotic combination therapy can be a strategy to overcome this problem. So far, no clin. available inhibitors of metallo-β-lactamases (MBLs) have been reported. In this study, L-benzyl tyrosine thiol carboxylic acid analogs (I) were synthesized after the study of computational simulation by adding of Me, chloro, bromo, and nitro groups to the benzyl ring for investigation of SAR anal. Although the synthesized mols. shows the potent inhibitory effects against metallo-β-lactamase (IMP-1) with the range of Kic values of 1.044.77 μM, they are not as potent as the candidate inhibitor.3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C6H4Cl2O2SIn 2019 ,《Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety》 appeared in Journal of Enzyme Inhibition and Medicinal Chemistry. The author of the article were Abdel-Maksoud, Mohammed S.; El-Gamal, Mohammed I.; Gamal El-Din, Mahmoud M.; Oh, Chang Hyun. The article conveys some information:

The present work describes the design and synthesis of a novel series of 1,3-diaryl-4-sulfonamidoarylpyrazole derivatives and their in vitro biol. activities. The target compounds were evaluated for antiproliferative activity against NCI-60 cell line panel. Compounds , and showed the highest mean inhibition percentages at 10 μM single-dose testing and were selected to be tested at 5-dose mode. The ICs50 of the most potent compounds were determined over the 60 cell lines. Compound exhibited the strongest activity against different cell lines with IC50 0.33 μM against A498 renal cancer cell line. Compound was tested over a panel of 20 kinases to determine its mol. target(s), and its IC50 values over the most sensitive kinases were defined. In vitro stability and in vivo pharmacokinetic profile of compound was also investigated. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C6H4Cl2O2S Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Butt, G.; Topsom, R. D. published an article in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The title of the article was 《Transmission of substituent effects through extended systems. III. p-Substituted ethyl trans-cinnamates and phenylpropiolates》.Electric Literature of C11H13ClO2 The author mentioned the following in the article:

IR and 13C chem. shifts were determined for Et p-substituted trans-cinnamates and Et phenylpropiolates. The IR data include intensities for the benzene, ethylene, and CO group vibrations which allow an estimation of resonance effects. The relative importance of the various mechanisms of transmission of substituent effects is discussed and compared with those previously reported for p-substituted trans-cinnamonitriles. The CC is less efficient in transmitting substituent effects than the C:C. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Electric Literature of C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Electric Literature of C11H13ClO2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis and characterization of a cyclometallated palladium(II) complex with (2-diphenylphosphino)ethylamine》 were Elsegood, Mark R. J.; Han, Jiabao; Smith, Martin B.; Wu, Shimeng. And the article was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2019. Category: chlorides-buliding-blocks The author mentioned the following in the article:

Reaction of com. available Ph2PCH2CH2NH2 with {PdCl(C9H12N)}2 (2:1) in CH2Cl2 afforded, instead of Pd(Cl)(P-Ph2PCH2CH2NH2)(C9H12N) , the cationic complex [Pd(P,N-Ph2PCH2CH2NH2)(C9H12N)]Cl which was characterized by single crystal x-ray crystallog. The lack of reactivity of towards Rhodamine 6G can therefore be rationalized. In the part of experimental materials, we found many familiar compounds, such as Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Category: chlorides-buliding-blocks)

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Miki, Ryotaro; Yamaki, Tsutomu; Uchida, Masaki; Natsume, Hideshi published an article in Colloids and Surfaces, A: Physicochemical and Engineering Aspects. The title of the article was 《Hydrogen peroxide-responsive micellar transition from spherical to worm-like in cetyltrimethylammonium bromide/3-fluorophenylboronic acid/fructose system》.SDS of cas: 768-35-4 The author mentioned the following in the article:

In this study, we successfully prepared a novel hydrogen peroxide (H2O2)-responsive micellar system, whose viscosity drastically changes depending on H2O2 levels. The cationic surfactant cetyltrimethylammonium bromide (CTAB)/3-fluorophenol (3FPhOH) and CTAB/3-fluorophenylboronic acid (3FPBA) systems exhibited high viscosity. The viscosity of the CTAB/3FPBA system significantly decreased with the addition of fructose (Fru). The zero-shear viscosity of the CTAB/3FPBA/Fru system with 40 mM H2O2 increased 4 x 104-fold in comparison to that without H2O2. We confirmed that both the CTAB/3FPhOH and CTAB/3FPBA/Fru with H2O2 systems form worm-like micelle (WLM) structures based on their rheol. properties. The results of dynamic light scattering measurements supported the micellar transition with the addition of H2O2. We successfully demonstrated H2O2-responsive micellar transition from spherical/shorter rod-like micelles to long WLMs. We utilized the two reactions in the CTAB-based micellar system to control micellar transitions and viscosities: (i) Phenylboronic acid (PBA) forms a reversible cyclic ester structure with Fru and (ii) PBA reacts with H2O2to convert phenol. In the part of experimental materials, we found many familiar compounds, such as (3-Fluorophenyl)boronic acid(cas: 768-35-4SDS of cas: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.SDS of cas: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Moghaddam, Firouz Matloubi; Daneshfar, Maryam; Azaryan, Reza published an article in 2021. The article was titled 《A green and efficient route for P – S – C bond construction using copper ferrite nanoparticles as catalyst: a TD-DFT study》, and you may find the article in Phosphorus, Sulfur and Silicon and the Related Elements.Name: 4-Chlorobenzenesulfonyl chloride The information in the text is summarized as follows:

Magnetic nanoparticles of CuFe2O4 were applied as catalyst system for one-pot thiophosphate synthesis via the reaction of aryl sulfonyl chlorides with H-phosphonates under conventional heating conditions. This is an extremely efficient and green method for thiophosphate synthesis under base- and solvent-free conditions. Various thiophosphates were obtained in good to excellent yields under the optimized reaction conditions in a short time. The catalyst can be easily recycled from the reaction by an external magnetic field and reused for the next run. In this study, TD-DFT B3LYP/6-31 + G(d) calculations are in good accord with the exptl. results. A comparison between exptl. and theor. UV-vis absorption spectra of the thiophosphate has been carried out; and a small hypsochromic shift (only ∼ 2 nm) was displayed at maximum absorption. The aim of this work is to investigate the best method and basis set for thiophosphate compounds; therefore, predictions for these compounds can be performed in theor. studies.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: Sodium chlorideIn 2019 ,《Rapid sample-saving biophysical characterization and long-term storage stability of liquid interferon alpha2a formulations: Is there a correlation?》 appeared in International Journal of Pharmaceutics (Amsterdam, Netherlands). The author of the article were Svilenov, Hristo; Winter, Gerhard. The article conveys some information:

The knowledge and tools to characterize proteins have comprehensively developed in the last two decades. Some of these tools are used in formulation development to select formulation conditions suitable for long-term storage. However, there is an ongoing debate whether the predictions obtained with these tools are in good agreement with the outcome from real-time long-term stability studies. In this work, we investigate whether some of the state-of-the-art microscale, microvolume and non destructive biophys. techniques can be applied to promptly select formulations that minimise the aggregation of interferon alpha2a during storage. Interferon alpha2a was used as a model protein as it is known to form aggregates at concentrations over an order of magnitude higher than used in the com. product. We apply a systematic formulation approach in which we investigate the effect of pH and ionic strength on protein stability. The predictions from the sample-saving biophys. characterization are validated by long-term stability studies at 4 °C and 25 °C for 12 mo on selected formulations. Interferon alpha2a shows minimal aggregation in 10 mM sodium acetate buffer with pH 4 and low ionic strength. The latter is indicated by the rapid sample-saving biophys. characterization and confirmed by the long-term stability data. In addition to this study using Sodium chloride, there are many other studies that have used Sodium chloride(cas: 7647-14-5Recommanded Product: Sodium chloride) was used in this study.

Sodium chloride(cas: 7647-14-5) has been used for the preparation of tris buffered saline, phosphate buffered saline, MPM-2 (mitotic protein monoclonal 2) cell lysis buffer, immunoprecipitation wash buffer, LB (Luria-Bertani) media and dialysis buffer.Recommanded Product: Sodium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Poirot, Alexandre; Saffon-Merceron, Nathalie; Leygue, Nadine; Benoist, Eric; Fery-Forgues, Suzanne published an article in 2021. The article was titled 《Crystal structure of methyl 1,3-benzoxazole-2-carboxylate》, and you may find the article in Acta Crystallographica, Section E: Crystallographic Communications.Product Details of 5781-53-3 The information in the text is summarized as follows:

The title compound, C9H7NO3, crystallizes in the monoclinic (P21) space group. In the crystal, the almost planar mols. display a flattened herringbone arrangement. Stacking mols. are slipped in the lengthwise and widthwise directions and are linked by π interactions [d(Cg…Cg = 3.6640 (11)) Å]. The structure is characterized by strong C-H…N and weak C-H…O hydrogen bonds, and further stabilized by C-O…π interactions. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics