Month: October 2022

《Boronic acid-mediated ring-opening and Ni-catalyzed arylation of 1-arylcyclopropyl tosylates》 was written by Mills, L. Reginald; Monteith, John J.; Rousseaux, Sophie A. L.. Category: chlorides-buliding-blocks And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The ring-opening arylation of 1-arylcyclopropyl tosylates, in which boronic acids promoted ring-opening and a Ni catalyst facilitated arylation in high regioselectivity was described. A number of 2-arylated allyl derivatives were synthesized, which are relevant motifs found in biol. active mols. The experimental part of the paper was very detailed, including the reaction process of (3-Fluorophenyl)boronic acid(cas: 768-35-4Category: chlorides-buliding-blocks)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thirupataiah, B.; Reddy, Gangireddy Sujeevan; Mounika, Guntipally; Kumar, Jetta Sandeep; Hossain, Kazi Amirul; Mudgal, Jayesh; Mathew, Jessy E.; Shenoy, Gautham G.; Rajadurai, Marina; Parsa, Kishore V. L.; Pal, Manojit published an article in 2021. The article was titled 《Pd-catalysed general access to 7-membered N/O-heterocyclic compounds as potential agents against inflammation》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Formula: C4H3ClO2S2 The information in the text is summarized as follows:

A Pd-catalyzed regioselective synthesis of 4,5-disubstituted 7-membered N/O-heterocycles was achieved via the 7-endo-dig cyclization followed by C-C bond formation of 2-(1-alkynyl)phenylacetamide. The ligand/additive free cascade reaction proceeded in the presence of PdCl2 in aqueous MeCN when the sep. and individual use of Me vinyl ketone and allyl bromide generally afforded an O- and N-heterocycle, resp. The pharmacol. assay was performed to identify the first example of a 1H-benzo[d]azepin-2(3H)-one based novel inhibitor of PDE4B. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Formula: C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 10007-84-8On May 31, 2015, Solyanikova, Inna P.; Emelyanova, Elena V.; Shumkova, Ekaterina S.; Egorova, Darya O.; Korsakova, Ekaterina S.; Plotnikova, Elena G.; Golovleva, Ludmila A. published an article in International Biodeterioration & Biodegradation. The article was 《Peculiarities of degradation of benzoate and its chloro- and hydroxy-substituted analogs by actinobacteria》. The article mentions the following:

This work investigates the ability of representatives of four actinobacterial genera (Arthrobacter, Microbacterium, Rhodococcus, Gordonia) to degrade benzoic acid and its hydroxylated or chlorinated analogs. Benzoate, 3-chlorobenzoate and 4-hydroxybenzoate were shown to support growth of most strains. We determined the maximal specific growth rates and doubling times for bacteria grown on these substrates. We examined the substrate specificities of actinobacterial benzoate dioxygenases towards 16 aromatic chems. The specificities varied among species, they were narrow for Rhodococcus opacus 1CP and Gordonia polyisoprenivorans 135 and broad for Rhodococcus ruber P25 and Microbacterium sp. B51. The genes encoding the benzoate dioxygenase α-subunit from R. opacus 1CP, R. opacus 6a, R. ruber P25, Rhodococcus wratislaviensis P1 and R. wratislaviensis G10 which were isolated at distant sites exhibited between 88 and 97% homol. with the homologous gene of Rhodococcus jostii RHA1. This indicates a common origin of these genes. Notably, in some strains, catechol 1,2-dioxygenase and gentisate dioxygenase were induced simultaneously during growth on benzoate. In the part of experimental materials, we found many familiar compounds, such as Sodium 2,6-dichlorobenzoate(cas: 10007-84-8SDS of cas: 10007-84-8)

Sodium 2,6-dichlorobenzoate(cas: 10007-84-8) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 10007-84-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis and biological activity of certain pyridobenzodiazepine derivatives》 were Botros, Samir; El-Gendy, Adel A.; Said, Mohamed M.; Oma, Adel H.. And the article was published in Bulletin of the Faculty of Pharmacy (Cairo University) in 2001. Recommanded Product: 66662-48-4 The author mentioned the following in the article:

The present work comprises the synthesis of 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine-5-one derivatives by condensation of 2-chloro-4,6-dimethylnicotinic acid with 1,2-phenylenediamines using 1-butoxyethanol as solvent. Monoalkylation of the products using one equivalent of the appropriate alkyl halide and 30% NaOH in DMSO gave the 6-alkyl derivatives. Some of the prepared compounds were screened for CNS depressant and anticonvulsant activities. After reading the article, we found that the author used 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Recommanded Product: 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《A visible light-mediated, decarboxylative, desulfonylative Smiles rearrangement for general arylethylamines syntheses》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Whalley, David M.; Duong, Hung A.; Greaney, Michael F.. Synthetic Route of C4H3ClO2S2 The article mentions the following:

A decarboxylative, desulfonylative Smiles rearrangement is presented that employs activated-ester/energy transfer catalysis to decarboxylate β-amino acid derived starting materials at room-temperature under visible light irradiation The radical Smiles rearrangement gives a range of biol. active arylethylamine products highly relevant to the pharmaceutical industry, chem. biol. and materials science. The reaction is then applied to the synthesis of a chiral unnatural amino acid, 2-thienylalanine, used in the treatment of phenylketonuria. It was also shown how the reaction can proceed under metal-free and catalyst-free conditions. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Crystal structure and anti-inflammatory activity of (3E,5E)-1-((4-chlorophenyl)sulfonyl)-3-(pyridin-4-ylmethylene)-5-(2-(trifluoromethyl)benzylidene)piperidin-4-one, C25H18ClF3N2O3S》 was published in Zeitschrift fuer Kristallographie – New Crystal Structures in 2020. These research results belong to Zhou, Yan-Qiu; Hou, Gui-Ge; Meng, Qing-Guo; Hou, Yun. Safety of 4-Chlorobenzenesulfonyl chloride The article mentions the following:

C25H18ClF3N2O3S, monoclinic, P21/n (number 14), a = 9.9087(5) Å, b = 21.7843(10) Å, c = 10.2512(6) Å, β = 94.749(5)°, V = 2205.2(2) Å3, Z = 4, Rgt(F) = 0.0448, wRref(F2) = 0.1028, T = 100 K. CCDC number: 1868651. 2-(Trifluoromethy)benzaldehyde (1.74 g, 10.0 mmol), 4-pyridinecarboxaldehyde (1.07 g, 10.0 mmol) and 4-piperidone hydrate hydrochloride (1.35 g, 10.0 mmol) were dissolved in dilute acetic acid (25 mL). This mixture was passed through by dry HCL gas for 30 min. After stirring at room temperature for about 24 h (monitored by thin layer chromatog. (TLC)), the precipitate was collected and washed with cold acetone. The precipitates were added into 100 mL water, and then aqueous Na2CO3 solution was added until the pH value was adjusted to about 7. The precipitates were filtered, subsequently washed by water, and purified on silica gel by column using methanol/petroleum ether/EtOAc (1:10:10, volume/volume/v) as the eluent to afford a yellow intermediate. Next, the intermediate (0.69 g, 2.0 mmol), and 4-chlorobenzenesulfonyl chloride (0.46 g, 2.2 mmol) were dissolved in dichloromethane (50 mL). Two drops of pyridine were added. After stirring for about 6 h at room temperature, the precipitate was collected, washed with water and recrystallized from dichloromethane/methanol (1:1, volume/volume) to get light yellow crystals of the title compound In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Safety of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Safety of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Selective hydrogenation of α,β-unsaturated carbonyl compounds on silica-supported copper nanoparticles》 were Mendes-Burak, Jorge; Ghaffari, Behnaz; Coperet, Christophe. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Safety of Ethyl 3-(4-chlorophenyl)propanoate The author mentioned the following in the article:

Silica-supported copper nanoparticles prepared via surface organometallic chem. are highly efficient for the selective hydrogenation of various α,β-unsaturated carbonyl compounds yielding the corresponding saturated esters, ketones, and aldehydes in the absence of additives. High conversions and selectivities (>99%) are obtained for most substrates upon hydrogenation at 100-150 °C and under 25 bar of H2. In the experiment, the researchers used many compounds, for example, Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Safety of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Safety of Ethyl 3-(4-chlorophenyl)propanoate Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

de Vasconcelos, Alana; Zulian Boeira, Ana Julia; Drawanz, Bruna Bento; Pedra, Nathalia Stark; Bona, Natalia Pontes; Stefanello, Francieli Moro; Cunico, Wilson published an article in Medicinal Chemistry (Sharjah, United Arab Emirates). The title of the article was 《2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Anti-glioma Activities in C6 and GL261 Cells》.HPLC of Formula: 620-20-2 The author mentioned the following in the article:

Thiazolidinediones (TZDs) represent an important class of heterocyclic compounds that have versatile biol. activities, including anticancer activity. Glioma is one of the most common primary brain tumors, and it is responsible for most of the deaths caused by primary brain tumors. In the present work, 2,4-thiazolidinediones were synthesized via a multicomponent microwave one-pot procedure. The cytotoxicity of compounds was analyzed in vitro using rat (C6) and mouse (GL261) glioblastoma cell lines and primary cultures of astrocytes. This study aims to synthesize and characterize 2,4-thiazolidinediones and evaluate their antitumor activity. TZDs were synthesized from three components: 2,4-thiazolidinedione, arene-aldehydes, and aryl chlorides. The reactions were carried out inside a microwave and monitored using thinlayer chromatog. (TLC). Compounds were identified and characterized using gas chromatog. coupled to mass spectrometry (CG-MS) and hydrogen (1H-NMR) and carbon NMR spectroscopy (13C-NMR). The antitumor activity was analyzed using the 3-(4,5- dimethyl)-2,5-diphenyltetrazolium bromide (MTT) reduction test, in which cell viability was verified in the primary cultures of astrocytes and in rat and mouse glioblastoma cells exposed to the synthesized compounds The cytotoxicity of all derivatives was analyzed at the 100 μM concentration, both in astrocytes and in the mouse and rat glioblastoma cell lines. The compounds that showed the best results, 4CI and 4DI, were also tested at concentrations 25, 50, 100, 175, and 250 μM to obtain the IC50. Seventeen TZD derivatives were easily obtained through one-pot reactions in 40 min with yields ranging from 12% to 49%. All compounds were cytotoxic to both glioblastoma cell lines without being toxic to the astrocyte primary cell line at 100 μM, thus demonstrating a selective activity. Compounds 4CI and 4DI showed the best results in the C6 cells: IC50 of 28.51 μM and 54.26 μM, resp. The compounds were not cytotoxic in astrocyte culture, demonstrating selectivity for malignant cells. Changes in both rings are important for anti-glioma activity in the cell lines tested. TZD 4CI had the best anti-glioma activity. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2HPLC of Formula: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.HPLC of Formula: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2004,Bulletin of the Faculty of Pharmacy (Cairo University) included an article by El-Shemy, Khaled; El-Badry, Ossama; Roshdy, Sameha; El-Enany, Mervat. Product Details of 66662-48-4. The article was titled 《Synthesis of certain novel pyridothiopyranoindazoles as potential DNA intercalators in cancer chemotherapy》. The information in the text is summarized as follows:

A series of 5-chloro-8,10-dimethyl-2-(aminoethyl)pyrido[3′,2′:5,6]thiopyrano[4,3,2-cd]indazole, e.g., I, was obtained by reacting 5-chloro-8,10-dimethyl-2-(2-chloroethyl)pyrido[3′,2′:5,6]thiopyrano[4,3,2-cd]indazole with certain primary or secondary amines. The in vitro cytotoxic effect of selected samples of the synthesized compounds were also achieved. The two synthesized series have structural relationship to certain anthrapyrazoles and benzothiopyranoindazoles which have been reported as potent antitumor agents. The experimental process involved the reaction of 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Product Details of 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Jun; Yang, Tianjiao; Wang, Jiayi; Song, Gonghua published an article on January 31 ,2021. The article was titled 《Multistep Synthesis and Nematicidal Activity of 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-One Derivatives》, and you may find the article in Chemistry of Heterocyclic Compounds (New York, NY, United States).Safety of 3-Chlorobenzylchloride The information in the text is summarized as follows:

Novel 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-ones I [R = H, 5-F, 6-MeO, 5-Cl; R1 = Me, benzyl, 4-chlorobenzyl, etc.; R2 = tert-Bu, cyclohexyl, 2-MeOC6H4, etc.] which derived from 5-HT3 receptor antagonists hexahydroazepinylbenzamides were designed and synthesized through isocyanide insertion reaction. All target compounds I were evaluated against pinewood nematodes B. xylophilus and root-knot nematodes M. incognita. Good lethal rate (75%) for I [R = 5-Cl, R1= Me, R2 = tert-butyl] and serious nervous curl effect against pinewood nematodes B. xylophilus for I [R = H, R1= Me, R2 = tert-butyl] were observed at 10 mg/l. The inhibition activities of I [R = H, R1= Me, R2 = 2-MeOC6H4, etc.] against root-knot nematodes M. incognita were 84% at 160 mg/l and 60% at 20 mg/l for in-vitro test and test tube test, resp. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics