Month: October 2022

《A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Fan, Huaqiang; Wan, Yi; Pan, Peng; Cai, Wenbin; Liu, Shihui; Liu, Chuanxu; Zhang, Yongqiang. Synthetic Route of C3H3ClO3 The article mentions the following:

An m-CPBA-mediated intramol. epoxidation-decarboxylative alkoxylation cascade reaction of olefinic oxamic acids, e.g., 2-oxo-2-((2-(prop-1-en-2-yl)phenyl)amino)acetic acid has been developed. The distinct ionic decarboxylative mechanism was preliminarily revealed. The protocol features mild reaction conditions and operational simplicity, allowing the construction of diverse medicinally valuable 5-7 membered 3D cyclic carbamate architectures e.g., 4-(hydroxymethyl)-4-methyl-1H-benzo[d][1,3]oxazin-2(4H)-one in moderate to high yields. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Desalination behavior and performance of flow-electrode capacitive deionization under various operational modes》 was written by Luo, Kunyue; Niu, Qiuya; Zhu, Yuan; Song, Biao; Zeng, Guangming; Tang, Wangwang; Ye, Shujing; Zhang, Jing; Duan, Mengbiao; Xing, Wenle. Recommanded Product: Sodium chloride And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2020. The article conveys some information:

Flow-electrode capacitive deionization (FCDI) has attracted growing attention due to its superior desalination capacity and continuous operation. This study, for the first time, systematically investigated the desalination behaviors of FCDI under a variety of operational modes and made a detailed comparison of relevant operation to provide useful information for selecting appropriate FCDI operational mode. Five operational modes with respect to the flow of electrodes and feed water were studied with both constant voltage and constant current applied. Results revealed that the effluent conductivity during charging decreased continuously in batch mode while decreased quickly and then leveled off in single-pass mode. pH of flow-electrodes fluctuated differently for the operational modes of isolated closed-cycle (ICC), short-circuited closed-cycle (SCC) and open cycle (OC), while pH of the effluent stream maintained stable for all operational modes. The variation of current or voltage could be explained by the change in the resistance of FCDI mainly induced by the middle-chamber salt concentration Based on the three performance indicators of average salt removal rate, charge efficiency and removed salt normalized energy consumption, ICC/single-pass and SCC/single-pass are the two most superior operational modes, followed by OC/single-pass, ICC/batch-mode and SCC/batch-mode. Further considering the advantage of SCC in the continuous charge neutralization and electrode regeneration, SCC/single-pass operational mode can be deemed optimal. In the experiment, the researchers used Sodium chloride(cas: 7647-14-5Recommanded Product: Sodium chloride)

Sodium chloride(cas: 7647-14-5) has been used for the preparation of tris buffered saline, phosphate buffered saline, MPM-2 (mitotic protein monoclonal 2) cell lysis buffer, immunoprecipitation wash buffer, LB (Luria-Bertani) media and dialysis buffer.Recommanded Product: Sodium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Electrochemical heterodifunctionalization of α-CF3 alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols》 was written by Ye, Zhi-Peng; Gao, Jie; Duan, Xin-Yu; Guan, Jian-Ping; Liu, Fang; Chen, Kai; Xiao, Jun-An; Xiang, Hao-Yue; Yang, Hua. Application In Synthesis of Thiophene-2-sulfonyl chlorideThis research focused ontrifluoromethyl sulfonyl tertiary alc green preparation; benzenesulfonyl hydrazide trifluoromethyl alkene electrochem heterodifunctionalization. The article conveys some information:

An unprecedented electrochem. heterodifunctionalization of α-CF3 alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcs. RSOOCH2C(OH)(CF3)R1 [R = i-Pr, Ph, 2-thienyl, etc.; R1 = Ph, 2-naphthyl, 3-thienyl, etc.] were assembled under mild conditions. Electrochem.-driven oxidative 1,2-difunctionalization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application In Synthesis of Thiophene-2-sulfonyl chloride) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application In Synthesis of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design, synthesis, and apoptosis-promoting effect evaluation of novel pyrazole with benzo[d]thiazole derivatives containing aminoguanidine units》 were Liu, Da Chuan; Gao, Mei Jia; Huo, Qiang; Ma, Tao; Wang, Ying; Wu, Cheng Zhu. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. Application In Synthesis of 3-Chlorobenzylchloride The author mentioned the following in the article:

New pyrazole with benzo[d]thiazoles containing hydrazinecarboximidamide substituent was synthesized and evaluated for cytotoxicity and apoptotic activity using the MTT assay, flow cytometry, and Western blot anal. Among the compounds studied, (E)-2-((1-(6-((4-fluorobenzyl)oxy)benzo[d]thiazol-2-yl)-3-phenyl-1H-pyrazol-4-yl)methylene) hydrazinecarboximidamide (8l) was potent, with IC50 values of 2.41 μM, 2.23 μM, 3.75 μM and 2.31 μM in vitro anti-proliferative activity testing against triple-neg. breast cancer cell line MDA-MB-231, non-triple-neg. breast cancer MCF-7 cells, and human hepatocarcinoma HepG2 cells, and SMMC-7721 cells, resp. Especially, the activity against MDA-MB-231 was similar to that of Doxorubicin, which was used as a pos. control in this study. Next, the Annexin V/PI flow cytometry assay was used at different concentrations of compound 8l to demonstrate that compound 8l induced apoptosis of MDA-MB-231 cells in a concentration-dependent manner. Finally, these results were further verified by Western blot anal. Taken together, the results of this study revealed that compound 8l may be a potential anticancer compound play a significant role in the subsequent researches. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2Application In Synthesis of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Application In Synthesis of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Analytical Chemistry (Washington, DC, United States) included an article by Tian, Zhenhao; Ding, Lele; Li, Kun; Song, Yunqing; Dou, Tongyi; Hou, Jie; Tian, Xiangge; Feng, Lei; Ge, Guangbo; Cui, Jingnan. Recommanded Product: Methyl 2-chloro-2-oxoacetate. The article was titled 《Rational Design of a Long-Wavelength Fluorescent Probe for Highly Selective Sensing of Carboxylesterase 1 in Living Systems》. The information in the text is summarized as follows:

Rational design of practical probes with excellent specificity and improved optical properties for a particular enzyme is always a big challenge. Herein, a practical and highly specific fluorescent probe for carboxylesterase 1 (CES1) was rationally designed using meso-carboxyl-BODIPY as the basic fluorophore based on the substrate preference and catalytic properties of CES1. Following mol. docking-based virtual screening combined with reaction phenotyping-based exptl. screening, we found that MMB (probe 7) exhibited the optimal combination of sensitivity and specificity toward human CES1 in contrast to other ester derivatives Under physiol. conditions, MMB could be readily hydrolyzed by CES1 and release MCB; such biotransformation brought great changes in the electronic properties at the meso position of the fluorophore and triggered a dramatic increase in fluorescence emission around 595 nm. Moreover, MMB was cell membrane permeable and was successfully applied to monitor the real activities of CES1 in various biol. samples including living cells, tissue slices, organs, and zebrafish. In summary, this study showed a good example for constructing specific fluorescent probe(s) for a target enzyme and also provided a practical and sensitive tool for real-time sensing of CES1 activities in complicated biol. samples. All these findings would strongly facilitate high-throughput screening of CES1 modulators and the studies on CES1-associated physiol. and pathol. processes. In the part of experimental materials, we found many familiar compounds, such as Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Recommanded Product: Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Donnelly, Kian; Baumann, Marcus published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives》.Synthetic Route of C3H3ClO3 The article contains the following contents:

A continuous flow process to generate [1.1.1]propellane on demand is presented rendering solutions of [1.1.1]propellane that can directly be derivatized into various bicyclo[1.1.1]pentane (BCP) species I [R = H, I, phenylsulfanyl, (butan-2-yloxy)carbonyl, etc.; R1 = I, (4-tert-butylphenyl)sulfanyl, N-(4-fluorophenyl)carbamoyl, etc.]. This was realized in throughputs up to 8.5 mmol h-1 providing an attractive and straightforward access to gram quantities of selected BCP building block I (R = R1 = I). Lastly, a continuous photochem. transformation of [1.1.1]propellane into valuable BCPs bearing mixed ester/acyl chloride moieties II (R2 = Me, Et, i-Pr, dodecyl, butan-2-yl) was developed. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Yi-Min; Yu, Yi; Wu, Shao-Fen; Yan, Hong; Yuan, Yaofeng; Ye, Ke-Yin published an article in 2021. The article was titled 《Electrochemical fluorosulfonylation of styrenes》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Quality Control of Thiophene-2-sulfonyl chloride The information in the text is summarized as follows:

An environmentally friendly and efficient electrochem. fluorosulfonylation of styrenes were developed. With the use of sulfonylhydrazides and triethylamine trihydrofluoride, a diverse array of β-fluorosulfones were readily obtained. This reaction featured mild conditions and a broad substrate scope, which was conveniently extended to a gram-scale preparation In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Quality Control of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Quality Control of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Hwang, Soo-Yeon; Park, Soo-Yeon; Hong, Jung Yeon; Lee, Soo Yeon; Shin, Jae-Ho; Na, Younghwa; Sohn, Myung Hyun; Yoon, Ho-Geun; Kwon, Youngjoo. Safety of 3-Chlorobenzylchloride The article mentions the following:

(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC50 = 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-β1-stimulated lung fibroblast cells and bleomycin-induced in vivo lung fibrosis mice. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Discovery and evaluation of novel synthetic 5-alkyl-4-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbox-amide derivatives as anti-inflammatory agents》 were Shen, Qing-Kun; Gong, Guo-Hua; Li, Gao; Jin, Mei; Cao, Li-Hua; Quan, Zhe-Shan. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. Name: 3-Chlorobenzylchloride The author mentioned the following in the article:

To develop novel anti-inflammatory agents, a series of 5-alkyl-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide derivatives were designed, synthesized, and evaluated for anti-inflammatory effects using RAW264.7 cells. Structures of the synthesized compounds were determined using 1H NMR, 13 C NMR, and HRMS. All the compounds were screened for anti-inflammatory activity based on their inhibitory effects against LPS-induced NO release. Among them, 5-(3,4,5-trimethoxybenzyl)-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide () showed the highest anti-inflammatory activity and inhibited NO release more potently than the lead compound . Further studies revealed that compound reduced the levels of NO, TNF-α, and IL-6, and that its anti-inflammatory activity involves the inhibition of COX-2 and iNOS and downregulation of the mitogen-activated protein kinases (MAPK) signal pathway. Notably, compound displayed more prominent anti-inflammatory activity than and the pos. control ibuprofen in the in vivo acute inflammatory model. Overall, these findings indicate that compound is a therapeutic candidate for the treatment of inflammation. The experimental part of the paper was very detailed, including the reaction process of 3-Chlorobenzylchloride(cas: 620-20-2Name: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Name: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Green synthesis of 1,2,3-triazoles via Cu2O NPs on hydrogen trititanate nanotubes promoted 1,3-dipolar cycloadditions》 were Bhoomireddy, Rajendra Prasad Reddy; Narla, L. G. Bhavani; Peddiahgari, Vasu Govardhana Reddy. And the article was published in Applied Organometallic Chemistry in 2019. Formula: C7H6Cl2 The author mentioned the following in the article:

Cu2O nanoparticles supported on hydrogen trititanate nanotubes (Cu2O/HTNT) catalysts have been efficiently catalyzed the multicomponent synthesis of 1,2,3-triazoles in water at room temperature from different azide precursors, for example organic halides, sulfonates and anilines. The catalysts were synthesized by hydrothermal & wet-impregnation methods and was characterized by HR-TEM, EDS, XRD, XPS, N2-adsorption desorption and ICP-MS anal. The catalyst could be recycled by centrifugation and reused up to seven cycles. The 1-benzyl-4-(4-chlorophenyl)-1H-1,2,3-triazole structure was proven by single crystal X-ray diffraction studies. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics