Month: October 2022

Han, Ying; Fang, Xing Zhong; Zuo, Xiu Xia published the artcile< The influence of molecular weight on properties of melt-processable copolyimides derived from thioetherdiphthalic anhydride isomers>, Electric Literature of 118-45-6, the main research area is thiobisisobenzofurandione oxydianiline polyimide strength melt processing.

A series of novel melt-processable copolyimides based on mixed thioetherdiphthalic anhydride (TDPA) isomers and 4,4′-oxydianiline (4,4′-ODA) were synthesized by a one-step polycondensation. Mol. weight of copolyimides was controlled with stoichiometric offsets in favor of 4,4′-ODA. All of the resulting polyimides (PIs) were amorphous and have nice solubility With increase in mol. weight, the glass transition temperatures of copolyimides increased from 248 to ca. 270 °C based on DSC measurements. These copolyimides displayed excellent thermal and thermooxidative stability, as evidenced by thermogravimetric anal. in both air and nitrogen atmospheres. The melt processability, thermoplastic response, melt stability, and their dependence on mol. weight of the copolyimides were investigated in terms of rheol. measurements by monitoring the melt viscosity after residence at various times and temperatures

Journal of Materials Science published new progress about Complex modulus, tan δ. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Electric Literature of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chang, Chun-Wei; Wu, Chia-Hui; Lin, Mei-Huei; Liao, Pin-Hsuan; Chang, Chun-Chi; Chuang, Hsiao-Han; Lin, Su-Ching; Lam, Sarah; Verma, Ved Prakash; Hsu, Chao-Ping; Wang, Cheng-Chung published the artcile< Establishment of Guidelines for the Control of Glycosylation Reactions and Intermediates by Quantitative Assessment of Reactivity>, SDS of cas: 128-09-6, the main research area is predicted stereocontrolled glycosylation relative reactivity thioglycoside; carbohydrates; diastereoselectivity; glycosylation.

Stereocontrolled chem. glycosylation remains a major challenge despite vast efforts reported over many decades and so far still mainly relies on trial and error. Now it is shown that the relative reactivity value (RRV) of thioglycosides is an indicator for revealing stereoselectivities according to four types of acceptors. Mechanistic studies show that the reaction is dominated by two distinct intermediates: glycosyl triflates and glycosyl halides from N-halosuccinimide (NXS)/TfOH. The formation of glycosyl halide is highly correlated with the production of α-glycoside. These findings enable glycosylation reactions to be foreseen by using RRVs as an α/β-selectivity indicator and guidelines and rules to be developed for stereocontrolled glycosylation.

Angewandte Chemie, International Edition published new progress about Diastereoselective synthesis. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Michael, William R.; King, William R.; Wakim, J. M. published the artcile< Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog, and monkey>, Reference of 118-45-6, the main research area is etidronate disodium metabolism; absorption etidronate disodium.

After administration by intragastric cannula, the absorption of disodium etidronate [7414-83-7] (10-20 mg/kg) from the gastrointestinal tract of adult rats, weanling rats, rabbits, monkeys, adult dogs, and young dogs was 3, 10.5, 3.8, 6, 14, and 21% resp. Absorption was primarily from the stomach. I was not metabolized by the rat or dog, and there was virtually no enterohepatic circulation of I in the rat. Approx. half of the absorbed I was excreted in the urine, while the remaining half was deposited in the skeleton. The half-life of I the skeleton of the rat was 12 days.

Toxicology and Applied Pharmacology published new progress about Bone. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Reference of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Albero, Beatriz; Perez, Rosa Ana; Sanchez-Brunete, Consuelo; Tadeo, Jose Luis published the artcile< Occurrence and analysis of parabens in municipal sewage sludge from wastewater treatment plants in Madrid (Spain)>, Category: chlorides-buliding-blocks, the main research area is sewage sludge paraben analysis occurrence GC tandem mass spectrometry; wastewater treatment sludge paraben analysis occurrence Madrid Spain.

A rapid method for determination of 7 parabens and 2 chlorinated byproducts in sewage sludge was developed based on matrix solid-phase dispersion and gas chromatog.-tandem mass spectrometry. The anal. procedure showed good recoveries that ranged from 80-125%, with relative standard deviations <12% and low detection limits, ranging from 0.1-2.0 ng g-1 dry weight The developed method was applied to the anal. of sewage sludge collected during 2010 in 19 wastewater treatment plants (WWTPs) located in various urban, industrial, or rural zones in Madrid (Spain). Methylparaben was found in most of the WWTPs sampled (95%) at levels between 5.1-26.2 ng g-1 dry weight and propylparaben was detected in 74% of the WWTPs at levels up to 44.1 ng g-1 dry weight To study the temporal variation of parabens and 2 chlorinated parabens during a 4-yr period, sludge samples were collected from 3 selected WWTPs. The levels of methylparaben encountered were rather constant throughout the sampling period whereas propylparaben levels slightly increased. In one of the WWTPs monitored, isopropylparaben was found at the beginning of the sampling period but its content decreased and was not detected in the 2010 sampling. Journal of Hazardous Materials published new progress about Gas chromatography-tandem mass spectrometry. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gao, Wei; Li, Xiaotian; Ren, Da; Sun, Susu; Huo, Jingqian; Wang, Yanen; Chen, Lai; Zhang, Jinlin published the artcile< Design and synthesis of N-phenyl phthalimides as potent protoporphyrinogen oxidase inhibitors>, Quality Control of 118-45-6, the main research area is phenyl phthalimide preparation protoporphyrinogen oxidase inhibitor herbicidal activity docking; N-phenyl phthalimides; herbicidal activity; molecular design; protoporphyrinogen oxidase.

A series of novel phthalimide derivatives I [R1 = H, F, Cl; R2 = H, Me, Cl, NO2; Ar = 5-methylisoxazol-3-yl, thiophen-2-ylmethyl, 4-bromo-2,6-difluorophenyl, etc.] were designed by mol. docking studies targeting the crystal structure of mitochondrial PPO from tobacco (mtPPO, PDB: 1SEZ) by using Flumioxazin as a lead, after which the derivatives were synthesized and characterized, and their herbicidal activities were subsequently evaluated. The herbicidal bioassay results showed that compounds such as I [R1 = R2 = H; Ar = 4-bromo-2,6-difluorophenyl], [R1 = Cl; R2 = H; Ar = 5-methylisoxazol-3-yl, thiophen-2-ylmethyl, 4-fluoro-3-methoxycarbonyl-phenyl] and [R1 = F; R2 = H; Ar = 4-bromo-2,6-difluorophenyl] had good herbicidal activities; among them I [R1 = R2 = H; Ar = 4-bromo-2,6-difluorophenyl], showed excellent herbicidal efficacy against A. retroflexus and B. campestris via the small cup method and via pre-emergence and post-emergence spray treatments. The efficacy was comparable to that of the com. herbicides Flumioxazin, Atrazine, and Chlortoluron. Further, the enzyme activity assay results suggest that the mode of action of compound I [R1 = R2 = H; Ar = 4-bromo-2,6-difluorophenyl] involved the inhibition of the PPO enzyme, and showed better inhibitory activity against PPO than did Flumioxazin. These results indicate that our mol. design strategy contributes to the development of novel promising PPO inhibitors.

Molecules published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Quality Control of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Terakado, Masahiko; Suzuki, Hidehiro; Hashimura, Kazuya; Tanaka, Motoyuki; Ueda, Hideyuki; Kohno, Hiroshi; Fujimoto, Taku; Saga, Hiroshi; Nakade, Shinji; Habashita, Hiromu; Takaoka, Yoshikazu; Seko, Takuya published the artcile< Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead>, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate, the main research area is ONO7300243 preparation lysophosphatidate receptor 1 antagonist drug discovery; GPCR; LPA1 antagonist; SAR; benign prostatic hyperplasia; hit-to-lead optimization.

Lysophosphatidic acid (LPA) evokes various physiol. responses through a series of G protein-coupled receptors known as LPA1-6. A high throughput screen against LPA1 gave compound 4′-{[(4-methoxybenzoyl)(3-phenylpropyl)amino]methyl}-2-biphenylcarboxylic acid (7a) as a hit. The subsequent optimization of 7a led to ONO-7300243 (17a) as a novel, potent LPA1 antagonist, which showed good efficacy in vivo. The oral dosing of 17a at 30 mg/kg led to reduced intraurethral pressure in rats. Notably, this compound was equal in potency to the α1 adrenoceptor antagonist tamsulosin, which is used in clin. practice to treat dysuria with benign prostatic hyperplasia (BPH). In contrast to tamsulosin, compound 17a had no impact on the mean blood pressure at this dose. These results suggest that LPA1 antagonists could be used to treat BPH without affecting the blood pressure. Herein, the authors report the hit-to-lead optimization of a unique series of LPA1 antagonists and their in vivo efficacy.

ACS Medicinal Chemistry Letters published new progress about Benign prostatic hyperplasia. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Martin-Bernabe, Alfonso; Tarrago-Celada, Josep; Cunin, Valerie; Michelland, Sylvie; Cortes, Rold An; Poignant, Johann; Boyault, Cyril; Rachidi, Walid; Bourgoin-Voillard, Sandrine; Cascante, Marta; Seve, Michel published the artcile< Quantitative proteomic approach reveals altered metabolic pathways in response to the inhibition of lysine deacetylases in A549 cells under normoxia and hypoxia>, Reference of 6055-19-2, the main research area is lysine deacetylase inhibition normoxia hypoxia metabolic pathway proteomics; NSCLC; cancer metabolism; hypoxia; lysine deacetylase inhibitors.

Growing evidence is showing that acetylation plays an essential role in cancer, but studies on the impact of KDAC inhibition (KDACi) on the metabolic profile are still in their infancy. Here, we analyzed, by using an iTRAQ-based quant. proteomics approach, the changes in the proteome of KRAS-mutated non-small cell lung cancer (NSCLC) A549 cells in response to trichostatin-A (TSA) and nicotinamide (NAM) under normoxia and hypoxia. Part of this response was further validated by mol. and biochem. analyses and correlated with the proliferation rates, apoptotic cell death, and activation of ROS scavenging mechanisms in opposition to the ROS production Despite the differences among the KDAC inhibitors, up-regulation of glycolysis, TCA cycle, oxidative phosphorylation and fatty acid synthesis emerged as a common metabolic response underlying KDACi. We also observed that some of the KDACi effects at metabolic levels are enhanced under hypoxia. Furthermore, we used a drug repositioning machine learning approach to list candidate metabolic therapeutic agents for KRAS mutated NSCLC. Together, these results allow us to better understand the metabolic regulations underlying KDACi in NSCLC, taking into account the microenvironment of tumors related to hypoxia, and bring new insights for the future rational design of new therapies.

International Journal of Molecular Sciences published new progress about Apoptosis. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Reference of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bolous, Mina; Arumugam, Natarajan; Almansour, Abdulrahman I.; Suresh Kumar, Raju; Maruoka, Keiji; Antharam, Vijay C.; Thangamani, Shankar published the artcile< Broad-spectrum antifungal activity of spirooxindolo-pyrrolidine tethered indole/imidazole hybrid heterocycles against fungal pathogens>, Safety of (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is spirooxindole pyrrolidine indole imidazole hybrid antifungal; 1,3-Dipolar cycloaddition; Antifungal agent; Candida; Cryptococcus; Fungi; Ionic liquids; Minimum inhibitory concentration (MIC); Spirooxindolo-pyrrolidine tethered indole/imidazole; Toxicity.

Invasive fungal infections are one of the leading causes of nosocomial bloodstream infections with a limited treatment option. A series of derivatized spirooxindolo-pyrrolidine tethered indole and imidazole heterocyclic hybrids have been synthesized, and their antifungal activity against fungal strains were determined Here we characterize the antifungal activity of a specific spirooxindolo-pyrrolidine hybrid, dubbed compound 9c (I), a spirooxindolo-pyrrolidine tethered imidazole synthesized with a 2-chloro and trifluoromethoxy substituent. The compound 9c exhibited no cytotoxicity against mammalian cell line at concentrations that inhibited fungal strains. Compound 9c also significantly inhibited the fungal hyphae and biofilm formation. Our results indicate that spirooxindolo-pyrrolidine heterocyclic hybrids potentially represent a broad class of chem. agents with promising antifungal potential.

Bioorganic & Medicinal Chemistry Letters published new progress about 1,3-Dipolar cycloaddition reaction, regioselective. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Safety of (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Robles-Hernandez, Beatriz; Gonzalez-Burgos, Marina; Pomposo, Jose A.; Colmenero, Juan; Alegria, Angel published the artcile< Glass-transition dynamics of mixtures of linear poly(vinyl methyl ether) with single-chain polymer nanoparticles: evidence of a new type of nanocomposite materials>, Electric Literature of 1592-20-7, the main research area is vinyl polymer chain nanoparticle glass transition dynamic mixture nanocomposite; dielectric relaxation; glass transition; nanocomposites; polymer blends; single-chain polymer nanoparticles.

Single-chain polymer nanoparticles (SCNPs) obtained through chain collapse by intramol. crosslinking are attracting increasing interest as components of all-polymer nanocomposites, among other applications. We present a dielec. relaxation study on the dynamics of mixtures of poly(vinyl Me ether) (PVME) and polystyrene (PS)-based SCNPs with various compositions Analogus dielec. measurements on a miscible blend of PVME with the linear precursor chains of the SCNPs are taken as reference for this study. Both systems present completely different behaviors: While the blend with the linear precursor presents dynamics very similar to that reported for PVME/PS miscible blends, in the PVME/SCNP mixtures there are an appreciable amount of PVME segments that are barely affected by the presence of SCNPs, which nearly vanishes only for mixtures with high SCNP content. Interestingly, in the frame of a simple two-phase system, our findings point towards the existence of a SCNP-rich phase with a constant PVME fraction, regardless of the overall concentration of the mixture Moreover, the dynamics of the PVME segments in this SCNP-rich phase display an extreme dynamic heterogeneity, a signature of constraint effects.

Polymers (Basel, Switzerland) published new progress about Dielectric constant. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Electric Literature of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shim, Jae Ho; Ahn, Byung Kook; Lee, Ji Yeon; Kim, Hyeon Soo; Ha, Deok-Chan published the artcile< Organocatalysis for the Asymmetric Michael Addition of Cycloketones and α, β-Unsaturated Nitroalkenes>, SDS of cas: 5153-70-8, the main research area is nitroalkene cycloketone Michael addition organocatalyst enantioselectivity diastereoselectivity.

Michael addition is one of the most important carbon-carbon bond formation reactions. In this study, an (R, R)-1,2-diphenylethylenediamine (DPEN)-based thiourea organocatalyst was applied to the asym. Michael addition of nitroalkenes and cycloketones to produce a chiral product. The primary amine moiety in DPEN reacts with the ketone to form an enamine and is activated through the hydrogen bond formation between the nitro group in the α, β-unsaturated nitroalkene and thiourea. Here, the aim was to obtain an asym. Michael product through the 1,4-addition of the enamine to an alkene to form a new carbon-carbon bond. As a result, the primary amine of the chiral diamine was converted into an enamine. The reaction proceeded with a relatively high level of enantioselectivity achieved using double activation through the hydrogen bonding of the nitro group and thiourea. Michael products with high levels of enantioselectivity (76-99% syn ee) and diastereoselectivity (syn/anti = 9/1) were obtained with yields in the range of 88-99% depending on the ketone.

Catalysts published new progress about Free energy. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, SDS of cas: 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics