Month: October 2022

Mecca, Tommaso; Ussia, Martina; Caretti, Daniele; Cunsolo, Francesca; Dattilo, Sandro; Scurti, Stefano; Privitera, Vittorio; Carroccio, Sabrina C. published the artcile< N-methyl-D-glucamine based cryogels as reusable sponges to enhance heavy metals removal from water>, Application In Synthesis of 1592-20-7, the main research area is methyl glucamine based cryogel adsorption heavy metal removal reusable.

The design of novel cryogels containing N-methyl-D-glucamine (NMG) group was herein reported. The macroporous materials were prepared via sustainable and feasible cryopolymn. by using as co-monomers (4-vinyl-benzyl)-N-methyl-D-glucamine (VbNMG) and 2-hydroxyethyl methacrylate (HEMA) at different percentages. Particularly, cryogel containing 100% of VbNMG (VbNMG-100) showed excellent ability in fast water uptake, removing arsenic (V) and chromium (VI) metal ions from it. Reusability up to six cycles was also demonstrated. The as-prepared materials were characterized by spectroscopic, thermal, and morphol. analyses. The effect of initial oxyanions concentration, kinetic profiles, interfering anions (phosphate and sulfate) were investigated and adsorption/desorption studies were carried out. Equilibrium sorption results well fitted the Langmuir isotherm for both ions tested, showing a startling aptitude in arsenic (76.3 mg/g) as well as chromium (130.9 mg/g) sorption properties if compared with similar polymers as well as other materials. Exploiting its spongy nature, only 5 mins were needed to absorb contaminated medium releasing purified water by a simple squeezing. Most importantly, the sponge can be easily regenerated and reused again up to three times without the depletion of its efficiency.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Adsorbents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application In Synthesis of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liger, Francois; Cadarossanesaib, Florence; Iecker, Thibaut; Tourvieille, Christian; Le Bars, Didier; Billard, Thierry published the artcile< 11C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles>, COA of Formula: C8H12N2O2, the main research area is carbon labeling intracyclic heterocycle cyclization.

Labeling of heterocycles with carbon-11 is generally performed through peripheral functionalizations and more scarcely inside heterocyclic core. Such less common approach usually requires preliminary multi-step synthesis of reactive species. Herein, a cyclization reaction by direct use of cyclotron-produced [11C]CO2 is described to obtain various heterocycles intracyclically labeled in only 10 min.

European Journal of Organic Chemistry published new progress about Cyclization. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, COA of Formula: C8H12N2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yin, Jinya; Rainier, Jon D. published the artcile< The one-pot synthesis of amidonaphthoquinones from aminonaphthoquinones>, Name: (E)-Cinnamoyl chloride, the main research area is amidonaphthoquinone preparation; aminonaphthoquinone acid chloride tandem hydrogenation coupling oxidation; amidoquinone; reduction; synthesis; tandem reaction.

One-pot method of synthesizing amidonaphthoquinones I [R = Ph, C(Me)=CH2, CH=CHMe, etc.; R1 = H, OMe, Cl] from the corresponding aminonaphthoquinones was described. The scope of amides that could be synthesized using this methodol. was relatively broad and the yield of product was higher than traditional methods of synthesizing these substrates.

Tetrahedron Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Name: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novotna, Vladimira; Stulov, Sergey; Hamplova, Vera; Cigl, Martin; Pacherova, Oliva published the artcile< New smectogens with (S)-2-methylbutyl lactate group in the terminal chain and chlorine-substituted molecular core>, Synthetic Route of 3964-57-6, the main research area is methylbutyl lactate group preparation.

Authors report the synthesis and mesomorphic properties of new chiral materials based on (S)-2-methylbutyl lactate group in the chiral chains and a lateral substitution by a chlorine atom in the mol. core. Authors have studied mesomorphic properties and found that homologues with only one lactate and methylbutyl in the chain exhibit the SmC* phase in a broad temperature range. Authors established the spontaneous polarisation and tilt angle values. The pitch values are rather small, being within the range 360-450 nm. On the other hand, a homolog with one addnl. lactate in the chiral part does not exhibit the mesomorphic properties. Authors have tried to establish the effect of lateral substitution by comparing all studied compounds with previously prepared (S)-2-methylbutyl lactate derivatives with non-substituted mol. core.

Liquid Crystals published new progress about Ferroelectricity. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Synthetic Route of 3964-57-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pettinari, Claudio; Pettinari, Riccardo; Xhaferai, Nertil; Giambastiani, Giuliano; Rossin, Andrea; Bonfili, Laura; Maria Eleuteri, Anna; Cuccioloni, Massimiliano published the artcile< Binuclear 3,3',5,5'-tetramethyl-1H,H-4,4'-bipyrazole Ruthenium(II) complexes: Synthesis, characterization and biological studies>, Reference of 67421-02-7, the main research area is binuclear arene tetramethylbipyrazole ruthenium preparation crystal mol structure antitumor; DNA interaction binuclear arene tetramethylbipyrazole ruthenium complex.

Organometallic Ru(II) arene complexes have emerged as potential alternative to platinum anti-tumor drugs due to their stability in solution and in the solid state, significant biol. activity and reduced toxicity and hydrophobicity of their ancillary arene groups. Authors report here a series of Ru(II)-arene dinuclear complexes prepared from 3,3′,5,5′-tetramethyl-1H,H-4,4′-bipyrazole and [(η6-arene)RuCl2] dimers. The new compounds were spectroscopically (FT-IR, 1H, 13C, ESI-MS) and structurally characterized. These complexes were found to adopt the piano stool coordination geometry around the Ru(II) ions, with the bipyrazole ligand bridging two metal centers through its pyridinic nitrogen. Their in vitro cytotoxicity was paralleled in human epithelial normal, cancerous and cisplatin-resistant cancerous cells. Ultimately, two possible mechanisms of drug biochem. action underlying the observed effects (DNA targeting and proteasome inhibitory abilities) were explored.

Inorganica Chimica Acta published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Reference of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhuang, Xiaohui; Shi, Xiayue; Zhu, Rui; Sun, Bin; Su, WeiKe; Jin, Can published the artcile< Photocatalytic intramolecular radical cyclization involved synergistic SET and HAT: synthesis of 3,3-difluoro-γ-lactams>, Synthetic Route of 29027-20-1, the main research area is difluoro lactam preparation regioselective; allyl propargyl bromo difluoro arylacetamide photocatalytic intramol radical cyclization.

A mild and metal-free protocol for visible-light induced intramol. radical cyclization of N-allyl(propargyl)-2-bromo-2,2-difluoro-N-arylacetamide was developed. This strategy showed excellent regioselectivity and simple operation to synthesize 4-substituted 3,3-difluoro-γ-lactams I [R1 = Ph, 4-FC6H4, 3,5-di-MeC6H3, etc.; R2 = H, Me; R3 = H, Me, CO2Me, etc.; R4 = H, 4-MeOC6H4; X = (CHR4)n; n = 1, 2] and II [R4 = H, Me, Et] with a broad substrate scope. Moreover, mechanistic studies revealed that this transformation proceeded through a cascade radical-type cyclization and hydrogen atom transfer process with PMDETA as a hydrogen-atom donor.

Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (allyl). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Synthetic Route of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Guan, Peng; Wang, Lei; Hou, Xuben; Wan, Yichao; Xu, Wenfang; Tang, Weiping; Fang, Hao published the artcile< Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif>, Quality Control of 70057-67-9, the main research area is antiproliferative thiadiazole preparation histone deacetylase inhibitor structure activity modeling; 1,3,4-Thiadiazole; Antiproliferation; Histone deacetylase inhibitor; Hydroxamic acid; Surface recognition motif.

A series of 1,3,4-thiadiazole-containing hydroxamic acids, in accord with the common pharmacophore of histone deacetylase (HDAC) inhibitors (a Zn2+ binding moiety-a linker-a surface recognition motif), was identified as submicromolar HDAC inhibitors by the authors’ group. In this study, the authors continued the efforts to develop 1,3,4-thiadiazole bearing hydroxamate analogs by modifying the surface recognition motif. The authors found that 1,3,4-thiadiazoles having a heteroaromatic substituent showed better HDAC inhibitory activity in enzymic assay and higher antiproliferative potency in cellular assay compared to SAHA.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Quality Control of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acikses, Aslisah; Comez, Necmittin; Biryan, Fatih published the artcile< Metal complexes of a homopolymer system containing diethanolamine side group: synthesis and dielectrical behaviors>, Electric Literature of 1592-20-7, the main research area is diethanolamine side group homopolymer metal complex preparation dielec property.

In this work, 4-diethanolaminomethyl styrene (DEAMSt) monomer was prepared by modification of 4-chloromethyl styrene with diethanolamine. The homopolymerization of modificated styrene was carried out by free radical polymerization method at 60 °C in presence of 1,4-dioxane and AIBN. The metal complexes were prepared by reaction of the homopolymer used as ligand P(DEAMSt)L1 and Ni(II), Co(II) metal ions in presence of ethanol and dilute NaOH at 65 °C for 48 h in pH 6. The structure of modificated monomer, homopolymer used as ligand and polymer-metal complexes were characterized by FT-IR, 1H-NMR, 13C-NMR, Raman spectroscopy techniques, elemental anal., SEM, XRD and magnetic measurements. Their geometric structures according to magnetic measurements of Co(II) and Ni(II) complexes were estimated that have a tetrahedral structure. P(DEAMSt)L1 polymer has a transition state between amorphous and crystalline, whereas metal complexes (Co(II) and Ni(II) are with a large crystal structure. The mol. weight of P(DEAMSt)L1 homopolymer was determined by gel permeation chromatog. The glass transition temperature (Tg) of homopolymer was measured by differential scanning calorimeter. The thermal behaviors of both ligand and polymer-metal complexes were investigated by thermogravimetric anal. and DTA. The results obtained were compared with each other. Then, the dielec. measurements (dielec. constant, dielec. loss and conductivity) of the ligand and polymer-metal complexes were investigated as a function of temperature and frequency. The activation energies (Ea) of the ligand and metal complexes were determined from the conductivity measurements.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry published new progress about Activation energy. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Electric Literature of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiao, Ke-Jin; Ma, Cong; Liu, Dong; Qiu, Hui; Cheng, Bin; Mei, Tian-Sheng published the artcile< Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids>, Application of C8H8BrCl, the main research area is alkyl acid bromoalkane nickel regioselective electrochem reductive cross coupling; dialkyl ketone preparation.

A highly regioselective Ni-catalyzed electrochem. (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides was developed. This strategy allowed the direct acylation of benzylic C(sp3)-H bonds in good yields from com. available alkyl carboxylic acids, thus provided an alternative strategy for the synthesis of dialkyl ketones. Various functional groups were tolerated under mild reaction conditions.

Organic Chemistry Frontiers published new progress about Acylation catalysts (regioselective, electrochem.). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Application of C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Calas, Michele; Ouattara, Mahama; Piquet, Gilles; Ziora, Zyta; Bordat, Y.; Ancelin, Marie L.; Escale, Roger; Vial, Henri published the artcile< Potent Antimalarial Activity of 2-Aminopyridinium Salts, Amidines, and Guanidines>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is aminopyridinium salt amidine guanidine derivative preparation antimalarial malaria Plasmodium.

The authors describe the design, synthesis, and antimalarial activity of 60 bis-tertiary amine, bis-2(1H)-imino-heterocycle, bis-amidine, and bis-guanidine series. Bis-tertiary amines with a linker from 12 to 16 methylene groups were active against the in vitro growth of Plasmodium falciparum within the 10-6-10-7 M concentration range. IC50 decreased by 2 orders of magnitude for bis-2-aminopyridinium salts, bis-amidines, and bis-guanidines (27 compounds with IC50 < 10 nM). Increasing the alkyl chain length from 6 to 12 methylene groups led to increased activity, while beyond this antimalarial activity decreased. Antimalarial activities appear to be strictly related to the basicity of the cationic head with an optimal pKa over 12.5. Maximal activity occurs for bis-2-aminopyridinium, two C-duplicated bis-amidines, and three bis-guanidines, with IC50 values lower than 1 nM. In comparison to similar quaternary ammonium salts, amidinium compounds have distinct structural requirements for antimalarial activity and likely addnl. binding opportunities on account of their hydrogen-bond-forming properties. Journal of Medicinal Chemistry published new progress about Antimalarials. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics