Month: October 2022

Li, Liang; Yang, Dongfeng; Zhao, Zhongrui; Song, Yongkang; Zhao, Lei; Liu, Rui; Liu, Guohua published the artcile< Boron tetrafluoride anion bonding dual active species within a large-pore mesoporous silica for two-step successive organic transformaion to prepare optically pure amino alcohols>, Category: chlorides-buliding-blocks, the main research area is boron tetrafluoride mesoporous silica amino alc organic transformaion preparation; anion bonding; asymmetric catalysis; heterogeneous catalyst; silica; tandem reaction.

Development of a simple and easy handing process for preparation of multifunctional heterogenous catalysts and exploration of their applications in sequential organic transformation are of great significance in heterogeneous asym. catalysis. Herein, through the utilization of a BF4- anion-bonding strategy, we anchor conveniently both organic bases and chiral ruthenium complex into the nanopores of Me-FDU-12, fabricating a Lewis base/Ru bifunctional heterogeneous catalyst. As we envisaged, cyclic amine as a Lewis base promotes an intermol. aza-Michael addition between enones and arylamines, affording γ-secondary amino ketones featuring with aryl motif, whereas ruthenium/diamine species as catalytic promoter boosts an asym. transfer hydrogenation of γ-secondary amino ketones to γ-secondary amino alcs. As expected, both enhance synergistically the aza-Michael addition/asym. transfer hydrogenation one-pot enantioselective organic transformation, producing chiral γ-secondary amino alcs. with up to 98% enantioselectivity. Unique features, such as operationally simple one-step synthesis of heterogeneous catalyst, homo-like catalytic environment as well as green sustainable process make this heterogeneous catalyst an attracting in a practical preparation of optically pure pharmaceutical intermediates of antidepressants.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Aza-Michael reaction catalysts. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rajak, Harish; Agarawal, Avantika; Parmar, Poonam; Thakur, Bhupendra Singh; Veerasamy, Ravichandran; Sharma, Prabodh Chander; Kharya, Murli Dhar published the artcile< 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: Design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors>, Formula: C8H6ClN3S, the main research area is tetrahydropyranyloxy aryloxadiazolecarboxamide arylthiadiazolecarboxamide preparation histone deacetylase inhibitor antitumor.

The enzymic inhibition of histone deacetylase activity has come out as a novel and effectual means for the treatment of cancer. Two novel series of 2-[5-(4-substituted phenyl)-[1,3,4]-oxadiazol- and -thiadiazol-2-ylamino]pyrimidine-5-carboxylic acid (tetrahydropyran-2-yloxy)amides were designed and synthesized as novel hydroxamic acid based histone deacetylase inhibitors. The antiproliferative activities of the compounds were investigated in vitro using histone deacetylase inhibitory assay and MTT assay. The synthesized compounds were also tested for antitumor activity against Ehrlich ascites carcinoma cells in Swiss albino mice. Efforts were also made to establish structure-activity relationships among synthesized compounds The results of the present study indicate that these compounds are promising surface recognition moieties for development of newer hydroxamic acid based histone deacetylase inhibitor.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Formula: C8H6ClN3S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bharathi Priya, Velumani; Ramya, Subramani; Uthayanila, Selvarasu; Karthikeyan, Parasuraman published the artcile< A development of a reusable copper supported imidazolium functionalized ionic liquid catalyzed asymmetric Michael addition reaction>, Computed Properties of 5153-70-8, the main research area is cyclohexanone nitrostyrene copper ionic liquid enantioselective Michael addition; nitro phenylethyl cyclohexanone preparation green chem.

An eco-friendly copper supported Imidazolium functionalized ionic liquid [[Gmim]Cl-Cu (II)] was used as green catalyst in solvent free asym. Michael addition at 25°C. This technique covers simplified product isolation, high conversion and catalyst recycling.

Journal of the Indian Chemical Society published new progress about Cyclohexanones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Computed Properties of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Padmanabhan, Seetharamaiyer; Lavin, Ruth C.; Thakker, Paresh M.; Guo, Jinqing; Zhang, Lu; Moore, Deke; Perlman, Michael E.; Kirk, Cassandra; Daly, Deborah; Burke-Howie, Kathy J.; Wolcott, Teresa; Chari, Suchitra; Berlove, David; Fischer, James B.; Holt, William F.; Durant, Graham J.; McBurney, Robert N. published the artcile< Solution-Phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers>, HPLC of Formula: 2905-54-6, the main research area is acylguanidine synthesis sodium channel blocker human cardiac.

Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, HPLC of Formula: 2905-54-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tsagdi, Artemis; Druvari, Denisa; Panagiotaras, Dionisios; Avramidis, Pavlos; Bekiari, Vlasoula; Kallitsis, Joannis K. published the artcile< Polymeric coatings based on water-soluble trimethylammonium copolymers for antifouling applications>, COA of Formula: C9H9Cl, the main research area is water soluble trimethylammonium copolymer coating antifouling application; antifouling coatings; aquaculture nets; crosslinked polymeric materials; high-pressure cleaning; quaternary trimethylammonium compounds; water-soluble copolymers.

Crosslinked polymeric materials based on a quaternary trimethylammonium compound were developed and evaluated as potential antifouling coatings. For this purpose, two water-soluble random copolymers, poly(4-vinylbenzyltrimethylammonium chloride-co-acrylic acid) P(VBCTMAM-co-AAx) and poly(N,N-dimethylacrylamide-co-glycidylmethacrylate) P(DMAm-co-GMAx), were synthesized via free radical polymerization A water based approach for the synthesis of P(VBCTMAM-co-AAx) copolymer was used. Coatings of the complementary reactive copolymers in different compositions were obtained by curing at 120°C for one day and were used to coat aquaculture nets. These nets were evaluated in respect to their release rate using Total Organic Carbon (TOC) and Total Nitrogen (TN) measurements. Finally, the antifouling efficacy of these newly-composed durable coatings was investigated for 14 days in accelerated conditions. The results showed that this novel polymeric material provides contact-killing antifouling activity for a short time period, whereas it functions efficiently in biofouling removal after high-pressure cleaning.

Molecules published new progress about Antifouling agents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chang, Chia-Lin published the artcile< Synthesis and structural pattern recognition of 5-(2'-alkoxycarbonyl-substituted phenoxy)furfural derivatives>, Computed Properties of 22717-55-1, the main research area is phenoxyfurfural phenoxyfurancarboxylate preparation structural recognition analysis NMR mass spectra; nitrofurfural phenol nucleophilic substitution.

The Et 5-(2′-alkoxycarbonyl-substituted phenoxy)furan-2-carboxylates e.g. I, showed good anti-platelet aggregation, anti-allergic and anti-inflammatory activities. A series of 5-(2′-alkoxycarbonyl-substituted phenoxy)furfurals e.g. II, were prepared for comparing the above activities. The objectives of this research are the synthesis and structural pattern recognition of 5-(2′-alkoxycarbonyl-substituted phenoxy)furfurals. The Silica Gel 60 column chromatog. method was employed to sep. and purify pure 5-(2′-alkoxycarbonyl-substituted phenoxy)furfurals, by three solvent systems. For the structure elucidation of 5-(2′-alkoxycarbonyl-substituted phenoxy)furfurals, four spectroscopic methods were used: electron impact mass (EI-MS), UV-VIS, IR and NMR spectrometers. With the help of spectrometers, investigations can be performed on spectroscopic data. A simple methodol. for recognizing structural patterns was carried out with the aid of statistical anal. designed to establish the classification model of the structural skeleton in this research. It was found that Et phenoxyfuran-2-carboxylate derivatives and phenoxyfurfural derivatives, have similar chem. profiles and are clustered into one group. The pattern plots revealed valuable information and showed good correlation between Et phenoxyfuran-2-carboxylate derivatives and phenoxyfurfural derivatives These findings correlate directly with the resulting spectroscopic data. These results with those obtained by EI-MS and NMR patterns give insight into a reliable pattern recognition for determining the skeletons of Et phenoxyfuran-2-carboxylate derivatives and phenoxyfurfural derivatives

Chemical & Pharmaceutical Bulletin published new progress about Electron ionization mass spectra. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Zhe; Tian, Xinzhe; Tang, Peichen; Ren, Yun-Lai; Zhao, Shuang; Zheng, Xianfu; Cheng, Xinqiang published the artcile< Autocatalytic Friedel-Crafts Acylation of Arenes without Additional Catalyst and Additive>, Formula: C9H7ClO, the main research area is acyl chloride arene autocatalysis regioselective Friedel Crafts acylation; aryl ketone preparation.

A new and autocatalytic method was developed for Friedel-Crafts acylation of arenes without addnl. catalyst and additive. A series of electron-rich arenes underwent the acylation to give the targeted product in low to high yields by using aryl, alkyl and vinyl acyl chlorides as the acylating reagent, which gave an effective method for the preparation of diaryl ketones, alkyl aryl ketones and α,β-unsaturated ketones. Preliminary mechanistic investigation suggested that the present acylation displayed an induction period and a sigmoid kinetic profile characteristic of autocatalytic systems, and the resulting H+ played a role of the catalyst.

ChemistrySelect published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Johnson, Sherida L.; Chen, Li-Hsing; Barile, Elisa; Emdadi, Aras; Sabet, Mojgan; Yuan, Hongbin; Wei, Jun; Guiney, Donald; Pellecchia, Maurizio published the artcile< Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors>, Reference of 42413-03-6, the main research area is benzothiazole preparation anthrax lethal factor inhibitor SAR.

We report on the identification of a novel small mol. inhibitor of anthrax lethal factor using a high-throughput screening approach. Guided by mol. docking studies, we carried out structure-activity relationship (SAR) studies and evaluated activity and selectivity of most promising compounds in in vitro enzyme inhibition assays and cellular assays. Selected compounds were further analyzed for their in vitro ADME properties, which allowed us to select two compounds for further preliminary in vivo efficacy studies. The data provided represents the basis for further pharmacol. and medicinal chem. optimizations that could result in novel anti-anthrax therapies.

Bioorganic & Medicinal Chemistry published new progress about Anthrax lethal factors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Reference of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hirose, Yuuka; Yamazaki, Mirai; Nogata, Misa; Nakamura, Akira; Maegawa, Tomohiro published the artcile< Aromatic Halogenation Using N-Halosuccinimide and PhSSiMe3 or PhSSPh>, Synthetic Route of 128-09-6, the main research area is arene aromatic halogenation halosuccinimide; haloarene preparation aromatic halogenation halosuccinimide.

We developed a mild aromatic halogenation reaction using a combination of N-halosuccinimide and PhSSiMe3 or PhSSPh. Less reactive aromatic compounds, such as Me 4-methoxybenzoate, were brominated with PhSSiMe3 or PhSSPh and N-bromosuccinimide in high yields. No reaction was observed in the absence of PhSSiMe3 or PhSSPh. This method is also applicable to chlorination reactions using N-chlorosuccinimide and PhSSPh.

Journal of Organic Chemistry published new progress about Anisoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Synthetic Route of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Amani, Javad; Molander, Gary A. published the artcile< Toward Efficient Nucleophilic Azaborine Building Blocks for the Synthesis of B-N Naphthyl (Hetero)arylmethane Isosteres>, Name: 1-Chloro-3,5-difluorobenzene, the main research area is aryl chloride coupling fluoroboratomethylborazaronaphthalene preparation arylmethylborazaronaphthalene arylmethylbenzazaborine.

To develop a method for the synthesis of a class of azaborines, K 2-(trifluoroboratomethyl)-2,1-borazaronaphthalenes were synthesized to serve as nucleophilic building blocks. In Pd-catalyzed cross-coupling reactions with (hetero)aryl chlorides they serve to produce a variety of pseudobenzylic (hetero)aryl substituted azaborines. K 2-(trifluoroboratomethyl)-2,1-borazaronaphthalenes are crystalline solids that are more stable than 2-(chloromethyl)-2,1-borazaronaphthalenes and have a broader substrate scope in cross-coupling reactions compared to their pseudobenzylic chloride counterparts.

Organic Letters published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Name: 1-Chloro-3,5-difluorobenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics