Month: October 2022

Guo, Bin; Li, Hong-Xi; Zha, Cheng-Hao; Young, David James; Li, Hai-Yan; Lang, Jian-Ping published the artcile< Visible-Light-Enhanced Suzuki-Miyaura Reactions of Aryl Chlorides in Water with Pd NPs Supported on a Conjugated Nanoporous Polycarbazole>, COA of Formula: C6H3ClF2, the main research area is biaryl preparation; boronic acid aryl halide Suzuki Miyaura coupling palladium nanocatalyst; Suzuki-Miyaura; aryl chloride; photocatalyst; polycarbazole; visible light.

In this work, palladium nanoparticles (Pd NPs) were grown on a conjugated nanoporous polycarbazole (CNP), named Pd/CNP. The hybrid material Pd/CNP could catalyze the Suzuki-Miyaura cross-coupling reactions of aryl chlorides RCl (R = 4-cyanophenyl, quinolin-2-yl, 1-benzothiophen-3-yl, etc.) with arylboronic acids R1B(OH)2 (R1 = Ph, 4-tert-butylphenyl, 1-benzothiophen-2-yl, etc.) in water under blue LED irradiation at room temperature with high efficiency. This protocol exhibited good functional group tolerance and the catalyst could be recycled without significant loss of its catalytic activity. CNP not only provided photogenerated electrons to enrich the electron d. of the Pd NPs but also generated holes for the activation of arylboronic acids.

ChemSusChem published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, COA of Formula: C6H3ClF2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rosen, Brandon R.; Ul Sharif, Ehesan; Miles, Dillon H.; Chan, Nicholas S.; Leleti, Manmohan R.; Powers, Jay P. published the artcile< Improved synthesis of sterically encumbered heteroaromatic biaryls from aromatic β-keto esters>, Product Details of C8H4ClF3O2, the main research area is sterically hindered aryl aminopyrimidine preparation keto ester guanidine condensation.

A protocol for the synthesis of hindered 4-aryl 2-aminopyrimidines from β-keto esters is described. The process employs trifluoroethanol as an essential additive to promote the guanidine condensation reaction, enabling the synthesis of 25 aryl- and heteroaryl substituted aminopyrimidines in good yields and high purities with no column chromatog. The conditions described herein are readily scalable and have been employed in the large-scale synthesis of the clin. A2a/A2bR antagonist AB928.

Tetrahedron Letters published new progress about Aminopyrimidines Role: SPN (Synthetic Preparation), PREP (Preparation). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Product Details of C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jiajia; Xia, Yuanzhi; Lee, Sunwoo published the artcile< Coupling of amides with ketones via C-N/C-H bond cleavage: a mild synthesis of 1,3-diketones>, Application In Synthesis of 17082-09-6, the main research area is diketone preparation; amides ketone coupling.

A variety of aryl and alkyl-substituted tertiary amides reacted with ketones in the presence of LiHMDS and a variety of primary and secondary amides in one pot to gave the corresponding 1,3-diketone products R1C(O)CH(R3)C(O)R2 [R1 = octyl, Ph, 4-MeC6H4, etc.; R2 = t-Bu, Ph, 2-BrC6H4, etc.; R3 = H, Me, n-Pr, hexyl] in good to excellent yields via C-N cleavage of amides and deprotonation of ketones. The reaction was conducted at room temperature under transition-metal-free conditions. N-Tosyl-, N-triflyl-, N-mesyl-, and N-Boc-substituted tertiary amides including N-benzoyl saccharin and N-benzoyl succinimide showed good activity in the reaction. The broad scope, good functional group tolerance of substrates and gram-scale synthesis showed the great importance and potential of this protocol in organic synthesis and industrial manufacture

Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hazeldine, Stuart T.; Polin, Lisa; Kushner, Juiwanna; Paluch, Jennifer; White, Kathryn; Edelstein, Matthew; Palomino, Eduardo; Corbett, Thomas H.; Horwitz, Jerome P. published the artcile< Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid (XK469)>, Recommanded Product: 5-Chloroquinoxalin-2-ol, the main research area is chloroquinoxalinyloxyphenoxypropionic acid structure antitumor; quinoxalinyloxyphenoxypropionic acid antitumor preparation.

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) I is among the most highly and broadly active antitumor agents to have been evaluated and scheduled to enter clin. trials in 2001. The mechanism or mechanisms of action of I remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogs of I and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions: I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety-to determine the resultant in vitro and in vivo effects of chem. alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of I showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A Me, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of I was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of I (region III), i.e., CONH2, CONHMe, CONMe2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 55687-19-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H5ClN2O, Recommanded Product: 5-Chloroquinoxalin-2-ol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mu, Wen-Wen; Li, Peng-Xiao; Liu, Yue; Yang, Jie; Liu, Guo-Yun published the artcile< The potential role of the 5,6-dihydropyridin-2(1H)-one unit of piperlongumine on the anticancer activity>, HPLC of Formula: 17082-09-6, the main research area is piperlongumine dihydropyridin anticancer activity.

Piperlongumine (PL), a potent anticancer agent from the plant long pepper (Piper longum), contains the 5,6-dihydropyridin-2(1H)-one heterocyclic scaffold and cinnamoyl unit. In this paper, we synthesized a series of PL analogs and evaluated their cytotoxicity against cancer cells for the sake of exploring which pharmacophore plays a more potent role in enhancing the anticancer activities of PL. These results illustrated that the position effect, not the electronic effect, of substituents plays a certain role in the cytotoxicity of PL and its analogs. More important, the 5,6-dihydropyridin-2(1H)-one unit, a potent pharmacophore in enhancing the antiproliferative activities of PL, could react with cysteamine and lead to ROS generation, and then bring about the occurrence of ROS-induced downstream events, followed by cell cycle arrest and apoptosis. This work suggests that introducing a lactam unit containing Michael acceptors may be a potent strategy to enhancing the anticancer activity of drugs.

RSC Advances published new progress about Antiproliferative agents. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Rui; Yang, Xiao; Ge, Yicen; Song, Jintong; Zheng, Xueli; Yuan, Maolin; Li, Ruixiang; Chen, Hua; Fu, Haiyan published the artcile< Visible-Light-Induced Oxazoline Formations from N-Vinyl Amides Catalyzed by an Ion-Pair Charge-Transfer Complex>, Synthetic Route of 17082-09-6, the main research area is oxazoline preparation photochem green chem; vinyl amide alc anhydride cyclization alkoxylation heteroarenium iodide catalyst.

Visible-light photoredox catalysis plays an important role in various reactions which are inaccessible under typical thermal conditions. Distinctly different from common visible-light photoredox catalysis which often involves transition-metal complexes, conjugated organic dyes, or electron donor-acceptor complexes, herein, the use of ion-pair charge-transfer (IPCT) complex-induced visible-light photoredox catalytic reactions are described, wherein the cyclization-methoxylation of N-vinyl amides in methanol was achieved under irradiation with blue LEDs. The reaction employs a heteroarenium iodide as the photocatalyst and can be extended to cyclization-alkoxylation, -acyloxylation, and -hydroxylation. This protocol provides an eco-friendly synthetic route to a wide range of oxazoline derivatives Mechanistic investigations with UV-visible spectroscopy and control experiments confirm the existence of the IPCT absorption band in the visible region for the heteroarenium iodide, which is responsible for the observed reactivity.

ACS Catalysis published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jinjin; Chang, Dan; Xiao, Fuhong; Deng, Guo-Jun published the artcile< Three-Component Ordered Annulation of Amines, Ketones, and Nitrovinylarenes: Access to Fused Pyrroles and Substituted Indoles under Metal-Free Conditions>, Category: chlorides-buliding-blocks, the main research area is fused pyrrole indole preparation; cyclocondensation cyclic ketone amine nitrostyrene; cyclohexanone arylamine nitrostyrene cyclocondensation aerobic aromatization iodine catalyst.

Ketones, primary amines such as aniline, and β-nitrostyrenes such as (E)-PhCH:CHNO2 underwent cyclocondensation reactions in toluene at 150° to yield fused pyrroles such as I [R = Me, Et, n-Pr, BuCH2, t-Bu, EtCMe2, Ph, 4-HOC6H4, EtO2C, AcNH, BocNH; X = (CH2)n, CHR, Me2C; n = 1, 2, 3, 7]. Thermal cyclocondensation of cyclohexanones, arylamines, and nitrostyrenes followed by aromatization with O2 and DMSO in the presence of I2 yielded indoles in 50-75% yields.

Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hammoud, Fatima; Giacoletto, Nicolas; Nechab, Malek; Graff, Bernadette; Hijazi, Akram; Dumur, Frederic; Lalevee, Jacques published the artcile< 5,12-Dialkyl-5,12-dihydroindolo[3,2-a]carbazole-Based Oxime-Esters for LED Photoinitiating Systems and Application on 3D Printing>, Quality Control of 17082-09-6, the main research area is carbazole ester lead emitting diode potoinitiating tree dimentional printing.

In order to expand the application of oxime-esters (OXEs) and to introduce a one-component photoinitiating system of high performance in visible light photopolymerization, a series of 5,12-dialkyl-5,12-dihydroindolo[3,2-a]carbazole-based oxime-esters with visible light absorption abilities is designed and synthesized. Notably, when irradiated with light-emitting diodes at 405 nm, the proposed structures can undergo a direct cleavage of the NO bond followed by decarboxylation, generating free radicals capable to efficiently initiate free radical photopolymerizations (FRP). Furthermore, the new OXEs showed good thermal initiation abilities and can be used as dual photo and thermal initiators. An interesting structure/reactivity/efficiency relationship can be obtained by comparing the reactivity of the different radicals generated upon photoexcitation at identical chromophore but also by comparing the photoinitiating ability of the hexyl derivatives (1)-(10) with that of Me derivatives (1′)-(10′) characterized by a lower solubility than the previous series in resins. Chem. mechanisms are studied through different techniques including real-time Fourier transform IR spectroscopy, UVvisible absorption spectroscopy, fluorescence (time-resolved or steady-state) as well as mol. modeling calculations To finish, OXEs are incorporated in new photosensitive 3D printing resins, furnishing 3D objects with a remarkable spatial resolution

Macromolecular Materials and Engineering published new progress about Absorption. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gung, Benjamin W.; Smith, Daniel T.; Wolf, Mark A. published the artcile< Evidence for synclinal transition state in the reactions of aromatic aldehydes with α-(alkoxy)allylstannanes>, Synthetic Route of 53581-86-5, the main research area is aldehyde aromatic reaction alkoxyallylstannane stereochem; transition state structure aldehyde reaction alkoxyallylstannane; ether enol preparation stereoselective.

Unlike aliphatic aldehydes, aromatic aldehydes produce greater than 95% of syn-(Z)-enol ether when treated with α-(alkoxy)allylstannanes in the presence of BF3·Et2O. However, in the presence of TiCl4, the reaction of p-chloro-o-methoxybenzaldehyde with α-(alkoxy)crotylstannane produced predominantly the syn-(E) isomer.

Tetrahedron published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Synthetic Route of 53581-86-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Terasaki, Masanori; Makino, Masakazu published the artcile< Disinfection by-products of para-hydroxybenzoate esters (parabens): synthesis and mass spectrometric study>, Name: Methyl 3-chloro-4-hydroxybenzoate, the main research area is paraben chlorination sulfuryl chloride; disinfection drinking water purification byproduct synthesis.

A simple and efficient procedure for the chlorination of para-hydroxybenzoate esters (parabens) with sulfuryl chloride is described. Fourteen monochlorinated or dichlorinated parabens were synthesized and their mass spectrometric characteristics were determined This work enabled the definitive identification and quantification of the chlorinated parabens in environmental samples.

Journal of Health Science published new progress about Chlorination. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 3-chloro-4-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics