Month: October 2022

Ivanova, Yu. B.; Chizhova, N. V.; Mamardashvili, N. Zh. published the artcile< Synthesis and Spectral and Coordination Properties of Perhalogenated Tetraphenylporphyrins>, Quality Control of 128-09-6, the main research area is zinc perhalogenated tetraphenylporphyrin preparation complexation kinetics.

The reaction of [5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]zinc(II) with N-halosuccinimides in chloroform-MeOH, chloroform-butan-1-ol, or DMF gave [2,3,7,8,12,13,17,18- octachloro(bromo)-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]zinc(II) which were treated with HO2CCF3 to obtain the corresponding free porphyrin ligands. The synthesized compounds and their dianions were studied by electronic absorption and 1H NMR spectroscopy and mass spectrometry. The kinetic parameters of the complexation of these ligands with Zn in the systems MeCN-Zn(OAc)2 and MeCN-Zn(OAc)2-1,8-diazabicyclo[5.4.0]undec-7-ene in the temperature range 298-318 K were determined

Russian Journal of General Chemistry published new progress about Complexation. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Quality Control of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

El Abbouchi, Abdelmoula; El Brahmi, Nabil; Hiebel, Marie-Aude; Bignon, Jerome; Guillaumet, Gerald; Suzenet, Franck; El Kazzouli, Said published the artcile< Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents>, Application In Synthesis of 22952-32-5, the main research area is ethacrynic acid sulfonamide preparation anticancer human safety; Anti-cancer; Anti-proliferative; Cancer cells; Ethacrynic acid; Safety ratios; Sulfonamides.

A series of ethacrynic acid (2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding two derivs, showed anti-proliferative activity with IC50s in the micromolar range (less than 4 uM). Three derivatives I-III were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRC5 as a normal cell line. These compounds displayed IC50 values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker’s best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Application In Synthesis of 22952-32-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sahoo, Manoj Kumar; Pradhan, Sourav; Kim, Dongwook; Park, Jung-Woo; Chang, Sukbok published the artcile< Head-to-Head Homocoupling of Ynamides via a Dual Activation Mode of Triple Bonds by Half-Sandwich Metal Complexes>, SDS of cas: 67421-02-7, the main research area is rhodium mediated cyclometalation homocoupling terminal ynamide amidosulfonyl compound; dienyl amidosulfonyl rhodacyclic complex preparation electrochem optimized geometry DFT; crystal structure dienyl amidosulfonyl rhodacyclic iridacyclic complex; mol structure dienyl amidosulfonyl rhodacyclic iridacyclic complex.

Reported herein is the half-sandwich Rh-mediated head-to-head homocoupling of terminal ynamides to furnish dienyl bisamido rhodacyclic complexes, where the Rh-vinyl bond was formed selectively at the α-C to the N atom. This transformation was extended to include piano-stool Ru and Ir complexes to display an analogous homocoupling reactivity. Based on d. functional theory studies, the reaction probably proceeds via a dual activation mode of the ynamide triple bonds: (i) generation of a zwitterionic keteniminyl metal species to induce an intramol. chloride transfer and (ii) syn-carbometalation of the 2nd coordinated alkynes by the alkenyl metal intermediate. An oxidative transformation of the homocoupled metal complexes gave multifunctional dienyl bisamide compounds

Organometallics published new progress about Crystal structure. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, SDS of cas: 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yu, Yu; Ran, Dongzhi; Jiang, Junhao; Pan, Tao; Dan, Yanrong; Tang, Qiang; Li, Wei; Zhang, Lin; Gan, LinLing; Gan, Zongjie published the artcile< Discovery of novel 9H-purin derivatives as dual inhibitors of HDAC1 and CDK2>, Electric Literature of 2382-10-7, the main research area is purin derivative preparation anticancer HDAC CDK dual inhibitor; Antitumor; CDKs; Dual inhibitors; HDACs; Purin.

HDAC and CDK inhibitors have been demonstrated to be synergistically in suppressing cancer cell proliferation and inducing apoptosis. In this work, we incorporated the pharmacophore groups of HDACs and CDKs inhibitors into one mol. to design and synthesize a series of purin derivatives as HDAC/CDK dual inhibitors. The lead compound I, showing good HDAC1 and CDK2 inhibitory activity with IC50 values of 5.8 and 56 nM, resp., exhibited attractive potency against several cancer cell lines in vitro. This work may lead to the discovery of a novel scaffold and potential dual HDAC/CDK inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Electric Literature of 2382-10-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Luzina, Elena L.; Popov, Anatoliy V. published the artcile< Synthesis of 1-aroyl(1-arylsulfonyl)-4-bis(trifluoromethyl)alkyl semicarbazides as potential physiologically active compounds>, Name: 4-(Difluoromethoxy)benzene-1-sulfonyl chloride, the main research area is preparation semicarbazide physiol active compound Lipinski Gelovani parameter.

1,1-Bis(trifluoromethyl)alkyl isocyanates obtained from perfluoroisobutene (PFIB) react with aroyl(arylsulfonyl)hydrazines. Twenty eight prospective biol. active polyfluorinated 1,4-substituted semicarbazides, e.g. I, were synthesized. The structure of each new product was confirmed by anal. and spectroscopic methods. The Lipinski’s and Gelovani’s parameters were then calculated Two adjustments to the Lipinski rules of five are suggested for fluorinated drug candidates.

Journal of Fluorine Chemistry published new progress about Semicarbazides Role: SPN (Synthetic Preparation), PREP (Preparation). 351003-34-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H5ClF2O3S, Name: 4-(Difluoromethoxy)benzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boogaerts, Ine I. F.; Fortman, George C.; Furst, Marc R. L.; Cazin, Catherine S. J.; Nolan, Steven P. published the artcile< Carboxylation of N-H/C-H Bonds Using N-Heterocyclic Carbene Copper(I) Complexes>, Name: 2-Oxazolecarboxylic acid, the main research area is arene heteroarene regioselective carboxylation copper heterocyclic carbene complex; carboxylic acid aromatic carbamate preparation.

The N-heterocyclic carbene copper(I) complex [Cu(IPr)(OH)] [IPr = 1,3-bis(2,6-diisopropylphenyl)-2-imidazolylidene] was demonstrated to be a synthetically versatile catalyst to enable the regioselective carboxylation of N-H and C-H bonds of arenes and heteroarenes which were predicted to be suitably acidic by Bronsted/Lowry theory.

Angewandte Chemie, International Edition published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 672948-03-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H3NO3, Name: 2-Oxazolecarboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ding, Mengxian; Li, Haiying; Yang, Zhenhua; Li, Yuesheng; Zhang, Jin; Wang, Xuqiang published the artcile< Comparative study on polyimides from 3,3'- and 4,4'-linked diphthalic anhydride>, Product Details of C8H3ClO3, the main research area is polyimide preparation property.

1,4-Bis(2,3-dicarboxyphenoxy)benzene dianhydride, 1,4-bis(3,4-dicarboxyphenoxy)benzene dianhydride, bis(2,3-dicarboxyphenoxy) sulfide dianhydride, bis(3,4-dicarboxyphenoxy) sulfide dianhydride, and 2,3,3′,4′-tetracarboxydiphenyl sulfide dianhydride were synthesized from 3-chlorophthalic anhydride and 4-chlorophthalic anhydride. Bis(2,3-dicarboxyphenyl) sulfone and bis(3,4-dicarboxyphenyl) sulfone were obtained by the oxidation of the corresponding bis(dicarboxyphenyl) sulfide by hydrogen peroxide. The polyimides from the dianhydrides mentioned above and 4,4′-oxydianiline were prepared The properties, such as dynamic mech. behavior, thermooxidative stability, stress-strain behavior, chem. resistance, and permeability to some gases have been in investigated for the isomeric polyimides.

Journal of Applied Polymer Science published new progress about Polyethers, polyimide- Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Product Details of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Plashkina, N. A.; Troitskaya, V. I.; Pushkareva, Z. V.; Ryapasova, T. P. published the artcile< Studies on riboflavine analogs. VIII. 7-(Trifluoromethyl)-8-chloroisoalloxazines>, Synthetic Route of 35375-74-7, the main research area is isoalloxazine chlorotrifluoromethyl; cyclocondensation alloxan ribityltoluidine; galactyltoluidine cyclocondensation; sorbityltoluidine cyclocondensation; rhamnityltoluidine cyclocondensation.

Chlorotoluidines I (R = H, Me, CH2CH2OH, ribityl, galactyl, sorbityl, rhamnityl), prepared in 72-95% yields by amination of the corresponding dichlorotoluene with RNH2, were reduced by Raney Ni and cyclized with alloxan to give 63-85% isoalloxazines II.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Condensation reaction. 35375-74-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3N2O2, Synthetic Route of 35375-74-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P. published the artcile< A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors>, Recommanded Product: 2,6-Dichloro-9-methyl-9H-purine, the main research area is imidazolo pyrrolo pyrazolo pyrimidine preparation mTOR inhibitor; Mammalian target of rapamycin; Oncology; PI3K/Akt/mTOR pathway; Structure based design; mTOR kinase inhibitors.

A series of N-7-methyl-imidazolopyrimidine inhibitors I [R1 = Me, Et; R2 = N-morpholinyl, N-homomorpholinyl, N-(S)-3-methylmorpholinyl, N-(R)-3-methylmorpholinyl] of the mTOR kinase have been designed and prepared, based on the hypothesis that the N-7-Me substituent on imidazolopyrimidine would impart selectivity for mTOR over the related PI3Kα and δ kinases. The corresponding N-Me substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines also show potent mTOR inhibition with selectivity toward both PI3α and δ kinases. The most potent compound synthesized is pyrazolo[4,3-d]pyrimidine II [R1 = Me, R2 = (S)-3-ethylmorpholin-4-yl]. Compound II shows a Ki of 2 nM against mTOR inhibition, remarkable selectivity (>2900×) over PI3 kinases, and excellent potency in cell-based assays.

Bioorganic & Medicinal Chemistry Letters published new progress about Molecular docking. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Recommanded Product: 2,6-Dichloro-9-methyl-9H-purine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shapiro, Robert H.; Jenkins, Thomas F. published the artcile< Evidence for anchimeric assistance in the expulsion of bromine from ring-substituted β-phenylethyl bromides: when is a simple cleavage a rearrangement>, Formula: C8H8BrCl, the main research area is phenethyl bromides Br expulsion; anchimeric assistance Br expulsion; dibromination phenacyl bromides.

Using the principles of the quasi-equilibrium theory, substituent effects, deuterium labeling, and comparison of compound behavior, evidence is given for aryl participation in the expulsion of Br from the mol. ion of β-phenylethyl bromide and eleven of its ring-substituted derivatives This reaction shows a kinetic behavior which is typical of rearrangements, its activation energy is lower than that of similar reactions where participation is partially or completely precluded and substituent effects are not only consistent with a participation process, but are also consistent with those predicted from solution chemistry.

Organic Mass Spectrometry published new progress about Electron beams. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Formula: C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics