Month: October 2022

Spitz, Cedric; Matteudi, Melanie; Tintori, Guillaume; Broggi, Julie; Terme, Thierry; Vanelle, Patrice published the artcile< Metal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols>, Reference of 611-19-8, the main research area is benzyl halide aldehyde super electron donor addition; dihydroisocoumarin preparation; diarylethanol preparation.

We report here the intermol. metal-free addition reaction of functionalized benzyl halides to aldehydes using a super electron donor (SED). The metal-free and mild conditions allowed the formation of 3,4-dihydroisocoumarins and 1,2-diarylethanols with unprecedented functional group tolerance.

Journal of Organic Chemistry published new progress about Addition reaction. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Reference of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ajenjo, Javier; Klepetarova, Blanka; Greenhall, Martin; Bim, Daniel; Culka, Martin; Rulisek, Lubomir; Beier, Petr published the artcile< Preparation of (Pentafluorosulfanyl)benzenes by Direct Fluorination of Diaryldisulfides: Synthetic Approach and Mechanistic Aspects>, Recommanded Product: 5-Chloro-2-methoxybenzenesulfonyl chloride, the main research area is pentafluorosulfanyl benzene preparation reaction mechanism radical; fluorine; pentafluorosulfanyl; radical reactions; reaction mechanisms; synthetic methods.

Direct fluorination of ortho-, meta- and para-substituted aromatic thiols and disulfides using elemental fluorine afforded substituted (pentafluorosulfanyl)benzenes ArSF5 [Ar = 4-FC6H4, 2-NCC6H4, 4-HOOCC6H4, etc.]. This work thus represented the first study of the scope and limitation of direct fluorination for the synthesis of new SF5-containing building blocks. Fluorinations in batch and flow modes were compared. A comprehensive computational study was carried out employing d. functional and wave function methods to elucidate the reaction mechanism of the transformation of ArSF3 into ArSF5. Eliminating various nonradical pathways, it was shown that the reaction proceeded by a radical mechanism, initiated by the attack of the F. on the ArSF3 moiety, propagated via an almost barrierless F2+ArSF4.→ArSF5+F. step and terminated by the ArSF4.+F.→ArSF5. Most of the calculated data were in very good agreement with exptl. observations concerning the ortho-substituent effect on the reaction rates and yields.

Chemistry – A European Journal published new progress about Aromatic compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) ((pentafluorosulfanyl)benzenes). 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Recommanded Product: 5-Chloro-2-methoxybenzenesulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aggarwal, Kanika; Bsoul, Saja; Douglin, John C.; Li, Songlin; Dekel, Dario R.; Diesendruck, Charles E. published the artcile< Alkaline Stability of Low Oxophilicity Metallopolymer Anion-Exchange Membranes>, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene, the main research area is oxophilicity metallopolymer anion exchange membrane alk stability; anion exchange membranes; fuel cells; gold; metallopolymers; oxophilicity.

Anion-exchange membrane fuel cells (AEMFCs) are promising energy conversion devices due to their high efficiency. Nonetheless, AEMFC operation time is currently limited by the low chem. stability of their polymeric anion-exchange membranes. In recent years, metallopolymers, where the metal centers assume the ion transport function, have been proposed as a chem. stable alternative. Here we present a systematic study using a polymer backbone with side-chain N-heterocyclic carbene (NHC) ligands complexed to various metals with low oxophilicity, such as copper, zinc, nickel, and gold. The golden metallopolymer, using the metal with the lowest oxophilicity, demonstrates exceptional alk. stability, far superior to state-of-the-art quaternary ammonium cations, as well as good in situ AEMFC results. These results demonstrate that judiciously designed metallopolymers may be superior to purely organic membranes and provides a scientific base for further developments in the field.

Chemistry – A European Journal published new progress about Anion exchange membranes. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hakura, Atsushi; Hori, Yuji; Uchida, Kanako; Sawada, Shigeki; Suganuma, Akiyoshi; Aoki, Toyohiko; Tsukidate, Kazuo published the artcile< Inhibitory effect of dimethyl sulfoxide on the mutagenicity of promutagens in the Ames test>, Name: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is dimethyl sulfoxide promutagen mutagenicity inhibition detoxification.

The effect of DMSO on the mutagenicity of 14 promutagens belonging to several chem. classes and one direct mutagen as a reference compound was examined in the Ames preincubation test, to clarify how much the test results were affected by its inhibitory activity on metabolic enzymes. The mutagens were assayed by the preincubation method using the TA100 or WP2uvrA (pKM101) bacterial test strains in the presence of 1% and 14% DMSO (concentrations in treatment mixture) with S9 mix for 12 promutagens that are known to be activated by CYP enzymes or without S9 mix for 2 promutagens that are known to be activated by bacterial nitroreductase enzymes, and the direct-mutagen. The data indicate that the mutagenicity of 11 of the 14 promutagens was significantly reduced in the presence of 14% DMSO as compared with that in the presence of 1% DMSO, while the 3 remaining promutagens and the direct mutagen exhibited mutagenicity of equal degree at both concentrations The largest inhibitory effect of DMSO was found on the nitrosamines in WP2uvrA(pKM101) and TA100, and no cytotoxicity was detected by survival test, with 14% DMSO in WP2uvrA(pKM101), at any amounts of dimethylnitrosamine. Further equivalent or slightly lower cytotoxicity in the presence of 14% DMSO than in the presence of 1% DMSO was detected by decrease in the bacterial background-lawn d., as a whole. These observations suggest that the reduction in the yield of revertant colonies in the presence of 14% DMSO with the 11 chems. was not due to cytotoxicity of DMSO. The inhibitory effect of DMSO on the mutagenicity of the promutagens can be explained by its inhibitory effect on the drug-metabolizing enzymes involved in the activation/detoxification pathways. Use of DMSO at a low concentration, such as 1%, may be suggested for the Ames test, as for other in vitro genotoxicity tests.

Genes and Environment published new progress about Biological detoxification. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Name: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wan, Zi-juan; Yuan, Xiao-feng; Luo, Jun published the artcile< Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)-H functionalization>, Application In Synthesis of 3240-10-6, the main research area is arylpropiolic acid ether photochem diastereoselective regioselective addition reaction; aryl acrylic acid preparation.

An intriguing and mild method for visible light induced regioselective addition of arylpropiolic acids by attacking exclusively at the 3-position with cyclic/acyclic ethers was developed. A variety of 3,3-bis-substituted acrylic acids were successfully obtained in moderate to excellent yields. A plausible reaction mechanism involving an energy transfer induced radical addition in the presence of visible light and photocatalyst was proposed.

Organic & Biomolecular Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Application In Synthesis of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dupuy, Stephanie; Nolan, Steven P. published the artcile< Gold(I)-Catalyzed Protodecarboxylation of (Hetero)Aromatic Carboxylic Acids>, Product Details of C4H3NO3, the main research area is heteroaromatic carboxylic acid decarboxylation gold catalyst protodeauration heterocyclic carbene; N-heterocyclic carbene; catalysis; decarboxylation; gold; protodeauration.

A general protocol for the gold-catalyzed protodecarboxylation of (hetero)aromatic carboxylic acids was developed. It was successfully applied to activated and deactivated benzoic acids and is compatible with a wide range of functionalities. Notably, the reaction requires relatively low catalyst loadings, and the isolation and purification of the reaction products are straightforward. This protocol is both practical and suitable for use in telescoped reaction sequences for which column chromatog. purification is undesirable (e.g., in directed C-H activation/protodecarboxylation/further characterization routes).

Chemistry – A European Journal published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 672948-03-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H3NO3, Product Details of C4H3NO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Chengcheng; Guo, Lin; Gao, Han; Luo, Mengqi; Yang, Chao; Xia, Wujiong published the artcile< Highly Diastereoselective Synthesis of γ-Lactams Enabled by Photoinduced Deaminative [3 + 2] Annulation Reaction>, Category: chlorides-buliding-blocks, the main research area is gamma lactam diastereoselective preparation; aminopyridinium alkene photochem cycloaddition.

The photoinitiated deaminative [3 + 2] annulation reaction of N-aminopyridinium salts with alkenes for the synthesis of functionalized γ-lactams is described. This transformation shows good functional group tolerance as well as excellent diastereoselectivity. Preliminary studies suggest that the employed N-aminopyridinium salts generate the key amidyl radical intermediates through N-N bond cleavage via a photoinduced single-electron transfer (SET) process. The amidyl radical species would add to the double bond of alkenes, followed by a radical-mediated annulation process, to afford the desired γ-lactams.

Organic Letters published new progress about [3+2] Cycloaddition reaction catalysts (photochem.). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tian, Maoqun; Abdelrahman, Aliaa; Baqi, Younis; Fuentes, Eduardo; Azazna, Djamil; Spanier, Claudia; Densborn, Sabrina; Hinz, Sonja; Schmid, Ralf; Mueller, Christa E. published the artcile< Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists>, Name: 5-Chloro-2-methoxybenzenesulfonyl chloride, the main research area is inflammation P2X1 receptor calcium influx allosteric modulators antagonists.

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity vs. other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 μM)(I) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 μM)(II), displayed >500-fold selectivity vs. P2X2 and P2X3, and 10-fold selectivity vs. P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as neg. allosteric modulators, and mol. modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

Journal of Medicinal Chemistry published new progress about Asthma. 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Name: 5-Chloro-2-methoxybenzenesulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, X.; Chen, X. L.; Zheng, Z. W.; Ji, H. M.; Ma, Y. L. published the artcile< Dense chalcopyrite CuInSe2 thin films prepared with ethanol-based In2Se3-Cu+ ink>, Computed Properties of 22519-64-8, the main research area is chalcopyrite copper indium diselenide thin film ethanol ink.

Here, we show a novel ink containing ethanol, In2Se3 nanosheets and Cu+ that can be used as the sol for filming by dip coating method. And pure chalcopyrite (CH) CuInSe2 (CIS) thin films were obtained when In2Se3 nanosheets with poor crystallinity as a component of the ink. We described the formation of the CH CIS films that exhibit (112)-orientation and dense structure without interspace. Hall measurement shows that the CIS film sintered at 550°C has an elec. resistivity of 3.19 Ω·cm and carrier concentration of 2.63×1017 cm-3, which meet the requirements of high performance solar cell absorption layer.

Chalcogenide Letters published new progress about Absorption. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Computed Properties of 22519-64-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cernicharo, J.; Cabezas, C.; Agundez, M.; Tercero, B.; Pardo, J. R.; Marcelino, N.; Gallego, J. D.; Tercero, F.; Lopez-Perez, J. A.; de Vicente, P. published the artcile< TMC-1, the starless core sulfur factory: discovery of NCS, HCCS, H2CCS, H2CCCS, and C4S and detection of C5S>, Category: chlorides-buliding-blocks, the main research area is chlorosuccinimide thioketene sulfur Taurus Mol cloud; Astrochemistry; ISM: individual (TMC-1); ISM: molecules; line: identification; molecular data.

We report the detection of the sulfur-bearing species NCS, HCCS, H2CCS, H2CCCS, and C4S for the first time in space. These mols. were found towards TMC-1 through the observation of several lines for each species. We also report the detection of C5S for the first time in a cold cloud through the observation of five lines in the 31-50 GHz range. The derived column densities are N(NCS) = (7.8 ± 0.6) x 1011 cm-2, N(HCCS) = (6.8 ± 0.6) x 1011 cm-2, N(H2CCS) = (7.8 ± 0.8) x 1011 cm-2, N(H2CCCS) = (3.7 ± 0.4) x 1011 cm-2, N(C4S) = (3.8 ± 0.4) x 1010 cm-2, and N(C5S) = (5.0 ± 1.0) x 1010 cm-2. The observed abundance ratio between C3S and C4S is 340, that is to say a factor of approx. one hundred larger than the corresponding value for CCS and C3S. The observational results are compared with a state-of-the-art chem. model, which is only partially successful in reproducing the observed abundances. These detections underline the need to improve chem. networks dealing with S-bearing species.

Astronomy & Astrophysics published new progress about Clouds (Taurus Mol.). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics