Month: October 2022

Cai, Zhengyan; Wen, Yingling; Zhang, Xuli; Liu, Zhenren; Hao, Qun published the artcile< Preparation and structural confirmation of the related substances of rivaroxaban>, Computed Properties of 31166-29-7, the main research area is rivaroxaban related substance synthesis.

According to the structural characteristics of rivaroxaban and its synthetic process, eight related substances: 5-chloro-N-[[2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide (A), N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1, 3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide (B), 4,5-dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl]methyl] thiophene-2-carboxamide (C), (S)-2-[[[2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl] methyl] carbamoyl] benzoic acid (D), N1, N2-bis-[[(S)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1, 3-oxazolidin-5-yl] methyl] phthalamide (E), 5-chloro-N-methylthiophene-2-carboxamide (F), 5-chloro-N,N-dimethylthiophene-2-carboxamide (G) and 1,3-bis-[[(S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl] methyl] urea (H), were synthesized and confirmed by 1H NMR and MS. These substances were taken as the references for the quality control of rivaroxaban.

Zhongguo Yiyao Gongye Zazhi published new progress about 31166-29-7. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, Computed Properties of 31166-29-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qu, Erdong; Li, Shangzhang; Bai, Jin; Zheng, Yan; Li, Wanfang published the artcile< Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides>, Category: chlorides-buliding-blocks, the main research area is amide preparation; acyl benzotriazole nitro compound reductive cross coupling nickel catalyzed; sulfonamide preparation; sulfonyl benzotriazole nitro compound reductive cross coupling nickel catalyzed.

Herein, a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope was reported. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

Organic Letters published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ren, Dajun; Jiang, Shan; Fu, Linjun; Wang, Zhaobo; Zhang, Shuqin; Zhang, Xiaoqing; Gong, Xiangyi; Chen, Wangsheng published the artcile< Laccase immobilized on amino-functionalized magnetic Fe3O4-SiO2 core-shell material for 2,4-dichlorophenol removal>, COA of Formula: C8H3ClO3, the main research area is laccase iron oxide silicon dioxide dichlorophenol core shell material; 2,4-dichlorophenol (2,4-DCP); degradation; immobilization; laccase; magnetic.

In this study, an amino-functionalized magnetic silica microsphere material (Fe3O4-SiO2 -NH2) was prepared Using glutaraldehyde as a crosslinking agent, Trametes versicolor laccase was adsorbed-covalently bonded and immobilized on the material to prepare Laccase @ Fe3O4-SiO2 . In addition, the materials were characterized and analyzed by SEM, TEM, XRD, FT-IR and VSM. Finally, the thermal inactivation dynamics of immobilized laccase in polar/non-polar/toxic systems and the adsorption and degradation of 2,4-DCP were studied. The results showed that Laccase @ Fe3O4-SiO2 under the optimal conditions (pH 6, temperature 65° C, initial concentration of 2,4-DCP 10 mg/L), the removal rate was as high as 81.6%. Moreover, compared with free laccase, immobilized laccase had good tolerance under low pH and high-temperature conditions, and storage stability was also greatly improved. After repeated use for 7 times, Laccase @ Fe3O4-SiO2 can still maintain 59% removal rate of 2,4-DCP, which gives it the potential for industrial applications.

Environmental Technology published new progress about Adsorbed substances. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, COA of Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yuqing; Meng, Huifeng; Huang, Jianhua; Zhan, Chuanlang published the artcile< Analysis of effects of substituent number on device performance through structural cutting of non-fullerene acceptors by chlorination>, Related Products of 118-45-6, the main research area is chlorination organic solar cell crystallinity external quantum efficiency; fullerene-free; halogenation; polymer solar cell; small-molecule acceptor; structural cutting.

Effects of chlorination on photovoltaic performance of organic solar cells are yet largely unclear though it is emerging as a special yet effective strategy to design highly efficient non-fullerene acceptors (NFAs). Herein, a bi-chlorine-substituted NFA with regioregularity, namely, bichlorinated dithienothiophen[3.2-b]- pyrrolobenzothiadiazole (BTP-2Cl-δ), is synthesized and compared to the non-chlorinated BTP and tetra-chlorine-substituted BTP-4Cl to study the effects of Cl number on the photovoltaic performance. From BTP to BTP-2Cl-δ and BTP-4Cl, the three mols. show gradually red-shifted absorption peaks, narrowed band gaps, and lowered highest occupied MOs (HOMOs) and lowest unoccupied MOs (LUMOs). Polymer solar cells are fabricated using PM6 as the donor and the three small mols. as the acceptors. From BTP to BTP-2Cl-δ, efficiencies (8.8 vs 15.4%) are significantly enhanced due to the better film morphol. and strong crystallization of the BTP-2Cl-δ-based device, giving rise to boosted fill factors (FFs) and short-circuit current densities (JSC’s). From BTP-2Cl-δ to BTP-4Cl, although JSC’s (24.3 vs 25.0 mA cm-2) are slightly elevated due to the higher crystallinity of BTP-4Cl, leading to improved exciton dissociation and collection efficiencies, FFs (71.1 vs 68.0%) are obviously decreased owing to the unfavorable film morphol., unbalanced hole-electron mobilities, and higher charge recombination in BTP-4Cl-based devices. As such, the efficiency of the BTP-2Cl-δ-based device (15.4%) is superior to that of the BTP-4Cl-based device (14.5%). This work elucidates a design strategy by cutting the numbers of substituent chlorine to obtain desired energy levels and crystallization with optimal performance.

ACS Applied Materials & Interfaces published new progress about Band gap. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Related Products of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ruffoni, Alessandro; Julia, Fabio; Svejstrup, Thomas D.; McMillan, Alastair J.; Douglas, James J.; Leonori, Daniele published the artcile< Practical and regioselective amination of arenes using alkyl amines>, Category: chlorides-buliding-blocks, the main research area is aromatic amine photoredox synthesis regioselective amination arene alkylamine.

The formation of carbon-nitrogen bonds for the preparation of aromatic amines is among the top five reactions carried out globally for the production of high-value materials, ranging from from bulk chems. to pharmaceuticals and polymers. As a result of this ubiquity and diversity, methods for their preparation impact the full spectrum of chem. syntheses in academia and industry. In general, these mols. are assembled through the stepwise introduction of a reactivity handle in place of an aromatic C-H bond (i.e., a nitro group, halogen or boronic acid) and a subsequent functionalization or cross-coupling. Here we show that aromatic amines can be constructed by direct reaction of arenes and alkyl amines using photocatalysis, without the need for pre-functionalization. The process enables the easy preparation of advanced building blocks, tolerates a broad range of functionalities, and multigram scale can be achieved via a batch-to-flow protocol. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of several drugs, agrochems., peptides, chiral catalysts, polymers and organometallic complexes.

Nature Chemistry published new progress about Amination, regioselective (photochem.). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mukherjee, N.; Delay, E. R. published the artcile< Cyclophosphamide-induced disruption of umami taste functions and taste epithelium>, COA of Formula: C7H17Cl2N2O3P, the main research area is cyclophosphamide monohydrate taste bud epithelium monosodium glutamate IMP.

Clin. studies have reported taste dysfunctions developing in patients undergoing chemotherapy. This adverse side effect is a major concern for the doctors and patients because disrupted taste can reduce appetite, cause malnutrition, delay recovery, and affect quality of life. Cyclophosphamide (CYP) is a common atenoplastic drug used during chemotherapy and is thought to affect taste through learned tasted aversions. This study asked whether CYP also alters umami taste sensory functions and disrupts taste epithelium of mice. Behavioral tests focused on taste acuity, assessed by the ability of mice to discriminate between the taste qualities of two umami substances, monosodium glutamate (MSG) and IMP, and taste sensitivity, assessed by detection thresholds of MSG and IMP, after an IP injection (75 mg/kg) of CYP. The behavioral results revealed a two-phase disturbance in taste acuity and loss of sensitivity, the first phase occurring within 2-4 days after injection and the second occurring 9-12 days after injection. The number of fungiform papillae (with and without pores) decreased immediately after injection and did not begin to recover until 12 days after injection. Circumvallate taste buds began to show disturbances by 8 days after injection and evidence of recovery beginning 12 days after injection. Von Ebner glands were smaller and secreted less saliva 4 days postinjection but not later. These findings suggest the initial behavioral deficits may be because of cytotoxic effects of the drug on taste sensory tissues, whereas the second phase may be because of a disturbance of the taste cell replacement cycle.

Neuroscience (Amsterdam, Netherlands) published new progress about Body weight. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, COA of Formula: C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brown, Roger F. C.; Gardner, D. V.; McOmie, John F. W.; Solly, R. K. published the artcile< Pyrolysis of polycarbonyl compounds. II. Synthesis of biphenylenes from phthalic anhydrides and other carbonyl compounds>, Recommanded Product: 5-Chloroisobenzofuran-1,3-dione, the main research area is BIPHENYLENE PYROLYSES PHTHALIC ANHYDRIDES; PHTHALIC ANHYDRIDES PYROLYSES BIPHENYLENE.

Pyrolysis of phthalic anhydride or o-sulfobenzoic anhydride at 700-1100°/0.1-10 mm. produces benzyne, as shown by the formation of biphenylene (I) and triphenylene. Biphenylene and several polychloro and polymethyl derivatives were conveniently synthesized by pyrolysis of the corresponding phthalic anhydrides in 3-26% yields. These reactions afford further examples of the parallel between the pyrolytic and mass spectral fragmentations of certain aromatic carbonyl compounds The yield of biphenylene obtained by pyrolysis of compounds structurally related to phthalic anhydride can be correlated with the instability of the corresponding mol. ions in the mass spectrometer.

Australian Journal of Chemistry published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Recommanded Product: 5-Chloroisobenzofuran-1,3-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Meng, Qing-Yuan; Doeben, Nadine; Studer, Armido published the artcile< Cooperative NHC and Photoredox Catalysis for the Synthesis of β-Trifluoromethylated Alkyl Aryl Ketones>, Electric Literature of 1592-20-7, the main research area is trifluoromethyl alkyl aryl ketone preparation; cooperative photoredox catalyzed trifluoromethylation styrene acid fluoride; NHC catalysis; trifluoromethylation; visible light catalysis.

Despite the great potential of radical chem. in organic synthesis, N-heterocyclic carbene (NHC)-catalyzed reactions involving radical intermediates are not well explored. This communication reports the three-component coupling of aroyl fluorides, styrenes and the Langlois reagent (CF3SO2Na) to give various β-trifluoromethylated alkyl aryl ketones with good functional group tolerance in moderate to high yields by cooperative photoredox/NHC catalysis. The alkene acyltrifluoromethylation proceeds via radical/radical cross coupling of ketyl radicals with benzylic C-radicals. The ketyl radicals are generated via SET reduction of in situ formed acylazolium ions whereas the benzylic radicals derive from trifluoromethyl radical addition onto styrenes.

Angewandte Chemie, International Edition published new progress about Acid fluorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Electric Literature of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Zhi; Zhuang, Xinming; Chen, Yao; Wang, Binghao; Yu, Junsheng; Huang, Wei; Marks, Tobin J.; Facchetti, Antonio published the artcile< Cinnamate-Functionalized Natural Carbohydrates as Photopatternable Gate Dielectrics for Organic Transistors>, COA of Formula: C9H7ClO, the main research area is cinnamate functionalized natural carbohydrate photopatternable gate dielec organic transistor.

Photolithog.-defined films play an important role in modern optoelectronics and are crucial for the development of advanced organic thin-film transistors (OTFTs). Here, we explore a facile photoresist-free photopatterning technique with natural carbohydrates and its use as an OTFT gate dielec. The effects of the cross-linkable chem. structure on the crosslinking chem. and dielec. strength of the corresponding films are investigated in cinnamate-functionalized carbohydrates from monomeric (glucose) to dimeric (sucrose) to polymeric (cellulose) backbones. UV illumination of the cinnamate esters of these carbohydrates leads to [2 + 2] cycloaddition and thus the formation of robust cross-linked dielec. films in the irradiated areas. Using propylene glycol monomethyl ether acetate as the solvent/developer, patterned dielec. films with micrometer-sized features can be readily fabricated. P- and N-type OTFTs are successfully demonstrated using unpatterned/patterned cross-linked films as the gate dielec. and pentacene and N,N’-1H,1H-perfluorobutyl dicyanoperylenecarboxydiimide (PDIF-CN2) as the p- and n-channel semiconducting layers, resp. These results demonstrate that natural-derived polymer gate dielecs., which are soluble and patternable using biomass-derived solvents, are promising for the realization of a more sustainable OTFT technol.

Chemistry of Materials published new progress about Carbohydrates Role: PRP (Properties) (natural). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jui, Nathan T.; Buchwald, Stephen L. published the artcile< Cascade Palladium Catalysis: A Predictable and Selectable Regiocontrolled Synthesis of N-Arylbenzimidazoles>, Electric Literature of 35852-58-5, the main research area is regioselective preparation arylbenzimidazole; cascade intermol amination amidation chloroaryl sulfonate halide; chemoselectivity; cross-coupling; heterocycles; palladium; synthetic methods.

Regioselective N-arylbenzimidazole was prepared via cascade intermol. amination and amidation reactions of 2-chloroaryl sulfonates (or halides). A single catalyst, based on iBuBrettPhos, is able to selectively perform both catalytic elements of this process for a broad range of arylamine (or heteroarylamine), amide, and bifunctional electrophile substrates to afford the corresponding benzimidazole products with complete regioselectivity. Moreover, it was demonstrated that different 2-chloroaryl sulfonates (triflate vs. mesylate), which are derived from the same chlorophenols, can be reacted under very similar reaction conditions to exclusively afford the opposite regioisomeric heterocycles.

Angewandte Chemie, International Edition published new progress about Amidation. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Electric Literature of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics