Month: October 2022

Ma, Junjie; Ni, Xin; Gao, Yali; Huang, Kun; Wang, Yu; Liu, Jiaan; Gong, Guowei published the artcile< Semicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study>, HPLC of Formula: 611-19-8, the main research area is semicarbazone phenyl preparation antitumor activity; anticancer activity; apoptosis; metabolic stability; semicarbazone; sub-G1.

A series of semicarbazone derivatives bearing Ph moiety I [R = Me, Et; R1 = H, benzyloxidanyl, 2-(2H-1,3-benzodioxol-5-ylmethyl)-(1,3-thiazol-4-yl)-methyloxy, [(4-chlorophenyl)methyl]oxidanyl, etc.; R2 = t-Bu, H, prop-2-en-1-yl; R3 = H, t-Bu] was synthesized and evaluated for the vitro anticancer activities in four human cancer cell lines (human colon cancer (HT29), human neuroblastoma (SK-N-SH), human breast cancer (MDA-MB-231), and human gastric cancer (MKN45)). Biol. evaluation led to the identification of I [(I) R = Me, R1 H, R2 = R3 = t-Bu; (II) R = Et, R1 H, R2 = R3 = t-Bu], which showed excellent anticancer activities against tested cancer cell lines with IC50 values ranging from 0.32 to 1.57 μM, resp., while exhibiting weak cytotoxicity on the normal cells (human umbilical vein endothelial cell (HUVEC)). Flow cytometric assay for cell cycle and apoptosis revealed that (I) and (II) caused an arrest in the Sub-G1 cell cycle and inhibited proliferation of cancer cells by inducing apoptosis in a dose-dependent manner. Further enzymic assay suggested that (I) and (II) could significantly activated procaspase-3 to caspase-3. Metabolic stability study indicated that (I) and (II) showed moderate stability in vitro in human and rat liver microsomes. In view of promising pharmacol. activities of (I) and (II), which had emerged as the valuable lead for further development in the treatment for cancer.

Chemical & Pharmaceutical Bulletin published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, HPLC of Formula: 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Tong; Rajabimoghadam, Khashayar; Puri, Ankita; Hebert, David D.; Qiu, Yi Lin; Eichelberger, Sidney; Siegler, Maxime A.; Swart, Marcel; Hendrich, Michael P.; Garcia-Bosch, Isaac published the artcile< A 4H+/4e- Electron-Coupled-Proton Buffer Based on a Mononuclear Cu Complex>, Application of C8H12N2O2, the main research area is copper dimethoxyphenylenebistertbutylurea complex preparation redox potential frontier mol orbital; crystal structure copper dimethoxyphenylenebistertbutylurea complex.

In this research article, we describe a 4H+/4e- electron-coupled-proton buffer (ECPB) based on Cu and a redox-active ligand. The protonated/reduced ECPB (complex 1: [Cu(8H+/14e-)]1+), consisting of CuI with 2 equiv of the ligand (LH4: 1,1′-(4,5-dimethoxy-1,2-phenylene)bis(3-(tert-butyl)urea)), reacted with H+/e- acceptors such as O2 to generate the deprotonated/oxidized ECPB. The resulting compound, (complex 5: [Cu(4H+/10e-)]1+), was characterized by X-ray diffraction anal., NMR (1H-NMR), and d. functional theory, and it is electronically described as a cuprous bis(benzoquinonediimine) species. The stoichiometric 4H+/4e- reduction of 5 was carried out with H+/e- donors to generate 1 (CuI and 2 equiv of LH4) and the corresponding oxidation products. The 1/5 ECPB system catalyzed the 4H+/4e- reduction of O2 to H2O and the dehydrogenation of organic substrates in a decoupled (oxidations and reductions are separated in time and space) and a coupled fashion (oxidations and reductions coincide in time and space). Mechanistic anal. revealed that upon reductive protonation of 5 and oxidative deprotonation of 1, fast disproportionation reactions regenerate complexes 5 and 1 in a stoichiometric fashion to maintain the ECPB equilibrium

Journal of the American Chemical Society published new progress about Crystal structure. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Application of C8H12N2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lidston, Claire A. L.; Abel, Brooks A.; Coates, Geoffrey W. published the artcile< Bifunctional Catalysis Prevents Inhibition in Reversible-Deactivation Ring-Opening Copolymerizations of Epoxides and Cyclic Anhydrides>, Electric Literature of 118-45-6, the main research area is bifunctional catalysis ring opening copolymerization epoxide cyclic anhydride.

Reversible-deactivation chain transfer is a viable strategy to increase the catalytic efficiency of ring-opening polymerizations, such as the alternating copolymerization of epoxides and cyclic anhydrides. In conjunction with the catalyst, protic chain transfer agents (CTAs) initiate polymerization and facilitate rapid proton transfer between active and dormant chains. Functional-group-tolerant Lewis acid catalysts are therefore required to successfully apply protic CTAs in reversible-deactivation ring-opening copolymerizations (RD-ROCOP), yet the predominant binary Lewis acid catalyst/nucleophilic cocatalyst systems suffer lower polymerization rates when used with protic CTAs. New mechanistic insight into the inhibition pathways reveals that the alc. chain ends compete with epoxide binding to the Lewis acid and hydrogen-bond with anionic chain ends to impede epoxide ring opening. We report that a bifunctional aminocyclopropenium aluminum salen complex maintains excellent activity in the presence of protic functionality, exhibiting resilience against these inhibition pathways, even at high CTA concentrations We apply reversible-deactivation chain transfer in the bifunctional ROCOP system to demonstrate precise mol.-weight control, CTA functional group scope, and accessible polymer architectures.

Journal of the American Chemical Society published new progress about Anhydrides, cyclic Role: RCT (Reactant), RACT (Reactant or Reagent). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Electric Literature of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Echemendia, Radell; de Oliveira, Kleber T.; Burtoloso, Antonio C. B. published the artcile< Visible-Light-Promoted Synthesis of 1,3-Dicarbonyl Sulfoxonium Ylides>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is dicarbonyl sulfoxonium ylide green preparation; diazoketone sulfoxonium ylide coupling visible light promoted.

A novel visible-light-promoted synthesis of 1,3-dicarbonyl sulfoxonium ylides I [R = Ph, 2-ClC6H4, 4-MeC6H4, etc.; R1 = Ph, 4-MeOC6H4, 4-O2NC6H4, etc.; R2 = H, Me] via coupling of diazoketones with sulfoxonium ylides was described in both batch and continuous flow conditions. This transformation permitted the direct synthesis of synthetically useful 1,3-dicarbonyl sulfoxonium ylides I (33 examples, 21-85% yields), by means of an acylation reaction from the in situ and selective generation of ketenes. The reaction performed under flow conditions proved to be very efficient, providing the 1,3-dicarbonyl sulfoxonium ylides with higher yields and shorter reaction times.

Organic Letters published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (sulfoxonium ylides). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liang, Mary; Tarr, Tyler B.; Bravo-Altamirano, Karla; Valdomir, Guillermo; Rensch, Gabriel; Swanson, Lauren; DeStefino, Nicholas R.; Mazzarisi, Cara M.; Olszewski, Rachel A.; Wilson, Gabriela Mustata; Meriney, Stephen D.; Wipf, Peter published the artcile< Synthesis and Biological Evaluation of a Selective N- and P/Q-Type Calcium Channel Agonist>, Safety of 2,6-Dichloro-9-methyl-9H-purine, the main research area is diaminopurine preparation calcium channel agonist structure activity; roscovitine analog preparation calcium channel agonist; cyclin dependent kinase inhibitor roscovitine analog; LEMS; Lambert−Eaton myasthenic syndrome; N/P/Q-type calcium channels; cdk2; neurological autoimmune disorder; roscovitine; selective agonist.

The acute effect of the potent cyclin-dependent kinase (cdk) inhibitor (R)-roscovitine on Ca2+ channels inspired the development of structural analogs as a potential treatment for motor nerve terminal dysfunction. On the basis of a versatile chlorinated purine scaffold, we have synthesized ca. 20 derivatives, I [R1 = n-Pr, Me, CHMe2, R2 = CH2Ph, CH(Ph)2, 3-pyridinylmethyl, etc.], and characterized their N-type Ca2+ channel agonist action. I were prepared by reacting 2,6-dichloro-9H-purine with R1X/K2CO3/DMSO (X = halo), followed by reaction with R2NH2/NEt2/BuOH, which gave the 4-chloro-6-amino derivatives; the final step consisted of treating the latter compounds with (R)-2-amino-1-butanol at 170°C. Agents that showed strong agonist effects were also characterized in a kinase panel for their off-target effects. Among several novel compounds with diminished cdk activity, we identified a new lead structure with a 4-fold improved N-type Ca2+ channel agonist effect and a 22-fold decreased cdk2 activity as compared to (R)-roscovitine. This compound was selective for agonist activity on N- and P/Q-type over L-type calcium channels.

ACS Medicinal Chemistry Letters published new progress about Cyclin-dependent kinase inhibitors. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Safety of 2,6-Dichloro-9-methyl-9H-purine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Kai; Jiang, Renqian; Zhao, Yulong; Mao, Liang; Gu, Xiuquan; Cai, Xiaoyan; Zhu, Mingshan published the artcile< Hierarchical NiCo2S4/ZnIn2S4 heterostructured prisms: High-efficient photocatalysts for hydrogen production under visible-light>, Product Details of Cl3H8InO4, the main research area is nickel cobalt zinc indium sulfide heterostructured prisms; zinc indium sulfide hydrogen production photocatalysts visible light; Charge separation; Co-catalyst; Hollow structure; Hydrogen; Photocatalyst.

Exploring low-cost co-catalyst to ameliorate the photocatalytic activity of semiconductors sets a clear direction for solving energy crisis and achieving efficient solar-chem. energy conversion. In this work, a unique hierarchical hollow heterojunction was constructed by in-situ growing ZnIn2S4 nanosheets on the porous NiCo2S4 hollow prisms through a low temperature solvothermal method, in which NiCo2S4 with semi-metal property acted as non-noble metal co-catalyst. NiCo2S4 co-catalyst was innovatively encapsulated in ZnIn2S4, which not only relieved the light shielding effect caused by the large loading amount of co-catalyst, but also supplied abundant active sites for H2 evolution. The hierarchical hollow heterostructure of NiCo2S4 /ZnIn2S4 provided a highly efficient channel for charge transfer. Combining these advantages, NiCo2S4 /ZnIn2S4 composite demonstrated excellent photocatalytic activity. In the absence of sacrificial agent, the NiCo2S4/ZnIn2S4 photocatalyst achieved a remarkable improved H2 yield of 0.77 mmol g-1h-1 under visible light irradiation (λ > 400 nm), which is 6.6 times greater than that of ZnIn2S4. Besides, NiCo2S4 even exhibited better performance on the H2 evolution improvement of ZnIn2S4 than precious metal Pt. This work will offer novel insights into the reasonable design of non-noble metal photocatalysts with respectable activity for water splitting.

Journal of Colloid and Interface Science published new progress about Centrifugation. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Product Details of Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Byun, Youngjoo; Vogel, Susan R.; Phipps, Andrew J.; Carnrot, Cecilia; Eriksson, Staffan; Tiwari, Rohit; Tjarks, Werner published the artcile< Synthesis and Biological Evaluation of Inhibitors of Thymidine Monophosphate Kinase from Bacillus anthracis>, Application of C7H7ClO4S2, the main research area is thymidine phosphate analog preparation inhibitor Bacillus thymidine monophosphate kinase.

Nineteen lipophilic thymidine phosphate-mimicking compounds were designed and synthesized as potential inhibitors of thymidine monophosphate kinase of Bacillus anthracis, a Gram-pos. bacterium that causes anthrax. These thymidine analogs were substituted at the 5′-position with sulfonamide-, amide-, (thio)urea-, or triazole groups, which served as lipophilic surrogates for phosphate. Three of the tested compounds produced inhibition of B. anthracis growth and/or thymidine monophosphate activity. Addnl. studies will be necessary to elucidate the potential of this type of B. anthracis thymidine monophosphate inhibitors as novel antibiotics in the treatment of anthrax.

Nucleosides, Nucleotides & Nucleic Acids published new progress about Anthrax (disease). 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Application of C7H7ClO4S2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gao, Wa; Wang, Lu; Gao, Chao; Liu, Jinqiu; Yang, Yong; Yang, Liuqing; Shen, Qing; Wu, Congping; Zhou, Yong; Zou, Zhigang published the artcile< Exquisite design of porous carbon microtubule-scaffolding hierarchical In2O3-ZnIn2S4 heterostructures toward efficient photocatalytic conversion of CO2 into CO>, Product Details of Cl3H8InO4, the main research area is carbon dioxide indium oxide zinc sulfur semiconductor heterostructure.

Porous carbon microtubule (PCMT)-scaffolding semiconductor heterostructures were exquisitely designed through the in situ growth of ZnIn2S4 (ZIS) ultrathin nanosheets onto In2O3 nanoparticle layers generated on the surface PCMT (abbreviated as PCMT@In2O3/ZIS) toward the efficient photocatalytic conversion of CO2 into CO. The pronounced photocatalytic performance for CO2 photoreduction into CO is attributed to a synergistic effect of the following factors: (1) the multistage hopping of the charge carriers among In2O3, ZIS, and PCMT greatly reduces the charge recombination in In2O3 and ZIS. An (2) The mesoporous feature of the PCMT renders the large surface area and abundant active sites to accumulate the local concentration of CO2 in the heterostructures. An (3) The existence of a large amount of carbon defects in PCMT promotes the activity of the absorbed CO2 mols. An (4) The tubular structures with two open ends of PCMT may favor the fast diffusion of the reactants and products, and the optical absorption can also be increased by multi-light scattering/reflection in the interior void. An (5) The unique fabrication route leads to an intimate and tight contact among PCMT, In2O3, and ZIS, which is also favorable for the charge migration. This work makes a contribution to the development of a complex hollow photocatalysis system for artificial photosynthesis.

Nanoscale published new progress about Band gap. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Product Details of Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yu, Wei; Zhai, Zhi-Wen; Wedge, David E.; Duke, Stephen O.; Wu, Hong-Ke; Weng, Jian-Quan; Tan, Cheng-Xia; Zhang, Yong-Gang; Liu, Xing-Hai published the artcile< Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety>, Name: 1-Chloro-2-(chloromethyl)benzene, the main research area is oxadiazole pyrazolyl preparation microwave irradiation antifungal herbicidal activity.

Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring I (R = cyano, 3,4-dichlorophenyl, 2-chlorothiazol-5-yl, etc.) were designed and synthesized from Et acetoacetate and tri-Et orthoformate as starting materials via multi-step reactions. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide.

Research on Chemical Intermediates published new progress about Agrochemical fungicides. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Name: 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bukuroshi, Esmeralda; Wong, Siena; Mudigonda, Thanmayee; Nova, Kyle; Dumont, Antoine; Holst, Devon; Lu, Zheng-Hong; Bender, Timothy P. published the artcile< Molecular engineering of α and β peripherally tri-halogenated substituted boron subphthalocyanines as mixed alloys to control physical and electrochemical properties for organic photovoltaic applications>, Application of C8H3ClO3, the main research area is trihalogenated substituted boron subphthalocyanine alloy organic photovoltaic electrochem property.

The chirality feature of C1 and C3 boron subphthalocyanines (BsubPcs) is an attractive property in material science and supramol. chem. Normally in the field, enantiomeric mixtures are separated through a standard process. The goal of this study was to determine if the mixture of BsubPc enantiomers could form a mixed alloyed composition in the solid state, which is very relevant to their potential application in the organic electronic field. We present the synthesis and phys. characteristics of a selection of four chiral BsubPc mixtures These BsubPcs are specifically trichlorinated and trifluorinated in the periphery, such as Cl-βF3BsubPc, Cl-αF3BsubPc, Cl-βCl3BsubPc and Cl-αCl3BsubPc. The isomeric (C1/C3) ratios of each BsubPc were determined by NMR. Single-crystal XRD of all four BsubPc mixtures showed that the C1 and C3 isomers co-crystallized within their resp. lattices forming solid-state mixed alloyed compositions The structures of Cl-αF3BsubPc and Cl-βF3BsubPc crystallized in the same lattice as Cl-BsubPc, with some expansion of the unit cell volume, while the trichlorinated BsubPcs did not due to the large van der Waals radii of the chlorine atoms. This set of mixed alloyed BsubPcs was also integrated into organic solar cells/photovoltaics (OSCs/OPVs) as both non-fullerene electron acceptors and as electron donors. It was confirmed that these BsubPc isomers/enantiomers are applicable in OPVs as mixed alloyed compositions, with more promising functionality as non-fullerene electron acceptors given their significant contribution to the EQE spectra. Further mol. engineering of these materials will be made to enhance their OPV performance and to explore their bifunctional charge carrier mobility roles.

Molecular Systems Design & Engineering published new progress about Alloys Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics