Month: October 2022

Zeng, Lingping; Liao, Yunchuan; Wang, Jianchuan; Wei, Zidong published the artcile< Construction of highly efficient ion channel within anion exchange membrane based on interpenetrating polymer network for H2/Air (CO2-free) alkaline fuel cell>, Quality Control of 1592-20-7, the main research area is alk fuel cell interpenetrating polymer network anion exchange membrane.

Interpenetrating polymer network anion exchange membrane (IPN AEM) consists of cross-linked quaternized poly (vinylbenzyl chloride) and cross-linked poly (vinyl alc.) is synthesized in this work. Electron microscope clearly reveals the IPN structure, and with this structural design, a highly efficient ion channel within IPN AEMs is constructed. This specially designed structure leads to high hydroxide (OH-) conductivity (e.g., 141.7 mS cm-1 at 80°C) at a moderate ion exchange capacity (IEC) of 1.61 mmol g-1, and a remarkable peak power d. of 0.64 W cm-2 with non-noble metal oxygen reduction reaction (ORR) catalyst in H2/Air (CO2-free) anion exchange membrane fuel cells (AEMFCs) test.

Journal of Power Sources published new progress about Alkaline fuel cells. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Quality Control of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Birgul, Kaan; Uba, Abdullah Ibrahim; Cuhadar, Ozan; Sevinc, Sevgi Kocyigit; Tiryaki, Selen; Tiber, Pinar Mega; Orun, Oya; Telci, Dilek; Yilmaz, Ozgur; Yelekci, Kemal; Guniz Kucukguzel, S. published the artcile< Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents>, Category: chlorides-buliding-blocks, the main research area is naproxen thiosemicarbazide triazole thioether preparation mol modeling antitumor human.

New thiosemicarbazides, 1,2,4-triazoles and thioethers I (R1 = Ph, 4-FC6H4, Bn, etc.; R2 = Bn, 3-FC6H4CH2, 4-MeOC6H4CH2, etc.) from derived (S)-Naproxen were synthesized in this study. The mol. binding of the compounds on MetAP-2 was performed. Anticancer effects of the synthesized compounds were studied by using MTT assay method on MCF-7 (includes estrogen and progesterone receptors) and MDA-MB-231 (lacks estrogen and progesterone receptors) adenocarcinoma cell lines at 0, 10, 25, 50, 75 and 100μM concentrations for 24 h. The IC50 values of novel (S)-Naproxen derivatives were determined between from 5 to 100μM on MCF-7 breast cancer cell line and MDA-MB-231 cell lines. The apoptotic activity of selected compounds I (R1 = 4-ClC6H4; R2 = 3-FC6H4CH2) and I (R1 = Ph; R2 = 4-MeC6H4CH2) were first analyzed by Annexin V staining using Tali Image-Based Cytometer. Mitochondrial membrane potential changes determined in fluorescence plate reader following JC-1 stain for compounds I (R1 = 4-ClC6H4; R2 = 3-FC6H4CH2) and I (R1 = Ph; R2 = 4-MeC6H4CH2) in MCF-7 and MDA-MB-231 cells. The effect of these compounds on the cell viability 4T1 mouse mammary tumor cell line was tested at 1 to 5 times of calculated IC50 value (IC50x1, IC50x2, IC50x3, IC50x4, and IC50x5). Next in order to determine the toxicity of the combination of compound I (R1 = Bn; R2 = 3-FC6H4CH2) and Docetaxel, WST-1 cell viability and proliferation assay was performed with 4T1.

Journal of Molecular Structure published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lee, Woorim; Marcotullio, Sandro; Yeom, Hoonsik; Son, Heejong; Kim, Tae-Hun; Lee, Yunho published the artcile< Reaction kinetics and degradation efficiency of halogenated methylparabens during ozonation and UV/H2O2 treatment of drinking water and wastewater effluent>, Recommanded Product: Methyl 3-chloro-4-hydroxybenzoate, the main research area is halogenated methylparaben degradation ozonation oxidative wastewater treatment; Hydroxyl radical; Micropollutant; Ozone; Paraben; UV/H(2)O(2).

This study investigated the reaction kinetics and degradation efficiency of methylparaben and its halogenated products (Cl-, Br-, Cl,Cl-, Br,Cl-, and Br,Br-methylparabens) during ozonation and UV254/H2O2 treatment. Second-order rate constants for reactions of the parabens with ozone and .OH were kO3 = 107 – 108 M-1 s-1 and [Formula Omitted] = (2.3 – 4.3)x 109 M-1 s-1 at pH 7. Species-specific kO3 values of the protonated and deprotonated parabens were closely related to phenol ring substituent effects via quant. structure-activity relationships with other substituted phenols. The UV photolysis rate of the parabens [kUV = (2.4 – 7.2)x 10-4 cm2 mJ-1] depended on the halogenation state of the paraben and solution pH, from which species-specific quantum yields were also determined In simulated treatments of drinking water and wastewater effluent, the parabens were efficiently eliminated during ozonation, requiring a specific ozone dose of > 0.26 gO3/gDOC for > 97% degradation During UV/H2O2 treatment with 10 mg L-1 H2O2, the degradation levels were > 90% at a UV fluence of 2000 mJ cm-2, except for Cl,Cl-methylparaben. Kinetic models based on the obtained reaction kinetic parameters could successfully predict the degradation levels of the parabens. Overall, ozonation and UV/H2O2 were effective in controlling parabens and their halogenated products during advanced water treatment.

Journal of Hazardous Materials published new progress about Absorptivity. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Recommanded Product: Methyl 3-chloro-4-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carney, Daniel W.; Lukesh, John C. III; Brody, Daniel M.; Brutsch, Manuela M.; Boger, Dale L. published the artcile< Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface>, Application of C4H3NO3, the main research area is ultrapotent vinblastine derivative preparation tubulin binding cancer; chemical synthesis; drug design; protein–protein interaction; tubulin; vinblastine.

Approaches to improving the biol. properties of natural products typically strive to modify their structures to identify the essential pharmacophore, or make functional group changes to improve biol. target affinity or functional activity, change phys. properties, enhance stability, or introduce conformational constraints. Aside from accessible semisynthetic modifications of existing functional groups, rarely does one consider using chem. synthesis to add mol. complexity to the natural product. In part, this may be attributed to the added challenge intrinsic in the synthesis of an even more complex compound Herein, we report synthetically derived, structurally more complex vinblastines inaccessible from the natural product itself that are a stunning 100-fold more active (IC50 values, 50-75 pM vs. 7 nM; HCT116), and that are now accessible because of advances in the total synthesis of the natural product. The newly discovered ultrapotent vinblastines, which may look highly unusual upon first inspection, bind tubulin with much higher affinity and likely further disrupt the tubulin head-to-tail α/β dimer-dimer interaction by virtue of the strategic placement of an added conformationally well-defined, rigid, and extended C20′ urea along the adjacent continuing protein-protein interface. In this case, the added mol. complexity was used to markedly enhance target binding and functional biol. activity (100-fold), and likely represents a general approach to improving the properties of other natural products targeting a protein-protein interaction.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Colorectal carcinoma. 672948-03-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H3NO3, Application of C4H3NO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kilic, Deniz; Karaca Balta, Demet; Saloglu, Didem; Temel, Gokhan published the artcile< Synthesis and characterization of POSS hybrid organogels using Menschutkin quaternization chemistry>, Reference of 1592-20-7, the main research area is POSS hybrid organogel Menschutkin quaternization chem.

The present research describes a series of organic-inorganic hybrid gels based on polystyrene and polyhedral oligomeric silsesquioxanes (POSSs) prepared using free radical copolymerization and Menschutkin chem. techniques. In the first step, poly(styrene-co-chloromethylstyrene) is readily achieved by thermally initiated radical copolymerization and the subsequently obtained copolymer reacts with diethanolamine functional POSS nanoparticles which are employed as the crosslinker. The resulting hybrid network possesses ionic moieties and inorganic POSS nanoparticles. The POSS-containing hybrid gels exhibit excellent organic solvent absorption and show good mech. behavior. Gel containing 0.8 × 10-3 mmol of POSS(DEA)8 (DEA, diethanolamine) reached the highest swelling ratio; hence, the corresponding gel can absorb organic solvent up to 20× its weight The rate constant, coefficients and diffusional behavior of hybrid organogels in organic solvent were examined as well. The organic solvent intake of the hybrid gel follows a non-Fickian type diffusion. © 2018 Society of Chem. Industry.

Polymer International published new progress about Crosslinking agents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Reference of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Han, Yingzhi; Sun, Yadong; Abdukader, Ablimit; Liu, Bifu; Wang, Duozhi published the artcile< PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is aminothiadiazole preparation; aldehyde thiosemicarbazide iodobenzene catalyst oxidative coupling reaction.

A highly efficient method for the synthesis of thiadiazole derivatives via intramol. oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents was developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields.

Catalysis Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

El’tsov, A. V.; Sokolova, N. B.; Grigor’ev, A. D.; Dmitrieva, N. M.; Shtol’vin, A. S. published the artcile< Synthesis of Quinizarin and Its Derivatives under Conditions of Microwave Activation>, Application In Synthesis of 118-45-6, the main research area is microwave quinizarin preparation; anthracenedione dihydroxy microwave quinizarin preparation; isoindoledione chlorophenol microwave quinizarin preparation; cyclocondensation phthalic anhydride chlorophenol microwave quinizarin preparation.

In a microwave field, phthalic anhydride reacts with p-chlorophenol to give 1,4-dihydroxyanthraquinone (quinizarin) within 10 min. The reaction with 4-chlorophthalic anhydride occurs similarly. Phthalic and chlorophthalic acids can be used instead of anhydrides. 3-Nitrophthalic acid and 3,4,5,6-tetrabromophthalic anhydride do not react with p-chlorophenol under these conditions.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about Cyclocondensation reaction. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application In Synthesis of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dayagi, Shlomo; Degani, Jair; Friedlander, Ruth; Patai, Saul published the artcile< Tritylation and detritylation of active methylene compounds. IV. Formation and reactions of some hexasubstituted ethanes>, Quality Control of 90940-40-2, the main research area is .

Attempts were made by various methods to prepare hexasubstituted ethanes Ph3CCXYZ, where X and Y are strongly electron-attracting groups and Z is alkyl or aryl. Use of different active methine compounds gave the desired products in only a few cases. Heterolysis of these compounds was much more difficult than when Z = H.

Journal of the Chemical Society published new progress about Methylene group. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Quality Control of 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Xia; Lu, Yuling; Guan, Zhenhua; Gu, Lianghu; Chen, Chunmei; Zhu, Hucheng; Luo, Zengwei; Zhang, Yonghui published the artcile< Synthesis of Succinimides via Intramolecular Alder-Ene Reaction of 1,6-Enynes>, Reference of 3240-10-6, the main research area is enyne diastereoselective Alder ene metal free green; succinimide stereoselective preparation.

A novel and convenient method has been developed for the facile synthesis of functionalized succinimide derivatives via intramol. Alder-ene reaction of 1,6-enynes. This reaction features mild and metal-free reaction conditions, which offers a green and efficient entry to synthetically important succinimide scaffolds. Preliminary mechanistic studies suggest that a diradical intermediate might be involved in this transformation.

Organic Letters published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Reference of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khairnar, Pankaj V.; Lung, Tsai-Hui; Lin, Yi-Jung; Wu, Chi-Yi; Koppolu, Srinivasa Rao; Edukondalu, Athukuri; Karanam, Praneeth; Lin, Wenwei published the artcile< An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes>, Synthetic Route of 17082-09-6, the main research area is diversity oriented synthesis pyrazole isoxazole chromenone oxime; intramol Wittig reaction alpha halohydrazone ketoxime.

α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base. Mechanistic investigations revealed the in situ formation of azo/nitroso olefin intermediates which underwent a tandem phospha-Michael/N- or O-acylation/intramol. Wittig reaction to afford the heteroarenes in moderate to good yields. Further, proper functionalization of α-haloketoximes and a change of conditions allowed the chemoselective synthesis of chromenone-oximes as well as rearranged isoxazoles, thereby realizing a diversity-oriented synthesis.

Organic Letters published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics