Month: October 2022

Laine, Ensio; Tuominen, Virpi; Jalonen, Hannu; Kahela, Paavo published the artcile< Effect of storage conditions on structure of cyclophosphamide>, Formula: C7H17Cl2N2O3P, the main research area is cyclophosphamide stability storage; dehydration cyclophosphamide monohydrate.

The effect of aging on the structure of cyclophosphamide (I) [50-18-0] was studied under different storage conditions. I hydrate [6055-19-2] is preserved as such if the relation humidity is >70% and the temperature is <30°, otherwise the monohydrate form will change to an anhydrous form. The monohydrate-anhydrous transition was reversible. Acta Pharmaceutica Fennica published new progress about Dehydration process. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Formula: C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gutorov, L. A.; Golovchinskaya, E. S. published the artcile< Syntheses in the purine series. XXXIV. Transformations of N,N'-dimethylxanthines in the reaction with phosphoryl chloride in the presence of tert-amines>, Electric Literature of 2382-10-7, the main research area is xanthine reaction phosphorus oxychloride; purine chloro methyl.

Purine derivative (I; X = OPOCl2) (II) was obtained in ∼18% yield by boiling theobromine with POCl3 in Me2NH for 8 hr. Hydrolysis of II with aqueous NaOH gave purine (I; X = Cl). Boiling the latter with PhCl afforded purine (III; R = p-Me2N- C6H4). III (R = Cl) was obtained in ∼90% yield by boiling theobromine with POCl3 containing Et3N·HCl.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 2382-10-7. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Electric Literature of 2382-10-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pasula, Chandra Sekhar; Tadakaluru, Yasodha Lakshmi; Sannidhi, Ranga Suresh; Pujari, Venkata Suresh Reddy; Chirumamilla, Venkata Satish Kumar; Reddy, Y. Raja Ratna published the artcile< Comparative analysis of cyclophosphamide monohydrate cytotoxicity in healthy human lymphocytes and L5178Y TK+/- mouse lymphoma cells>, Product Details of C7H17Cl2N2O3P, the main research area is cyclophosphamide monohydrate cytotoxicity human lymphocyte TK lymphoma cell.

The study was conducted to evaluate and compare the cytotoxicity of cyclophosphamide monohydrate in In vitro Mammalian Chromosome Aberration Test (CAT) using cultured healthy human whole blood lymphocytes and In vitro Cell Gene Mutation Assay (CGM) using L5178Y TK+/- mouse lymphoma cells as per OECD guidelines Number 473 & 476 resp., both in the presence (2%volume/volume) and absence of metabolic activation system. Cyclophosphamide monohydrate is cytotoxic at the doses 250, 125, 62.5, 31.25 μg/mL and non-cytotoxic at 15.62 μg/mL in CGM, where 250, 125, 62.5 μg/mL of doses are cytotoxic and 31.25, 15.62 μg/mL doses are non-cytotoxic in CAT, in the presence of metabolic activation system. Cytotoxicity was not observed in all the test doses 250, 125, 62.5, 31.25, 15.62 μg/mL, in the absence of metabolic activation system both in CGM and CAT. Cyclophosphamide monohydrates require metabolic activation for its cytotoxicity. A lower dose of cyclophosphamide monohydrate is cytotoxic in In vitro Cell Gene Mutation Assay (CGM) than Mammalian Chromosome Aberration Test (CAT) In vitro. Cyclophosphamide monohydrate is non cytotoxic in both assays, in the absence of metabolic activation system indicates that metabolic activation system play a key role in the cytotoxicity of cyclophosphamide monohydrate.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about Antitumor agents. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Product Details of C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hong, Cynthia M.; Whittaker, Aaron M.; Schultz, Danielle M. published the artcile< Nucleophilic Fluorination of Heteroaryl Chlorides and Aryl Triflates Enabled by Cooperative Catalysis>, Synthetic Route of 2382-10-7, the main research area is heteroaryl chloride crown ether catalyst nucleophilic fluorination; heteroaromatic fluoride preparation; phenyl triflate crown ether catalyst nucleophilic fluorination; fluorobenzene preparation.

A new approach that leverages the cooperative action of 18-crown-6 ether and tetramethylammonium chloride to catalytically access the reactivity of tetramethylammonium fluoride and achieve halex fluorinations under mild conditions with operational ease was reported. The described methodol. readily converts both heteroaryl chlorides and aryl triflates to their corresponding (hetero)aryl fluorides in high yields and purities.

Journal of Organic Chemistry published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Synthetic Route of 2382-10-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hu, Min; Ding, Liang; Shehzad, Muhammad A.; Ge, Qianqian; Liu, Yahua; Yang, Zhengjin; Wu, Liang; Xu, Tongwen published the artcile< Comb-shaped anion exchange membrane with densely grafted short chains or loosely grafted long chains?>, Name: 1-(Chloromethyl)-4-vinylbenzene, the main research area is comb shaped anion exchange membrane densely grafted chain.

Anion exchange membranes (AEMs) are crucial components for advanced energy and environment processes including alk. fuel cells, redox flow batteries, and industrial effluent treatment; while low anionic conductivity and poor stability remain the major challenges for the widespread implementation of AEMs. Through mol. engineering, comb-shaped AEMs have been proved possessing the capability of delivering both high conductivity and good alk. stability. However, how to precisely control the side chain topol. and how the chain topol. would influence the membrane properties need to be further elucidated. We hereby propose a radically novel and readily scalable route towards the controllable synthesis of comb-shaped AMEs and we were able to determine the length of side chains and the number of ionic groups along the side chains. To probe the effect of side chain topol. on membrane properties, two types of AEMs of densely grafted short side chains or loosely grafted long side chains with similar ion exchange capacity (IEC, ∼1.7 mmol/g) were synthesized and compared. We found that the comb-shaped AEMs with loosely grafted long chains (LG-LS-DIm), with higher hydroxide conductivity (55 mS cm-1 at 30 °C) and better alk. stability (∼80 % of IEC retention after soaking in 2 mol L-1 NaOH solution at 60 °C for 25 days), outperform those with densely grafted short chains (HG-SS-DIm) and the benchmark main-chain type AEMs (DIm-PPO), which is also superior to those of conventional linear AEMs with densely functionalized structure.

Journal of Membrane Science published new progress about Acrylic polymers, polyoxyphenylene-, graft Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PROC (Process), PREP (Preparation), USES (Uses). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Name: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Wei; Xiang, Xin-Xin; Chen, Junyi; Yang, Chen; Pan, Yu-Liang; Cheng, Jin-Pei; Meng, Qingbin; Li, Xin published the artcile< Direct C-H difluoromethylation of heterocycles via organic photoredox catalysis>, Reference of 2382-10-7, the main research area is difluoromethylation regioselective organic photoredox catalysis; heteroarene sodium difluoromethanesulfinate difluoromethylation aerobic.

The discovery of modern medicine relies on the sustainable development of synthetic methodologies to meet the needs associated with drug mol. design. Heterocycles containing difluoromethyl groups are an emerging but scarcely investigated class of organofluoro mols. with potential applications in pharmaceutical, agricultural and material science. Herein, authors developed an organophotocatalytic direct difluoromethylation of heterocycles using O2 as a green oxidant. The C-H oxidative difluoromethylation obviates the need for pre-functionalization of the substrates, metals and additives. The operationally straightforward method enriches the efficient synthesis of many difluoromethylated heterocycles in moderate to excellent yields. The direct difluoromethylation of pharmaceutical moleculars demonstrates the practicability of this methodol. to late-stage drug development. Moreover, 2′-deoxy-5-difluoromethyluridine exhibits promising activity against some cancer cell lines, indicating that the difluoromethylation methodol. might provide assistance for drug discovery.

Nature Communications published new progress about Antitumor agents. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Reference of 2382-10-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chekan, Jonathan R.; Lee, Ga Young; El Gamal, Abrahim; Purdy, Trevor N.; Houk, K. N.; Moore, Bradley S. published the artcile< Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase>, Formula: C4H4ClNO2, the main research area is crystal structure tetrabromopyrrole debrominase dehalogenation thyroid deiodinase.

Enzymic dehalogenation is an important and well-studied biol. process in both the detoxification and catabolism of small mols., many of which are anthropogenic in origin. However, dedicated dehalogenation reactions that replace a halogen atom with a hydrogen are rare in the biosynthesis of natural products. In fact, the debrominase Bmp8 is the only known example. It catalyzes the reductive debromination of the coral settlement cue and the potential human toxin 2,3,4,5-tetrabromopyrrole as part of the biosynthesis of the antibiotic pentabromopseudilin. Using a combination of protein crystallog., mutagenesis, and computational modeling, we propose a catalytic mechanism for Bmp8 that is reminiscent of that catalyzed by human deiodinases in the maintenance of thyroid hormones. The identification of the key catalytic residues enabled us to recognize divergent functional homologs of Bmp8. Characterization of one of these homologs demonstrated its debromination activity even though it is found in a completely distinct genomic context. This observation suggests that addnl. enzymes outside those associated with the tetrabromopyrrole biosynthetic pathway may be able to alter the lifetime of this compound in the environment.

Biochemistry published new progress about Crystal structure. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Saito, Masato; Kawamata, Yu; Meanwell, Michael; Navratil, Rafael; Chiodi, Debora; Carlson, Ethan; Hu, Pengfei; Chen, Longrui; Udyavara, Sagar; Kingston, Cian; Tanwar, Mayank; Tyagi, Sameer; McKillican, Bruce P.; Gichinga, Moses G.; Schmidt, Michael A.; Eastgate, Martin D.; Lamberto, Massimiliano; He, Chi; Tang, Tianhua; Malapit, Christian A.; Sigman, Matthew S.; Minteer, Shelley D.; Neurock, Matthew; Baran, Phil S. published the artcile< N-Ammonium Ylide Mediators for Electrochemical C-H Oxidation>, Product Details of C8H4ClF3O2, the main research area is ketone preparation regioselective chemoselective; aldehyde preparation regioselective chemoselective; hydrocarbon electrochem oxidation; ammonium ylide preparation.

Herein, a rationally designed platform that provides a step toward this challenge using N-ammonium ylides e.g., acetamidotrimethylazanium-tetrafluoroboranuide as electrochem. driven oxidants for site-specific, chemoselective C(sp3)-H oxidn was presented. By taking a first-principles approach guided by computation, these new mediators were identified and rapidly expanded into a library using ubiquitous building blocks and trivial synthesis techniques. The ylide-based approach to C-H oxidation exhibits tunable selectivity that is often exclusive to this class of oxidants and can be applied to real-world problems in the agricultural and pharmaceutical sectors.

Journal of the American Chemical Society published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Product Details of C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Qian; Mgimpatsang, Kumchok C.; Konstantinidou, Markella; Shishkina, Svitlana V.; Doemling, Alexander published the artcile< 1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction>, Product Details of C8H4ClF3O2, the main research area is oxadiazole aminoalkyl metal free multicomponent preparation; Ugi reaction amine aldehyde azidotrimethylsilane isonitrile; Huisgen reaction aminoalkyl tetrazole acyl chloride pyridine solvent.

Amines, aldehydes, Me3SiN3, and tert-octyl isonitrile t-BuCH2CMe2N+C- underwent Ugi reactions to yield aminoalkyltetrazoles such as I; acid cleavage of the tert-octyl group followed by Huisgen reactions with acyl chlorides in pyridine yielded oxadiazoles such as II.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Product Details of C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Wen-Ke; Guo, Jia-Ming; Chen, Zhao-Dan; Si, Chang-Mei; Wei, Bang-Guo published the artcile< Titanium Tetrachloride-Mediated Approach to Access 2-Chloro-2-Substituted Isoindolin-1-ones through the Addition of Alkynes to Acyliminium ions>, Computed Properties of 118-45-6, the main research area is isoindolinone chlorovinyl hydroxyethyl preparation diastereoselective; oxazoloidoindole ring opening addition chlorination terminal alkyne titanium tetrachloride.

An asym. approach to access 2-substituted isoindolin-1-ones I (R1 = R2 = H, MeO; R1 = Cl, R2 = H; R = n-pentyl, cyclopropyl, Ph, 4-FC6H4, 2-MeC6H4, 2-naphthyl, etc.) through TiCl4-mediated addition-chlorination of N,O-acetals II with terminal alkynes RCCH has been developed. A range of substrates were amenable to this transformation and the desired substituted isoindolin-1-ones were obtained in moderate to good yields with moderate diastereoselectivities.

European Journal of Organic Chemistry published new progress about Addition reaction, stereoselective. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Computed Properties of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics