Month: October 2022

Hameurlaine, Edhawya; Guezzoul, M’hamed; Bouslama, M’HAMMED; Ouerdane, Abdellah; Derri, Amira; Bedrouni, Mahmoud; Bensassi, Kadda Benmohktar; Baizid, Abdelhak; Abdelkrim, Mahfoud; Kharoubi, Bachir published the artcile< IMPACT OF INDIUM DOPING ON ZnO THIN FILM SUBJECTED TO APPROPRIATE UHV TREATMENT CHARACTERIZED BY XPS, XRD, AND PL TECHNIQUES>, Recommanded Product: Indium(III) chloride tetrahydrate, the main research area is indium doping zinc oxide thin film UHV treatment; photoluminescence X ray diffraction photoelectron spectroscopy.

The chem. composition, crystalline structure and optical properties of un-doped ZnO (UZO) and indium (6%)-doped ZnO (IZO) thin films grown on Si substrate were studied using XPS, X-ray diffraction (XRD) and photoluminescence (PL) techniques. The results are complementary and confirm each other. The surface is cleaned using checked ultra-high vacuum (UHV) treatment (argon ion sputtering followed by successive heating). For IZO, the XPS anal. displays that the indium incorporates in the ZnO matrix to form the In-O-Zn-type chem. bonds. The PL of UZO reveals structural defects, including oxygen interstitial (Oi), oxygen vacancies (VO), zinc vacancies (VZn) and interstitial zinc (Zni), and they decrease with the In doping and UHV treatment. For IZO, the PL measurements show the great interest of UHV treatment to stimulate the incorporation of indium into the ZnO matrix. There is an increase in the UV emission intensity and improvement of its phys. structure. The In (6%) doping of ZnO is convenient to compensate the zinc vacancies (VZn), eliminate Zni and VO, and ensure the structural homogeneity of IZO film. All the detected peaks of the XRD patterns are matched to the wurtzite crystalline structure for both UZO and IZO thin films grown mainly along the (002) orientation plane.

Surface Review and Letters published new progress about Binding energy. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Recommanded Product: Indium(III) chloride tetrahydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Abraham, Raymond J.; Cooper, M. Ashley published the artcile< A re-investigation of 4JFF and 5JFF nuclear spin-spin couplings in substituted benzenes, a novel conformational tool>, Quality Control of 1435-43-4, the main research area is benzene nuclear spin coupling B3LYP.

A theor. anal. of the 4JFF and 5JFF couplings in fluorobenzenes separates the σ and π components of the substituent coefficients The π bond mechanism is dominant but the σ bond mechanism must be included to give accurate values of the couplings. For monosubstituted difluorobenzenes the 4JFF and 5JFF couplings can be predicted from the calculated π densities by linear equations. The use of additive substituent effects allows the prediction of the meta4JFF couplings for multisubstituted compounds The π dependence of the 4JFF coupling in 2,6-difluorobenzenes provides a novel and simple method of determining the torsional angle of the C1 substituent and the benzene ring for non-sym. functional groups (acetyl, carboxymethyl, dimethylamino, amide, nitro etc.). This could be used to determine the geometries of such mols. in biol. systems. The π dependence of the 4JFF coupling is also of importance in the charged species of 2,6-difluoroanilinium (4JFF 2.1 Hz) and 2,6-difluoro-N,N,N-trimethylanilinium (4JFF 0.0 Hz) due to the very different π electron densities.

Physical Chemistry Chemical Physics published new progress about Bond angle, torsional. 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Quality Control of 1435-43-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jing, Ke; Wei, Ming-Kai; Yan, Si-Shun; Liao, Li-Li; Niu, Ya-Nan; Luo, Shu-Ping; Yu, Bo; Yu, Da-Gang published the artcile< Visible-light photoredox-catalyzed carboxylation of benzyl halides with CO2: Mild and transition-metal-free>, Application In Synthesis of 611-19-8, the main research area is aryl acetic acid preparation visible light; benzyl chloride bromide carbon dioxide carboxylation photoredox catalyst.

The visible-light photoredox-catalyzed carboxylation of benzyl chlorides and bromides with CO2 has been reported. With inexpensive organic dyes as photocatalysts and amines as electron donors, this carboxylation proceeds well in the absence of sensitive organometallic reagents, transition metal catalysts, or metallic reductants. A wide range of com. available and inexpensive benzyl halides undergo such carboxylation to give valuable aryl acetic acids, including several pharmaceutical mols. and drug precursors, in moderate to high yields. Moreover, this reaction features mild reaction conditions (one atm. pressure of CO2 and room temperature), broad substrate scope, good functional group tolerance, easy scalability, and low catalyst loading, thus providing an efficient approach for the assembly of aryl acetic acids.

Chinese Journal of Catalysis published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Application In Synthesis of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aksenov, Alexander V.; Aksenov, Dmitrii A.; Arutiunov, Nikolai A.; Aksenov, Nicolai A.; Aleksandrova, Elena V.; Zhao, Zhenze; Du, Liqin; Kornienko, Alexander; Rubin, Michael published the artcile< Synthesis of Spiro[indole-3,5'-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles>, Application In Synthesis of 5153-70-8, the main research area is spiroindoleisoxazole preparation anticancer formal spirocyclization nitroalkene indole.

An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4’H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic mols. exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells.

Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ishitani, Haruro; Kanai, Kan; Yoo, Woo-Jin; Yoshida, Tomoko; Kobayashi, Shu published the artcile< A Nickel-Diamine/Mesoporous Silica Composite as a Heterogeneous Chiral Catalyst for Asymmetric 1,4-Addition Reactions>, SDS of cas: 5153-70-8, the main research area is nitroalkylmalonate enantioselective preparation; supported nickel diamine complex preparation recyclable catalyst enantioselective addition; enantioselective addition malonate nitroalkene supported nickel diamine catalyst; nitromethane enantioselective addition alkylidenemalonate supported nickel diamine catalyst; asymmetric 1,4-addition; asymmetric catalysis; flow synthesis; heterogeneous catalysis; mesoporous materials.

A nonracemic nickel diamine complex supported on the mesoporous silica MCM-41 was prepared from NiI2, (R,R)-BnNHCHPhCHPhNHBn, and MCM-41 was prepared as a recyclable catalyst for the enantioselective addition of di-Me malonate to nitroalkenes and for the enantioselective addition of nitromethane to alkylidenemalonates in the presence of morpholine. MCM-41 enhanced the reactivity and improved the stability of the included nickel diamine complex.

Angewandte Chemie, International Edition published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, SDS of cas: 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Min; Huang, Min; Li, Wenzhe; Yan, Yingkun; Li, Min; Zhang, Xiaomei published the artcile< Enantioselective Synthesis of Axially Chiral N-Aryl-3-methyleneisoindolin-1-ones>, Synthetic Route of 118-45-6, the main research area is aryl methyleneisoindolinone preparation enantioselective; aniline acetyl benzoic acid phosphoric catalyst.

A chiral phosphoric acid catalyzed enantioselective condensation of 2-acetylbenzoic acid derivatives 2-R-3-R1-4-R2-5-(C(O)CH3)C6HCOOH (R = H, F, Cl, OH; R1 = H, Cl, Me, etc.; R2 = H, F; R1 = R2 = -CH2-CH-CH-CH2-;) with 2-substituted aniline derivatives, 2-R3-4-R4-C6H3NH2 (R3 = t-Bu, i-Pr, I; R4 = H, Br, Ph, etc.) leading to the construction of a series of novel C-N axially chiral N-aryl-3-methylene-isoindolin-1-ones I in moderate to good yields (up to 97%) with generally moderate enantioselectivities (up to 87% ee) was described. In addition, the absolute configuration of product I (R = Cl; R1 = H; R2 = H; R3 = t-Bu; R4 = H) was determined by an X-ray crystal structural anal. Furthermore, one product I was subjected to oxidative cleavage to generate an axially chiral phthalimide.

Asian Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Synthetic Route of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kim, Junhyoung; Jung, Dong Hyun; Rhee, Hokyoung; Choi, Seung-Hoon; Sung, Min Jae; Choi, Woo Sik published the artcile< Aqueous solubility of poorly water-soluble drugs: prediction using similarity and quantitative structure-property relationship models>, Quality Control of 3964-57-6, the main research area is solubility QSPR phenytoin biphenyl dimethyl dicarboxylate ursodeoxycholic cholic.

The aqueous solubility of poorly water-soluble drugs is an important property of many factors affecting their bioavailability such as the solubility and rate of dissolution in water. The quant. structure-property relationship approach using genetic algorithm was applied to make models for predicting some poorly water-soluble drugs such as ursodeoxycholic acid, di-Ph hydrantoin and biphenyl di-Me dicarboxylate. The exptl. solubility data of 3518 chem. structures were collected from the web and used to build a model. Three data sets of 50 compounds were extracted according to their structural similarity with each drug. A fast and predictive similarity based approach was developed and validated with conventional method. This can be used to predict the aqueous solubility for drugs by using a small set of compounds, especially for poorly water-soluble compounds Moreover, the estimation values of various sets were further compared with fine grinding experiment data.

Korean Journal of Chemical Engineering published new progress about Drug design. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Quality Control of 3964-57-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marivingt-Mounir, Cecile; Norez, Caroline; Derand, Renaud; Bulteau-Pignoux, Laurence; Nguyen-Huy, Dung; Viossat, Bernard; Morgant, Georges; Becq, Frederic; Vierfond, Jean-Michel; Mettey, Yvette published the artcile< Synthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels>, Related Products of 2905-54-6, the main research area is benzoquinolizinium preparation cystic fibrosis transmembrane conductance regulator channel activation; benzoindoloquinolizinium preparation cystic fibrosis transmembrane conductance regulator channel activation.

Chloride channels play important roles in homeostasis and regulate cell volume, transepithelial transport, and elec. excitability. Despite recent progress made in the genetic and mol. aspect of chloride channels, their pharmacol. is still poorly understood. The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated epithelial chloride channel for which mutations cause cystic fibrosis. Here we have synthesized benzo[c]quinolizinium, e.g., I, and benzo[f]indolo[2,3-a]quinolizinium salts (MPB), e.g., II, and performed a SAR to identify the structural basis for activation of the CFTR chloride channel. Synthesized compounds were evaluated on wild-type CFTR and on CFTR having the glycine-to-aspartic acid missense mutation at codon 551 (G551D-CFTR), using a robot and cell-based assay. The presence of an hydroxyl group at position 6 of the benzo[c]quinolizinium skeleton associated with a chlorine atom at position 10 or 7 and an alkyl chain at position 5 determined the highest activity. The most potent product is 5-butyl-7-chloro-6-hydroxybenzo[c]quinolizinium chloride (I, MPB-104). I is 100 times more potent than the parent compound III (MPB-07).

Journal of Medicinal Chemistry published new progress about CFTR (cystic fibrosis transmembrane conductance regulator) Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Related Products of 2905-54-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kaiser, Carl; Lester, Bruce M.; Zirkle, Charles L.; Burger, Alfred; Davis, Charles S.; Delia, Thomas J.; Zirngibl, Ludwig published the artcile< 2-Substituted cyclopropylamines. I. Derivatives and analogs of 2-phenylcyclopropylamine>, Application In Synthesis of 90940-40-2, the main research area is .

A series of derivatives (I, II) of 2-phenylcyclopropylamine and analogs, 2-arylcyclopropanecarboxhydrazides, -carboxamides, -methyl-amines, -carboxylic acids, esters, and chlorides has been prepared in order to study relationships between chem. structure and monoamine oxidase-inhibiting activity.

Journal of Medicinal & Pharmaceutical Chemistry published new progress about 90940-40-2. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Application In Synthesis of 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti published the artcile< Asymmetric Michael Addition of Unactivated Ketones with β-Nitrostyrenes Mediated by Bifunctional L-Prolinamide Organocatalysts>, Quality Control of 5153-70-8, the main research area is nitrostyrene ketone orgnocatalyst diastereoselective Michael addition; nitrophenylethyl ketone preparation.

The catalytic activity of two types of L-prolinamide organocatalysts was investigated for asym. Michael addition reaction of cyclic/acyclic ketones with β-nitrostyrens. L-Prolinamides bearing amino groups as efficient catalyst as well as selectivity was found to be dependent upon the position of amine group to the amide bond. Organocatalyst having -NH2 group ortho to amide bond provided the best results. Substrate scope was also studied by performing the reaction of various β-nitrostyrenes with ketones to afforded the corresponding Michael adducts in excellent yields with very high diastereoselectivities and enantioselectivities in almost all cases.

ChemistrySelect published new progress about Alkenes, nitro Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Quality Control of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics