Month: October 2022

Chen, Yi-Chun; Reddy, Kamani Sudhir K.; Lin, Yu-An; Wang, Meng-Wei; Lin, Ching-Hsuan published the artcile< Tetrafluorophenylene-Containing Vinylbenzyl Ether-Terminated Oligo(2,6-dimethyl-1,4-phenylene ether) with Better Thermal, Dielectric, and Flame-Retardant Properties for Application in High-Frequency Communication>, Safety of 1-(Chloromethyl)-4-vinylbenzene, the main research area is vinylbenzyl ether terminated oligodimethylphenylene ether flame retardant.

In an integrated circuit, signal propagation loss is proportional to the frequency, dissipation factor (Df), and square root of dielec. constant (Dk). The loss becomes obvious as we move to high-frequency communication. Therefore, a polymer having low Dk and Df is critical for copper-clad laminates at higher frequencies. For this purpose, a 4-vinylbenzyl ether phenoxy-2,3,5,6-tetrafluorophenylene-terminated OPE (VT-OPE) resin was synthesized and its properties were compared with the thermoset of com. OPE-2St resin. The thermoset of VT-OPE shows a higher Tg (242 vs. 229°C), a relatively high crosslinking d. (1.59 vs. 1.41 mmole cm-3), a lower coefficient of thermal expansion (55 vs. 76 ppm/°C), better dielec. characteristic at 10 GHz (Dk values of 2.58 vs. 2.75, Df values of 0.005 vs. 0.006), lower water absorption (0.135 vs. 0.312 weight %), and better flame retardancy (UL-94 VTM-0 vs. VTM-1 with dropping seriously) than the thermoset of OPE-2St. To verify the practicability of VT-OPE for copper-clad laminate, a laboratory process was also performed to prepare a copper-clad laminate, which shows a high peeling strength with copper foil (5.5 lb/in), high thermal reliability with a solder dipping test at 288°C (>600 s), and the time for delamination of the laminate in thermal mech. anal. (TMA) at 288°C is over 60 min.

ACS Omega published new progress about Complex modulus, tan δ. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Safety of 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kotova, N.; Hebert, N.; Haernwall, E.-L.; Vare, D.; Mazurier, C.; Douay, L.; Jenssen, D.; Grawe, J. published the artcile< A novel micronucleus in vitro assay utilizing human hematopoietic stem cells>, Product Details of C7H17Cl2N2O3P, the main research area is micronucleus assay human erythrocyte hematopoietic stem cell genotoxicity; Erythrocytes; Flow cytometry; Genotoxicity in vitro; Micronucleus test; Stem cells.

The induction of micronucleated reticulocytes in the bone marrow is a sensitive indicator of chromosomal damage. Therefore, the micronucleus assay in rodents is widely used in genotoxicity and carcinogenicity testing. A test system based on cultured human primary cells could potentially provide better prediction compared to animal tests, increasing patient safety while also implementing the 3Rs principle, i.e., replace, reduce and refine. Hereby, the authors describe the development of an in vitro micronucleus assay based on animal-free ex vivo culture of human red blood cells from hematopoietic stem cells. To validate the method, five clastogens with direct action, three clastogens requiring metabolic activation, four aneugenic and three non-genotoxic compounds have been tested. Also, different metabolic systems have been applied. Flow cytometry was used for detection and enumeration of micronuclei. Altogether, the results were in agreement with the published data and indicated that a sensitive and cost effective in vitro assay to assess genotoxicity with a potential to high-throughput screening has been developed.

Toxicology In Vitro published new progress about Aneugens. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Product Details of C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zeng, Chao; Hu, Yingmo published the artcile< Hydrothermal synthesis of a CoIn2S4/g-C3N4 heterojunctional photocatalyst with enhanced photocatalytic H2 evolution activity under visible light illumination>, Category: chlorides-buliding-blocks, the main research area is cobalt indium sulfide carbon nitride hydrogen heterojunction photocatalyst; hydrogen hydrothermal treatment photocatalytic activity.

CoIn2S4, a black semiconducting material, possesses an outstanding visible light response and is employed to modify g-C3N4. A series of CoIn2S4/g-C3N4 heterojunctional photocatalysts are synthesized via a hydrothermal method, whereby cubic CoIn2S4 nanosheets are in situ immobilized on the surfaces of porou g-C3N4 nanosheets. Compared with the pristine g-C3N4 and CoIn2S4, under visible light (λ> 420 nm) irradiation, the CoIn2S4/g-C3N4 composite samples show markedly enhanced photocatalytic activity in hydrogen evolution. Among all of the samples, the 30% CoIn2S4/g-C3N4 sample shows the maximum H2 evolution rates, 5.2 and 23.9 times higher than those of g-C3N4 and CoIn2S4, resp. The efficient photocatalytic activity of CoIn2S4/g-C3N4 composite photocatalysts is attributed to the formation of an intimate heterostructure, which not only significantly facilitates charge migration, but also enhances visible light absorption. Moreover, a plausible photocatalytic mechanism for the composite photocatalyst has been elucidated. This research provides a novel hint for fabricating visible-light-responsive heterojunction photocatalysts with high performance for energy production

Nanotechnology published new progress about Absorption. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Kevin G.; Kim, Ji-In; Olszewski, Kellen; Barsotti, Anthony M.; Morris, Koi; Lamarque, Christophe; Yu, Xuemei; Gaffney, Jack; Feng, Xiao-Jiang; Patel, Jeegar P.; Poyurovsky, Masha V. published the artcile< Discovery and Optimization of Glucose Uptake Inhibitors>, Safety of 2,6-Dichloro-9-methyl-9H-purine, the main research area is glucose transporters inhibitors GLUT1 GLUT3 bioavailable ADME SAR.

Aerobic glycolysis, originally identified by Warburg as a hallmark of cancer, has recently been implicated in immune cell activation and growth. Glucose, the starting material for glycolysis, is transported through the cellular membrane by a family of glucose transporters (GLUTs). Therefore, targeting glucose transporters to regulate aerobic glycolysis is an attractive approach to identify potential therapeutic agents for cancers and autoimmune diseases. Herein, we describe the discovery and optimization of a class of potent, orally bioavailable inhibitors of glucose transporters, targeting both GLUT1 and GLUT3.

Journal of Medicinal Chemistry published new progress about Autoimmune disease. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Safety of 2,6-Dichloro-9-methyl-9H-purine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Box, Vernon G. S.; Meleties, Panayiotis C. published the artcile< The thermal [3,3] Claisen rearrangement of the 3-substituted phenyl allyl and propargyl ethers. The synthesis of 4-halobenzo[b]furans>, Computed Properties of 22717-55-1, the main research area is Claisen rearrangement allyl phenyl ether regioselectivity mechanism; propargyl phenyl ether Claisen rearrangement regioselectivity mechanism.

The thermal [3,3] Claisen rearrangement of 3-substituted Ph allyl and propargyl ethers is regioselective. The major product of the reaction incorporates a 1,2,3-trisubstituted benzene ring. The 2-allenylphenol intermediates can be manipulated into the preparation of 4-substituted benzo[b]furans. The observed regioselectivity supports the biradicaloid mechanism of the Claisen rearrangement.

Heterocycles published new progress about Aromatic ethers Role: RCT (Reactant), RACT (Reactant or Reagent). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gensini, Martina; Battaglia, Gianluca; Nannicini, Rossano; Guerri, Annalisa; Altamura, Maria; Quartara, Laura published the artcile< Solvent-dependent benzylic radical bromination in aromatic sulfonyl chlorides>, Computed Properties of 42413-03-6, the main research area is bromination toluenesulfonyl chloride derivative solvent effect; bromomethylphenylsulfonyl chloride derivative preparation x ray; crystal structure bromomethylphenylsulfonyl chloride derivative; mol structure bromomethylphenylsulfonyl chloride derivative.

The title reaction of sulfonyl chloride I (R = H) in MeCN gave I (R = Br) with high yield and reproducibility and no byproducts. Three analogs of I (R = H) were similarly brominated.

Letters in Organic Chemistry published new progress about Arenesulfonyl chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Computed Properties of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

El Hage, Krystel; Piquemal, Jean-Philip; Hobaika, Zeina; Maroun, Richard G.; Gresh, Nohad published the artcile< Approaching the double-faceted nature of the CX bond in halobenzenes with a bifunctional probe>, Product Details of C6H3ClF2, the main research area is halobenzene carbon halogen bond.

In halobenzenes, the CX bond (X = Cl, Br) is doubly faceted, electron-deficient along the CX direction, and electron-rich on its flanks. We have recently shown that both features could be enhanced by appropriate electron-withdrawing and electron-donating groups, resp. In this letter we further highlight this dual character by approaching a bifunctional probe, N-methylformamide, to both regions in representative substituted halobenzenes. We report the results of interaction energy computations, ELF, and NCI analyses. These methods used in conjunction show the responsiveness of the CX bond to both kinds of substitutions, enabling significant interaction energy gains with respect to the parent compound

Chemical Physics Letters published new progress about Aryl bromides Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Product Details of C6H3ClF2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jung, Hyun-Joo; Chen, Zheng; McCarty, Nami published the artcile< Stem-like tumor cells confer drug resistant properties to mantle cell lymphoma>, Recommanded Product: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is chemotherapy resistance mantle cell lymphoma cytotoxic.

We recently identified clonogenic malignant stem cell populations in human mantle cell lymphoma (MCL), a particularly deadly subtype of non-Hodgkin lymphoma (NHL). We discovered that CD45++CD19– MCL cells, which we termed MCL-initiating cells (MCL-ICs), are highly tumorigenic and display self-renewal capacity in vivo; in contrast, CD45++CD19++ MCL cells, which constitute the vast majority of cells within the tumors, show no self-renewal capacity and greatly reduced tumorigenicity. Given the newly appreciated role of cancer-initiating cells in the drug resistance of cancers, it is critical to investigate whether CD45++CD19– MCL-ICs play a role in the drug resistance of human MCL. We discovered that MCL-ICs were more resistant to clin. relevant chemotherapeutic agents, in combination or in a single regimen, compared to CD45++CD19++ cells, and that this drug resistance was largely due to quiescent properties with enriched ABC transporters. In conclusion, designing novel therapies to kill CD45++CD19– MCL-ICs may prevent relapse and increase patient survival.

Leukemia & Lymphoma published new progress about Antitumor agent resistance. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Recommanded Product: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khadse, Saurabh C.; Talele, Gokul S.; Agrawal, Surendra S. published the artcile< Aminocarbonyl Arylvinylbenzamides as Gastric Sparing Anti-inflammatory Agents>, HPLC of Formula: 29027-20-1, the main research area is aminocarbonyl arylvinylbenzamide preparation antiinflammatory gastrotoxicity gastrointestinal ulcer hypermotility.

Some (E/Z)-aminocarbonyl arylvinylbenzamides (B1-B15) were synthesized, evaluated for anti-inflammatory activity and ulcerogenic tendency, and their effect on gastro-intestinal motility in the rats was studied. These benzamides comprising of aliphatic unsaturated region situated between two amide linkages were synthesized by nucleophilic ring opening of appropriate az-lactones (AZ1-AZ4) by suitable amines. The characterization of newly synthesized benzamides was performed by IR, 1H- and 13C-NMR, mass and elemental anal. Amongst the tested compounds, benzamide B1, B2, B4, B5, and B13 were able to produce comparable or superior anti-inflammatory activity at 10 and 20 mg/kg p.o. dose with respect to standard diclofenac in carrageenan induced rat paw edema model with lessened propensity to cause gastro-intestinal hypermotility and were found to have nil tendencies to generate gastric ulcers.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Anti-inflammatory agents. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, HPLC of Formula: 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marshall, Philip; Mooney, Brett; Prager, Rolf; Ward, A. David published the artcile< A convenient synthesis of (E)-Δ3,3'-biphthalides>, Related Products of 118-45-6, the main research area is biphthalide; phthalic anhydride condensation triphenylphthalidylphosphonium bromide.

Treating phosphonium salts I (R = R1 = H, MeO; X = halo) with phthalic anhydrides II (R2 = H, Cl, Me, MeO; R3 = H, MeO, NO2; R4 = H, MeO; R3R4 = OCH2O; Z = S O) in CH2Cl2 in the presence of Et3N gave 70-95% biphthalides III.

Synthesis published new progress about 118-45-6. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Related Products of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics