Month: October 2022

Huang, Lin; Xu, Jun; He, Lei; Liang, Chenfeng; Ouyang, Yani; Yu, Yongping; Li, Wanmei; Zhang, Pengfei published the artcile< Rapid alkenylation of quinoxalin-2(1H)-ones enabled by the sequential Mannich-type reaction and solar photocatalysis>, Related Products of 55687-19-9, the main research area is dihydroquinoxalinone derivative green preparation diastereoselective; quinoxalinone ketone alkenylation Mannich solar photocatalysis.

A rapid alkenylation of quinoxalin-2(1H)-ones with ketones enabled by a combination of Mannich-type reaction and solar photocatalysis to afford 3,4-dihydroquinoxalin-2(1H)-one derivatives I [R1 = 5-Me, 5-F, 7-tBu, etc.; R2 = Me, Et, Bn, etc.; R3 = Me, Et, 2-furyl, etc.] in moderate-to-good yields was demonstrated. Control experiments illustrated that the in situ generated 1O2 played a central role in this reaction. This green and efficient strategy provided a practical solution for the synthesis of potentially bioactive compounds I that containing a 3,4-dihydroquinoxalin-2(1H)-one structure.

Chinese Chemical Letters published new progress about Alkenylation. 55687-19-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H5ClN2O, Related Products of 55687-19-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Honghao; Ouyang, Lufeng; Liu, Jidan; Shi, Wen-Jing; Chen, Guoshu; Zheng, Liyao published the artcile< Synthesis of Multisubstituted 1-Naphthoic Acids via Ru-Catalyzed C-H Activation and Double-Alkyne Annulation under Air>, Recommanded Product: 5-Chloroisobenzofuran-1,3-dione, the main research area is phthalic acid alkyne annulation ruthenium; naphthoic acid preparation; ruthenium annulation catalyst.

An efficient [2 + 2 + 2] benzannulation of phthalic acids/anhydrides with two alkynes was developed for synthesis of multisubstituted 1-naphthoic acids via Ru-catalyzed C-H activation. The reaction preceded well using atm. oxygen as the sole oxidant with high atom/step economies. Facilitated by the free carboxyl group, the products can be easily converted to diverse polycyclic mols.

Journal of Organic Chemistry published new progress about Air. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Recommanded Product: 5-Chloroisobenzofuran-1,3-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tykvart, Jan; Schimer, Jiri; Barinkova, Jitka; Pachl, Petr; Postova-Slavetinska, Lenka; Majer, Pavel; Konvalinka, Jan; Sacha, Pavel published the artcile< Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery>, SDS of cas: 22717-55-1, the main research area is glutamate carboxypeptidase II inhibitor prostate cancer targeting; GCPII; PSMA; Specific drug targeting; Structure-aided drug design.

Glutamate carboxypeptidase II (GCPII), also known as prostate specific membrane antigen (PSMA), is an established prostate cancer marker and is considered a promising target for specific anticancer drug delivery. Low-mol.-weight inhibitors of GCPII are advantageous specific ligands for this purpose. However, they must be modified with a linker to enable connection of the ligand with an imaging mol., anticancer drug, and/or nanocarrier. Here, we describe a structure-activity relationship (SAR) study of GCPII inhibitors with linkers suitable for imaging and drug delivery. Structure-assisted inhibitor design and targeting of a specific GCPII exosite resulted in a 7-fold improvement in Ki value compared to the parent structure. X-ray structural anal. of the inhibitor series led to the identification of several inhibitor binding modes. We also optimized the length of the inhibitor linker for effective attachment to a biotin-binding mol. and showed that the optimized inhibitor could be used to target nanoparticles to cells expressing GCPII.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chou, Teh-Chang; Cheng, Ju-Fang; Gholap, Atul R.; Huang, Jim Jing-Kai; Chen, Jyun-Chang; Huang, Jing-Kai; Tseng, Jui-Chang published the artcile< Aromatization-driven Grob-fragmentation approach toward polyazaacenes. Synthesis and amination of multi-functionalized diazapentacenes>, Synthetic Route of 27841-33-4, the main research area is dichloro dimethoxy tetrahydro methanoanthracene preparation Grob fragmentation; methoxycarbonyl chloro diazapentacene regioselective preparation amine amination; amino methoxycarbonyl diazapentacene preparation.

A general approach toward the synthesis of multi-functionalized diazapentacene derivatives I [R1 = R4 = H, nitro; R2 = R3 = H, MeO, nitro; R2R3 = 15-crown-5-ether, 18-crown-6-ether] using 1,2,3,4-tetrachloro-5,5-dimethoxycyclopentadiene (TDCp), a substituted benzene-1,2-diamine (ADA), and a naphthalene-1,4-dione (BQ) as the building units, was described. The synthesis basically entails three operations: (i) oxidation of the dichloroetheno-bridge in the Diels-Alder cycloadduct of TDCp and 1,4-naphthaquinone, (ii) condensation of the 1,2-diketone thus generated with an ADA to give quinoxaline-fused polycyclic compounds, followed by (iii) an one-pot, three-reaction process keyed upon the base- or acid-catalyzed aromatization-driven Grob-type fragmentation to produce compounds I. The compound I [R1 = R2 = R3 = R4 = H] underwent the nucleophilic aromatic ipso-amination with primary and secondary amines to afford the amino-substituted derivatives II [R5 = n-Bu, cyclohexyl, Ph, etc.], which tend to self-assemble in solid state driven by the cofacial π-stacking interactions, demonstrated by the crystal packing structures of compounds II [R5 = n-Bu, N1-(anthracen-9-ylmethyl)propane-1,3-diamino].

Tetrahedron published new progress about Amination. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Synthetic Route of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Tianjiao; Wang, Jiayi; Song, Gonghua published the artcile< Synthesis and nematicidal activity of azabicyclo[3.3.1]nonane-thiadiazole derivatives>, SDS of cas: 70057-67-9, the main research area is nematicidal azabicyclo nonane thiadiazole preparation agrochem.

Nematodes are crop pests which can cause serious loss in crop production and food crisis. Traditional nematicides, such as Carbamate, isothiocyanate and organophosphates, have largely inhibited the damages of nematodes on agriculture, but they also generate neg. effects on both plants and human health, such as root harm and human poisoning. Hence developing novel nematicides with low toxicity and high nematicidal efficiency are extremely urgent. 5-HT(5-hydroxytryptamine) is an important monoamine neurotransmitter which plays important role in mammalian endocrine function as well as in the central and peripheral nervous system. 5-HT was also found to be an important substance which can control the physiol. activities of nematodes including feeding, movement and reproduction So far, some studies have been reported on the development of 5-HT receptor as potential target for nematicides. Based on the previous achievements performed in our group and the principles of drug development, MDL 72222, a typical 5-HT3 receptor antagonist which can significantly inhibit the swallowing function of the pharyngeal pump in caenorhabditis elegans, has a lethal effect on nematicides at certain doses. Upon changing the configuration or number of carbon atoms of the bridged ring and introducing the bioactive group thiadiazole into the structure of compound MDL 72222, 23 new 3-azabicyclo[3.3.1]nonane-thiadiazoles derivatives were designed and synthesized. All the involved compounds were characterized by 1H-NMR, 13C-NMR and HRMS. The in vivo bioactivity test was performed using the root-knot nematodes, and the com. nematocidal agent Avermectin was used as the control product. The nematicidal activity against root-knot nematode was determined Ten target compounds exhibited certain inhibitory activity against root-knot nematodes at a concentration of 40 mg/L.

Huadong Ligong Daxue Xuebao, Ziran Kexueban published new progress about 5-HT antagonists. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, SDS of cas: 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hayashi, Mosuke; Furusawa, Ikuzo published the artcile< Preparation of 4-chlorophthalic acid. II>, Product Details of C8H3ClO3, the main research area is .

4-Aminophthalic acid diazotized and treated with CuCl solution gives 4-chlorophthalic acid, m. 149-9.5° (anhydride, m. 97°).

Kogyo Kagaku Zasshi published new progress about 118-45-6. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Product Details of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qu, Tengfei; Qu, Lailiang; Wang, Xiaoguang; Xu, Ting; Xiao, Xiao; Ding, Min; Deng, Li; Guo, Yong published the artcile< Design, synthesis, and antibacterial activity of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety>, Related Products of 70057-67-9, the main research area is arylthiadiazolyl methoxyquinoline carboxamide preparation antibacterial activity SAR; 1,3,4-thiadiazole; 2-methyl-8-hydroxyquinoline; antibacterial activity; structure-activity relationships.

A series of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety was designed and synthesized by using an active substructure combination method. Then, the antibacterial activities of all the target compounds were evaluated in-vitro against three Gram-pos. bacteria and three Gram-neg. bacteria. The antibacterial assay showed that some target compounds displayed moderate to good antibacterial efficacy in comparison with the reference drug chloromycin. Some interesting results of structure-activity relationships were also discussed.

Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Related Products of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nagatani, Takeshi; Sasaki, Takaaki; Saito, Kyoichi published the artcile< Preparation of crosslinked cation-exchange membranes by sulfonation of polymer chains cografted with St and CMS>, Application In Synthesis of 1592-20-7, the main research area is chloromethyl styrene polymer chain cation exchange membrane sulfonation.

Cation-exchange membranes with improved electrodialysis and mech. strength for manufacturing edible salt were prepared by electron-beam-induced graft polymerization First, styrene (St) and chloromethyl styrene (CMS) were co-grafted onto an EB-irradiated ultra-high mol. weight polyethylene film. Second, through a reaction with chlorosulfonic acid, a sulfonic acid group was introduced while incorporating the crosslinked structure into the cograft chains. The cation-exchange membranes that were prepared with various CMS contents in a vinyl monomer solution were stored in 0.5 mol/L NaCl at 25°C to evaluate the time course of the water content, membrane resistance, and tensile strength. Over a 150-day storage period, the water content increased and the membrane resistance and tensile strength decreased. This tendency can be explained by the fact that the cograft chains are crosslinked to depress water inclusion in the sulfonic acid group containing a polymer network. The CMS content in the vinyl monomer solution governed the degree of crosslinking of the polymer network of the membrane, affecting the performance of the electrodialysis. The cation-exchange membrane, prepared at a CMS content of 17°C, and a degree of cografting of 74°C, exhibited 20°C higher chloride ion concentration of brine for the electrodialysis compared with a com. available cation-exchange membrane.

Salt and Seawater Science & Technology published new progress about Cation exchange membranes. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application In Synthesis of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Qinghua; Zhang, Lei; Li, Zehua; Zhang, Lixia; Li, Daping published the artcile< Enhancement of fipronil degradation with eliminating its toxicity in a microbial fuel cell and the catabolic versatility of anodic biofilm>, Electric Literature of 35852-58-5, the main research area is fipronil degradation anodic biofilm microbial fuel cell toxicity; Catabolic versatility; Fipronil degradation; Microbial cell fuel; Microbial community; Toxicity elimination.

The degradation of fipronil was investigated in microbial fuel cells (MFCs). Almost 79% of 30 mg/L fipronil was rapidly degraded within 12 h by MFC biofilm. Based on the constructed quadratic polynomial model, a maximum fipronil degradation rate of 94.22% could be theor. achieved at pH of 7.01, 33.39 °C, and the initial fipronil concentration 74 mg/L after incubation for 72 h. The high acute toxicity of fipronil toward zebrafish was largely eliminated after degradation by the MFC. In addition, the MFC biofilm showed catabolic versatility to 4-chloronitrobenzene, sulfanilamide, fluoroglycofen, and azoxystrobin. The microbial community anal. revealed that the functional bacteria Sphaerochaeta, Pseudomonas, Azospirillum, Azoarcus, and Chryseobacterium were major predominant bacteria in the anodic biofilm. Therefore, the MFC offers a promising approach in treating the environmental contaminants due to its abilities of energy capture from waste substances and catabolic versatility to different organic compounds

Bioresource Technology published new progress about Azoarcus. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Electric Literature of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Di; Li, Qian; Qu, Yidi; Wang, Mengya; Li, Lanzhou; Liu, Yang; Li, Yu published the artcile< The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice>, Application In Synthesis of 6055-19-2, the main research area is cyclophosphamide monohydrate mouse immunosuppression Gloeostereum polysaccharide immunomodulatory activity; Gloeostereum incaratum; cyclophosphamide; immunomodulatory effect; oxidative stress; polysaccharides.

Gloeostereum incarnatum, a precious edible mushroom, displays anti-bacterial and anti-inflammatory activities; however, its immunomodulatory effect has not been studied yet. The present study aimed to investigate whether polysaccharide compositions of G. incarnatum polysaccharides possess immunomodulatory and immuno-enhancing effects in a Cyclophosphamide monohydrate -induced BALB/c mice model. The 28-day GIPS administration at doses of 0.1, 0.3 and 0.9 g/kg remarkably reversed the bodyweight loss, increased the thymic index and promoted T lymphocyte proliferation in CTX-induced immunosuppressed mice. GIPS significantly raised the serum levels of IgA and IgG, promoted the production of interleukins , including IL-2, IL-3 and IL-6, interferons, including interferon IFN-α and IFN-γ, and monocyte chemotactic protein 1 in the spleen, which resulted in accelerating recovery of immunosuppression. Finally, GIPS showed anti-oxidative effects indicated by the increased superoxide dismutase levels in the serum and spleen, and the reduced level of reactive oxygen species in the spleen. The results of the current study demonstrated that GIPS pos. adjusts the immune system, which may serve as a potential immunostimulatory agent.

Experimental and Therapeutic Medicine published new progress about Cell proliferation. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Application In Synthesis of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics