Month: October 2022

Kesavan, Arunachalam; Anbarasan, Pazhamalai published the artcile< Catalytic enantioselective oxysulfenylation of o-vinylanilides>, Electric Literature of 128-09-6, the main research area is thio tethered benzoxazine preparation; vinylanilide imide catalytic enantioselective oxysulfenylation.

Tf2NH-Assisted BINAM-derived thiophosphoramide catalysis was accomplished for the enantioselective oxysulfenylation of o-vinylanilides with N-(aryl/alkylthio)imides. The developed reaction offered access to diverse substituted aryl/alkylthio tethered 3,1-benzoxazines I [R = 6-MeO, 6-Cl, 7-Cl, 8-MeO, 8-BzO; R1 = Ph, 4-EtC6H4, 4-FC6H4, etc.; Ar = Ph, Bn, 2-MeC6H4, etc.; Ar1 = Ph, 4-MeC6H4, 3-IC6H4, etc.] in excellent yields and enantiomeric ratios. Furthermore, synthetic applications of benzoxazines and aryl/alkylthio moieties and a transition state model for the observed enantioselectivity were also discussed.

Chemical Communications (Cambridge, United Kingdom) published new progress about Anilides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-vinylanilides). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Electric Literature of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oberdisse, Julian; Gonzalez-Burgos, Marina; Mendia, Ander; Arbe, Arantxa; Moreno, Angel J.; Pomposo, Jose A.; Radulescu, Aurel; Colmenero, Juan published the artcile< Effect of Molecular Crowding on Conformation and Interactions of Single-Chain Nanoparticles>, Synthetic Route of 1592-20-7, the main research area is single chain nanoparticle mol crowding conformation interaction.

The conformation of single-chain nanoparticles (SCNPs) in the presence of linear polystyrene crowding mols. has been studied by small-angle neutron scattering under contrast-matching of the crowders. A model describing the scattering of aggregating polydisperse SCNPs has been developed, resulting in the determination of the potentially squeezed size of the individual SCNPs within aggregates, their local chain statistics, and the average aggregation number, as a function of crowding. Two different crowders, of low and high mol. weights, are shown to have a different effect: while long chains tend to impede their aggregation above their overlap concentration, short ones are found to mediate depletion interactions leading to aggregation. Self-imposed crowding within the aggregates has a similar impact on chain conformation independently of the crowding of the surrounding medium. Our results are compared to recent simulations and shall contribute to the microscopic understanding of the phase behavior of soft intrinsically disordered nano-objects and in particular the effect of crowding on biomacromols.

Macromolecules (Washington, DC, United States) published new progress about Aggregation. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Synthetic Route of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Katane, Masumi; Osaka, Naoko; Matsuda, Satsuki; Maeda, Kazuhiro; Kawata, Tomonori; Saitoh, Yasuaki; Sekine, Masae; Furuchi, Takemitsu; Doi, Issei; Hirono, Shuichi; Homma, Hiroshi published the artcile< Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is Amino acid oxidase inhibitor screening.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

Journal of Medicinal Chemistry published new progress about Antipsychotics. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yu, Xiao-Long; Kuang, Liping; Chen, Su; Zhu, Xiao-Long; Li, Zhong-Liang; Tan, Bin; Liu, Xin-Yuan published the artcile< Counteranion-Controlled Unprecedented Diastereo- and Enantioselective Tandem Formal Povarov Reaction for Construction of Bioactive Octahydro-Dipyrroloquinolines>, SDS of cas: 29027-20-1, the main research area is metal phosphate catalyst counteranion stereoselective tandem formal Povarov reaction; octahydro dipyrroloquinoline stereoselective preparation antiproliferative activity.

The asym. inverse-electron-demand hetero-Diels-Alder (IEHDA) reactions of imines and dienophiles have emerged as an attractive tool for derivatizing optically active complex azaheterocycles. In comparison, such reactions involving iminium ions remain great challenges because of low association of iminium ions with neutral catalytic centers. To overcome this, we report a metal-phosphate-catalyzed asym. tandem hydroamination/formal Povarov reaction of secondary aminoalkynes via a chiral counteranion-controlled iminium ion intermediate strategy. Critical to the success of this challenging strategy was chiral phosphate as an ion pair to achieve counteranion-controlled asym. reaction of in situ-generated iminium ions. This method enables a convenient, powerful, and atom-economical access to tetracyclic octahydro-dipyrroloquinoline frameworks bearing multiple contiguous stereogenic centers in good yields with diastereo- and enantioselectivities, from acyclic starting materials, and the catalyst loadings could be as low as 1 mol %. The asym. cross-coupling reaction of different aminoalkynes has further been demonstrated with good results. Furthermore, this methodol. was applied to enantioselective synthesis of incargranine B aglycon epimer in only two steps. The reaction is demonstrated to proceed through a stepwise process for formal Povarov reaction.

ACS Catalysis published new progress about Alkynyl compounds, alkynyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, SDS of cas: 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Porter, John; Lumb, Simon; Franklin, Richard J.; Gascon-Simorte, Jose M.; Calmiano, Mark; Le Riche, Kelly; Lallemand, Benedicte; Keyaerts, Jean; Edwards, Helen; Maloney, Alison; Delgado, Jean; King, Lloyd; Foley, Anne; Lecomte, Fabien; Reuberson, James; Meier, Christoph; Batchelor, Mark published the artcile< Discovery of 4-azaindoles as novel inhibitors of c-Met kinase>, Reference of 5335-40-0, the main research area is azaindole preparation cMet tyrosine kinase inhibitor.

A series of 4-azaindole inhibitors of c-Met kinase, e.g. I (R1 = H, NH2, CO2H, 1-piperazinyl, etc.; R2 = PhSO2, 2-O2NC6H4SO2, benzofurazan-4-ylsulfonyl, etc.), is described. The postulated binding mode was confirmed by an X-ray crystal structure of complex of I (R1 = CONH2; R2 = 2-O2NC6H4SO2) with c-Met kinase and series optimization was performed on the basis of this structure. Future directions for series development are discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibitors. 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Reference of 5335-40-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Luo, Yong; Ding, Hao; Zhen, Jing-Song; Du, Xian; Xu, Xiao-Hong; Yuan, Han; Li, Yi-Hui; Qi, Wan-Ying; Liu, Bing-Zhe; Lu, Shi-Man; Xue, Can; Ding, Qiuping published the artcile< Catalyst-free arylation of sulfonamides via visible light-mediated deamination>, Synthetic Route of 5335-40-0, the main research area is diaryl sulfone preparation photochem; sulfonamide aryl boronic acid arylation deamination visible light.

A novel arylation of sulfonamides RSO2N(R1)C(O)R2 (R = 4-methylphenyl, naphthalen-2-yl, 2,3-dihydro-1-benzofuran-6-yl, etc.; R1 = Ph, Me, Bn, etc.; R2 = Ph, Me, Bn, n-pentyl, 4-cyanophenyl) with boronic acids R3B(OH)2 [R3 = 4-(methoxycarbonyl)phenyl, 4-methylnaphthalen-1-yl, 1-benzofuran-2-yl, etc.] to afford numerous diaryl sulfones RS(O)2R3 via a visible light-mediated N-S bond cleavage, rather than the typical transition-metal-catalyzed C(O)-N bond activation, is described. This methodol., which represents the first catalyst-free protocol for the sulfonylation of boronic acids, is characterized by its simple reaction conditions, good functional group tolerance and high efficiency. Several successful examples for the late-stage functionalization of diverse sulfonamides indicate the high potential utility of this method in pharmaceutical science and organic synthesis.

Chemical Science published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Synthetic Route of 5335-40-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Su, Hang; Lou, Hongming; Zhao, Zhipeng; Zhou, Lan; Pang, Yuxia; Xie, Haijiao; Rao, Cheng; Yang, Dongjie; Qiu, Xueqing published the artcile< In-situ Mo doped ZnIn2S4 wrapped MoO3 S-scheme heterojunction via Mo-S bonds to enhance photocatalytic HER>, Computed Properties of 22519-64-8, the main research area is molybdenum doped indium zinc sulfide hydrogen evolution reaction photocatalyst.

The construction of ZnIn2S4 based heterogeneous structure combined with in-situ relatively metal doping remains a great challenge. A direct Step-scheme (S-scheme) of in-situ Mo doped ZnIn2S4 wrapped MoO3 (MoO3@Mo-ZIS) was prepared in this work based on the thermal solubility properties of MoO3. The optimized photocatalyst of MoO3@Mo-ZIS exhibits superior H2 evolution rate of 5.5 mmol/g/h without co-catalysts, which is the 6.5 and 1.3 times of ZIS and 40 Mo doped ZIS (40 Mo-ZIS), resp. The excellent photocatalytic activity was attributed to the Mo doping and formation of Mo-S species. The d. functional theory (DFT) calculations demonstrate that the Mo-S species would form a new hybridized state near the Fermi level, reducing the ΔGH* to enhance photocatalytic hydrogen evolution reaction (HER). Furthermore, the direct S-scheme heterojunction of MoO3@Mo-ZIS confirmed by ESR (EPR) and Kelvin probe force microscopy (KPFM) promotes photogenerated carrier separation, thus enhancing the performance of photocatalytic HER.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Density functional theory. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Computed Properties of 22519-64-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fischer, A.; Koeper, L. M.; Vohr, H.-W. published the artcile< Specific antibody responses of primary cells from different cell sources are able to predict immunotoxicity in vitro>, Quality Control of 6055-19-2, the main research area is immunotoxicity test antibody spleen PBMC cell.

Alternative methods for the prediction of immunotoxicity are highly desirable. However, until now no in vitro test for this purpose has been fully validated or accepted by regulatory authorities. MD cultures are in vitro equivalent to the widely used ex vivo primary T cell dependent antibody responses (TDAR), which has been identified in a regulatory context as a main functional test for immunotoxicol. investigations. The purpose of the present study was to use MD cultures of spleen and blood cells to compare data from three different chems. using SRBC as antigen in two different species. Using this approach we were able to show that cell sources from both rats and mice were able to correctly predict all tested compounds and to clearly distinguish immunosuppressants from control substances. Furthermore, animal studies can be refined by using MD cultures of PBMC. During a 28d benzo(a)pyrene treatment of rats we were able to follow the kinetic of an immune response by in vitro analyses. Addnl. evaluation of in vitro antibody responses of spleen cells and PBMC from rats treated with cyclophosphamide revealed similar results compared to the conventional ex vivo plaque forming cell assay (PFCA). In conclusion, investigation of in vitro antibody responses is a sensitive and reliable approach for detection of a compound induced specific effect on the immune system. MD cultures may not only replace the ex vivo TDAR in the future, but their implementation in routine toxicol. also enables refinement of existing in vivo studies by reducing the numbers of animals.

Toxicology In Vitro published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Quality Control of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pan, Jingwen; Guan, Zhongjie; Yang, Jianjun; Li, Qiuye published the artcile< Facile fabrication of ZnIn2S4/SnS2 3D heterostructure for efficient visible-light photocatalytic reduction of Cr(VI)>, Product Details of Cl3H8InO4, the main research area is tin zinc indium sulfide chromium heterostructure light photocatalytic reduction.

Photocatalytic method has been intensively explored for Cr(VI) reduction owing to its efficient and environmentally friendly natures. In order to obtain a high efficiency in practical application, efficient photocatalysts need to be developed. Here, ZnIn2S4/SnS2 with a three-dimensional (3D) heterostructure was prepared by a hydrothermal method and its photocatalytic performance in Cr(VI) reduction was investigated. When the mass ratio of SnS2 to ZnIn2S4 is 1:10, the ZnIn2S4/SnS2 composite exhibits the highest photocatalytic activity with 100% efficiency for Cr(VI) (50 mg/L) reduction within 70 min under visible-light irradiation, which is much higher than those of pure ZnIn2S4 and SnS2. The enhanced charge separation and the light absorption have been confirmed from the photoluminescence and UV-vis absorption spectra to be the two reasons for the increased activity towards photocatalytic Cr(VI) reduction In addition after three cycles of testing, no obvious degradation is observed with the 3D heterostructured ZnIn2S4/SnS2, which maintains a good photocatalytic stability.

Chinese Journal of Catalysis published new progress about Absorption. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Product Details of Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Zhongzheng; Shi, Jialin; Zhu, Tianyang; Zhang, Lina; Wei, Wei published the artcile< Nitrogen-doped mesoporous carbon single crystal-based Ag nanoparticles for boosting mild CO2 conversion with terminal alkynes>, Category: chlorides-buliding-blocks, the main research area is nitrogen carbon silver nanoparticle diffusion porosity particle size; Ag nanoparticles; CO(2) conversion; Mild condition; N-doped mesoporous carbon; Terminal alkynes.

Fabrication of efficient heterogeneous catalysts with high turnover frequency (TOF) is intriguing for rapid and scalable CO2 conversion under mild conditions, but it still faces some challenges due to use of some bulky and irregular supports causing inaccessible inner pores and insufficient utilization of active sites. Herein, using a unique nitrogen-doped mesoporous single-crystal carbon (named IRFC) as a host for loading Ag nanoparticles for the first time, a series of Ag/IRFC catalysts with high TOF (8.7-22.3 h-1) were facilely prepared by a novel “”impregnation and in-situ reduction”” strategy. The neat morphol. and high porosity of IRFC with abundant N species, providing homogeneous surface, adequate space and anchoring sites for Ag immobilization, greatly facilitated the formation of highly-distributed ultrasmall Ag nanoparticles (2.3 nm). Meanwhile, smooth and short diffusion pathways were inherited from the ordered mesopores and small particle sizes of IRFC. Owing to these unparalleled structural features, the Ag/IRFC catalysts exhibited excellent catalytic activity, stability, and generality for mild CO2 conversion even under diluted conditions. This work not only presents a novel catalyst for mild CO2 conversion, but also brings some inspirations to designing highly efficient catalysts using well-shaped supporting nanomaterials for direct utilization of low-concentration CO2, such as flue gas.

Journal of Colloid and Interface Science published new progress about Binding energy. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics