Month: October 2022

Busetti, Francesco; Linge, Kathryn L.; Heitz, Anna published the artcile< Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry>, Safety of 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is pharmaceutical determination indirect potable water reuse system; solid phase extraction liquid chromatog tandem mass spectrometry.

A solid-phase extraction (SPE) LC-MS/MS method for 18 com. drugs in secondary wastewater and product water from water recycling plants using microfiltration (MF) and reverse osmosis (RO) has been developed, optimized and validated. The method incorporates a range of multi-class pharmaceuticals including lipid lowering agents, analgesics, antipyretics, non-steroidal anti-inflammatory drugs, antidepressants, anticoagulants, tranquilizers, cytostatic agents, and antiepileptics. Method limits of quantitation (MLQs) in secondary wastewater were 15-250 ng/L, while MLQs in post-RO water were 1-25 ng/L. Results from anal. of secondary wastewater from Western Australia are presented, and represent the largest survey of non-antibiotic pharmaceuticals within Australia to date. Anal. of post-RO water from 2 MF/RO water recycling facilities also demonstrate that MF/RO treatment removes most pharmaceuticals to below the anal. limits of detection, and more importantly, ≤7 orders of magnitude below health-based guideline values.

Journal of Chromatography A published new progress about Analgesics. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Safety of 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nitsche, Tobias; Steinkoenig, Jan; De Bruycker, Kevin; Bloesser, Fabian R.; Blanksby, Stephen J.; Blinco, James P.; Barner-Kowollik, Christopher published the artcile< Mapping the Compaction of Discrete Polymer Chains by Size Exclusion Chromatography Coupled to High-Resolution Mass Spectrometry>, Computed Properties of 1592-20-7, the main research area is polystyrene tetrazole fumarate exclusion chromatog mass spectrometry.

We introduce a powerful approach based on the combination of size exclusion chromatog. with high-resolution mass spectrometry to selectively follow the compaction of discrete polymer chains that have uniform elemental composition Single-chain nanoparticles (SCNP) have attracted considerable interest for a wide range of applications associated with their adjustable morphol. However, the precise characterization of morphol. changes during the compaction is still challenging using existing anal. techniques. We employ a polystyrene backbone functionalized with tetrazole and fumarate moieties to utilize the nitrile imine-mediated tetrazole-ene cycloaddition for compaction. As every compaction step is associated with an elimination of one nitrogen mol., it can be monitored via high-resolution electrospray ionization mass spectrometry. The combination with size exclusion chromatog. enables the direct correlation of changes in mass with changes in morphol. associated with the compaction. By establishing a calibration between the retention time and the hydrodynamic radius, ion chromatograms of discrete chains can be directly applied to determine the reduction in hydrodynamic radius associated with each crosslinking event. Therefore, accessing the compaction of discrete polymer chains becomes possible for the first time.

Macromolecules (Washington, DC, United States) published new progress about Hydrodynamic radius. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Computed Properties of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhandu, Priyanka; Verma, Himanshu; Singh, Manmeet; Kumar, Manoj; Narendra, Gera; Choudhary, Shalki; Singh, Pankaj Kumar; Silakari, Om published the artcile< Rational designing of quinazolin-4(3H)-one based ALR2 inhibitors: Synthesis and biological evaluation>, COA of Formula: C7H6Cl2, the main research area is quinazolinone benzyl chloride nucleophilic substitution reaction; benzyl quinazolinone preparation ALR2 inhibition SAR mol docking.

Herein, using scaffold hoping, quinazolin-4(3H)-one was obtained as one of the top bioisostere with good BIF, shape and field scores. The designed inhouse library of quinazolin-4(3H)-one was studied for their SAR profile based on the developed qual. model via Activity atlas option. Important field points i.e., pos. and neg. electrostatics along with shape properties were analyzed that are crucial for ALR2 inhibitory activity. Some structure-based approaches including mol. docking and dynamics also suggested that the designed quinazolin-4(3H)-one based derivatives can be putative ALR2 inhibitors. These mols. were synthesized and evaluated for in-vitro ALR2 inhibitory activity. It was observed that compound three of the compounds were most potent inhibitors with IC50 values of 2.56 ± 0.03, 1.72 ± 0.02 and 1.47 ± 0.03μM, resp. Addnl., the predicted ADMET properties were also found to be favorable in comparison to Zenarestat.

Journal of Molecular Structure published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wan, Zi-juan; Wang, Jin-yuan; Luo, Jun published the artcile< NiCl2-catalyzed radical cross decarboxylative coupling between arylpropiolic acids and cyclic ethers>, Reference of 3240-10-6, the main research area is internal alkene preparation diastereoselective; arylpropiolic acid cyclic ether cross decarboxylative coupling nickel catalyst.

A direct alkenylation of cyclic ethers with arylpropiolic acids was developed for the synthesis of internal alkenes ArCH=CHR [Ar = Ph, 4-CNC6H4, 2-thienyl, etc.; R = tetrahydrofuran-2-yl, 1,3-dioxolan-4-yl, 1,4-dioxan-2-yl] via radical cross decarboxylative coupling process catalyzed by NiCl2 and using DTBP as radical initiator and oxidant. Mechanistic experiments were conducted to determine the nature of the reaction intermediates and a plausible reaction mechanism involving NiCl2-promoted radical process was proposed.

Tetrahedron Letters published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Reference of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ivanova, Yu. B.; Chizhova, N. V.; Khrushkova, Yu. V.; Rusanov, A. I.; Mamardashvili, N. Zh. published the artcile< Synthesis, Spectral, and Coordination Properties of Halogen-Substituted Tetraarylporphyrins>, Application In Synthesis of 128-09-6, the main research area is chloro bromo tetraarylporphyrin cobalt preparation spectrum coordination kinetics acidity.

2,3,7,8,12,13,17,18-Octabromo-5,10,15,20-tetra(4-chlorophenyl)porphyrin and 2,3,7,8,12,13,17,18-octachloro-5,10,15,20-tetra(4-bromophenyl)porphyrin were synthesized. The obtained compounds were identified by electronic absorption and 1H NMR spectroscopy as well as mass spectrometry. The complex-forming properties of the synthesized porphyrins in the Zn acetate(II)-MeCN system at 278-298 K were studied. Kinetic parameters of the formation of the corresponding Zn complexes in MeCN were determined

Russian Journal of General Chemistry published new progress about Acidity. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application In Synthesis of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ageberg, Malin; Rydstroem, Karin; Linden, Ola; Linderoth, Johan; Jerkeman, Mats; Drott, Kristina published the artcile< Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines>, HPLC of Formula: 6055-19-2, the main research area is anticancer geranylgeranyl transferase inhibitor chemosensitivity apoptosis B cell lymphoma.

Prenylation is a post-translational hydrophobic modification of proteins, important for their membrane localization and biol. function. The use of inhibitors of prenylation has proven to be a useful tool in the activation of apoptotic pathways in tumor cell lines. Rab geranylgeranyl transferase (Rab GGT) is responsible for the prenylation of the Rab family. Overexpression of Rab GGTbeta has been identified in CHOP refractory diffuse large B cell lymphoma (DLBCL). Using a cell line-based model for CHOP resistant DLBCL, we show that treatment with simvastatin, which inhibits protein farnesylation and geranylgeranylation, sensitizes DLBCL cells to cytotoxic treatment. Treatment with the farnesyl transferase inhibitor FTI-277 or the geranylgeranyl transferase I inhibitor GGTI-298 indicates that the reduction in cell viability was restricted to inhibition of geranylgeranylation. In addition, treatment with BMS1, a combined inhibitor of farnesyl transferase and Rab GGT, resulted in a high cytostatic effect in WSU-NHL cells, demonstrated by reduced cell viability and decreased proliferation. Co-treatment of BMS1 or GGTI-298 with CHOP showed synergistic effects with regard to markers of apoptosis. We propose that inhibition of protein geranylgeranylation together with conventional cytostatic therapy is a potential novel strategy for treating patients with CHOP refractory DLBCL.

Experimental Cell Research published new progress about Antitumor agents. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, HPLC of Formula: 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Tao; Zheng, Meifang; Antonietti, Markus; Wang, Xinchen published the artcile< Ceramic boron carbonitrides for unlocking organic halides with visible light>, Category: chlorides-buliding-blocks, the main research area is boron carbonitride preparation surface structure; aryl halide boron carbonitride photocatalyst hydrodehalogenation; aromatic hydrocarbon preparation; arene aryl halide boron carbonitride photocatalyst cross coupling arylation; biaryl preparation; haloarene sodium sulfinate boron carbonitride photocatalyst cross coupling sulfonylation; arylsulfone preparation.

Here, boron carbonitride (BCN) ceramics were such a system and can reduce organic halides, including (het)aryl and alkyl halides, with visible light irradn was reported. Cross-coupling of halides to afford new C-H, C-C, and C-S bonds was proceeded at ambient reaction conditions. Hydrogen, (het)aryl, and sulfonyl groups were introduced into the arenes and heteroarenes at the designed positions by means of mesolytic C-X (carbon-halogen) bond cleavage in the absence of any metal-based catalysts or ligands. BCN was used not only for half reactions, like reduction reactions with a sacrificial agent, but also redox reactions through oxidative and reductive interfacial electron transfer. The BCN photocatalyst showed tolerance to different substituents and conserved activity after five recycles. The apparent metal-free system opened new opportunities for a wide range of organic catalysts using light energy and sustainable materials, which were metal-free, inexpensive and stable.

Chemical Science published new progress about Aromatic compounds, sulfones Role: SPN (Synthetic Preparation), PREP (Preparation). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Prabhakar, Virupakshi; Babu, Kondra Sudhakar; Ravindranath, L. K. published the artcile< Design and facile method for synthesis of novel 1,3,4-oxadiazole derivatives by using Biginelli reaction>, Quality Control of 672948-03-7, the main research area is oxadiazole preparation; tetrahydropyrimidine carbohydrazide carboxylic acid Biginelli reaction.

An efficient synthesis of 3,4-dihydropyrimidinones I from the thieno[2,3-d]pyrimidine-6-carboxaldehyde, Et 2-acetoacetate and urea in ethanol, using zirconium tetrachloride as the catalyst is described. A new series of 6-methyl-4-(thieno[2,3-d]pyrimidin-6-yl)-5-(5-p-substituted-1,3,4-oxadiazol-2-yl)-3,4-dihydropyrimidin-2(1H)-one derivatives II (R = C6H5, pyridin-4-yl, furan-2-yl, etc.) was synthesized after refluxing 6-methyl-2-oxo-4-(thieno[2,3-d]pyrimidin-6-yl)-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide with different aromatic/heterocyclic carboxylic acids RC(O)OH in the presence of POCl3.

Heterocyclic Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 672948-03-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H3NO3, Quality Control of 672948-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khadse, Saurabh C.; Chatpalliwar, Vivekananda A. published the artcile< Synthesis of benzamides by microwave assisted ring opening of less reactive dimethylaminobenzylidene oxazolone>, HPLC of Formula: 29027-20-1, the main research area is dimethylaminobenzylidene oxazolone amine microwave irradiation ring opening; benzamide preparation.

The synthesis of some benzamide compounds by microwave-assisted ring opening of 4-(4-dimethylaminobenzylidene)-2-phenyl-5-oxazolone was presented. By conventional synthesis involving heating, it was found difficult to obtain ring-opened products, probably due to poor tendency of the carbonyl carbon (C5) of oxazolone derivative to undergo nucleophilic attack by mono/or disubstituted anilines. Microwave assisted reactions were easy to perform, have reduced the reaction time and produced good yields.

Arabian Journal of Chemistry published new progress about Benzamides Role: SPN (Synthetic Preparation), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, HPLC of Formula: 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Amir, Faheem; Liles, Kevin P.; Delawder, Abigail O.; Colley, Nathan D.; Palmquist, Mark S.; Linder, Houston R.; Sell, Scott A.; Barnes, Jonathan C. published the artcile< Reversible hydrogel photopatterning: spatial and temporal control over gel mechanical properties using visible light photoredox catalysis>, Quality Control of 1592-20-7, the main research area is hydrogel photopatterning reversible photoredox catalysis viologen; artificial molecular muscles; hydrogel; photomechanical actuator; photopatterning; photoredox catalysis; redox-responsive materials; viologen.

There is a growing interest in being able to control the mech. properties of hydrogels for applications in materials, medicine, and biol. Primarily, changes in the hydrogel’s phys. properties, i.e., stiffness, toughness, etc., are achieved by modulating the network crosslinking chem. Common crosslinking strategies rely on (i) irreversible network bond degradation and reformation in response to an external stimulus, (ii) using dynamic covalent chem., or (iii) isomerization of integrated functional groups (e.g., azobenzene or spiropyran). Many of these strategies are executed using UV or visible light since the incident photons serve as an external stimulus that affords spatial and temporal control over the mech. adaptation process. Here, we describe a different type of hydrogel crosslinking strategy that uses a redox-responsive cross-linker, incorporated in poly(hydroxyethyl acrylate)-based hydrogels at three different weight percent loadings, which consists of two viologen subunits tethered by hexaethylene glycol and capped with styrene groups at each terminus. These dicationic viologen subunits (V2+) can be reduced to their monoradical cations (V•+) through a photoinduced electron transfer (PET) process using a visible light-absorbing photocatalyst (tris(bipyridine)ruthenium(II) dichloride) embedded in the hydrogel, resulting in the intramol. stacking of viologen radical cations, through radical-radical pairing interactions, while losing two pos. charges and the corresponding counteranions from the hydrogel. It is shown how this concerted process ultimately leads to collapse of the hydrogel network and significantly (p < 0.05) increases (by nearly a factor of 2) the soft material's stiffness, tensile strength, and percent elongation at break, all of which is easily reversed via oxidation of the viologen subunits and swelling in water. Application of this reversible PET process was demonstrated by photopatterning the same hydrogel multiple times, where the pattern was ""erased"" each time by turning off the blue light (∼450 nm) source and allowing for oxidation and reswelling in between patterning steps. The areas of the hydrogel that were masked exhibited lower (by 1-2 kPa) shear storage moduli (G') than the areas that were irradiated for 1.5 h. Moreover, because the viologen subunits in the functional cross-linker are electrochromic, it is possible to visualize the regions of the hydrogel that undergo changes in mech. properties. This visualization process was illustrated by photopatterning a larger hydrogel (∼9.5 cm on its longest side) with a photomask in the design of an array of stars. ACS Applied Materials & Interfaces published new progress about Acrylic polymers Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PROC (Process), PREP (Preparation), USES (Uses). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Quality Control of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics