Month: October 2022

In 2022,Cater, Henry L.; Balynska, Iana; Allen, Marshall J.; Freeman, Benny D.; Page, Zachariah A. published an article in Macromolecules (Washington, DC, United States). The title of the article was 《User Guide to Ring-Opening Metathesis Polymerization of endo-Norbornene Monomers with Chelated Initiators》.Product Details of 172222-30-9 The author mentioned the following in the article:

The development of facile synthetic strategies to access well-defined polymers promises to provide advanced soft materials with functionality that rivals that observed from nature. To this end, ring-opening metathesis polymerization (ROMP) presents a compositionally simple and rapid strategy for controlled polymerization, yet it has received far less attention relative to radical counterparts. This limited attention arises in part from scattered reports on optimization strategies and a narrow monomer scope. Contemporary ROMP methods favor the use of exo-norbornene derivatives and highly reactive nonchelated Ru-alkylidenes, such as Grubbs Catalysts. In contrast, endo-norbornene derivatives, from which analogous exo-forms are often generated, present a more accessible alternative, yet examples of their utility in ROMP remain scarce. Herein, a systematic examination of ROMP with endo-norbornene monomers using stable chelated Ru-alkylidene initiators is presented. Through initiator screening and polymerization optimization, the ROMP process is shown to be versatile and robust, providing rapid access to polymers with excellent mol. weight control, low dispersities (D < 1.1), good functional group tolerance, and high chain-end fidelity that enabled the preparation of block copolymers via sequential monomer addition Furthermore, the process is oxygen-tolerant, allowing for ROMP to be performed under ambient conditions on the bench, which was showcased in synthesizing mech. robust endo-norbornene imide thermoplastics with high glass transition and decomposition temperatures This report provides a comprehensive overview of the scope and limitations of endo-norbornene ROMP with chelated initiators, serving as a user guide for the polymer chem. community to develop well-defined next-generation functional plastics. In the experiment, the researchers used many compounds, for example, Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Product Details of 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Product Details of 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 622-95-7In 2019 ,《Thiourea dioxide as a source of sulfonyl groups: photoredox generation of sulfones and sulfonamides from heteroaryl/aryl halides》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Ye, Shengqing; Li, Yuewen; Wu, Jie; Li, Zhiming. The article contains the following contents:

Thiourea dioxide as the source of sulfonyl groups for the efficient synthesis of heteroaryl sulfones and sulfonamides from heteroaryl halides under visible light irradiation is reported. This transformation proceeds smoothly via heteroaryl sulfinate intermediates, which can be trapped in situ by various electrophiles. A broad reaction scope is demonstrated, especially for the electron-deficient heteroaryl halides. Mechanistic studies show that the radical coupling of the heteroaryl radical and sulfur dioxide radical anion may be the key step during the reaction process, as supported by EPR spectroscopy and DFT calculations In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application of 622-95-7) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Application of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2020,Chemical Communications (Cambridge, United Kingdom) included an article by Tao, Mengna; Li, Wenbo; Zhang, Junliang. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II). The article was titled 《Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization of norbornene and norbornadiene》. The information in the text is summarized as follows:

A highly enantioselective Pd/Xiang-Phos-catalyzed carboheterofunctionalization of norbornene is described, giving a direct access to various chiral norbornane-fused dihydrofurans and dihydropyrroles. This synthetic methodol. provides the first example of asym. carboetherification of norbornene, and also tolerates norbornadiene well. The experimental part of the paper was very detailed, including the reaction process of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thines, Eckhard; Daussmann, Thomas; Semar, Martin; Sterner, Olov; Anke, Heidrun published their research in Zeitschrift fuer Naturforschung, C: Biosciences on December 31 ,1995. The article was titled 《Fungal melanin biosynthesis inhibitors: introduction of a test system based on the production of dihydroxynaphthalene (DHN) melanin in agar cultures》.Reference of 3,5-Dichloro-4-methoxybenzoic acid The article contains the following contents:

In a screening for inhibitors of fungal melanin biosynthesis a novel test system was successfully employed. With this test system, based on the production of dihydroxynaphthalene melanin (DHN melanin) by a Lachnellula species in agar cultures, extracts of cultures of basidiomycetes, ascomycetes and deuteromycetes were tested. From fermentation of Collybia dryophila, 6-methylpurine and 6-methyl-9-β-D-ribofuranosyl purine were isolated as the active principles and 3,5-dichloro-4-methoxybenzoic acid (I) was obtained from cultures of Stropharia squamosa. The corresponding alc. (II) and aldehyde (III) previously isolated from several basidiomycetes were also active in this test system. In a screening of fungal metabolites, 1-methoxy-8-hydroxynaphthalene and 1,8-dimethoxynaphthalene inhibited biosynthesis of DHN melanin. Among the inhibitors identified, compounds I-III were the most selective ones. They were the only metabolites without cytotoxic activities. In the experiment, the researchers used many compounds, for example, 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Chemical Engineering Journal (Amsterdam, Netherlands) included an article by Xu, Xingtao; Allah, Abeer Enaiet; Wang, Chen; Tan, Haibo; Farghali, Ahmed A.; Khedr, Mohamed Hamdy; Malgras, Victor; Yang, Tao; Yamauchi, Yusuke. Formula: ClNa. The article was titled 《Capacitive deionization using nitrogen-doped mesostructured carbons for highly efficient brackish water desalination》. The information in the text is summarized as follows:

Capacitive deionization (CDI) has emerged as a promising way to obtain freshwater from saline H2O, but its implementation is in its infancy and remains challenging due to the low salt adsorption capacity (SAC) of commonly used activated carbons (ACs). It is thus desirable to develop C electrodes that can exceed the performance of ACs benchmarks. N-doped mesostructured C nanocrystals (NMCs) were developed by direct carbonization of highly ordered mesostructured polymers. Due to their mesoporous structure, high N content and large surface area, NMCs exhibit a maximum SAC of 20.63 mg g-1. This state-of-the-art C electrode largely surpasses common ACs. This work demonstrates the significance of the material synthetic chem. and the importance of nanostructuring C materials for CDI applications. The experimental process involved the reaction of Sodium chloride(cas: 7647-14-5Formula: ClNa)

Sodium chloride(cas: 7647-14-5) has been used for the preparation of tris buffered saline, phosphate buffered saline, MPM-2 (mitotic protein monoclonal 2) cell lysis buffer, immunoprecipitation wash buffer, LB (Luria-Bertani) media and dialysis buffer.Formula: ClNa

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis, and evaluation of novel N′-substituted-1-(4-chlorobenzyl)-1H-indol-3-carbohydrazides as antitumor agents》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. These research results belong to Huan, Le Cong; Anh, Duong Tien; Hai, Pham-The; Anh, Lai Duc; Park, Eun Jae; Ji, A. Young; Kang, Jong Soon; Dung, Do Thi Mai; Oanh, Dao Thi Kim; Tung, Truong Thanh; Hai, Dinh Thi Thanh; Han, Sang-Bae; Nam, Nguyen-Hai. Computed Properties of C7H6BrCl The article mentions the following:

In continuity of our search for novel anticancer agents acting as procaspase activators, we have designed and synthesized two series of (E)-N′-benzylidene-carbohydrazides (4a-m) and (Z)-N′-(2-oxoindolin-3-ylidene)carbohydrazides (5a-g) incorporating 1-(4-chlorobenzyl)-1H-indole core. Bioevaluation showed that the compounds, especially compounds in series 4a-m,, exhibited potent cytotoxicity against three human cancer cell lines (SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer). Within series , compounds with 2-OH substituent (4g-i) exhibited very strong cytotoxicity in three human cancer cell lines assayed with IC50 values in the range of 0.56-0.83 μM. In particular, two compounds 4d and 4f bearing 4-CL and 4-NO2 substituents, resp., were the most potent in term of cytotoxicity with IC50 values of 0.011-0.001 μM. In caspase activation assay, compounds 4b and 4f were found to activate caspase activity by 314.3 and 270.7% relative to PAC-1. This investigation has demonstrated the potential of these simple acetohydrazides, especially compounds 4b, 4d, and 4f as anticancer agents. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Computed Properties of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Computed Properties of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics