Month: October 2022

The author of 《The synthesis and biological assessment of [[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides with an 1,2,4-oxadiazole cycle in positions 6, 7 and 8》 were Karpina, V. R.; Kovalenko, S. S.; Kovalenko, S. M.; Zaremba, O. V.; Silin, O. V.; Langer, T.. And the article was published in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2019. SDS of cas: 6313-54-8 The author mentioned the following in the article:

A novel method was developed for the synthesis of 32 analogs of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides and biol. assessment was conducted. A convenient scheme for the synthesis of the title compounds started from com. available 2-chloropyridine-3-/4-/5-carboxylic acids with amidoximes to form the corresponding 2-chloro-[1,2,4-oxadiazol-5-yl]pyridines then followed by the hydrazinolysis with an excess of hydrazine hydrate. The process continued via the ester formation with the pyridine ring closure, followed by amide formation. A series of new 2-[6/7/8-(1,2,4-oxadiazol-5-yl)[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides were obtained in good yields and their structures were proved by the method of 1H NMR spectroscopy. The prognosis and study of their pharmacol. activity were also conducted. The synthetic approach of obtaining the representatives of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4] triazolo[4,3-a]pyridine-3-yl]acetamides previously unknown can be used as an applicable method for the synthesis of diverse functionalized [1,2,4]triazolo[4,3-a]pyridine derivatives2-Chloroisonicotinic acid(cas: 6313-54-8SDS of cas: 6313-54-8) was used in this study.

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 6313-54-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《AIE-Active Random Conjugated Copolymers Synthesized by ADMET Polymerization as a Fluorescent Probe Specific for Palladium Detection》 was published in Macromolecules (Washington, DC, United States) in 2020. These research results belong to Liu, Xiaoqing; Chen, Taixin; Yu, Feng; Shang, Yuxuan; Meng, Xue; Chen, Zhong-Ren. Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium The article mentions the following:

Using acyclic diene metathesis (ADMET) polymerization, we have synthesized a series of random conjugated copolymers from diene monomers based on tetraphenylethene (TPE), which is an aggregation-induced emission (AIE)-active mol., and comonomers such as 1,9-decadiene, 2,7-divinyl-9,9-di-n-octylfluorene, and 1,4-dihexyl-2,5-divinylbenzene. These all-hydrocarbon copolymers exhibit good solubility and high mol. weights As proved by 1H NMR spectra, chain segments composed of two monomers are randomly distributed in the polymers. Absorption and emission features from both TPE units and those conventional diene segments in conjugated copolymers are observed in their optical spectra. Because of the presence of AIE-active TPE units, emission intensities of the copolymers are greatly enhanced in tetrahydrofuran/water mixtures with increased water content. Moreover, the fluorescence of ADMET polymers can be quenched by palladium ions in quasi-aqueous solutions following a dynamic quenching mechanism. The fluorescence quench degrees are affected by both chem. structures of the copolymers and the solvent polarity. Our findings demonstrate that ADMET conjugated polymers have enormous potential as fluorescent “”turn-off”” probes specific for palladium ions even in the absence of a particular coordination interaction. After reading the article, we found that the author used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《The synthesis of sulfonated 4H-3,1-benzoxazines via an electro-chemical radical cascade cyclization》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to He, Tian-Jun; Zhong, Wei-Qiang; Huang, Jing-Mei. Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The article mentions the following:

A new route for the synthesis of sulfonated 4H-3,1-benzoxazines I (R1 = H, Me, C6H5; R2 = H, 4-Me, 4-F, etc.; R3 = C6H5, 4-FC6H4, 2-furyl, etc.) has been accomplished by electrochem. radical cascade cyclizations of styrenyl amides with sulfonylhydrazines. This process demonstrates a wide substrate scope with diverse functional group compatibility under metal- and external oxidant-free conditions at ambient temperature4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gonsales, Stella A.; Mueller, Zoe C.; Zhao, Fengyue; Paioti, Paulo H. S.; Karmazin, Lydia; Wan, Jing; Liu, Fang; Houk, K. N.; Hoveyda, Amir H. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Cross-metathesis of Allenes. Mechanistic Analysis and Identification of a Ru-CAAC as the Most Effective Catalyst》.Name: Benzylidenebis(tricyclohexylphosphine)dichlororuthenium The article contains the following contents:

The first examples of cross-metathesis between two different allenes is disclosed. First- and second-generation Ru complexes were ineffective, at most affording only oligomeric products. The exception was a first-generation complex bearing a bidentate Ph isopropoxy ligand (i.e., PCy3 is not released upon initiation), reactions with which afforded a 1,3-disubstituted allenyl boronate in 22% yield. On the basis of mechanistic studies designed to gain deeper understanding of the reasons for the ineffectiveness of different Ru catalysts, it was discovered that phosphine-free Ru-CAAC complexes have the steric and electronic attributes to be highly effective. The results of these investigations pave the way for development of addnl. olefin metathesis reactions that generate allenes. In the experimental materials used by the author, we found Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Name: Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Name: Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yuxiu; Li, Xiangqian; Li, Xiaowei; Shi, Dayong published an article in 2021. The article was titled 《Visible-light-promoted E-selective synthesis of α-fluoro-β-arylalkenyl sulfides via the deoxygenation/isomerization process》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Electric Literature of C4H3ClO2S2 The information in the text is summarized as follows:

Regioselective synthesis of α-fluoro-β-arylalkenyl sulfides (E/Z)-Ar(R1)C=C(F)SR (R = 4-ClC6H4, 2-naphthyl, 2-thienyl, etc.; R1 = H, CH3, C6H5; Ar = 4-BrC6H4, 2-naphthyl, quinolin-3-yl, etc.) has been established with gem-difluoroalkenes Ar(R1)C=C(F)2 and sodium sulfinates RS(O)2Na in a transition-metal-free manner. A series of control experiments was executed to demonstrate thiol radicals and anions as the proposed intermediates. Notably, regioselective Z → E isomerization was achieved under green light irradiation in the absence of a photoinitiator. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Electric Literature of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Electric Literature of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Li, Shichao; Li, Muyao; Li, Shu-Sen; Wang, Jianbo published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Pd-Catalyzed coupling of benzyl bromides with BMIDA-substituted N-tosylhydrazones: synthesis of trans-alkenyl MIDA boronates》.Synthetic Route of C7H6BrCl The author mentioned the following in the article:

A palladium-catalyzed stereoselective synthesis of alkenyl boronates from N-methyliminodiacetyl boronate (BMIDA)-substituted N-tosylhydrazone and benzyl bromides is developed. A range of trans-alkenyl MIDA boronates as single stereoisomers were obtained in moderate yields with good functional group compatibility. The resultant boronate products may be transformed to other boron-containing compounds and may also be directly used in cross-coupling reactions. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C3H3ClO3In 2020 ,《Metal catalyst-free photo-induced alkyl C-O bond borylation》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Ma, Guobin; Chen, Changzhou; Talukdar, Sangita; Zhao, Xinluo; Lei, Chuanhu; Gong, Hegui. The article contains the following contents:

Metal catalyst free, blue visible light-induced C-O bond borylation of unactivated tertiary alkyl Me oxalates was developed to furnish tertiary alkyl boronates. From the secondary alcs. activated with imidazolylthionyl, moderate yields of boronates were attained under standard photo-induced conditions. Preliminary mechanistic studies confirmed the involvement of a (DMF)2-B2cat2 adduct that weakly absorbs light at 437 nm so as to initiate a Bcat radical. A radical-chain process is proposed wherein the alkyl radical is engaged. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Synthetic Route of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B》 was written by Ruddraraju, Kasi Viswanatharaju; Aggarwal, Devesh; Niu, Congwei; Baker, Erica Anne; Zhang, Ruo-yu; Wu, Li; Zhang, Zhong-Yin. Formula: C3H3ClO3This research focused ontuberculosis Mycobacterium tuberculosis mPTPB SAR mol docking metabolic stability. The article conveys some information:

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). Mtb protein tyrosine phosphatase B (mPTPB) is a virulence factor required for Mtb survival in host macrophages. Consequently, mPTPB represents an exciting target for tuberculosis treatment. Here, we identified N-Ph oxamic acid as a highly potent and selective monoacid-based phosphotyrosine mimetic for mPTPB inhibition. SAR studies on the initial hit, compound 4 (IC50 = 257 nM), resulted in several highly potent inhibitors with IC50 values lower than 20 nM for mPTPB. Among them, compound 4t(I) showed a Ki of 2.7 nM for mPTPB with over 4500-fold preference over 25 mammalian PTPs. Kinetic, mol. docking, and site-directed mutagenesis analyses confirmed these compounds as active site-directed reversible inhibitors of mPTPB. These inhibitors can reverse the altered host cell immune responses induced by the bacterial phosphatase. Furthermore, the inhibitors possess mol. weights <400 Da, log D7.4 < 2.5, topol. polar surface area < 75, ligand efficiency > 0.43, and good aqueous solubility and metabolic stability, thus offering excellent starting points for further therapeutic development. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and Metathesis Polymerization of New Monomer 7-Trimethylsilyltricyclo[4.2.2.02,5]deca-3,9-diene》 was written by Zhigarev, V. A.; Gringolts, M. L.; Filatova, M. P.; Finkelshtein, E. Sh.. SDS of cas: 172222-30-9This research focused ontrimethylsilyltricyclo decadiene preparation metathesis polymerization characterization. The article conveys some information:

The reaction of 1,3,5,7-cyclooctatetraene with silicon-substituted ethylenes has been studied for the first time. It is shown that vinyltrimethylsilane is inactive in the reaction, and vinyltrichlorosilane forms 7-trichlorosilyltricyclo[4.2.2.02,5]deca-3,9-diene in up to 12% yield. A new silicon-substituted monomer 7-trimethylsilyltricyclo[4.2.2.02,5]deca-3,9-diene containing 92% of the endo-isomer has been synthesized by methylation of the chloroadduct. The metathesis polymerization of the final monomer mediated by the Grubbs Ru catalysts of the first and second generations is studied. A new poly(7-trimethylsilyltricyclo[4.2.2.02,5]deca-3,9-diene) containing a bulky bicyclic fragment and predominantly trans-double bonds in the main chain (up to 94%) is obtained in 90-96% yields. The polymer is characterized by the highest glass transition point (187°C) in the series of monotrimethylsilyl-substituted polynorbornenes. The double bonds present in the monomer unit open up prospects for further modification. In addition to this study using Benzylidenebis(tricyclohexylphosphine)dichlororuthenium, there are many other studies that have used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9SDS of cas: 172222-30-9) was used in this study.

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.SDS of cas: 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of Sodium 2,6-dichlorobenzoateOn May 31, 1986, Menkisoglou-Spyroudi, Ourania; Varvoglis, Anastasios published an article in Journal of the Chemical Society. The article was 《[Bis[(aryloxy)acetoxy]iodo]benzenes》. The article mentions the following:

The title compounds were prepared and their chem. properties studied. With iodine they gave ROCH2CO2CH2OR (I, R = aryl) via (aryloxy)acetyl hypoiodites and α-iodoanisoles. The former were unstable but were trapped with pyridine to give N-iodopyridinium (aryloxy)acetates, whereas the latter were stable and reacted independently with the title compounds to give I. The thermolysis of the title compounds was studied and, besides I, aryl (aryloxy)acetates were formed. The mechanism of the thermolysis was briefly discussed. Thus, 4-BrC6H4OCH2CO2Na in MeCN treated with (CF3CO2)2IPh gave 95% (4-BrC6H4OCH2CO2)2IPh (II). Treatment of II with iodine gave 37% 4-BrC6H4OCH2CO2CH2OC6H4Br-4 (III). Heating II at 200° for 30 min, gave 65% 4-BrC6H4OCH2CO2C6H4Br-4 and 49% III. The experimental part of the paper was very detailed, including the reaction process of Sodium 2,6-dichlorobenzoate(cas: 10007-84-8Application In Synthesis of Sodium 2,6-dichlorobenzoate)

Sodium 2,6-dichlorobenzoate(cas: 10007-84-8) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of Sodium 2,6-dichlorobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics