Month: October 2022

《Oxidative chlorination of various iodoarenes to (dichloroiodo)arenes with chromium(VI) oxide as the oxidant》 was published in Journal of Chemical Research, Synopses in 1999. These research results belong to Kaimierczak, Pawet; Skulski, Lech; Obeid, Nicolas. Quality Control of 3,5-Dichloro-4-methoxybenzoic acid The article mentions the following:

Chromium(VI) oxide dissolved in a mixture of acetic acid with concentrated hydrochloric acid converts, at or near room temperature, iodoarenes to (dichloroiodo)arenes, in a very simple and efficient procedure. In the experimental materials used by the author, we found 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Quality Control of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and Characterization of Rigid-Rod Polymers with Silsesquioxanes in the Main Chain》 was written by Guan, Jun; Zhang, Zijing; Laine, Richard M.. Application of 172222-30-9This research focused onvinyl silsesquioxane main chain metathesis photopolymerization. The article conveys some information:

Two double-decker silsesquioxane-based rigid-rod polymers/oligomers were synthesized using olefin self-metathesis and photolysis. In both synthetic routes, double-decker (DD) silsesquioxanes (SQs) with di- and tetra-vinyl functionalities were studied, and all products were characterized in detail by NMR (NMR), MALDI-TOF, GPC, TGA, and Fourier transform IR (FTIR) spectroscopy. The catalytic self-metathesis of di-vinyl-functionalized DD SQs results in rigid-rod oligomers with a simple ethene bridge linking SQ cages with a decomposition temperature Td5% of ~530° C in air. Due to steric hindrance, only one ethene bridge forms between tetra-vinyl-functionalized DD SQs using either Grubb’s 1st or 2nd generation catalysts, with other vinyl groups remaining unreacted, as indicated by MALDI-TOF. As an alternative approach, photolysis of di-vinylDD SQs in the UVA and UVB regions leads to linear polymers with cyclobutane linkers between SQ cages and a Td5% of ~530° C. In both configurations, the degrees of freedom are limited solely to rotation around the single bonds joining the ethene or cyclobutane groups to the DD SQs along the chain axis, leading to rigid-rod polymers. Rigid-rod polymers remain both highly thermally stable and soluble in common solvents such as dichloromethane and THF, which points to new opportunities in easily processable rigid-rod polymers. In contrast, photolysis of tetra-vinylDD SQs leads to insoluble and unmeltable products, implying a high degree of crosslinking. The results came from multiple reactions, including the reaction of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Application of 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Application of 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis of 1,2,3-triazole benzophenone derivatives and evaluation of in vitro sun protection, antioxidant properties, and antiproliferative activity on HT-144 melanoma cells》 was written by Dias, Maria C. F.; de Sousa, Bianca L.; Ionta, Marisa; Teixeira, Robson R.; Goulart, Thiago Q.; Ferreira-Silva, Guilherme A.; Pilau, Eduardo J.; dos Santos, Marcelo H.. Product Details of 622-95-7This research focused ontriazole benzophenone derivative antioxidant antitumor photoprotective human. The article conveys some information:

Two series of 1,2,3-triazole-benzophenone derivatives I [R = R1 = Ph, 3-MeC6H4, 4-ClC6H4, etc.] and II [R2 = Ph, 2-pyridyl, 4-BrC6H4, etc.] were synthesized and their antioxidant, anticancer and photoprotective effects evaluated. For the compounds synthesis, 4,4′-dihydroxybenzophenone and 2,4-dihydroxybenzophenone were propargylated and afforded alkynes, bis(4-(prop-2-yn 1-yloxy))benzophenone and (2-hydroxy-4-(prop-2-yn-1-yloxy))benzophenone, resp. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between the alkynes and several benzyl azides gave the compounds I and II with yields ranging from 35 to 95%. Compounds I and II at the concentration of 0.2μg mL-1 (a no-cytotoxic concentration) exhibited a solar protection factor (SPF) comparable to pos. control benzophonen-3 (BP-3). Concerning their antioxidant and cytotoxic effects, the derivatives from 2,4-dihydroxybenzophenone showed high in vitro antioxidant effects as well as cytotoxicity against A549 (lung carcinoma), MCF-7 (breast carcinoma) and HT-144 (metastatic melanoma) cell lines, without significant cytotoxicity to a non-cancerous cell line. Derivatives II [R2 = Ph, 4-MeC6H4, 2,4-F2C6H3] induced cell death and cell cycle arrest at G1/S in HT-144 melanoma cells. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 37908-97-7On October 14, 2020 ,《Marine Natural Product for Pesticide Candidate: Pulmonarin Alkaloids as Novel Antiviral and Anti-Phytopathogenic-Fungus Agents》 was published in Journal of Agricultural and Food Chemistry. The article was written by Zhang, Mingjun; Ding, Xin; Kang, Jin; Gao, Yongyue; Wang, Ziwen; Wang, Qingmin. The article contains the following contents:

Plant diseases are seriously endangering agricultural production The emergence of drug resistance has brought great challenges to the prevention and control of plant diseases. There is an urgent need for the emergence of new drug candidates. In this work, we achieved the efficient synthesis of pulmonarins A and B in 64% and 59% overall yield, resp. Pulmonarins A and B were found to have good antiviral activities against tobacco mosaic virus (TMV) for the first time. A series of pulmonarin derivatives were designed, synthesized, and evaluated for their antiviral and fungicidal activities systematically. Most compounds displayed higher anti-TMV activities than com. ribavirin. Compounds Pulmonarin B, -Benzyl-2-((3,5-dibromo-4-methoxybenzoyl)oxy)-N,N-dimethylethan-1-aminium Bromide (I), and 2-((4-(Allyloxy)-3,5-dibromobenzoyl)oxy)-N,N,N-trimethylethan-1-aminium Iodide with better inactivation effects than ningnanmycin emerged as new antiviral candidates. We selected I for further antiviral mechanism research, which revealed that it could inhibit virus assembly by interacting with TMV coat protein (CP). The mol. docking results further confirmed that these compounds could interact with CP through hydrogen bonding. These compounds also displayed broad spectrum fungicidal activities. Especially compound 2-(2-(3,5-Dibromo-4-methoxyphenyl)acetoxy)-N,N,N-trimethylethan-1-aminium Iodide with prominent antifungal activity emerged as a new fungicidal candidate for further research. The current work provides a reference for understanding the application of pulmonarin alkaloids in plant protection. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Recommanded Product: 37908-97-7)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Recommanded Product: 37908-97-7 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C8H6Cl2O3On October 31, 2008 ,《Bioactive metabolites from Penicillium sp., an endophytic fungus residing in Hopea hainanensis》 appeared in World Journal of Microbiology & Biotechnology. The author of the article were Wang, F. W.; Hou, Z. M.; Wang, C. R.; Li, P.; Shi, D. H.. The article conveys some information:

The metabolites of endophytic fungus Penicillium sp. from the leaf of Hopea hainanensis were reported for the first time. By bioassay-guided fractionation, the EtOAc extract of a solid-matrix steady culture of this fungus afforded six compounds, which were identified through a combination of spectral and chem. methods (IR, MS, 1H- and 13C-NMR) to be monomethylsulochrin (1), rhizoctonic acid (2), asperfumoid (3), physcion (4), 7,8-dimethyl-iso-alloxazine (5) and 3,5-dichloro-p-anisic acid (6). Compounds 2, 3 and 6 were obtained from Penicillium sp. for the first time. All of the six isolates were subjected to in vitro bioactive assays including antifungal action against three human pathogenic fungi Candida albicans, Trichophyton rubrum and Aspergillus niger and cytotoxic activity against the human nasopharyngeal epidermoid tumor KB cell line and human liver cancer HepG2 cell line. As a result, compounds 2-4 and 6 inhibited the growth of C. albicans with MICs of 40.0, 20.0, 50.0 and 15.0 μg/mL, resp. and the compound 6 showed growth inhibition against A. niger with MICs of 40.0 μg/mL. In addition, compounds 1-3 and 6 exhibited cytotoxic activity against KB cell line with IC50 value of 30.0, 20.0, 20.0, 5.0 μg/mL, resp. and against HepG2 cell line with IC50 value of 30.0, 25.0, 15.0, 10.0 μg/mL, resp. The results came from multiple reactions, including the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Computed Properties of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acidOn September 1, 2012 ,《N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Vallin, Karl S. A.; Sterky, Karin J.; Nyman, Eva; Bernstroem, Jenny; From, Rebecka; Linde, Christian; Minidis, Alexander B. E.; Nolting, Andreas; Naerhi, Katja; Santangelo, Ellen M.; Sehgelmeble, Fernando W.; Sohn, Daniel; Strindlund, Jennie; Weigelt, Dirk. The article contains the following contents:

A series of potent antagonists of the ion channel transient receptor potential A1 (TRPA1) was developed by modifying lead structure 16 that was discovered by high-throughput screening. Based on lead compound 16, a SAR was established, showing a narrow region at the nitro-aromatic R1 moiety and at the warhead, while the R2 side had a much wider scope including ureas and carbamates. Compound 16 inhibits Ca2+-activated TRPA1 currents reversibly in whole cell patch clamp experiments, indicating that under in vivo conditions, it does not react covalently, despite its potentially electrophilic ketone. The experimental process involved the reaction of 5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acid)

5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hameed, Shehryar; Kanwal; Seraj, Faiza; Rafique, Rafaila; Chigurupati, Sridevi; Wadood, Abdul; Rehman, Ashfaq Ur; Venugopal, Vijayan; Salar, Uzma; Taha, Muhammad; Khan, Khalid Mohammed published their research in European Journal of Medicinal Chemistry on December 1 ,2019. The article was titled 《Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in-vitro: Structure-activity relationship, molecular docking and kinetic studies》.Quality Control of 2-Chloro-3,4-difluorobenzoic acid The article contains the following contents:

Benzotriazoles were synthesized which were further reacted with different substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives I [R1 = R2 = H, Me, Cl; R3 = H, 4-Br, 3-Me-4-NO2, etc.] and II [R4 = R5 = H, Me, Cl; R6 = H, 2-OH, 4-Ph, etc.]. The synthetic compounds I and II were characterized via different spectroscopic techniques including EI-MS, HREI-MS, 1H- and 13C-NMR. These mols. were examined for their anti-hyperglycemic potential hence were evaluated for α-glucosidase and α-amylase inhibitory activities. All benzotriazoles displayed moderate to good inhibitory activity in the range of IC50 values of 2.00-5.6 and 2.04-5.72 μM against α-glucosidase and α-amylase enzymes, resp. The synthetic compounds were divided into two categories “”A”” and “”B””, in order to understand the structure-activity relationship. Compounds II [R4 = R5 = H; R6 = 4-Cl] (IC50 = 2.41 ± 1.31 μM), (IC50 = 2.5 ± 1.21 μM), II [R4 = R5 = Me; R6 = 3,4-di-Cl] (IC50 = 2.12 ± 1.35 μM), (IC50 = 2.21 ± 1.08 μM) and II [R4 = R5 = Me; R6 = 4-Cl] (IC50 = 2.00 ± 1.22 μM), (IC50 = 2.04 ± 1.4 μM) with chloro substitution/s at aryl ring were found to be most active against α-glucosidase and α-amylase enzymes. Mol. docking studies on all compounds were performed which revealed that chloro substitutions were playing a pivotal role in the binding interactions. The enzyme inhibition mode was also studied and the kinetic studies revealed that the synthetic mols. showed competitive mode of inhibition against α-amylase and non-competitive mode of inhibition against α-glucosidase enzyme. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2Quality Control of 2-Chloro-3,4-difluorobenzoic acid)

2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of 2-Chloro-3,4-difluorobenzoic acid The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,European Journal of Inorganic Chemistry included an article by Werle, Christophe; Karmazin, Lydia; Bailly, Corinne; Djukic, Jean-Pierre. Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II). The article was titled 《Effect of Enhanced Electron Withdrawal on the Cohesion of Cr-Pd Hemichelates》. The information in the text is summarized as follows:

Bimetallic chromium-palladium and trimetallic dichromium-palladium fluorenyl hemichelates I (4a, M absent, Q = CH2, R = Me, X = H; 4b, M = (CO)3Cr, Q = CH2, R = Me, X = H; 5a, M absent, R2NQ = 4-tert-butyl-2-pyridyl, X = NMe2; 5b, M = (CO)3Cr, R2NQ = 4-tert-butyl-2-pyridyl, X = NMe2) were synthesized and fully characterized. Their mol. structures obtained by X-ray diffraction anal. do not show major differences – in interat. bond lengths within the Pd coordination sphere – when compared to previously reported bimetallic analogs. Theor. investigations were performed using methods of the D. Functional Theory (ZORA-PBE-D3(BJ)/all electron TZP level, EDA, ETS-NOCV and QTAIM-IQA) to analyze the influence of a second Cr(CO)3 moiety in the process of formation of the Cr-Pd hemichelate. Theory shows that despite the extensive charge delocalization in the anion of trans-bistricarbonylchromium(fluorene), the formation of a stable hemichelate is still possible albeit requiring a moderate energy payload to funnel charge d. towards the formation of the benzylic carbon-palladium bond. IQA analyses of hemichelates show the important role of attractive electrostatic interactions in the dominantly noncovalent Cr(CO)3-Pd interactions. In the experiment, the researchers used Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Joshi, Bhuwan C.; Tyagi, R. P.; Dobhal, M.P.; Rawat, Ratna; Chauhan, Madhu published an article in Indian Journal of Heterocyclic Chemistry. The title of the article was 《Synthesis of some new sulfide, sulfone and triazolo derivatives of pyridobenzodiazepines》.Recommanded Product: 66662-48-4 The author mentioned the following in the article:

Synthesis of some new sulfide derivatives of 2,4-dimethyl-5,11-dihydro-5H-pyrido[2,3-b][1,4]benzodiazepin-5-thione (2) was carried out by reacting 2 with benzyl chloride and 2-bromobutane, resp. On oxidizing the benzyl sulfide derivative with oxone, the corresponding sulfone was obtained. 3,11,13-Trimethylpyridobenzo[2,3-b]-1,2,4-triazolo[4,3-d][1,4]diazepine was synthesized from 2. In the experiment, the researchers used 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Recommanded Product: 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lemoine, Remy C.; Petersen, Ann C.; Setti, Lina; Wanner, Jutta; Jekle, Andreas; Heilek, Gabrielle; deRosier, Andre; Ji, Changhua; Berry, Pamela; Rotstein, David published an article on January 15 ,2010. The article was titled 《Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.SDS of cas: 54453-94-0 The information in the text is summarized as follows:

Replacement of a secondary amide with an N-acyl or N-sulfonyl gem-disubstituted azacyle in a series of CCR5 antagonists led to the identification of compounds with excellent in vitro HIV antiviral activity and increased intrinsic membrane permeability. The experimental process involved the reaction of Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0SDS of cas: 54453-94-0)

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 54453-94-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics