Month: October 2022

Wang, Shouming; Miller, Warren; Milton, John; Vicker, Nigel; Stewart, Alistair; Charlton, Peter; Mistry, Prakash; Hardick, David; Denny, William A. published an article on February 11 ,2002. The article was titled 《Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Formula: C15H10N2O2 The information in the text is summarized as follows:

As part of a program to identify further analogs of the dual topo I/II inhibitor XR11576, we describe here the syntheses and SAR studies of various ‘minimal’ and 3,4-benzofused phenazine chromophores of the phenazine template of XR11576. In the experiment, the researchers used 3-Phenylquinoxaline-5-carboxylic acid(cas: 162135-93-5Formula: C15H10N2O2)

3-Phenylquinoxaline-5-carboxylic acid(cas: 162135-93-5) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Formula: C15H10N2O2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Journal of the Brazilian Chemical Society included an article by Dias, Maria C. F.; Gularte, Thiago Q.; Teixeira, Robson R.; Santos, Jorge A. N.; Pilau, Eduardo J.; Mendes, Tiago A. O.; Demuner, Antonio J.; dos Santos, Marcelo H.. Safety of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Synthesis of 1,2,3-triazole derivatives of 4,4′-dihydroxybenzophenone and evaluation of their elastase inhibitory activity》. The information in the text is summarized as follows:

The synthesis of a series of novel triazole derivatives I (R = 4-iodophenyl, 2-methylphenyl, 2,6-dichlorophenyl, etc.) from 4,4′-dihydroxybenzophenone along with their elastase inhibitory activity has been described. The 1,2,3-triazoles I were obtained via the copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), also known as click reaction, between bis(4-(prop-2-yn-1-yloxy))benzophenone and several benzyl azides RCH2N3. It was found that five derivatives exhibited significant inhibitory effects, presenting half maximal inhibitory concentration (IC50) values in the range of 16.6 to 72.1 μM. The most active compound, namely I (R = 4-iodophenyl) (IC50 = 16.6 ± 1.9 μM), was found to bind to elastase with the inhibition constant (Ki) of 11.12 μM, thereby illustrating competitive inhibitory behavior. Further, docking investigations provided insights on the possible binding mode of the most active compound with the elastase. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Safety of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Safety of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and evaluation of nematicidal activity of compounds derived from norbornadiene》 was published in Journal of the Brazilian Chemical Society in 2020. These research results belong to Gomes, Anni C. S.; Demuner, Antonio J.; Alvarenga, Elson S.; Gondim, Joao P. E.; Fonseca, Andressa R.; Buonicontro, Dalila S.; Pilau, Eduardo J.; Silva, Evandro. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

Nematode is a major problem in agriculture, the effective way to control this pest is through chem. control, but the efficient mols. present in the market have great toxicity to mammals and birds. Thus, there is a constant demand for the development of new nematicide mols. This study describes the synthesis of norbornadiene derived esters I (R = H, Me, Bn, etc.) and evaluation of their potential activity against Meloidogyne javanica. The esters I presented 50% mortality of the nematodes. The compounds acid II and the ester I (R = Me) caused 96 and 93% mortality of the nematodes, resp. The lethal concentration to kill 50% of the nematodes (LD50) were determined as being 11.8μg mL-1 for the acid II and 99.4μg mL-1 for the ester I (R = Me). According to the results obtained it is believed that polarity seems to be a key factor for the higher activity of compound II compared to structurally similar ester derivatives After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Fabricating Organic Nanotubes through Selective Disassembly of Two-Dimensional Covalent Organic Frameworks》 was published in Journal of the American Chemical Society in 2020. These research results belong to Liang, Rong-Ran; A, Ru-Han; Xu, Shun-Qi; Qi, Qiao-Yan; Zhao, Xin. Recommanded Product: 172222-30-9 The article mentions the following:

Covalent organic frameworks (COFs) are an emerging class of crystalline porous organic polymers with potential for innovative applications. Here we report the use of COFs as precursors for the fabrication of well-defined tubular nanomaterials. A proof-of-concept study is presented for the controllable fabrication of organic nanotubes through selective disassembly of two-dimensional heteropore COFs. Two dual-pore COFs are constructed based on orthogonal reactions. Each COF possesses two different kinds of pores, which are formed by linking all-hydrazone-bonded nanopores with boroxines. Selectively hydrolyzing boroxine rings in the COFs while keeping hydrazone linkages untouched gives rise to organic nanotubes with diameters and shapes corresponding to the nanochannels of the COFs. The experimental part of the paper was very detailed, including the reaction process of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Recommanded Product: 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Recommanded Product: 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Ring-closing metathesis of prochiral oxaenediynes to racemic 4-alkenyl-2-alkynyl-3,6-dihydro-2H-pyrans》 was written by Kolarikova, Viola; Rybackova, Marketa; Svoboda, Martin; Kvicala, Jaroslav. Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium And the article was included in Beilstein Journal of Organic Chemistry in 2020. The article conveys some information:

The prochiral 4-(allyloxy)hepta-1,6-diynes, optionally modified in the positions 1 and 7 with an alkyl or ester group, undergo a chemoselective ring-closing enyne metathesis yielding racemic 4-alkenyl-2-alkynyl-3,6-dihydro-2H-pyrans. Among the catalysts tested, Grubbs 1st generation precatalyst in the presence of ethene (Mori conditions) gives superior results compared to the more stable Grubbs or Hoveyda-Grubbs 2nd generation precatalysts. This was probably caused by a suppression of the subsequent sidereactions of the enyne metathesis product with ethene. On the other hand, the 2nd generation precatalysts gives better yields in the absence of ethene. The metathesis products, containing both a triple bond and a conjugated system, can be successfully orthogonally modified. For example, the metathesis product of 5-(allyloxy)nona-2,7-diyne reacted chemo- and stereoselectively in a Diels-Alder reaction with N-phenylmaleimide affording the tricyclic products as a mixture of two separable diastereoisomers, the configuration of which was estimated by DFT computations. The reported enediyne metathesis paves the way to the enantioselective enyne metathesis yielding chiral building blocks for compounds with potential biol. activity, e.g., norsalvinorin or cacospongionolide B. In the experiment, the researchers used many compounds, for example, Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis of high-molecular weight poly(1,1-dimethyl-1-silapentene) by olefin metathesis polymerization in the presence of Grubbs catalysts》 was written by Morontsev, Alexander; Gringolts, Maria; Lakhtin, Valentin; Finkelshtein, Eugene. Application of 172222-30-9 And the article was included in Journal of Organometallic Chemistry in 2020. The article conveys some information:

Heterochain polycarbosilanes are well-known materials possessed important properties. Some of their applications, such as gas separation membranes, require polymers with high mol. weight that provide good film-forming and mech. properties. In this research, the synthesis of poly(1,1-dimethyl-1-silapentene) via the ring-opening metathesis polymerization (ROMP) of 1,1-dimethyl-1-silacyclopentene and the acyclic dienes metathesis (ADMET) of diallyl dimethylsilane mediated by Ru-carbene Grubbs complexes 1st – 3rd generations as well as Hoveyda-Grubbs 2nd generation catalyst were studied for the first time. High mol. weight poly(1,1-dimethyl-1-silapentene) was synthesized by ROMP of 1,1-dimethyl-1-silacyclopentene. Varying the type and loading catalyst, temperature and monomer concentration, we obtained poly(1,1-dimethyl-1-silapentene) with Mw = 100-143 kDa, which is significantly higher (5-7 times) than that reached previously by olefin metathesis polymerization The activities of 1,1-dimethyl-1-silacyclopentene and cyclopentene in ROMP were compared using 1H NMR monitoring the conversion of their double bonds. The ADMET polymerization of diallyl dimethylsilane led to oligomers with the average polymerization degree not exceeded 4.4. In the part of experimental materials, we found many familiar compounds, such as Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Application of 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Application of 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Long, Zhou-Qing; Yang, Lin-Li; Zhang, Jun-Rong; Liu, Shi-Tao; Jiao Xie; Wang, Pei-Yi; Zhu, Jian-Jun; Shao, Wu-Bin; Liu, Li-Wei; Yang, Song published their research in Journal of Agricultural and Food Chemistry in 2021. The article was titled 《Fabrication of Versatile Pyrazole Hydrazide Derivatives Bearing a 1,3,4-Oxadiazole Core as Multipurpose Agricultural Chemicals against Plant Fungal, Oomycete and Bacterial Diseases》.HPLC of Formula: 5781-53-3 The article contains the following contents:

An array of versatile pyrazole hydrazide derivatives bearing a 1,3,4-oxadiazole core I [R = Ph, 3-FC6H4, 4-MeOC6H4, etc.; R1 = 1H-pyrrol-2-yl, 1H-indol-2-yl, 3-(difluoromethyl)-1-methyl-pyrazol-4-yl, etc.] were initially synthesized and biol. evaluated the antifungal, antioomycetes and antibacterial activities. In addition, the pyrazole ring was replaced by the correlative pyrrole, thiazole and indole scaffolds to extend the mol. diversity. The results showed that most of these hybrid compounds were empowered with multifunctional bioactivities. For the antifungal activity, the minimal EC50 values could afford against the corresponding fungi Gibberella zeae, Fusarium oxysporum, Botryosphaeria dothidea and Rhizoctonia solani. In vivo pot experiments against corn scab (caused by G. z.) revealed that the compound I [R = 2-FC6H4; R1 = 3-(difluoromethyl)-1-methyl-pyrazol-4-yl] was effective with protective and curative activities of 90.2 and 86.3% at 200μg/mL, which was comparable to those of fungicides boscalid and fluopyram. Further mol. docking study and enzymic activity anal. indicated that target compounds were promising succinate dehydrogenase inhibitors. Addnl., compounds I [R = Ph, 4-FC6H4; R1 = 3-(difluoromethyl)-1-methyl-pyrazol-4-yl, 1-methyl-3-(trifluoromethyl)pyrazol-4-yl] yielded superior anti-oomycete and antibacterial activities toward Phytophora infestins and Xanthomonas oryzae pv. oryzae with EC50 values of 2.92 and 8.43μg/mL, resp. In vivo trials against rice bacterial blight provided the control efficiency within 51.2-55.3% at 200μg/mL, which were better than that of bismerthiazol. Given their multipurpose characteristics, these structures should be pos. explored as agricultural chems. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of Thiophene-2-sulfonyl chlorideIn 2022 ,《The performance of different AgTiO2 loading into poly(3-nitrothiophene) for efficient adsorption of hazardous brilliant green and crystal violet dyes》 appeared in International Journal of Polymer Science. The author of the article were Alqarni, Sara A.. The article conveys some information:

The in-situ polymerization technol. was used to successfully produce nanostructured binary nanocomposites (NCs) made from a poly(3-nitrothiophen) matrix (P3NT) that were loaded effectively with nanoparticles (NPs) of silver titanium dioxide (AgTiO2), of varying percentages (10%, 20%, and 30%). A uniform coating of P3NT covers the AgTiO2 NPs. Various methods were performed to confirm the fabrication of the binary P3NT/AgTiO2 NCs adsorbents, such as FTIR, XRD, SEM, and EDX. Both dyes (brilliant green (B.G.) and crystal violet (C.V.)) were removed from liquid media by using the binary P3NT/AgTiO2 NCs. A range of batch adsorption studies was used to optimize various factors that impact the elimination of B.G. or C.V. dyes, including the pH, weight of the binary P3NT/AgTiO2 NC, proportion of AgTiO2 NP, time, and temperature The pseudo-second-order kinetics (R2 = 0.999) was better adapted for the adsorption procedure’s empirical data whereby the maximum adsorption capacity of the C.V. dye was 43.10 mg/g and (R2 = 0.996) the maximum adsorption potential was 40.16 mg/g for B.G. dye, succeeded by the pseudo-second-order kinetics. Moreover, the adhesion of B.G. and C.V. pigments on the layers of NCs involves an endothermic reaction. In addition, the concocted adsorbent not only exhibited strong adsorption characteristics during four consecutive cycles but also possessed a higher potential for its reuse. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application In Synthesis of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application In Synthesis of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 172222-30-9In 2020 ,《One-Step Ring Opening Metathesis Block-Like Copolymers and their Compositional Analysis by a Novel Retardation Technique》 was published in Angewandte Chemie, International Edition. The article was written by Yasir, Mohammad; Liu, Peng; Markwart, Jens C.; Suraeva, Oksana; Wurm, Frederik R.; Smart, Jansie; Lattuada, Marco; Kilbinger, Andreas F. M.. The article contains the following contents:

Using a one-step synthetic route for block copolymers avoids the repeated addition of monomers to the polymerization mixture, which can easily lead to contamination and, therefore, to the unwanted termination of chain growth. For this purpose, monomers (M1-M5) with different steric hindrances and different propagation rates are explored. Copolymerization of M1 (propagating rapidly) with M2 (propagating slowly), M1 with M3 (propagating extremely slowly) and M4 (propagating rapidly) with M5 (propagating slowly) yielded diblock-like copolymers using Grubbs’ first (G1) or third generation catalyst (G3). The monomer consumption was followed by 1H NMR spectroscopy, which revealed vastly different reactivity ratios for M1 and M2. In the case of M1 and M3, we observed the highest difference in reactivity ratios (r1=324 and r2=0.003) ever reported for a copolymerization method. A triblock-like copolymer was also synthesized using G3 by first allowing the consumption of the mixture of M1 and M2 and then adding M1 again. In addition, in order to measure the fast reaction rates of the G3 catalyst with M1, we report a novel retardation technique based on an unusual reversible G3 Fischer-carbene to G3 benzylidene/alkylidene transformation. In the part of experimental materials, we found many familiar compounds, such as Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Product Details of 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Product Details of 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors》 was written by La Pietra, Valeria; Sartini, Stefania; Botta, Lorenzo; Antonelli, Alessandro; Ferrari, Silvia Martina; Fallahi, Poupak; Moriconi, Alessio; Coviello, Vito; Quattrini, Luca; Ke, Yi-Yu; Hsing-Pang, Hsieh; Da Settimo, Federico; Novellino, Ettore; La Motta, Concettina; Marinelli, Luciana. Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate And the article was included in European Journal of Medicinal Chemistry on April 25 ,2018. The article conveys some information:

It is now known that “”gain of function”” mutations of RET (REarranged during Transfection) kinase are specific and key oncogenic events in the onset of thyroid gland cancers such as the Medullary Thyroid Carcinoma (MTC). Although a number of RET inhibitors exist and are capable of inhibiting RET variants, in which mutations are outside the enzyme active site, the majority becomes dramatically ineffective when mutations are within the protein active site (V804L and V804M). Pursuing a receptor-based virtual screening against the kinase domain of RET, the authors found that compound (I) is able to inhibit efficiently both wild type and V804L mutant RET. Compound(I) was able to significantly reduce proliferation of both com. available TT cell lines and surgical thyroid tissues obtained from patients with MTC and displayed a suitable drug-like profile, thus standing out as a promising candidate for further development towards the treatment of clin. unresponsive MTC. The results came from multiple reactions, including the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics