Month: October 2022

《Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety》 was written by Al-Sa’Doni, Haitham Husein; Delmani, Fatima-Azzahra; Al Balushi, Abdullah Mohammed; Al-Ahmad, Ala’A. Hamed; Alsawakhneh, Sondos Omar; Al-Soud, Yaseen Ahmad. HPLC of Formula: 16629-19-9This research focused ontriazolyl carbohydrazide preparation antibacterial activity; thione triazolyl preparation antibacterial activity. The article conveys some information:

In this study, a series of 1,2,4-triazol-3-carbohydrazide derivatives like 3-methoxy-benzoic acid N'[2-(1,5-diethyl-1H-[1,2,4]triazole3-yl)-acetyl]-hydrazide, 3,5-dinitro-benzoic acid N'[2-(1, 5-diethyl-1H-[1, 2, 4]triazole-3-yl)-acetyl]-hydrazide and compound of 1,2,4- triazole-3-(4H)-thion I (R = C6H5, 2-thienyl, 7-methoxy-4-methyl-2-oxo-2H-chromen-6-yl; R1 = Me, Et; R2 = Et) have been synthesized. Structures and purity of the new compounds I were confirmed by the use of their chromatog. and spectral data besides microanal. Four different bacterial stains for the study of the biol. activity of compounds I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 3-CF3C6H4, R1 = Et, R2 = Et; R = 2,5-(Cl)2C6H3, R1 = Et, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et); two Gram-pos. strains, and two Gram-neg. strains have been used. Compound I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et) was found to be the most active of the four tested compounds against Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus, with an inhibition zone diameter of 16, 9, and 10 mm, resp. Calculating the minimal inhibitory concentration value (MIC) for the pos. drugs which formed an inhibition zone in the agar well diffusion method, it was found that both I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et) were the most active of the four tested compounds against Pseudomonas aeruginosa and Bacillus cereus with an MIC value of 0.5μg/mL for both bacteria. These results suggest that these two compounds I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et) could be considered as potential antibacterial agents against a range of bacteria. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9HPLC of Formula: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. HPLC of Formula: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 350-30-1On September 20, 2019 ,《Development and Scale-up of Continuous Electrocatalytic Hydrogenation of Functionalized Nitro Arenes, Nitriles, and Unsaturated Aldehydes》 was published in Organic Process Research & Development. The article was written by Egbert, Jonathan D.; Thomsen, Edwin C.; O’Neill-Slawecki, Stacy A.; Mans, Douglas M.; Leitch, David C.; Edwards, Lee J.; Wade, Charles E.; Weber, Robert S.. The article contains the following contents:

Electrolysis flow reactors based on the filter-press architecture of redox flow batteries have proven to be effective and scalable toward the production of com. relevant, pharmaceutical quantities of anilines ( > 500 kg/yr) from halogen-, hydroxyl-, and carbonyl-substituted nitroarenes. Turbulent flow through the carbon felts on which the catalysts were supported facilitated scaling toward production levels because it conferred on the reactors scale-independent, plug flow-like residence time distributions and high mass transfer coefficients Equipping the cells with microreference electrodes made it possible to transfer reaction conditions first developed in batch systems to the continuous flow reactors. The catalysts prepared by incipient wetness impregnation of metal salts into lightly oxidized carbon felt supports were readily generalizable. In the experiment, the researchers used many compounds, for example, 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Product Details of 350-30-1)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 350-30-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 3,5-Dichloro-4-methoxybenzoic acidOn September 25, 2006 ,《Proton mobility in 2-substituted 1,3-dichlorobenzenes: “”ortho”” or “”meta”” metalation?》 was published in European Journal of Organic Chemistry. The article was written by Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario. The article contains the following contents:

Nine 1,3-dichlorobenzene congeners were selected as model compounds to assess the relative rates of proton abstraction from 4- and 5-positions (“”ortho”” vs. “”meta”” metalation). Using lithium 2,2,6,6-tetramethylpiperidide as the basic reagent, the chlorine-adjacent 4-position underwent metalation exclusively. In contrast, attack at the chlorine-remote 5-position became significant even in the case of moderately sized 2-substituents (such as dimethylamino or ethyl) when sec-butyllithium was employed. The “”ortho/para”” (4-/5-) ratios ranged from 80:20 to 65:35. The more pronounced “”meta-orienting”” effect of silicon as opposed to carbon substituents can be attributed to dissimilarities in the π polarization of the aromatic ring.3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Quality Control of 3,5-Dichloro-4-methoxybenzoic acid) was used in this study.

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 3,5-Dichloro-4-methoxybenzoic acid Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 6313-54-8On May 11, 2022 ,《Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids》 appeared in Journal of the American Chemical Society. The author of the article were Chen, Tiffany Q.; Pedersen, P. Scott; Dow, Nathan W.; Fayad, Remi; Hauke, Cory E.; Rosko, Michael C.; Danilov, Evgeny O.; Blakemore, David C.; Dechert-Schmitt, Anne-Marie; Knauber, Thomas; Castellano, Felix N.; MacMillan, David W. C.. The article conveys some information:

A general catalytic method for direct decarboxylative halogenation of (hetero)aryl carboxylic acids RC(O)OH (R = 4-sulfamoylphenyl, 5-methylpyridin-2-yl, isoquinolin-1-yl, etc.) via ligand-to-metal charge transfer was reported. This strategy accommodates an exceptionally broad scope of substrates. An aryl radical intermediate is leveraged toward divergent functionalization pathways: (1) atom transfer to access bromo- or iodo(hetero)arenes or (2) radical capture by copper and subsequent reductive elimination to generate chloro- or fluoro(hetero)arenes. The proposed ligand-to-metal charge transfer mechanism is supported through an array of spectroscopic studies.2-Chloroisonicotinic acid(cas: 6313-54-8Related Products of 6313-54-8) was used in this study.

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Related Products of 6313-54-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C11H13ClO2On September 15, 2006 ,《Synthesis, biochemical evaluation and rationalization of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P45017α)》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Patel, Chirag H.; Dhanani, Sachin; Owen, Caroline P.; Ahmed, Sabbir. The article contains the following contents:

The preliminary results of the synthesis, biochem. evaluation and rationalization of the inhibitory activity of 1-(arylalkyl)imidazoles 4-RC6H4(CH2)nIm (R = H, F, Cl, Br; n = 1 – 3; Im = 1-imidazolyl) (I) as inhibitors of the two components of the enzyme complex P 45017α, i.e., 17α-hydroxylase (17α-OHase) and 17,20-lyase (lyase), are reported. I (R = Br; n = 3) (IC50 = 2.95 μM against 17α-OHase and IC50 = 0.33 μM against lyase) is the most potent compound within the current study and is more potent than ketoconazole (IC50 = 3.76 μM against 17α-OHase and IC50 = 1.66 μM against lyase). Modeling of these compounds suggests that the length of the alkyl chain enhances the interaction between the inhibitor and the area of the active site corresponding to the C(3) area of the steroid backbone, thereby increasing potency. In addition to this study using Ethyl 3-(4-chlorophenyl)propanoate, there are many other studies that have used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2) was used in this study.

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Formula: C11H13ClO2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H7ClFNOn November 25, 2020 ,《X-ray Structure and Molecular Docking Guided Discovery of Novel Chitinase Inhibitors with a Scaffold of Dipyridopyrimidine-3-carboxamide》 appeared in Journal of Agricultural and Food Chemistry. The author of the article were Yuan, Pengtao; Jiang, Xi; Wang, Siyu; Shao, Xusheng; Yang, Qing; Qian, Xuhong. The article conveys some information:

Chitinases are the glycosyl hydrolase for catalyzing the degradation of chitin and play an indispensable role in bacterial pathogenesis, fungal cell wall remodeling, and insect molting. Thus, chitinases are attractive targets for therapeutic drugs and pesticides. Here, we present a strategy of developing a novel chemotype of chitinase inhibitors by the construction of planar heterocycles that can stack with conserved aromatic residues. The rational design, guided by crystallog. anal. and docking results, leads to a series of dipyridopyrimidine-3-carboxamide derivatives as chitinase inhibitors. Among them, compound 6t showed the most potent activity against bacterial chitinase SmChiB and insect chitinase OfChi-h, with a Ki value of 0.14 and 0.0056μM, resp. The strong stacking interaction of compound 6p with Trp99 and Trp220 found in the SmChiB-6p co-crystal structure verifies the feasibility of our design. Our results provide novel insights into developing potent chitinase inhibitors for pathogen and pest control. After reading the article, we found that the author used (2-Chloro-3-fluorophenyl)methanamine(cas: 72235-54-2Computed Properties of C7H7ClFN)

(2-Chloro-3-fluorophenyl)methanamine(cas: 72235-54-2) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C7H7ClFN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sugimoto, Yuichi; Shimizu, Atsushi; Kato, Tetsuya; Satoh, Atsushi; Ozaki, Satoshi; Ohta, Hisashi; Okamoto, Osamu published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis, and biological evaluation of indole derivatives as novel nociceptin/orphanin FQ (N/OFQ) receptor antagonists》.Formula: C11H13ClO2 The author mentioned the following in the article:

A novel series of 2-(1,2,4-oxadiazol-5-yl)-1H-indole derivatives as nociceptin/orphanin FQ (N/OFQ) receptor antagonists was discovered. Systematic modification of our original lead by changing the pendant functional groups, linker, heterocyclic core, and basic side chain revealed the structure-activity requirements for this novel template and resulted in the identification of more potent analog with improved potency as compared to the parent compound The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Formula: C11H13ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《4-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4-oxo-2-butenoic acid derivatives: design, synthesis and anti-HIV-1 activity》 were Karimi, Nafiseh; Roudsari, Rouhollah Vahabpour; Movahed, Mahsa Azami; Hajimahdi, Zahra; Zarghi, Afshin. And the article was published in Iranian Journal of Pharmaceutical Research in 2021. Category: chlorides-buliding-blocks The author mentioned the following in the article:

Integrase, targeted in highly active antiretroviral therapy (HAART), was a crucial enzyme in viral replication. In this study, new benzimidazolyl diketo acid derivatives I [R = Ph, 2-MeC6H4, 2-FC6H4, etc.] were designed according to required features for inhibitors of HIV-1 integrase. Designed compounds I were evaluated for anti-HIV-1 effects and docking studies indicated that the binding mode of compound I [R = 2-FC6H4] was similar to INSTIs. According to the cell-based biol. assay’s results, most of the tested compounds I demonstrated good anti-HIV-1 activity, ranging from 40-90μM concentration with no severe cytotoxicity. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design, synthesis, and antifungal activity of novel 1,2,4-triazolo[4,3-c] trifluoromethylpyrimidine derivatives bearing the thioether moiety》 were Liu, Chunyi; Fei, Qiang; Pan, Nianjuan; Wu, Wenneng. And the article was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2022. Recommanded Product: 3-Chlorobenzylchloride The author mentioned the following in the article:

Crop disease caused by fungi seriously affected food security and economic development. Inspired by the utilization of fungicide containing 1,2,4-triazole and trifluoromethylpyrimidine, a novel series of 1,2,4-triazolo[4,3-c]trifluoromethylpyrimidine derivatives I (R = CO2C2H5, 2-MeC6H4, 2-FC6H4, etc.) bearing the thioether moiety were synthesized. Meanwhile, the antifungal activities of the title compounds were evaluated and most compounds exhibited obvious antifungal activities against cucumber Botrytis cinerea, strawberry Botrytis cinerea, tobacco Botrytis cinerea, blueberry Botrytis cinerea, Phytophthora infestans, and Pyricularia oryzae Cav. Among the compounds, 5-methyl-7-(trifuoromethyl)-[1,2,4]triazolo[4,3-c]pyrimidine-3-thiol and I (R = 4-BrC6H4, 4-Br-2-FC6H3 and 2,6-diClC6H3) showed significant antifungal activities against three of the four Botrytis cinerea, which indicated the potential to become the leading structures or candidates for resistance to Botrytis cinerea. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics