Month: October 2022

Parada, Luz Karime Luna; Kouznetsov, Vladimir V. published the artcile< 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is triazolyl quinoline hybrid preparation; alkyne azide dipolar cycloaddition copper catalyst.

The title quinoline derivative, 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline, was synthesized in a common three-step procedure from 5-chloro-8-hydroxyquinoline using O-propargylation reaction/copper-catalyzed 1,3-dipolar cycloaddition sequence. The hybrid obtained could be an interesting model for antifungal bio-essays or a suitable precursor in the synthesis of more complex triazolyl-quinoline hybrids, potential pharmacol. agents.

Molbank published new progress about 1,3-Dipolar cycloaddition reaction. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Goldfeld, David J.; Silver, Eric S.; Radlauer, Madalyn R.; Hillmyer, Marc A. published the artcile< Synthesis and Self-Assembly of Block Polyelectrolyte Membranes through a Mild, 2-in-1 Postpolymerization Treatment>, Computed Properties of 1592-20-7, the main research area is self assembly polyelectrolyte membrane mild postpolymn.

Block polymer systems containing spatially separated pos. and neg. charges are desirable for a number of applications, including biomedical devices, membrane separations, and coatings. Unfortunately, the tendency of pos. and neg. block polymers to charge cancel and form an insoluble coacervate precipitate leads to processing difficulties in the fabrication of charged thin films. We use postpolymn. modifications to simultaneously add both neg. and pos. charges to self-assembled neutral ABC triblock polymer thin films. Using reversible addition-fragmentation chain transfer polymerization, we synthesized triblock terpolymers consisting of poly(Pr styrene sulfonic ester), poly(4-chlorostyrene), and poly(vinylbenzyl chloride). The chem. functionalization of both charged blocks was accomplished simultaneously through exposure to gaseous trimethylamine in a single step at room temperature, simplifying the synthetic procedure and preserving the microstructure of the thin film. The quant. functionalization was tracked through attenuated total reflectance IR spectroscopy, and the thin film morphol. was evaluated using intermodulation at. force microscopy, transmission electron microscopy, and grazing-incidence small-angle X-ray scattering.

ACS Applied Polymer Materials published new progress about Amphoteric materials. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Computed Properties of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lee, Hiu-Fung; Lacbay, Cyrus M.; Boutin, Rebecca; Matralis, Alexios N.; Park, Jaeok; Waller, Daniel D.; Guan, Tian Lai; Sebag, Michael; Tsantrizos, Youla S. published the artcile< Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase>, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride, the main research area is multiple myeloma antimyeloma liver toxicity thienopyrimidine hGGPPS inhibitor pharmacokinetics.

Novel analogs of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and exhibit antimyeloma activity in vivo. A key structural element of these inhibitors is a linker moiety that connects their (((2-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)bisphosphonic acid core to various side chains. The structural diversity of this linker moiety, as well as the side chains attached to it, was investigated and found to significantly impact the toxicity of these compounds in MM cells. The most potent inhibitor CML-07-119(13c)(I) was evaluated in mouse and rat for liver toxicity and systemic exposure, resp., providing further optimism for the potential value of such compounds as human therapeutics.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yasunaga, Katsuaki; Kiyonari, Akiko; Nakagawa, Munehiro; Yoshikawa, Kunie published the artcile< Investigation into the ability of the Salmonella umu test to detect DNA damage using antitumor drugs>, Safety of 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is antitumor genotoxicity Salmonella umu gene.

In order to examine the ability of the umu test detecting system, 18 antitumor drugs were tested using the Salmonella umu test. The tested antitumor drugs were selected so as to produce different biochem. actions, and they were classified into three categories; five agents of group I (antimetabolites), eight agents of group II (alkylating agents), and five agents of group III (antibiotics). The results showed that all antimetabolites, all alkylating agents, and three of the antibiotics had pos. responses, but the antibiotics aclarubicin (ACR) and chromomycin A3 (CHR) had neg. responses. Both antibiotics that gave neg. responses were anthracyclines, but daunomycin (DNR), which was one of the anthracyclines, had a pos. result in the umu test. These results suggest that it is possible for the umu test to detect genotoxicity of chems. regardless of the types of DNA damage (inhibition of DNA synthesis relative enzyme, DNA base alkylating, DNA strand-break, and DNA adduct), but difficult for it to detect genotoxicity of any anthracyclines.

Toxicology in Vitro published new progress about Anthracyclines Role: ADV (Adverse Effect, Including Toxicity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Safety of 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Priya, V.; Subalakshmi, M. published the artcile< Study of oxidation of dyes by N-chlorosuccinimide in aqueous acetic acid medium: A kinetic and mechanistic>, SDS of cas: 128-09-6, the main research area is dye chlorosuccinimide acetic acid medium oxidation kinetic.

Kinetics of oxidation of Dyes by N-Chlorosuccinamide(NCS) in acetic acid medium has been done in the presence of hydrochloric acid. The reaction follows first order kinetics with respect to both [NCS], [Substrate] and [HCl]. Increases in ionic strength increases the rate and addition of the reaction product succinamide has a slight retarding effect on the reaction rate. Increase in the dielec. constant of the medium decreases the rate. Activation parameters have been evaluated from Arrhenius plot by studying the reaction at different temperature [40-55 oC] and oxidation products are identified. A most probable reaction mechanism is proposed and an appropriate rate law is deduced to account for the observed kinetic data.

International Journal of Chemical Studies published new progress about Activation energy. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Lin; Liu, Jiaqing; Yang, Weijie; Wan, Jun; Fu, Feng; Wang, Danjun published the artcile< Constructing a Z-scheme ZnIn2S4-S/CNTs/RP nanocomposite with modulated energy band alignment for enhanced photocatalytic hydrogen evolution>, Application of Cl3H8InO4, the main research area is zinc indium sulfide carbon red phosphorus photocatalytic hydrogen evolution; Energy band alignment; Nanocomposite; Photocatalytic hydrogen evolution; Red phosphorus; Sulfur vacancies.

Energy band structures greatly determine the charge separation and transfer properties in heterojunction photocatalysts and consequently their photocatalytic activities. Herein, a well-designed Z-scheme ZnIn2S4-S/CNTs/RP (ZIS-S/CNTs/RP) nanocomposite was fabricated according to an energy band alignment steering strategy to realize superior photocatalytic H2 evolution performance. The ZIS-S/CNTs/RP nanocomposite shows an efficient photocatalytic H2 evolution rate of 1639.9μmol g-1h-1, which is noticeably higher than that of pristine red phosphorus (RP) and CNTs/RP and ZIS-S/RP composites, as well as those of the compared heterojunctions using bulk RP or ZnIn2S4. Owing to the modification of nanosized RP and the introduction of sulfur vacancies in ZnIn2S2, a tailored energy band alignment of the heterojunction with a higher reduction potential and larger Fermi level p.d. was achieved, which resulted in significantly increased photogenerated electron-hole separation efficiency and a more efficient Z-scheme charge transfer mechanism, thus promoting the photocatalytic activity of ZIS-S/CNTs/RP. This work aims to provide a novel effective strategy for the construction of high-performance heterojunction photocatalysts by energy band engineering.

Journal of Colloid and Interface Science published new progress about Band structure. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Application of Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Zhefu; Yan, Guangming; Lu, Jiehong; Zhang, Gang; Yang, Jie published the artcile< Thermal Plastic and Optical Transparent Polyimide Derived from Isophorone Diamine and Sulfhydryl Compounds>, COA of Formula: C8H3ClO3, the main research area is thermoplastic optically transparent polythioether polyimide.

A series of thermoplastic and optical transparent polyimide-bearing aliphatic rings were manufactured through a two-step approach. The solubility and melt processability were significantly enhanced after embedded with flexible thio-ether moieties. The complex viscosity was within 225.6-3980 Pa·s from 330 to 300 °C. The modified polyimide exhibited moderate mech. strength to 76 MPa. The 5% thermal weight loss temperature was around 443 °C, with a glass transition temperature of 204.6-234.8 °C. Although the cyclic aliphatic segments endowed the obtained PIs with improved optical performance, the transmittance could be up to 82% at 450 nm, while the transmittance of industrialized thermoplastic polyimide derived from PMDA and ODA was less than 20% under the same condition.

Industrial & Engineering Chemistry Research published new progress about Elongation at break. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, COA of Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cao, Xiufang; Xu, Shengzhen; Li, Xuegang; Shen, Xiaoxia; Zhang, Qingye; Li, Jianhong; Chen, Changshui published the artcile< N-nitrourea derivatives as novel potential fungicides against Rhizoctonia solani: synthesis, antifungal activities, and 3D-QSAR>, Application In Synthesis of 29027-20-1, the main research area is antifungal nitrourea derivative.

N-nitrourea derivatives bearing various aryl substituents were obtained via three steps, including nitration, carbamic chlorination, and aminolysis reactions. The structures of all the newly synthesized compounds were characterized and confirmed by IR, 1H-NMR, MS, and elemental anal. Bioassays indicated that five of the compounds possess fungicidal activity against Rhizoctonia solani. Structure-activity relationship (SAR) is also discussed based on the exptl. data, and the further quant. structure-activity relationship (QSAR) was analyzed using comparative mol. field anal. and comparative mol. similarity indexes anal.

Chemical Biology & Drug Design published new progress about Fungicides (antifungal). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application In Synthesis of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Matsuno, Kenji; Takai, Kazushige; Isaka, Yoshinobu; Unno, Yuka; Sato, Masayuki; Takikawa, Osamu; Asai, Akira published the artcile< S-Benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase>, Category: chlorides-buliding-blocks, the main research area is benzylisothiourea derivative preparation indoleamine dioxygenase inhibitor.

S-Benzylisothiourea was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit leads to the identification of sub-μM inhibitors of which suppressed kynurenine production in A431 cells. Synthesis and structure-activity relationship of S-benzylisothiourea analogs as small-mol. inhibitors of IDO are described.

Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibitors (indoleamine dioxygenase). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Hong-Kun; Ji, Hai-Zhe; Meng, Xian-chao; Li, Rong-Rong published the artcile< Solubility of 3-Chlorophthalic Anhydride and 4-Chlorophthalic Anhydride in Organic Solvents and Solubility of 3-Chlorophthalic Acid and 4-Chlorophthalic Acid in Water from (283.15 to 333.15) K>, Application of C8H3ClO3, the main research area is chlorophthalic acid anhydride isomer water organic solvent solubility.

The solubility of 3-chlorophthalic anhydride and 4-chlorophthalic anhydride in Et acetate, acetone, and 1,4-dioxane and the solubility of 3-chlorophthalic acid and 4-chlorophthalic acid in water were measured using Schreinemaker’s wet residue method at temperatures ranging from (283.15 to 333.15) K at atm. pressure. Results of these measurements were correlated with the modified Apelblat equation.

Journal of Chemical & Engineering Data published new progress about Anhydrides, aryl Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics