Month: October 2022

Su, Shijun; Chen, Mei; Li, Qin; Wang, Yihui; Chen, Shuai; Sun, Nan; Xie, Chengwei; Huai, Ziyou; Huang, Yinjiu; Xue, Wei published the artcile< Novel penta-1,4-diene-3-one derivatives containing quinazoline and oxime ether fragments: Design, synthesis and bioactivity>, Reference of 611-19-8, the main research area is quinazolinyl pentadieneone oxime ether preparation diastereoselective antitumor SAR drug; Anticancer; Oxime ether; Penta-1, 4-diene-3-one; Quinazoline; SMMC-7721 cells.

A series of novel penta-1,4-diene-3-one derivatives I [R = H, [(2,4-dichlorophenyl)methyl]oxidanyl, [(2-chlorophenyl)methyl]oxidanyl, [(4-chlorophenyl)methyl]oxidanyl, [(2-fluorophenyl)methyl]oxidanyl; R1 = thiophen-2-yl, pyridin-2-yl; R2 = H, [(2-fluorophenyl)methyl]oxidanyl, [(2,4-dichlorophenyl)methyl]oxidanyl, [(3-methylphenyl)methyl]oxidanyl, etc.; R3 = H, 6-Cl, 8-Me] containing quinazoline and oxime ether moieties were designed and synthesized. Their anticancer activities were evaluated by MTT assay, and the results showed that most compounds exhibited extremely inhibitory effects against hepatoma SMMC-7721 cells. In particular, compounds I [R = R3 = H; R1 = pyridin-2-yl; R2 = [(3-methylphenyl)methyl]oxidanyl] (II) and I [R = H; R1 = pyridin-2-yl; R2 = [(4-chlorophenyl)methyl]oxidanyl; R3 = 6-Cl] (III) displayed the more potent inhibitory activity with IC50 values of 0.64 and 0.63μM, which were better than that of gemcitabine (1.40μM). Further mechanism studies indicated that compounds II, III, I [R = [(2,4-dichlorophenyl)methyl]oxidanyl; R1 = pyridin-2-yl; R2 = R3 = H] and I [R = [(2,4-dichlorophenyl)methyl]oxidanyl; R1 = pyridin-2-yl; R2 = H; R3 = 6-Cl] could control the migration of SMMC-7721 cells effectively, and inhibit the proliferation of cancer cells by inhibiting the DNA replication. Western-blot results showed that compounds II and III induced irreversible apoptosis of SMMC-7721 cells by regulating the expression level of apoptose-related proteins. Those studies demonstrated that the penta-1,4-diene-3-one derivatives I containing quinazoline and oxime ether fragments merited further research as potential anticancer agents.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Reference of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zeng, Fang; Zhang, Mingjuan; Li, Yiqun published the artcile< Cu2+ ion crosslinked carboxymethylcellulose/diatomite composite beads as an efficient catalyst for CuAAC reactions>, Recommanded Product: 1-Chloro-2-(chloromethyl)benzene, the main research area is diatomite supported copper ion crosslinked CM cellulose preparation surface structure; alkyne benzyl halide sodium azide copper catalyst regioselective cycloaddition; benzyl triazole preparation green chem.

Cu2+-crosslinked CM-cellulose/diatomite composite beads (CuII@CMC/DE) were prepared in simple and efficient way using ionic crosslinking techniques. In CuII@CMC/DE beads, diatomite serves as a reinforcing filler, and divalent copper cation acts as crosslinking agent. The chem. structure and morphol. of as-fabricated CuII@CMC/DE beads were well characterized using various techniques such as ICP, FT-IR, XRD, SEM, EDS, elemental mapping, TEM, XPS, and TGA. The CuII@CMC/DE beads exerted superior catalytic performance in CuAAC reactions of benzyl halides, sodium azide, and alkynes to yield regioselective 1,4-disubstituted-1,2,3-triazoles in excellent yields under green conditions. In these resultant catalytic composite beads, Cu2+ was used not only as a crosslinking agent but also as a metal catalyst for CuAAC reaction. The composite beads can be easily separated by filter and reused at least four times without any significant decrease on its activity and selectivity.

Polymers for Advanced Technologies published new progress about 1,3-Dipolar cycloaddition catalysts. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Recommanded Product: 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ghosh, Swarbhanu; Ghosh, Aniruddha; Riyajuddin, Sk.; Sarkar, Somnath; Chowdhury, Arpita Hazra; Ghosh, Kaushik; Islam, Sk. Manirul published the artcile< Silver Nanoparticles Architectured HMP as a Recyclable Catalyst for Tetramic Acid and Propiolic Acid Synthesis through CO2 Capture at Atmospheric Pressure>, SDS of cas: 3240-10-6, the main research area is recyclable silver nanoparticle architecture hypercrosslinked microporous polymer preparation; propargylic amine preparation carbon dioxide silver catalyst green chem; tetramic acid preparation; phenylacetylene carbon dioxide silver catalyst green chem; phenylpropiolic acid preparation.

The synthesis of hypercrosslinked microporous polymer (HMP-2) was assembled significant concentration by the virtue of its adjustable porosity, operative design and absolutely ordering structure. This perfectly structured Ag NPs supported carbocatalyst (Ag-HMP-2) was been synthesized by Friedel-Crafts alkylation between 4,4′-Bis(bromomethyl)-1,1′-biphenyl and carbazole over anhydrous iron(III)chloride catalysis followed by the appending of the silver nanoparticles (Ag NPs) onto the material. The silver nanoparticle was decorated over the HMP-2 to prepare the corresponding catalyst (Ag-HMP-2). The characterization of the newly produced material was conducted by N2 adsorption/desorption studies, XPS, FE-SEM, transmission electron microscopy (TEM) and Powder X-ray diffraction (PXRD) methods. This microporous catalyst was spectacular activities for the production of tetramic acids from various types of propargylic amine derivatives at 60C under atm. carbon dioxide pressure. Parallel attempt on fixation of CO2 was executed over terminal alkynes to synthesize propiolic acids under 1 atm pressure. The catalyst (Ag-HMP-2) exhibited sufficient recycling ability for the generation of tetramic acids and propiolic acids up to five catalytic runs without reduction in its catalytic activity.

ChemCatChem published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, SDS of cas: 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lambert, Romain; Wirotius, Anne-Laure; Vignolle, Joan; Taton, Daniel published the artcile< C-C couplings in water by micellar catalysis at low loadings from a recyclable polymer-supported Pd(II)-NHC nanocatalyst>, COA of Formula: C9H9Cl, the main research area is polymer supported palladium nanocatalyst micellar catalysis coupling reaction.

A specifically devised amphiphilic star-like polymer-supported Pd(II)-NHC2 unit (NHC = N-heterocyclic carbene) enables highly efficient micellar catalysis in pure water. An amphiphilic block copolymer carrying benzimidazolium moieties randomly distributed along the hydrophobic block is precisely synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization Addition of Pd(OAc)2 followed by nanopptn. in water drives the metal-ligand coordination core-crosslinking reaction and the segregation of Pd-NHC2 units in the hydrophobic core to form robust polymeric micelles. This approach confers multiple advantages to both the Suzuki-Miyaura and Heck cross-coupling reactions, including robustness, almost no metal leaching, low catalyst loadings (0.1 mol% rel. to the substrate), easy recycling, very broad substrate scope and exceptionally high catalytic activity in water.

Polymer Chemistry published new progress about Heck reaction catalysts. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cazotti, Jaime C.; Fritz, Alexander T.; Garcia-Valdez, Omar; Smeets, Niels M. B.; Dube, Marc A.; Cunningham, Michael F. published the artcile< Graft Modification of Starch Nanoparticles Using Nitroxide-Mediated Polymerization and the ""Grafting to"" Approach>, HPLC of Formula: 1592-20-7, the main research area is graft starch nanoparticle nitroxide polymerization Grafting.

Starch nanoparticles (SNP) were modified with synthetic polymers using the “”grafting to”” approach and nitroxide-mediated polymerization SG1-capped poly(Me methacrylate-co-styrene) (P(MMA-co-S)) copolymers with low dispersity and high degree of livingness were first synthesized in bulk. These macroalkoxyamines were then grafted to vinyl benzyl-functionalized SNP to obtain biosynthetic hybrids. The grafted materials, SNP-g-P(MMA-co-S), were characterized by 1H NMR, FTIR, TGA, and elemental anal. The total amount of grafted polymer and the grafting efficiency were evaluated for different mol. weights (5870-12150 g·mol-1) of the grafted polymer, the polymer addition approach (batch or semibatch) and the initial polymer loading (2.5, 5, or 10 g polymer/g SNP). The proposed approach presented in this work to graft modify SNP allows for a precise surface modification of the nanoparticles, while permitting that the final properties of the resulting biohybrid to be tunable according to the choice of polymer grafted.

Biomacromolecules published new progress about Coating materials. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, HPLC of Formula: 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khan, Nazish; Pradhan, Alka published the artcile< Synthesis and characterization of some unique oxazolone analogs>, COA of Formula: C9H7ClO, the main research area is oxazolone preparation; phenylpropenoyl amino acetic acid aldehyde condensation.

A series of oxazolone derivatives have been prepared by the condensation of {[(2E)-3-phenylprop-2-enoyl]amino}acetic acid with different aldehydes in presence of ethanol, acetic anhydride and sodium acetate.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Wenmu; Chen, Guang; Zhang, Suobo; Wang, He; Yan, Donghang published the artcile< Synthesis and properties of novel regioirregular polyimides from easily synthesized asymmetrical dichlorophthalimide monomers>, Application of C8H3ClO3, the main research area is asym dichlorophthalimide monomer regioirregular polyimide.

New asym. aromatic dichlorophthalimide monomers containing pendant groups (trifluoromethyl or methyl) were conveniently prepared from inexpensive and com. available compounds With these monomers, a new class of soluble polyimides with a regioirregular structure within the polymer backbone was obtained by the Ni(0)-catalyzed polymerization method. The structures of the polymers were confirmed by various spectroscopic techniques. The polyimides displayed better solubility and higher thermal stability than the corresponding regular polyimides. In addition, fluorinated polyimides in this study had low dielec. constants ranging from 2.52 to 2.78, low moisture absorptions of less than 0.59%, and low thermal expansion coefficients between 10.6 and 19.7 ppm/°C. The oxygen permeability coefficients and permeability selectivity of oxygen to nitrogen of the films were in the ranges of 2.99-4.20 barrer and 5.55-7.50, resp. We have demonstrated that the synthetic pathway for polyimides provides a successful approach to increasing the solubility and processability of polyimides without sacrificing their thermal stability.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about Dielectric constant. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jia, Degong; Ma, Long; Wang, Yuan; Zhang, Wenli; Li, Jing; Zhou, Yu; Wang, Jun published the artcile< Efficient CO2 enrichment and fixation by engineering micropores of multifunctional hypercrosslinked ionic polymers>, Name: 1-(Chloromethyl)-4-vinylbenzene, the main research area is hypercrosslinked ionic polymer preparation cycloaddition epoxide cyclic carbonate.

Efficient chem. fixation of carbon dioxide (CO2) into valuable fine chems. requires porous materials with highly active catalytic centers. Herein, multifunctional imidazolium based hypercrosslinked ionic polymers with versatile functional groups (sulfonic, hydroxyl, amino, carboxyl, and alkyl group), abundant microporosity and high ionic site d. were constructed in a two-step solvothermal route including free-radical copolymerization of divinylbenzene (DVB), 4-vinylbenzyl chloride (VBC) and imidazolium bromide ionic liquids (ILs) and successive Friedel-Crafts alkylation based hypercrosslinkage. The resultant hydroxyl-functional ionic polymer demonstrated promising performances in selective adsorption and conversion of CO2 via cycloaddition with epoxide. High yield associating with large turnover number (TON) and turnover frequency (TOF), stable reusability and well substrate compatibility were achieved, affording an efficient metal-free heterogeneous catalyst for CO2 fixation. The full microporous structure resulted in CO2 enrichment around the robust hydroxyl-functional ionic sites, showing a synergistic effect to promote CO2 transformation.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Adsorption. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Name: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Franchini, Davide; Dapiaggi, Federico; Pieraccini, Stefano; Forni, Alessandra; Sironi, Maurizio published the artcile< Halogen bonding in the framework of classical force fields: The case of chlorine>, Recommanded Product: 1-Chloro-3,5-difluorobenzene, the main research area is aryl chloride alanine halogen bonding Van der Waals force.

Halogen bonding is nowadays a consolidated tool in chem. Only recently, the importance of halogen bonding has been demonstrated also in biol. systems, owing to the presence of halogens in drugs. This interaction is due to the anisotropy of the electron d. around the halogen that leads to the formation of the ‘σ-hole’, which is responsible for the interaction with a nucleophile site. Unfortunately, classical force fields used in the study of ligand-receptor systems are not able to describe the ‘σ-hole’. Here, we propose a pseudo-atom based methodol. able to correctly describe halogen bonding involving chlorine using classical force field.

Chemical Physics Letters published new progress about Aryl chlorides Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Recommanded Product: 1-Chloro-3,5-difluorobenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Zixu; Sun, Ruixue; Feng, Shengyu; Wang, Dengxu; Liu, Hongzhi published the artcile< Porosity-Induced Selective Sensing of Iodide in Aqueous Solution by a Fluorescent Imidazolium-Based Ionic Porous Framework>, COA of Formula: C9H9Cl, the main research area is porosity fluorescence imidazolium sensor iodide framework; imidazolium; iodide sensing; paper sensor; porous polymers; silsesquioxane.

Developing a chemosensor for rapid, sensitive, and visual detection of iodide (I-) by a simple synthetic strategy is still challenging. Herein, the authors report a highly efficient iodide sensor by simply introducing ionic imidazolium groups into the porous network. This sensor, i.e., a fluorescent ionic porous framework (IPF), was prepared by the quaternization reaction of octa((benzylchloride)ethenyl)silsesquioxane and 1,4-bis(1H-imidazole-1-yl)benzene and exhibited moderate porosity with a Brunauer-Emmett-Teller surface area of 379 m2 g-1 and blue fluorescence when excited by UV light. The IPF suspension in water can detect I- with high sensitivity and selectivity among various anions and quick response by fluorescence quenching. In contrast to no response toward I- by the linear model compound and the enhanced sensing performance with an increment of porosity, this finding indicates that the porosity of IPF is important for the detection of I- and an inducement of the sensing process. A fluorescent paper sensor was further developed, which shows high efficiency for the visual detection of I- similar to the abovementioned sensor, suggesting its potential in convenient and on-site sensing of I-. In addition, the paper sensor is recyclable with a remarkable fluorescence resuming ratio of 83% after 10 times cycle detection. Moreover, the developed sensor is used for the anal. of real samples. This work represents the first example of the detection of I- by an ionic porous polymer. Compared with conventional iodide sensors, the present sensor does not require unique structures to form the pseudocavity during sensing I- and can easily achieve high efficiency by incorporating ionic hydrogen bond donors into the porous network, indicating the importance of porosity and the feasibility of replacing the pseudocavity with a real cavity (or pore). More iodide sensors with high efficiency can be designed and fabricated by this novel and simple strategy.

ACS Applied Materials & Interfaces published new progress about Drinking waters. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics