Month: October 2022

Chen, Xiaohong; Liu, Xiaoguang; Martinez, Jenny S.; Mohr, Justin T. published the artcile< Practical regioselective halogenation of vinylogous esters: synthesis of differentiated mono-haloresorcinols and polyhalogenated resorcinols>, Electric Literature of 42413-03-6, the main research area is regioselective halogenation vinylogous ester; synthesis differentiated haloresorcinol polyhalogenated resorcinol.

A practical and efficient method for the direct, regioselective conversion of vinylogous esters to haloresorcinols is reported. Control of the reaction conditions enables synthesis of either the 4- or 6-haloresorcinol isomers from a common precursor with excellent regiocontrol and high yield. The generality and functional group tolerance of this novel protocol is demonstrated. The utility of this methodol. to access polyhaloresorcinols is also reported. These methods create useful functionalized building blocks for further synthetic applications.

Tetrahedron published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (vinylogous). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Electric Literature of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Yan; Wang, Zhenbo; Ding, Caifeng; Luo, Xiliang published the artcile< Ratiometric antifouling electrochemiluminescence biosensor based on bi-functional peptides and low toxic quantum dots>, Recommanded Product: Indium(III) chloride tetrahydrate, the main research area is quantum dot peptide antifouling electrochemiluminescence biosensor.

It is a great challenge to detect the target selectively and accurately in complex biol. samples. A ratiometric signal amplification strategy based on antifouling peptide is proposed to detect thrombin (TB) in this work. The electrode is modified with conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and Au@Luminol. Then the bi-functional peptide anchors to the modified electrode and captures the low toxic electrochemiluminescence (ECL) probe. The bi-functional peptide includes a new antifouling sequence (DRDRDRDR) and a TB recognizable sequence (SGRPVLG), while the former can greatly reduce the non-specific adsorption in complex samples and the latter can be cleaved by TB. The new self-enhanced luminescence probe labeled as PAMAM-QDs is composed of low toxic and water-soluble CuInZnS/ZnS quantum dots (CIZS/ZnS QDs) and polyamidoamine (PAMAM) via amide bonds. Concentration of TB can be obtained via the ratio of the signals of ECLQDs/ECLAu@Luminol accurately and sensitively. The ECL biosensor with the detection line 1.82 fM can work from 10 fM to 1 nM. Thanks to the antifouling property of the designed peptide and the amplification of the new ECL probe, the biosensor can be used for quantifying TB in practical complex samples with high selectivity and sensitivity.

Sensors and Actuators, B: Chemical published new progress about Bioelectric current, current-potential relationship. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Recommanded Product: Indium(III) chloride tetrahydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Yang; Ohnoutek, Lukas; Ajmal, Saira; Zheng, Xiuzhen; Feng, Yiqing; Li, Kejian; Wang, Tao; Deng, Yue; Liu, Yangyang; Xu, Dong; Valev, Ventsislav K.; Zhang, Liwu published the artcile< ""Hot edges"" in an inverse opal structure enable efficient CO2 electrochemical reduction and sensitive in situ Raman characterization>, COA of Formula: Cl3H8InO4, the main research area is carbon dioxide electrochem reduction sensitivity inverse opal structure.

Conversion of CO2 into fuels and chems. via electroreduction has attracted significant interest. Via mesostructure design to tune the elec. field distribution in the electrode, it is demonstrated that the Cu-In alloy with an inverse opal (CI-1-IO) structure provides efficient electrochem. CO2 reduction and allows for sensitive detection of the CO2 reduction intermediates via surface-enhanced Raman scattering. The significant enhancement of Raman signals of the intermediates on the CI-1-IO surface can be attributed to elec. field enhancement on the “”hot edges”” of the inverse opal structure. Addnl., a highest CO2 reduction faradaic efficiency (FE) of 92% (sum of formate and CO) is achieved at -0.6 V vs. RHE on the CI-1-IO electrode. The diffuse reflectance IR Fourier transform spectroscopy (DRIFTS) results show that the Cu-In alloy with an inverse opal structure has faster adsorption kinetics and higher adsorption capacity for CO2. The “”hot edges”” of the bowl-like structure concentrate elec. fields, due to the high curvature, and also concentrate K+ on the active sites, which can lower the energy barrier of the CO2 reduction reaction. This research provides new insight into the design of materials for efficient CO2 conversion and the detection of intermediates during the CO2 reduction process.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Current density. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, COA of Formula: Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Derand, Renaud; Bulteau-Pignoux, Laurence; Mettey, Yvette; Zegarra-Moran, Olga; Howell, L. Daniel; Randak, Christoph; Galietta, Luis J. V.; Cohn, Jonathan A.; Norez, Caroline; Romio, Leila; Vierfond, Jean-Michel; Joffre, Michel; Becq, Frederic published the artcile< Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation>, Synthetic Route of 2905-54-6, the main research area is cystic fibrosis transmembrane conductance regulator mutant activation MPB91 preparation; benzoquinolizinium derivative preparation activation CFTR chloride channel mutant.

We have designed and synthesized benzo[c]quinolizinium derivatives and evaluated their effects on the activity of G551D cystic fibrosis transmembrane conductance regulator (CFTR) expressed in Chinese hamster ovary and Fisher rat thyroid cells. We demonstrated, using iodide efflux, whole cell patch clamp, and short-circuit recordings, that 5-butyl-6-hydroxy-10-chlorobenzo[c]quinolizinium chloride (MPB-91) restored the activity of G551D CFTR (EC50 = 85 μM) and activated CFTR in Calu-3 cells (EC50 = 47 μM). MPB-91 has no effect on the ATPase activity of wild-type and G551D NBD1/R/GST fusion proteins or on the ATPase, GTPase, and adenylate kinase activities of purified NBD2. The activation of CFTR by MPB-91 is independent of phosphorylation because (1) kinase inhibitors have no effect and (2) the compound still activated CFTR having 10 mutated protein kinase A sites (10SA-CFTR). The new pharmacol. agent MPB-91 may be an important candidate drug to ameliorate the ion transport defect associated with CF and to point out a new pathway to modulate CFTR activity.

American Journal of Physiology published new progress about CFTR (cystic fibrosis transmembrane conductance regulator) Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Synthetic Route of 2905-54-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yi, Xiaofeng; Wang, Di; Li, Fan; Zhang, Jian; Zhang, Lei published the artcile< Molecular bixbyite-like In12-oxo clusters with tunable functionalization sites for lithography patterning applications>, Recommanded Product: Indium(III) chloride tetrahydrate, the main research area is indium oxo cluster mol bixbyite lithog patterning application.

Indium oxides have been widely applied in many technol. areas, but their utilization in lithog. has not been developed. Herein, we illustrated a family of unprecedented In12-oxo clusters with a general formula [In12(Μ4-O)4(Μ2-OH)2(OCH2CH2NHCH2CH2O)2(OR)4X4]X2 (where X = Cl or Br; R = CH3, C6H4NO2 or C6H4F), which not only present the largest size record in the family of indium-oxo clusters (InOCs), but also feature the first mol. model of bixbyite-type In2O3. Moreover, through the labile coordination sites of the robust diethanolamine-stabilized In12-oxo core, these InOCs can be accurately functionalized with different halides and alc. or phenol derivatives, producing tunable solubility Based on the high solution stability as confirmed by ESI-MS anal., homogeneous films can be fabricated using these In12-oxo clusters by the spin-coating method, which can be further used for electron beam lithog. (EBL) patterning studies. Accordingly, the above structural regulations have significantly influenced their corresponding film quality and patterning performance, with bromide or p-nitrophenol functionalized In12-oxo clusters displaying better performance of sub-50 nm lines. Thus, the here developed bixbyite-type In12-oxo cluster starts the research on indium-based patterning materials and provides a new platform for future lithog. radiation mechanism studies.

Chemical Science published new progress about Atomic force spectroscopy. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Recommanded Product: Indium(III) chloride tetrahydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Hang; Wang, Peng; Suzuki, Shin; Farmer, Marcus E.; Yu, Jin-Quan published the artcile< Ligand Promoted meta-C-H Chlorination of Anilines and Phenols>, Synthetic Route of 29027-20-1, the main research area is regioselective chlorination aniline phenol norbornene mediator.

Pd-Catalyzed meta-C-H chlorination of anilines and phenols was developed using norbornene as the mediator. Heterocycles, including indole, thiophene, and indazole, are tolerated. The identification of a new pyridone-based ligand, I (R = CF3, cyano), was crucial for the success of this meta-C-H chlorination reaction. Subsequent diverse transformations of the chlorinated products demonstrate the versatility of meta-C-H chlorination.

Journal of the American Chemical Society published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Synthetic Route of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Melngaile, Renate; Sperga, Arturs; Baldridge, Kim K.; Veliks, Janis published the artcile< Diastereoselective Monofluorocyclopropanation Using Fluoromethylsulfonium Salts>, Formula: C7H7ClO4S2, the main research area is diastereoselective monofluorocyclopropanation vinyl sulfone sulfonamide; monofluorocyclopropanation fluoromethylsulfonium salt.

Diarylfluoromethylsulfonium salts, alternatives to freons or advanced fluorinated building blocks, are bench stable and easy-to-use sources of direct fluoromethylene (:CHF) transfer to alkenes. These salts enabled development of a trans-selective monofluorinated Johnson-Corey-Chaykovsky reaction with vinyl sulfones or vinyl sulfonamides to access synthetically challenging monofluorocyclopropane scaffolds. The described method offers rapid access to monofluorinated cyclopropane building blocks with further functionalization opportunities to deliver more complex synthetic targets diastereoselectively.

Organic Letters published new progress about Arenesulfonium compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Formula: C7H7ClO4S2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Moon, Jihyeon; Seo, Kyutae; Kang, Hyo published the artcile< Vertical alignment of liquid crystals on comb-like renewable chavicol-modified polystyrene>, Formula: C9H9Cl, the main research area is vertical alignment liquid crystal chavicol polystyrene copolymer; alignment; chavicol; liquid crystal; phytochemical; renewable.

This study demonstrates liquid crystal (LC) alignment behaviors on the surface of phytochem.-based and renewable chavicol-modified polystyrene (PCHA#, # = 20, 40, 60, 80, and 100, where # represent the molar content of chavicol moiety in the side group) via polymer modification reactions. Generally, a LC cell fabricated with a polymer film containing a high molar content of the chavicol side group exhibited a vertical LC alignment property. There is a correlation between the vertical alignment of LC mols. and the polar surface energy value of the polymer films. Therefore, vertical LC alignment was observed when the polar surface energy values of these polymer films were smaller than about 1.3 mJ/m2, induced by the nonpolar chavicol moiety having long and bulky carbon groups. Aligning stability under harsh conditions such as UV irradiation of about 5 J/cm2 was observed in the LC cells fabricated from PCHA 100 film. Therefore, it was found that the plant-based chavicol-substituted polymer system can produce an eco-friendly and sustainable LC alignment layer for next-generation applications.

Polymers (Basel, Switzerland) published new progress about Contact angle (water, diiodomethane). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Mu-Yi; Pannecoucke, Xavier; Jubault, Philippe; Besset, Tatiana published the artcile< Pd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature>, Computed Properties of 128-09-6, the main research area is palladium catalyzed stereoselective chlorination acrylamide.

In this Letter, the transition-metal-catalyzed chlorination of alkenes is reported. In the presence of the com. available and inexpensive N-chlorosuccinimide and without additive, the Pd-catalyzed chlorination of acrylamides by C-H bond activation was developed at room temperature under air. Under these mild reaction conditions, the versatility of the methodol. was demonstrated as an array of acrylamides was functionalized to selectively provide the corresponding difficult-to-synthesize chlorinated olefins as a single Z stereoisomer. Mechanistic studies were conducted to get insights into the reaction mechanism, and post-functionalization reactions further demonstrated the synthetic utility of the approach toward the access to high value-added chlorinated compounds

Organic Letters published new progress about Acrylamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Computed Properties of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carmona, Maria; Rodriguez, Ricardo; Passarelli, Vincenzo; Carmona, Daniel published the artcile< Mechanism of the Alkylation of Indoles with Nitrostyrenes Catalyzed by Chiral-at-Metal Complexes>, Electric Literature of 5153-70-8, the main research area is alkylation indole nitrostyrene catalyzed chiral phosphinobenzyl pyridylmethyl amine rhodium; mol structure calculation phosphinobenzyl pyridylmethyl amine rhodium nitrostyrene complex.

Chiral-at-metal rhodium(III) complexes of the formula [Rh(κ4C,N,N’,P-L)A(Solv)][SbF6]n (Solv = A = MeCN, n = 2 (1); Solv = H2O, A = MeCN, n = 2 (2); Solv = MeCN, A = Cl, n = 1 (3); Solv = H2O, A = Cl, n = 1 (4)) catalyze the Friedel-Crafts reaction of trans-β-nitrostyrene and N-methyl-2-methylindole. Complex 4 reacts with trans-β-nitrostyrene, affording [RhCl(κ4C,N,N’,P-L)(trans-β-nitrostyrene)]+ (5). In the presence of N-methyl-2-methylindole, complex 5 reversibly gives a mixture of aci-nitro complexes 6 in high diastereoselectivity which, in turn, evolve to the FC adducts through 1,3-prototropy mediated by a water mol. On the basis of exptl. NMR studies and DFT calculations, a detailed mechanistic pathway for the alkylation reaction is proposed, including an explanation of the origin of the measured enantiomeric ratio.

Organometallics published new progress about Alkylation. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Electric Literature of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics