Month: October 2022

El Nady, Jehan; Ali, Magdy; Kamel, Ola A.; Ebrahim, Shaker; Soliman, Moataz published the artcile< Room temperature synthesis of aqueous ZnCuInS/ZnS quantum dots>, Electric Literature of 22519-64-8, the main research area is zinc sulfide quantum dot room temperature.

In this work a new method was developed for synthesis of aqueous cadmium-free, CuInS (CIS) quantum dots (QDs) at room temperature CIS QDs as cores were alloyed with 25% of Zn2+ ions at room temperature and followed by the growth of ZnS shell to form CIS and ZCIS QDs. X-ray diffraction (XRD) anal. confirmed that the ZCIS QDs have a wurtzite structure. Moreover, the energy-dispersive X-ray (EDX) anal. demonstrated that ZCIS QDs are composed of Cu, In, Zn and S elements. It was found that Zn ions introduced into CIS QDs lattice structure did not change in the crystal structure. ZCIS/ZnS QDs showed high photoluminescence (PL) peak and its position and intensity depend on the Cu:In ratio. High resolution transmission electron microscope (HRTEM) images showed that ZCIS and ZCIS/ZnS QDs have a spherical shape with average diameter sizes of 4.0 nm and 7.0 nm, resp. The selected area electron diffraction (SAED) suggested that the prepared ZCIS QDs are crystalline with an interplanar distance of 0.320 nm.

Journal of Dispersion Science and Technology published new progress about Crystal growth. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Electric Literature of 22519-64-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sonawane, Rahul B.; Sonawane, Swapnali R.; Rasal, Nishant K.; Jagtap, Sangeeta V. published the artcile< Room-Temperature, Base-Mediated Selective Synthesis of 2-(Arylamino)ethanols and 2-Aryloxyethanols>, Reference of 611-19-8, the main research area is aniline chloroethanol potassium dichromate alkylation; phenyllamino ethanol bishydroxyethyl aniline preparation; phenol chloroethanol potassium dichromate alkylation; phenoxyethanol preparation.

A simple and efficient protocol for base-mediated selective synthesis of 2-(arylamino)ethanols from primary aromatic amines and 2-aryloxyethanols from phenols, promoted by K2CO3 was achieved under mild conditions. Even in presence of excess alkyl halide, selective mono-N-alkylation was achieved. Tolerance of a variety of functional groups was demonstrated by 15 examples of selective N-alkylation of aromatic amines and 19 examples of O-alkylation of phenols. The efficacy of the protocol was demonstrated by the formal synthesis of Ticlopidine, Vildagliptin, Quetiapine and Gemfibrozil .

SynOpen published new progress about Alkylation. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Reference of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Bo; Sun, Jianfei; Mei, Qiong; An, Zexiu; Wang, Xueyu; Cao, Haijie; Han, Dandan; He, Maoxia published the artcile< Feasibility of carbon-doped BN nanosheets as photocatalyst for degradation of 4-chloroguaiacol and ecotoxicity fate during indirect photochemical transformation>, Recommanded Product: 4-Chloro-2-methoxyphenol, the main research area is chloroguaiacol water degradation oxidation photocatalyst carbon boron nitride ecotoxicity.

Although carbon-doped BN nanosheet (BCN) has been successfully synthesized and used, it has not been reported as a photocatalyst for the degradation of organic pollutants. In this study, 4-chloroguaiacol (4-CG) was selected as a representative substance to investigate the potential of utilizing BCN as photocatalyst for organic removal by use of computational simulation. The adsorption mechanisms, degradation mechanisms, and kinetics of 4-CG with the presence of different catalysts were determined The adsorption energy of 4-CG on BCN was 10.71 kcal mol-1, and the ΔG≠s of initial reactions of 4-CG with ·OH were also reduced onto the BCN substrate. The band gap of BCN was 1.54 eV. Our computations depicted that the doping of aromatic carbon into BN narrows bandgap, and retains well catalytic performance and adsorption properties. Therefore, BCN nanosheet is a promising photocatalyst for organic pollutants removal. Possible degradation pathways of 4-CG and aquatic toxicity assessment during degradation were also carried out. More toxic products would be formed and the transformation products were still harmful to three trophic levels of aquatic organisms (fish, green algae, and daphnia).

Journal of Catalysis published new progress about Adsorption. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Recommanded Product: 4-Chloro-2-methoxyphenol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liang, He; Yin, Jie; Man, Kenny; Yang, Xuebin B.; Calciolari, Elena; Donos, Nikolaos; Russell, Stephen J.; Wood, David J.; Tronci, Giuseppe published the artcile< A long-lasting guided bone regeneration membrane from sequentially functionalised photoactive atelocollagen>, Safety of 1-(Chloromethyl)-4-vinylbenzene, the main research area is bone regeneration membrane photoactive atelocollagen; Atelocollagen; Barrier membrane; Enzymatic stability; Guided Bone Regeneration; Sequential functionalisation; UV curing.

The fast degradation of collagen-based membranes in the biol. environment remains a critical challenge, resulting in underperforming Guided Bone Regeneration (GBR) therapy leading to compromised clin. results. Photoactive atelocollagen (AC) systems functionalised with ethylenically unsaturated monomers, such as 4-vinylbenzyl chloride (4VBC), have been shown to generate mech. competent materials for wound healing, inflammation control and drug delivery, whereby control of the mol. architecture of the AC network is key. Building on this platform, the sequential functionalisation with 4VBC and methacrylic anhydride (MA) was hypothesised to generate UV-cured AC hydrogels with reduced swelling ratio, increased proteolytic stability and barrier functionality for GBR therapy. The sequentially functionalised atelocollagen precursor (SAP) was characterised via TNBS and ninhydrin colorimetric assays, CD and UV-curing rheometry, which confirmed nearly complete consumption of collagen′s primary amino groups, preserved triple helixes and fast (< 180 s) gelation kinetics, resp. Hydrogel′s swelling ratio and compression modulus were adjusted depending on the aqueous environment used for UV-curing, while the sequential functionalisation of AC successfully generated hydrogels with superior proteolytic stability in vitro compared to both 4VBC-functionalised control and the com. dental membrane Bio-Gide. These in vitro results were confirmed in vivo via both s.c. implantation and a proof-of-concept study in a GBR calvarial model, indicating integrity of the hydrogel and barrier defect, as well as tissue formation following 1-mo implantation in rats. Collagen-based membranes remain a key component in Guided Bone Regeneration (GBR) therapy, but their properties, e.g. proteolytic stability and soft tissue barrier functionality, are still far from optimal. This is largely attributed to the complex mol. configuration of collagen, which makes chem. accessibility and structure-function relations challenging. Here, we fabricated a UV-cured hydrogel network of atelocollagen, whereby triple helixes were sequentially functionalised with two distinct ethylenically unsaturated monomers. The effects of the sequential functionalisation and UV-curing on the macroscopic properties, degradation behavior and GBR capability were investigated in vitro and in vivo. The results highlight the key role of the sequential functionalisation and provide important insights for the design of future, longer-lasting resorbable membranes for GBR therapy. Acta Biomaterialia published new progress about Bone. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Safety of 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lan, Xingwang; Li, Qing; Cao, Lili; Du, Cheng; Ricardez-Sandoval, Luis; Bai, Guoyi published the artcile< Rebuilding supramolecular aggregates to porous hollow N-doped carbon tube inlaid with ultrasmall Ag nanoparticles: A highly efficient catalyst for CO2 conversion>, Application In Synthesis of 3240-10-6, the main research area is alkyne carboxylation nitrogen doped carbon tube silver nanoparticle catalyst.

Fabrication of novel heterogeneous catalysts with well-designed structures is unusually intriguing for CO2 conversion. In this study, we have prepared a porous hollow N-doped carbon tube through the pyrolysis of self-assembled melamine cyanurate aggregate supramol. precursor. Ultrasmall Ag nanoparticles were tightly anchored in the hollow N-doped carbon tube via an in-situ fabrication. The average size of Ag nanoparticles was confined in only 2.19 nm with the assistance of abundant surface functional groups and porous structures. Addnl., inherent hollow N-doped carbon tube structure could prevent nanoparticles aggregating and leaching; also, they facilitated gas adsorption and mass transfer in CO2 catalysis. Due to their remarkable properties, the novel material was utilized as heterogeneous catalyst for the carboxylation of alkynes with CO2, and exhibited outstanding catalytic activity and stability at ambient pressure and low temperature

Applied Surface Science published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Application In Synthesis of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Blazejewski, Jean Claude; Dorme, Regine; Wakselman, Claude published the artcile< Chlorous acid oxidation of trifluoromethylphenols: cyclopentenolones by benzilic acid ring contraction>, Formula: C7H4ClF3O, the main research area is oxidation fluoromethylphenol chlorous acid; chlorohydroxyoxotrifluoromethylcyclopentenecarboxylic acid preparation decarboxylation; cyclopentenecarboxylic acid chloro hydroxy oxo fluoromethyl; cyclopentanedione chloro fluoromethyl.

HClO2 oxidation of 2- and 3-F3CC6H4OH initially gives isolable (trifluoromethyl)cyclopentenecarboxylic acid I, which decarboxylates upon heating to give 2-chloro-2-(trifluoromethyl)-1,3-cyclopentanedione.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Oxidation. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Formula: C7H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Giorgianni, Giuliana; Nori, Valeria; Baschieri, Andrea; Palombi, Laura; Carlone, Armando published the artcile< Organocatalyzed Michael addition to nitroalkenes via masked acetaldehyde>, Reference of 5153-70-8, the main research area is nitroaldehyde preparation enantioselective; acetaldehyde nitroalkene Michael addition organocatalyst.

A novel and safe reaction protocol for the enantioselective enamine-catalyzed addition of acetaldehyde to nitroalkenes R1CH=CHNO2 (R1 = Bu, 4-chloropheny, 2-phenylethyl, etc.) is presented; this protocol makes use of a safe acetaldehyde precursor to access important intermediates R/S-R1CH(CH2C(O)H)CH2NO2 to Active Pharmaceutical Ingredients (APIs), and allows the use of fewer equivalent of acetaldehyde and lower catalyst loadings. The reaction developed proved to be suitable to be performed on gram-scale and to produce key intermediates, such as (R)-5-methyl-3-(nitromethyl)hexanal for the synthesis of pharmacol. active compounds such as pregabalin.

Catalysts published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (nitro). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Reference of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Harmsen, S.; Meijerman, I.; Beijnen, J. H.; Schellens, J. H. M. published the artcile< Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor>, Name: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is pregnane X receptor cytochrome P450 3A4 colon adenocarcinoma anticancer.

Induction of cytochrome P 450 (CYP) 3A4, an enzyme that is involved in the biotransformation of more than 50% of all drugs, by xenobiotics is an important cause of pharmacokinetic drug-drug interactions in oncol. In addition to rifampicin and hyperforin, the anticancer drug paclitaxel has also been shown to be an inducer of CYP3A4 via activation of the pregnane X receptor (PXR). We therefore screened 18 widely used anticancer drugs for their ability to activate PXR-mediated CYP3A4 induction. A CYP3A4 reporter gene assay was employed to identify PXR agonists among the eighteen anticancer drugs. Subsequently CYP3A4 mRNA and protein expression following treatment with these PXR agonists was assessed. Finally, the effect of pre-treatment with these agents on the 1′-hydroxylation of midazolam (a specific CYP3A4 probe) was determined Paclitaxel, erlotinib, tamoxifen, ifosfamide, flutamide and docetaxel are able to activate PXR, while only strong PXR activation leads to significant induction of CYP3A4 activity. The identified PXR agonists may have the propensity to cause clin. relevant drug-drug interactions as a result of CYP3A4 induction.

Cancer Chemotherapy and Pharmacology published new progress about Antitumor agents. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Name: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kalani, Komal; Chaturvedi, Vinita; Trivedi, Priyanka; Tondon, Sudeep; Srivastava, Santosh Kumar published the artcile< Dihydroartemisinin and its Analogs: A New Class of Antitubercular Agents>, Application of C9H7ClO, the main research area is Mycobacterium dihydroartemisinin antitubercular agent; Anti-tubercular activity; Dihydroartemisinin; Semi-synthetic derivatives; Synergistic effect Artemisia annua; Tuberculosis..

Chem. transformation of dihydroartemisinin for anti-tubercular lead optimization. Dihydroartemisinin, a metabolite of artemisinin was chem. converted into eight acyl derivatives and were evaluated for anti-tubercular potential against H37Rv virulent strain of Mycobacterium tuberculosis by agar-based proportion assay. Further, synergistic activity of 12-O-m-anisoyl dihydroartemisinin was also studied with the front-line anti-TB drugs, isoniazid and rifampicin. Results: The results showed that all the derivatives were active but out of eight, 12-O-m-anisoyl dihydroartemisinin and 12-O-p-anisoyl dihydroartemisinin were significantly active (MIC 25.0μg/mL). In synergistic activity evaluation, the 12-O-m-anisoyl dihydroartemisinin derivative showed reduction in MIC (by 1/8th, i.e. 3.12μg/mL and that of rifampicin by 1/4th, i.e. 0.05μg/mL) with the front-line anti-TB drug, rifampicin. The sumfractional inhibitory concentration (Σ FIC) was 0.375. These results suggested a synergistic effect of the 12-O-m-anisoyl dihydroartemisinin with rifampicin and established its base for the development of anti-tubercular agents from an in-expensive and non-toxic natural product. To the best of our knowledge this is the first ever report on the anti-tubercular potential of dihydroartemisinin and its derivatives

Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Mycobacterium tuberculosis. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nishii, Yuji; Ikeda, Mitsuhiro; Hayashi, Yoshihiro; Kawauchi, Susumu; Miura, Masahiro published the artcile< Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides>, COA of Formula: C4H4ClNO2, the main research area is arene triptycenyl sulfide catalyst electrophilic aromatic halogenation halosuccinimide regioselective; aryl halide preparation.

A Lewis base catalyst Trip-SMe (Trip = triptycenyl) for electrophilic aromatic halogenation using N-halosuccinimides (NXS) is introduced. In the presence of an appropriate activator (as a noncoordinating-anion source), a series of unactivated aromatic compounds were halogenated at ambient temperature using NXS. This catalytic system was applicable to transformations that are currently unachievable except for the use of Br2 or Cl2: e.g., multihalogenation of naphthalene, regioselective bromination of BINOL, etc. Controlled experiments revealed that the triptycenyl substituent exerts a crucial role for the catalytic activity, and kinetic experiments implied the occurrence of a sulfonium salt [Trip-S(Me)Br][SbF6] as an active species. Compared to simple dialkyl sulfides, Trip-SMe exhibited a significant charge-separated ion pair character within the halonium complex whose structural information was obtained by the single-crystal X-ray anal. A preliminary computational study disclosed that the π system of the triptycenyl functionality is a key motif to consolidate the enhancement of electrophilicity.

Journal of the American Chemical Society published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, COA of Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics