The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Category: chlorides-buliding-blocks.
Zhang, Mao-feng;Luo, Xiao-yu;Zhang, Cheng;Wang, Chao;Wu, Xi-shan;Xiang, Qiu-ping;Xu, Yong;Zhang, Yan research published 《 Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia》, the research content is summarized as follows. BRD4 plays a key role in the regulation of gene transcription and has been identified as an attractive target for cancer treatment. In this study, we designed 26 new compounds by modifying 3-ethyl-benzo[d]isoxazole core with sulfonamides. Most compounds exhibited potent BRD4 binding activities with ΔTm values exceeding 6 °C. Two crystal structures of N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-2methoxybenzenesulfonamide and N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide in complex with BRD4(1) were obtained to characterize the binding patterns. Compounds N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-2methoxybenzenesulfonamide and N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide were effective for BRD4(1) binding and showed remarkable anti-proliferative activity against MV4-11 cells with IC50 values of 0.78 and 0.87 μM. Furthermore, N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide (0.5-10 μM) concentration-dependently inhibited the expression levels of oncogenes including c-Myc and CDK6 in MV4-11 cells. Moreover, N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide (0.5-10 μM) concentration-dependently blocked cell cycle in MV4-11 cells at G0/G1 phase and induced cell apoptosis. Compound N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide may serve as a new lead compound for further drug development.
2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics