Chlorinated organic compounds are found in nearly every class of biomolecules. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Quality Control of 104-86-9.
Yao, Chuansheng;Jiang, Xiaoying;Zhao, Rui;Zhong, Zhichao;Ge, Jiamin;Zhu, Junlong;Ye, Xiang-Yang;Xie, Yuanyuan;Liu, Zhen;Xie, Tian;Bai, Renren research published 《 HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids》, the research content is summarized as follows. A series of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids inhibitors combining the typical pharmacophores of hydroxamic acid/o-aminobenzamide and propargylamine I [R = H, 2-Cl, 3-F, etc.] and II [R1 = H, 2-CH3, 4-F, etc.] were designed and synthesized as HDAC1/MAO-B dual inhibitors for the treatment of Alzheimer’s disease. Most of the hybrids displayed moderate to good MAO-B inhibitory activities. Among them, Hybrid I [R = 3-Cl] exhibited the most potent activity against MAO-B and HDAC1 (MAO-B, IC50 = 99.0 nM; HDAC1, IC50 = 21.4 nM) and excellent MAO selectively (MAO-A, IC50 = 9923.0 nM; SI = 100.2). Moreover, compound I [R = 3-Cl] significantly reversed Aβ1-42-induced PC12 cell damage and decreased the production of intracellular ROS, exhibiting favorable antioxidant activity. More importantly, hybrid If instantly penetrated the BBB and accumulated in brain tissue as well as markedly ameliorated cognitive dysfunction in a Morris water maze ICR mice model. In summary, HDAC1/MAO-B dual inhibitor I [R = 3-Cl] was a promising potential agent for the therapy of Alzheimer’s disease.
Quality Control of 104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics