The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Computed Properties of 3900-89-8.
Yang, Juan;Lai, Jixing;Kong, Wenlong;Li, Shengkun research published 《 Asymmetric Synthesis of Sakuranetin-Relevant Flavanones for the Identification of New Chiral Antifungal Leads》, the research content is summarized as follows. The sakuranetin-directed synergistic exploration of an asym. synthesis and an antifungal evaluation of chiral flavanones I [R = Ph, 2-chlorophenyl, naphthalen-2-yl, etc.; R1 = H, MeO; R2 = H, Me, MeO, F, Br; R3 = H, MeO, F, Br, OH] was reported. A new palladium catalytic system with CarOx-type ligands was successfully identified for the highly enantioselective addition of arylboronic acids to chromones. This enabled the facile and programmable construction of a constellation of chiral flavanones (up to 98% yield and 97% ee), in which (R)-pinostrobin was efficiently constructed without laborious protecting/deprotecting operations. Its good performance in asym. induction and functional tolerance expanded the chem. space of pharmaceutically important flavanones. The chiral differentiation of flavanones based on antifungal activity and a concise structure-activity relationship model was disclosed and summarized. This synergistic project culminated with acquisition of the naturally unprecedented flavanones with better antifungal potentials than sakuranetin, in which the R-enantiomer of flavanone I [R = 4-chlorophenyl, R1 = H, R2 = F, R3 = H] (EC50 = 0.8μM) demonstrated better performance than boscalid against Rhizoctonia solani. The novel scaffold and predicted new target compared with the com. fungicides in the FRAC reinforce the value of further exploration.
Computed Properties of 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics