Chloride substituents modify the physical properties of organic compounds in several ways. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Recommanded Product: (2-Chlorophenyl)boronic acid.
Willis, Nicky J.;Mahy, William;Sipthorp, James;Zhao, Yuguang;Woodward, Hannah L.;Atkinson, Benjamin N.;Bayle, Elliott D.;Svensson, Fredrik;Frew, Sarah;Jeganathan, Fiona;Monaghan, Amy;Benvegnu, Stefano;Jolly, Sarah;Vecchia, Luca;Ruza, Reinis R.;Kjaer, Svend;Howell, Steven;Snijders, Ambrosius P.;Bictash, Magda;Salinas, Patricia C.;Vincent, Jean-Paul;Jones, E. Yvonne;Whiting, Paul;Fish, Paul V. research published 《 Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit》, the research content is summarized as follows. Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human diseases such as colorectal cancer and Alzheimer’s disease, supporting the need to discover improved inhibitors, especially for use in models of neurodegeneration. Here, authors have described the discovery and profile of I (ARUK3001185) as a potent, selective, and brain-penetrant inhibitor of Notum activity suitable for oral dosing in rodent models of disease. Crystallog. fragment screening of the Diamond-SGC Poised Library for binding to Notum, supported by a biochem. enzyme assay to rank inhibition activity, identified II (R = H) and II (R = Cl) as a pair of outstanding hits. Fragment development of II delivered I that restored Wnt signaling in the presence of Notum in a cell-based reporter assay. Assessment in pharmacol. screens showed I to be selective against serine hydrolases, kinases, and drug targets.
3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Recommanded Product: (2-Chlorophenyl)boronic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics