The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Synthetic Route of 349-88-2.
Wang, Yi;Chen, Xiaoli;Lin, Shuang;Gao, Hui;Liu, Fu-Xiaomin;Zhou, Zhi;Yi, Wei research published 《 Hexafluoroisopropanol (HFIP)-prompted rearrangement of N-phenoxysulfonamides for the direct assembly of ortho-sulfonamide phenols: A combined experimental and computational study》, the research content is summarized as follows. Herein an efficient metal-free rearrangement reaction was developed for the construction of ortho-sulfonamide phenols I [R = H, 4-Me, 2,4,6-Cl3, etc.; R1 = H, 4-Me, 4-t-Bu, 3,5-di-Me] via HFIP-prompted intramol. sulfonamide group 1,3-migration. This protocol featured mild reaction conditions, broad functional group compatibility and good regioselectivity. Combined exptl. mechanistic study and detailed DFT calculations clarified the crucial role of HFIP mols. in facilitating this reaction and the unique hydrogen bond network had been deduced to account for the observed reactivity.
Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics