Chloride substituents modify the physical properties of organic compounds in several ways. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. HPLC of Formula: 3900-89-8.
Seal, Jonathan T.;Atkinson, Stephen J.;Bamborough, Paul;Bassil, Anna;Chung, Chun-wa;Foley, James;Gordon, Laurie;Grandi, Paola;Gray, James R. J.;Harrison, Lee A.;Kruger, Ryan G.;Matteo, Jeanne J.;McCabe, Michael T.;Messenger, Cassie;Mitchell, Darren;Phillipou, Alex;Preston, Alex;Prinjha, Rab K.;Rianjongdee, Francesco;Rioja, Inmaculada;Taylor, Simon;Wall, Ian D.;Watson, Robert J.;Woolven, James M.;Wyce, Anastasia;Zhang, Xi-Ping;Demont, Emmanuel H. research published 《 Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors》, the research content is summarized as follows. The profound efficacy of pan-BET inhibitors is well documented, but these epigenetic agents have shown pharmacol.-driven toxicity in oncol. clin. trials. The opportunity to identify inhibitors with an improved safety profile by selective targeting of a subset of the eight bromodomains of the BET family has triggered extensive medicinal chem. efforts. In this article, we disclose the identification of potent and selective drug-like pan-BD2 inhibitors such as pyrazole 23 (GSK809) and furan 24 (GSK743) that were derived from the pyrrole fragment 6. We transpose the key learnings from a previous pyridone series (GSK620 2 as a representative example) to this novel class of inhibitors, which are characterized by significantly improved solubility relative to our previous research.
HPLC of Formula: 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics