Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 12112-67-3, formula is C16H24Cl2Ir2, Name is Chloro(1,5-cyclooctadiene)iridium(I) dimer. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Computed Properties of 12112-67-3.
Qu, Bo;Wei, Xudong;Zeng, Xingzhong;Yang, Bing-Shiou;Desrosiers, Jean-Nicolas;Savoie, Jolaine;Wang, Jun;Marsini, Maurice A.;Li, Zhibin;Haddad, Nizar;Lorenz, Jon C.;Tielmann, Patrick;Maier, Nora;Song, Jinhua J.;Senanayake, Chris H. research published 《 Large-Scale Enantioselective Reduction of 2,3-Disubstituted Indenopyridine Enables a Practical Manufacturing Process for an 11β-HSD-1 Inhibitor》, the research content is summarized as follows. An economical and practical manufacturing process for an 11β-HSD-1 inhibitor was reported. The key feature of synthesis was identification of a unique and effective MeO-BoQPhos ligand for Ir-catalyzed asym. hydrogenation of a fused tricyclic indenopyridinium salt. It was first highly reactive chiral P,N ligand system to be utilized in asym. pyridine reduction The enantioenriched indanopiperidine was produced with a low catalyst loading of 1000 ppm [Ir(COD)Cl]2. The challenges and solutions for final active pharmaceutical ingredient (API) physicochem. properties were also described. This asym. synthesis of API was accomplished in 38% overall yield with >99.8% ee and >99.5 area % purity. This overall process resulted in a much shorter production cycle and significant waste reduction on manufacturing scale.
12112-67-3, Bis(1,5-cyclooctadiene)diiridium(I) is a useful research compound. Its molecular formula is C16H24Cl2Ir2-2 and its molecular weight is 671.7 g/mol. The purity is usually 95%.
Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.
Bis(1,5-cyclooctadiene)diiridium(I) dichloride is an acid that can be prepared using a preparative method. It is an organometallic compound that can be used in the cross-coupling of activated terminal alkynes with aryl halides. Bis(1,5-cyclooctadiene)diiridium(I) dichloride has been synthesized by reacting furfural with chloride and acetonitrile. The ligand used was 2,2′-bipyridine. The reaction time to produce bis(1,5-cyclooctadiene)diiridium(I) dichloride is approximately three hours.
, Computed Properties of 12112-67-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics