The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Quality Control of 6334-18-5.
Pedrood, Keyvan;Azizian, Homa;Montazer, Mohammad Nazari;Mohammadi-Khanaposhtani, Maryam;Asgari, Mohammad Sadegh;Asadi, Mehdi;Bahadorikhalili, Saeed;Rastegar, Hossein;Larijani, Bagher;Amanlou, Massoud;Mahdavi, Mohammad research published 《 Arylmethylene hydrazine derivatives containing 1,3-dimethylbarbituric moiety as novel urease inhibitors》, the research content is summarized as follows. A new series of arylmethylene hydrazine derivatives bearing 1,3-dimethylbarbituric moiety I (Ar = Ph, 2,3-dichlorophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) was designed, synthesized, and evaluated for their in vitro urease inhibitory activity. All the title compounds I displayed high anti-urease activity, with IC50 values in the range of 0.61 ± 0.06-4.56 ± 0.18μM as compared to the two standard inhibitors hydroxyurea (IC50 = 100 ± 0.15μM) and thiourea (IC50 = 23 ± 1.7μM). Among the synthesized compounds I, compound I (Ar = 2-nitrophenyl) with 2-nitro benzylidene group was found to be the most potent compound Kinetic study of this above compound revealed that it is a mix-mode inhibitor against urease. Evaluation of the interaction modes of the synthesized compounds in urease active site by mol. modeling revealed that that compounds with higher urease inhibitor activity (I (Ar = 2-nitrophenyl, thiophen-2-yl, 2,4-dihydroxyphenyl, 5-chloro-2-nitrophenyl, 4-nitrophenyl and naphthalen-1-yl), with IC50 of 0.61, 0.86, 1.2, 1.34, 1.33, 1.94μM, resp.) could interact with higher number of residues, specially Arg609, Cys592 (as part of urease active site flap) and showed higher computed free energy, while compounds with lower urease activity (I (Ar = 4-chlorophenyl, 5-chlorothiophen-2-yl, 3-bromophenyl and Ph) with IC50 of 3.56, 4.56, 3.62 and 4.43μM, resp.) and could not provide the proper interaction with Arg609, and Cys592 as the key interacting residues along with lower free binding energy. MD investigation revealed that compound I (Ar = 2-nitrophenyl) interacted with Arg609 and Cys592 which are of the key residues at the root part of mobile flap covering the active site. Interaction with the mentioned residue for a significant amount of time affects the flexibility of the mobile flap covering the active site and causes inhibition of the ureolytic activity. Furthermore, in silico physico-chem. study of compounds I predicted that all these compounds are drug-likeness with considerable orally availability.
Quality Control of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics